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Article ; Online: Time course of capillary regression and an expression balance between vascular endothelial growth factor-A and thrombospondin-1 in the soleus muscle of hindlimb unloaded rats.

Tanaka, Masayuki / Kanazashi, Miho / Kondo, Hiroyo / Fujino, Hidemi

2022 Volume 65, Issue 3, Page(s) 350–360

Abstract: Introduction/aims: Skeletal muscle capillaries regress with disuse; however, information on time-dependent changes in the expression of pro- and anti-angiogenic factors in disused muscle is limited. This study aimed to clarify time-dependent changes in ... ...

Abstract	Introduction/aims: Skeletal muscle capillaries regress with disuse; however, information on time-dependent changes in the expression of pro- and anti-angiogenic factors in disused muscle is limited. This study aimed to clarify time-dependent changes in skeletal muscle capillarization, pro-angiogenic vascular endothelial growth factor-A (VEGF-A), and anti-angiogenic thrombospondin-1 (TSP-1) in the soleus muscle of hindlimb unloaded rat. Methods: Eight-week-old male Sprague Dawley rats were randomly divided into four groups corresponding to different hindlimb unloading (HU) duration at 0, 1, 2, and 3 wk. Results: Muscle atrophy and capillary regression worsened in the soleus muscle with longer periods of HU. The VEGF-A protein expression level was lower at week 1 than at week 0. In addition, the value at week 3 was also lower than those at weeks 0, 1, and 2. The TSP-1 protein expression level was higher at week 1 than that at week 0 but was similar at weeks 2 and 3. Moreover, reactive oxygen species, assessed by dihydroethidium fluorescence intensity on cryosection, were higher at weeks 2 and 3 than that at week 0. Discussion: Depending on the HU period, VEGF-A and TSP-1 showed different expression patterns. In the early HU phase, TSP-1 may play an important role in capillary regression. However, when HU extends for a longer period, decreased VEGF-A, and/or increased oxidative stress may be more involved in capillary regression.
MeSH term(s)	Animals ; Capillaries/pathology ; Hindlimb ; Hindlimb Suspension/physiology ; Male ; Muscle, Skeletal/pathology ; Muscular Atrophy/pathology ; Rats ; Rats, Sprague-Dawley ; Thrombospondin 1/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Thrombospondin 1 ; Vascular Endothelial Growth Factor A ; thrombospondin 1, rat ; vascular endothelial growth factor A, rat
Language	English
Publishing date	2022-01-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	438353-9
ISSN	1097-4598 ; 0148-639X
ISSN (online)	1097-4598
ISSN	0148-639X
DOI	10.1002/mus.27478
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Article ; Online: Impacts of Astaxanthin Supplementation on Walking Capacity by Reducing Oxidative Stress in Nursing Home Residents.

Nakanishi, Ryosuke / Kanazashi, Miho / Tanaka, Masayuki / Tanaka, Minoru / Fujino, Hidemi

International journal of environmental research and public health

2022 Volume 19, Issue 20

Abstract: Oxidative stress is associated with deterioration of endurance and muscle strength, which are mostly accompanied by aging. Astaxanthin supplement has excellent antioxidant activity without any pro-oxidative properties. In this study, we investigated how ... ...

Abstract	Oxidative stress is associated with deterioration of endurance and muscle strength, which are mostly accompanied by aging. Astaxanthin supplement has excellent antioxidant activity without any pro-oxidative properties. In this study, we investigated how astaxanthin supplementation affects walking endurance and muscle strength in nursing home residents. Healthy elderly individuals (age: 67 to 94) were divided into two groups: 13 subjects received a daily dose of 24 mg of astaxanthin for 16 weeks (astaxanthin group) and 11 subjects received a placebo (placebo group). These subjects were compared using body component measurements, serum d-ROM levels, the distance of 6-min walking, blood lactate levels after the 6-min walking test, and muscle strength. After supplementation, the levels of d-ROMs and blood lactate after the 6-min walking test in the astaxanthin group significantly decreased compared with the placebo group (
MeSH term(s)	Humans ; Aged ; Aged, 80 and over ; Antioxidants/pharmacology ; Walking ; Oxidative Stress ; Dietary Supplements ; Lactic Acid ; Nursing Homes
Chemical Substances	astaxanthine (8XPW32PR7I) ; Antioxidants ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2022-10-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192013492
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Article ; Online: Facilitatory effect of low-pulse repetition frequency ultrasound on release of extracellular vesicles from cultured myotubes.

