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Article: Intraoperative cholangiography and bile duct flushing in 47 dogs receiving laparoscopic cholecystectomy for benign gallbladder disease: A retrospective analysis

Kanai, Hiroo / Minamoto, Tomomi / Nukaya, Aya / Kondo, Motoki / Aso, Toshihide / Fujii, Ayako / Hagiwara, Ken

Veterinary surgery. 2022 July, v. 51 Suppl S1

2022

Abstract: OBJECTIVE: To describe a laparoscopic approach for performing intraoperative cholangiography (IOC) and bile duct flushing (BDF) during laparoscopic cholecystectomy (LC) in dogs. To investigate the clinical outcomes of dogs undergoing these procedures for ...

Abstract	OBJECTIVE: To describe a laparoscopic approach for performing intraoperative cholangiography (IOC) and bile duct flushing (BDF) during laparoscopic cholecystectomy (LC) in dogs. To investigate the clinical outcomes of dogs undergoing these procedures for the treatment of benign gallbladder disease, ie gallbladder mucocele (GM) or cholecystitis. STUDY DESIGN: Retrospective study. ANIMALS: Forty‐seven client‐owned dogs. METHODS: Medical records of client‐owned dogs with benign gallbladder diseases that underwent IOC and BDF during LC between September 2016 and December 2019 were reviewed. Of these dogs, only dogs with GM or cholecystitis were included in the study. The fundus dissection first method was used for LC. Intraoperative cholangiography and BDF procedures were performed laparoscopically using a catheter inserted into the cystic duct following dissection within the subserosal layer of the gallbladder. Videos recorded during each procedure were reviewed, and data on procedure duration, completion, outcome, and technical approach were recorded. RESULTS: Forty‐seven dogs were included in the study. The median procedure time for BDF and IOC was 4 min (range, 2‐48 min), and no intraoperative or postoperative complications occurred. CONCLUSION: During LC, BDF and IOC were performed safely and successfully. Intraoperative cholangiography identified obstructions and strictures in the common bile duct that were not detected using BDF alone. CLINICAL SIGNIFICANCE: Our findings suggest that BDF and IOC are both safe and time effective and should be considered for routine use by surgeons during LC.
Keywords	bile ducts ; catheters ; cholecystitis ; dissection ; gall bladder ; retrospective studies ; surgery
Language	English
Dates of publication	2022-07
Size	p. O150-O159.
Publishing place	John Wiley & Sons, Inc.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1491071-8
ISSN	1532-950X ; 0161-3499
ISSN (online)	1532-950X
ISSN	0161-3499
DOI	10.1111/vsu.13731
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Intraoperative cholangiography and bile duct flushing in 47 dogs receiving laparoscopic cholecystectomy for benign gallbladder disease: A retrospective analysis.

Kanai, Hiroo / Minamoto, Tomomi / Nukaya, Aya / Kondo, Motoki / Aso, Toshihide / Fujii, Ayako / Hagiwara, Ken

Veterinary surgery : VS

2021 Volume 51 Suppl 1, Page(s) O150–O159

Abstract: Objective: To describe a laparoscopic approach for performing intraoperative cholangiography (IOC) and bile duct flushing (BDF) during laparoscopic cholecystectomy (LC) in dogs. To investigate the clinical outcomes of dogs undergoing these procedures ... ...