Ma, Xiaoqi / Yamaguchi, Atomu / Maeshige, Noriaki / Tanida, Kento / Uemura, Mikiko / Lu, Fuwen / Kondo, Hiroyo / Fujino, Hidemi

Journal of medical ultrasonics (2001)

2024

Abstract: Purpose: Extracellular vesicles (EVs) serve as carriers of intracellular factors with therapeutic effects, including tissue regeneration and attenuation of inflammatory responses. The majority of EVs in vivo are derived from skeletal muscle, which is ... ...

Abstract	Purpose: Extracellular vesicles (EVs) serve as carriers of intracellular factors with therapeutic effects, including tissue regeneration and attenuation of inflammatory responses. The majority of EVs in vivo are derived from skeletal muscle, which is reported to have anti-inflammatory effects. While high-intensity pulsed ultrasound (US) irradiation has been shown to promote EV secretion from myotubes, the impact of pulse repetition frequency, a US parameter affecting pulse length, on EV release remains unclear. This study aimed to investigate the impact of pulse repetition frequency of US on the release of EVs from myotubes. Methods: C2C12 myoblasts were used in this study. After differentiation into C2C12 myotubes, US was performed for 5 min at an intensity of 3.0 W/cm Results: US did not cause a reduction in cell viability across all US groups compared to the control. The concentration of EVs was significantly higher in all US groups compared to the control group. In particular, the highest increase was observed in the 1-Hz group on EV concentration as well as intracellular Ca Conclusion: This study investigated the effect of three different pulse repetition frequencies of US on the release of EVs from cultured myotubes. It is concluded that a low-pulse repetition frequency of 1 Hz is the most effective for enhancing EV release from cultured myotubes with pulsed ultrasound.
Language	English
Publishing date	2024-04-04
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1396630-3
ISSN	1613-2254 ; 0287-0592 ; 1346-4523
ISSN (online)	1613-2254
ISSN	0287-0592 ; 1346-4523
DOI	10.1007/s10396-024-01429-9
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Article: Lemon Myrtle (Backhousia citriodora) Extract and Its Active Compound, Casuarinin, Activate Skeletal Muscle Satellite Cells In Vitro and In Vivo

Yamamoto, Ayumi / Honda, Shinichi / Ogura, Mineko / Kato, Masanori / Tanigawa, Ryuichi / Fujino, Hidemi / Kawamoto, Seiji

Nutrients. 2022 Mar. 04, v. 14, no. 5

2022

Abstract: Sarcopenia is an age-related skeletal muscle atrophy. Exercise is effective in improving sarcopenia via two mechanisms: activation of skeletal muscle satellite cells (SCs) and stimulation of muscle protein synthesis. In contrast, most nutritional ... ...

Abstract	Sarcopenia is an age-related skeletal muscle atrophy. Exercise is effective in improving sarcopenia via two mechanisms: activation of skeletal muscle satellite cells (SCs) and stimulation of muscle protein synthesis. In contrast, most nutritional approaches for improving sarcopenia focus mainly on muscle protein synthesis, and little is known about SC activation. Here, we investigated the effect of lemon myrtle extract (LM) on SC activation both in vitro and in vivo. Primary SCs or myoblast cell lines were treated with LM or its derived compounds, and incorporation of 5-bromo-2′-deoxyuridine, an indicator of cell cycle progression, was detected by immunocytochemistry. We found that LM significantly activated SCs (p < 0.05), but not myoblasts. We also identified casuarinin, an ellagitannin, as the active compound in LM involved in SC activation. The structure–activity relationship analysis showed that rather than the structure of each functional group of casuarinin, its overall structure is crucial for SC activation. Furthermore, SC activation by LM and casuarinin was associated with upregulation of interleukin-6 mRNA expression, which is essential for SC activation and proliferation. Finally, oral administration of LM or casuarinin to rats showed significant activation of SCs in skeletal muscle (p < 0.05), suggesting that LM and casuarinin may serve as novel nutritional interventions for improving sarcopenia through activating SCs.
Keywords	Backhousia citriodora ; active ingredients ; cell cycle ; exercise ; gene expression ; immunocytochemistry ; interleukin-6 ; muscle protein ; myoblasts ; oral administration ; protein synthesis ; sarcopenia ; skeletal muscle ; structure-activity relationships
Language	English
Dates of publication	2022-0304
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14051078
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Article: Exercise preconditioning attenuates atrophic mediators and preserves muscle mass in acute sepsis.

Al-Nassan, Saad / Fujino, Hidemi

General physiology and biophysics

2018 Volume 37, Issue 4, Page(s) 433–441

Abstract: Sepsis is an inflammatory condition that causes a severe and rapid loss of body proteins, especially skeletal muscles. The ubiquitin-proteasome system plays a major role in skeletal muscle proteolysis. Understanding the effects of exercise ... ...

Abstract	Sepsis is an inflammatory condition that causes a severe and rapid loss of body proteins, especially skeletal muscles. The ubiquitin-proteasome system plays a major role in skeletal muscle proteolysis. Understanding the effects of exercise preconditioning on septic-induced ubiquitin-proteasome activation plays a pivotal role in planning rehabilitation strategies for patients who are susceptible for developing cachexia. In this study, we applied mild preconditioning exercises in the form of treadmill running for adult mice for a period of two weeks, before they were injected with lipopolysaccharide to induce sepsis. Our results show that the body weight and cross-sectional area (CSA) of muscle fibers were preserved in the pre-exercised mice. The main finding in our study was that pre-exercised mice maintained a low level of tumor necrosis factor-alpha in the gastrocnemius muscle, which resulted in a down-regulated profile of main atrophic mediators: p38, FOXO3A, and multi-ubiquitin proteins. By these findings, we conclude that a mild program of preconditioning exercises can prevent atrophy and preserve muscle mass in acute sepsis. This provides further evidence to the importance of rehabilitation planning in acute illness.
MeSH term(s)	Acute Disease ; Animals ; Gene Expression Regulation ; Male ; Mice ; Mice, Inbred ICR ; Muscles/metabolism ; Muscles/pathology ; Muscular Atrophy/complications ; Muscular Atrophy/metabolism ; Muscular Atrophy/pathology ; Muscular Atrophy/physiopathology ; Organ Size ; Physical Conditioning, Animal ; Sepsis/complications ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Tumor Necrosis Factor-alpha
Language	English
Publishing date	2018-06-29
Publishing country	Slovakia
Document type	Journal Article
ZDB-ID	791184-1
ISSN	0231-5882
ISSN	0231-5882
DOI	10.4149/gpb_2018001
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Article ; Online: Effects of reloading after chronic neuromuscular inactivity on the three-dimensional capillary architecture in rat soleus muscle.

Kanazashi, Miho / Tanaka, Masayuki / Maezawa, Toshiyuki / Fujino, Hidemi

Acta histochemica

2020 Volume 122, Issue 7, Page(s) 151617

Abstract: The purpose of the study was to investigate the effects of ambulatory reloading following hindlimb unloading on the three-dimensional (3D) capillary architecture of rat soleus muscle. In this study, 15 male Sprague-Dawley rats were used. The rats were ... ...

Abstract	The purpose of the study was to investigate the effects of ambulatory reloading following hindlimb unloading on the three-dimensional (3D) capillary architecture of rat soleus muscle. In this study, 15 male Sprague-Dawley rats were used. The rats were randomly assigned to the following 3 groups: a normal weight bearing control group (CON), 14 days of hindlimb unloading group (HU), and 14 days of hindlimb unloading followed by 7 days of ambulatory reloading group (HU-RL). The capillary diameter and volume were measured using confocal laser microscopy, and capillary number was determined by two-dimensional (2D) capillary staining in the soleus muscle of each group. The capillary diameter and volume as well as the capillary number were significantly lower in the HU group than in the CON group and significantly higher in the HU-RL group than in the HU group. These results provided novel information about the effectiveness of reloading following unloading on not only the 2D increase in capillary number but also the 3D capillary remodeling in the diameter and volume within the unloaded soleus muscle.
MeSH term(s)	Animals ; Capillaries/pathology ; Hindlimb/pathology ; Hindlimb Suspension/physiology ; Male ; Muscle, Skeletal/pathology ; Muscle, Skeletal/physiology ; Muscular Atrophy/pathology ; Organ Size/physiology ; Rats, Sprague-Dawley
Language	English
Publishing date	2020-08-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	77-2
ISSN	1618-0372 ; 0065-1281
ISSN (online)	1618-0372
ISSN	0065-1281
DOI	10.1016/j.acthis.2020.151617
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Article ; Online: Lemon Myrtle (

Yamamoto, Ayumi / Honda, Shinichi / Ogura, Mineko / Kato, Masanori / Tanigawa, Ryuichi / Fujino, Hidemi / Kawamoto, Seiji