Abstract	Objective: To describe a laparoscopic approach for performing intraoperative cholangiography (IOC) and bile duct flushing (BDF) during laparoscopic cholecystectomy (LC) in dogs. To investigate the clinical outcomes of dogs undergoing these procedures for the treatment of benign gallbladder disease, ie gallbladder mucocele (GM) or cholecystitis. Study design: Retrospective study. Animals: Forty-seven client-owned dogs. Methods: Medical records of client-owned dogs with benign gallbladder diseases that underwent IOC and BDF during LC between September 2016 and December 2019 were reviewed. Of these dogs, only dogs with GM or cholecystitis were included in the study. The fundus dissection first method was used for LC. Intraoperative cholangiography and BDF procedures were performed laparoscopically using a catheter inserted into the cystic duct following dissection within the subserosal layer of the gallbladder. Videos recorded during each procedure were reviewed, and data on procedure duration, completion, outcome, and technical approach were recorded. Results: Forty-seven dogs were included in the study. The median procedure time for BDF and IOC was 4 min (range, 2-48 min), and no intraoperative or postoperative complications occurred. Conclusion: During LC, BDF and IOC were performed safely and successfully. Intraoperative cholangiography identified obstructions and strictures in the common bile duct that were not detected using BDF alone. Clinical significance: Our findings suggest that BDF and IOC are both safe and time effective and should be considered for routine use by surgeons during LC.
MeSH term(s)	Animals ; Bile Ducts/surgery ; Cholangiography/methods ; Cholangiography/veterinary ; Cholecystectomy, Laparoscopic/methods ; Cholecystectomy, Laparoscopic/veterinary ; Cholecystitis/surgery ; Cholecystitis/veterinary ; Dog Diseases/diagnostic imaging ; Dog Diseases/surgery ; Dogs ; Gallbladder Diseases/surgery ; Gallbladder Diseases/veterinary ; Intraoperative Care/veterinary ; Retrospective Studies
Language	English
Publishing date	2021-09-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491071-8
ISSN	1532-950X ; 0161-3499
ISSN (online)	1532-950X
ISSN	0161-3499
DOI	10.1111/vsu.13731
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Article: Canine idiopathic chylothorax: Anatomic characterization of the pre‐ and postoperative thoracic duct using computed tomography lymphography

Kanai, Hiroo / Furuya, Masaru / Yoneji, Kensuke / Hagiwara, Ken / Nukaya, Aya / Kondo, Motoki / Aso, Toshihide / Fujii, Ayako / Sasai, Kazumi

Veterinary radiology & ultrasound. 2021 July, v. 62, no. 4

2021

Abstract: Surgical treatment has improved the prognosis of canine idiopathic chylothorax, although a recurrence of the disease occurs occasionally after the procedure. An improved understanding of possible causes for this recurrence would be helpful for prognosis ... ...

Abstract	Surgical treatment has improved the prognosis of canine idiopathic chylothorax, although a recurrence of the disease occurs occasionally after the procedure. An improved understanding of possible causes for this recurrence would be helpful for prognosis and treatment planning in affected patients. In this retrospective case series study, we described the detailed pre‐ and postoperative computed tomographic lymphography (CTLG) imaging characteristics for a group of dogs with surgically confirmed idiopathic chylothorax. Preoperative CTLG was performed in 12 of 14 dogs diagnosed with idiopathic chylothorax. Thoracic ducts were present on the right side in 10 dogs, left side in one dog, and bilaterally in one dog. All the 14 dogs received a combination therapy of pericardiectomy and thoracic duct ligation (TDL) by video‐assisted thoracoscopic surgery. One week after surgery, a postoperative CTLG was performed, and the thoracic ducts were apparent in seven of 14 dogs. Three dogs had an unchanged course of the thoracic duct, which could have resulted from a missed duct. Four dogs were identified as having a bypass formation: the oblique duct originated at the ligation site and connected to the duct on the other side. Our findings indicated that one of the possible causes for postoperative recurrence of chylothorax in dogs could be “invisible or sleeping” fine ducts that are collapsed and not visible in preoperative CTLG scans. After TDL causes a change in the pressure of lymphatic flow, these fine thoracic ducts may become apparent using postoperative CTLG.
Keywords	chylothorax ; computed tomography ; dogs ; prognosis ; radiology ; thoracic duct ; thoracoscopy ; ultrasonics
Language	English
Dates of publication	2021-07
Size	p. 429-436.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2142058-0
ISSN	1740-8261 ; 1058-8183
ISSN (online)	1740-8261
ISSN	1058-8183
DOI	10.1111/vru.12966
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: To Be in Remission or in Corticosteroid-free Remission: That Is the Question for Women With Inflammatory Bowel Disease at Conception.

Kunisaki, Reiko / Ikeda, Aya / Yaguchi, Katsuki / Onishi, Misa / Shibui, Shunsuke / Nishida, Daisuke / Madarame, Akira / Toritani, Kenichiro / Nakamori, Yoshinori / Nishio, Masafumi / Ogashiwa, Tsuyoshi / Fujii, Ayako / Kimura, Hideaki / Suzuki, Ryoichi / Aoki, Shigeru / Maeda, Shin

Inflammatory bowel diseases

2023 Volume 29, Issue 6, Page(s) e20–e21

MeSH term(s)	Pregnancy ; Female ; Humans ; Colitis, Ulcerative ; Pregnant Women ; Inflammatory Bowel Diseases/drug therapy ; Crohn Disease ; Adrenal Cortex Hormones/therapeutic use
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2023-03-06
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izad023
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Canine idiopathic chylothorax: Anatomic characterization of the pre- and postoperative thoracic duct using computed tomography lymphography.

Kanai, Hiroo / Furuya, Masaru / Yoneji, Kensuke / Hagiwara, Ken / Nukaya, Aya / Kondo, Motoki / Aso, Toshihide / Fujii, Ayako / Sasai, Kazumi

Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

2021 Volume 62, Issue 4, Page(s) 429–436

Abstract	Surgical treatment has improved the prognosis of canine idiopathic chylothorax, although a recurrence of the disease occurs occasionally after the procedure. An improved understanding of possible causes for this recurrence would be helpful for prognosis and treatment planning in affected patients. In this retrospective case series study, we described the detailed pre- and postoperative computed tomographic lymphography (CTLG) imaging characteristics for a group of dogs with surgically confirmed idiopathic chylothorax. Preoperative CTLG was performed in 12 of 14 dogs diagnosed with idiopathic chylothorax. Thoracic ducts were present on the right side in 10 dogs, left side in one dog, and bilaterally in one dog. All the 14 dogs received a combination therapy of pericardiectomy and thoracic duct ligation (TDL) by video-assisted thoracoscopic surgery. One week after surgery, a postoperative CTLG was performed, and the thoracic ducts were apparent in seven of 14 dogs. Three dogs had an unchanged course of the thoracic duct, which could have resulted from a missed duct. Four dogs were identified as having a bypass formation: the oblique duct originated at the ligation site and connected to the duct on the other side. Our findings indicated that one of the possible causes for postoperative recurrence of chylothorax in dogs could be "invisible or sleeping" fine ducts that are collapsed and not visible in preoperative CTLG scans. After TDL causes a change in the pressure of lymphatic flow, these fine thoracic ducts may become apparent using postoperative CTLG.
MeSH term(s)	Animals ; Chylothorax/diagnostic imaging ; Chylothorax/pathology ; Chylothorax/surgery ; Chylothorax/veterinary ; Dog Diseases/diagnostic imaging ; Dog Diseases/pathology ; Dog Diseases/surgery ; Dogs ; Lymphography/veterinary ; Male ; Pericardiectomy/veterinary ; Postoperative Period ; Preoperative Period ; Recurrence ; Retrospective Studies ; Thoracic Duct/surgery ; Tomography, X-Ray Computed/veterinary
Language	English
Publishing date	2021-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2142058-0
ISSN	1740-8261 ; 1058-8183
ISSN (online)	1740-8261
ISSN	1058-8183
DOI	10.1111/vru.12966
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identifying the origin of nitrous oxide dissolved in deep ocean by concentration and isotopocule analyses.

Toyoda, Sakae / Yoshida, Osamu / Yamagishi, Hiroaki / Fujii, Ayako / Yoshida, Naohiro / Watanabe, Shuichi

Scientific reports

2019 Volume 9, Issue 1, Page(s) 7790

Abstract: Nitrous oxide ( ... ...

Abstract	Nitrous oxide (N
Language	English
Publishing date	2019-05-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-44224-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficacy of en bloc thoracic duct ligation in combination with pericardiectomy by video-assisted thoracoscopic surgery for canine idiopathic chylothorax.

Kanai, Hiroo / Furuya, Masaru / Hagiwara, Ken / Nukaya, Aya / Kondo, Motoki / Aso, Toshihide / Fujii, Ayako / Sasai, Kazumi

Veterinary surgery : VS

2019 Volume 49 Suppl 1, Page(s) O102–O111

Abstract: Objective: To compare the outcomes of pericardiectomy performed with conventional clipping thoracic duct ligation (C-TDL) to those with en bloc thoracic duct ligation (EB-TDL) using video-assisted thoracoscopic surgery (VATS) for canine idiopathic ... ...

Abstract	Objective: To compare the outcomes of pericardiectomy performed with conventional clipping thoracic duct ligation (C-TDL) to those with en bloc thoracic duct ligation (EB-TDL) using video-assisted thoracoscopic surgery (VATS) for canine idiopathic chylothorax. Study design: Retrospective consecutive case series. Animals: Thirteen client-owned dogs with idiopathic chylothorax. Methods: Medical records of dogs treated with pericardiectomy in combination with TDL by VATS without intraoperative contrast were reviewed. Five and seven dogs underwent C-TDL and EB-TDL, respectively, and 11 dogs were evaluated by preoperative and 7- to 10-days-postoperative computed tomography-lymphography (CTLG). No clinical symptoms with absent or minimal pleural effusion was defined as clinical improvement. Long-term remission (LTR) was defined as rapid resolution of pleural effusion and no recurrence for more than 1 year. Anesthesia time, operation time, the duration of hospitalization, and time until pleural effusion resolution were compared. Results: Clinical improvement was achieved in 91.7% of the cases (C-TDL, 4/5; EB-TDL, 7/7), excluding one case of intraoperative death. The LTR rate was significantly higher with EB-TDL (6/7 [85.7%]) than with C-TDL (1/5 [20%]). Anesthesia time, operation time, and time until pleural effusion resolution were significantly better with EB-TDL than with C-TDL. The rates of thoracic ducts visualization by postoperative CTLG were 100% (5/5) with C-TDL and 42.9% (3/7) with EB-TDL. Conclusion: En bloc TDL was an effective treatment for canine idiopathic chylothorax in this patient population. It compared favorably to C-TDL, although missed branches at the time of surgery may explain the difference between C-TDL and EB-TDL in this small population of cases. Clinical significance: En bloc TDL by VATS was an effective minimally invasive treatment for canine idiopathic chylothorax. Computed tomography-lymphography can be used for surgical planning and postoperative evaluation.
MeSH term(s)	Animals ; Chylothorax/surgery ; Chylothorax/veterinary ; Dog Diseases/surgery ; Dogs ; Female ; Ligation/methods ; Ligation/veterinary ; Lymphography/veterinary ; Male ; Pericardiectomy/veterinary ; Pleural Effusion/veterinary ; Postoperative Period ; Recurrence ; Retrospective Studies ; Thoracic Duct/surgery ; Thoracic Surgery, Video-Assisted/methods ; Thoracic Surgery, Video-Assisted/veterinary ; Treatment Outcome
Language	English
Publishing date	2019-12-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491071-8
ISSN	1532-950X ; 0161-3499
ISSN (online)	1532-950X
ISSN	0161-3499
DOI	10.1111/vsu.13370
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effective photoexcitation in gold nanowells based on localized surface plasmon.

Ishida, Akito / Fujii, Ayako

Chemical communications (Cambridge, England)

2005 , Issue 5, Page(s) 608–610

Abstract: The localization of the surface plasmon (SP) field in nanospace using wavelength-sized gold wells prepared on a glass substrate and its application to excite fluorophores immobilized on the bottom surfaces have been studied. ...

Abstract	The localization of the surface plasmon (SP) field in nanospace using wavelength-sized gold wells prepared on a glass substrate and its application to excite fluorophores immobilized on the bottom surfaces have been studied.
Language	English
Publishing date	2005-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/b413847c
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Article: Effective photoexcitation in gold nanowells based on localized surface plasmon

Ishida, Akito / Fujii, Ayako

Chemical communications. 2005 Jan. 25, , no. 5

2005

Abstract	The localization of the surface plasmon (SP) field in nanospace using wavelength-sized gold wells prepared on a glass substrate and its application to excite fluorophores immobilized on the bottom surfaces have been studied.
Keywords	fluorescent dyes ; glass ; gold ; nanogold ; photochemical reactions
Language	English
Dates of publication	2005-0125
Size	p. 608-610.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/b413847c
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Dexamethasone-mediated transcriptional regulation of rat carboxylesterase 2 gene.

Hori, Takeshi / Jin, Liangjing / Fujii, Ayako / Furihata, Tomomi / Nagahara, Yuko / Chiba, Kan / Hosokawa, Masakiyo

Xenobiotica; the fate of foreign compounds in biological systems

2012 Volume 42, Issue 7, Page(s) 614–623

Abstract: Rat carboxylesterase 2 (rCES2), which was previously identified as a methylprednisolone 21-hemisuccinate hydrolase, is highly inducible by dexamethasone in the liver. In the present study, we investigated the molecular mechanisms by which this induction ... ...

Abstract	Rat carboxylesterase 2 (rCES2), which was previously identified as a methylprednisolone 21-hemisuccinate hydrolase, is highly inducible by dexamethasone in the liver. In the present study, we investigated the molecular mechanisms by which this induction occurs. Injection of dexamethasone (1 mg/kg weight) into rats resulted in increases in the expression of rCES2 mRNA in a time-dependent manner with a peak at 12 h after injection. In primary rat hepatocytes, the expression level of rCES2 mRNA was increased by treatment with 100 nM dexamethasone, and the increase was completely blocked in the presence of 10 µM mifepristone (RU-486), a potent inhibitor of glucocorticoid receptor (GR), or 10 µg/mL cycloheximide, a translation inhibitor. Luciferase assays revealed that 100 nM dexamethasone increased rCES2 promoter activities, although the effect of dexamethasone on the promoter activity was smaller than that on rCES2 mRNA expression. The increased activities were completely inhibited by treatment of the hepatocytes with 10 µM RU-486. Based on these results, it is concluded that dexamethasone enhances transcription of the rCES2 gene via GR in the rat liver and that the dexamethasone-mediated induction of rCES2 mRNA may be dependent on de novo protein synthesis. Our results provide clues to understanding what compounds induce rCES2.
MeSH term(s)	Animals ; Carboxylesterase/genetics ; Carboxylesterase/metabolism ; Cells, Cultured ; Dexamethasone/administration & dosage ; Dexamethasone/metabolism ; Dexamethasone/pharmacology ; Gene Expression Regulation/drug effects ; Glucocorticoids/administration & dosage ; Glucocorticoids/metabolism ; Glucocorticoids/pharmacology ; Hepatocytes ; Male ; Mifepristone/pharmacology ; Promoter Regions, Genetic ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Glucocorticoid/metabolism ; Transcription, Genetic
Chemical Substances	Glucocorticoids ; RNA, Messenger ; Receptors, Glucocorticoid ; Mifepristone (320T6RNW1F) ; Dexamethasone (7S5I7G3JQL) ; Carboxylesterase (EC 3.1.1.1)
Language	English
Publishing date	2012-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120287-x
ISSN	1366-5928 ; 0049-8254
ISSN (online)	1366-5928
ISSN	0049-8254
DOI	10.3109/00498254.2011.648670
Database	MEDical Literature Analysis and Retrieval System OnLINE

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ab Jg. 2022: Lesesaal (EG)

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