Nutrients

2022 Volume 14, Issue 5

Abstract	Sarcopenia is an age-related skeletal muscle atrophy. Exercise is effective in improving sarcopenia via two mechanisms: activation of skeletal muscle satellite cells (SCs) and stimulation of muscle protein synthesis. In contrast, most nutritional approaches for improving sarcopenia focus mainly on muscle protein synthesis, and little is known about SC activation. Here, we investigated the effect of lemon myrtle extract (LM) on SC activation both in vitro and in vivo. Primary SCs or myoblast cell lines were treated with LM or its derived compounds, and incorporation of 5-bromo-2′-deoxyuridine, an indicator of cell cycle progression, was detected by immunocytochemistry. We found that LM significantly activated SCs (p < 0.05), but not myoblasts. We also identified casuarinin, an ellagitannin, as the active compound in LM involved in SC activation. The structure−activity relationship analysis showed that rather than the structure of each functional group of casuarinin, its overall structure is crucial for SC activation. Furthermore, SC activation by LM and casuarinin was associated with upregulation of interleukin-6 mRNA expression, which is essential for SC activation and proliferation. Finally, oral administration of LM or casuarinin to rats showed significant activation of SCs in skeletal muscle (p < 0.05), suggesting that LM and casuarinin may serve as novel nutritional interventions for improving sarcopenia through activating SCs.
MeSH term(s)	Animals ; Cells, Cultured ; Hydrolyzable Tannins/pharmacology ; Myrtaceae/chemistry ; Plant Extracts/pharmacology ; Rats ; Satellite Cells, Skeletal Muscle/drug effects ; Satellite Cells, Skeletal Muscle/metabolism
Chemical Substances	Hydrolyzable Tannins ; Plant Extracts ; casuarinin
Language	English
Publishing date	2022-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14051078
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Article ; Online: Beneficial effects of mild hyperbaric oxygen exposure on microcirculation in peripheral tissues in healthy subjects: a pilot study.

Nisa, Badur U / Hirabayashi, Takumi / Maeshige, Noriaki / Kondo, Hiroyo / Fujino, Hidemi

The Journal of sports medicine and physical fitness

2022 Volume 62, Issue 12, Page(s) 1600–1604

Abstract: Background: Exposure to mild hyperbaric oxygen (HBO) increases blood oxygenation by dissolving oxygen into blood plasma and increased oxygen bound to hemoglobin in red blood cells. This research is an attempt to provide insight into the responses of ... ...

Abstract	Background: Exposure to mild hyperbaric oxygen (HBO) increases blood oxygenation by dissolving oxygen into blood plasma and increased oxygen bound to hemoglobin in red blood cells. This research is an attempt to provide insight into the responses of exposure to mild HBO on microcirculation in peripheral tissues. Methods: Fifteen healthy individuals were exposed to normobaric oxygen (1.00 ATA, 20.9% oxygen, NBO) and mild HBO (1.4 ATA, 35-39.5% oxygen) in a mild HBO chamber for 70 minutes under each condition. Peripheral oxygen saturation (SpO<inf>2</inf>), heart rate, blood flow in skin, and hemodynamics in capillaries of finger nailfold were measured under both exposures. Results: The value of SpO<inf>2</inf> was increased from 98% to 100% after mild HBO exposure although that of SpO<inf>2</inf> under NBO was unaltered (P=0.000; P=0.818). Heart rate was decreased after exposure to the mild HBO although that unchanged under the NBO (P=0.000; P=0.706). The mean value of high frequency power in heart rate variability increased after exposure to the mild HBO (P=0.045). Average blood velocity and flow rate in capillaries of finger nailfold were not increased under to NBO whereas those were significantly increased from 92 μm/s to 126 μm/s (P=0.040, P=0.000), and 12247 μm/s to 20926 μm/s after exposure to mild HBO (P<0.05), (P=0.002, P=0.875), respectively. Conclusions: These results indicate that exposure to mild HBO increases blood flow in the capillaries of peripheral tissues by regulating parasympathetic nerve activities through increasing oxygen delivery, oxygen bound to hemoglobin in red blood cells and dissolved oxygen content in plasma.
MeSH term(s)	Humans ; Microcirculation ; Hyperbaric Oxygenation/methods ; Pilot Projects ; Healthy Volunteers ; Oxygen ; Hemoglobins
Chemical Substances	Oxygen (S88TT14065) ; Hemoglobins
Language	English
Publishing date	2022-02-18
Publishing country	Italy
Document type	Journal Article
ZDB-ID	410823-1
ISSN	1827-1928 ; 0022-4707
ISSN (online)	1827-1928
ISSN	0022-4707
DOI	10.23736/S0022-4707.22.13363-3
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Article ; Online: Enhancement of astaxanthin incorporation by pulsed high-intensity ultrasound in LPS-stimulated macrophages.

Ma, Xiaoqi / Yamaguchi, Atomu / Maeshige, Noriaki / Uemura, Mikiko / Noguchi, Hikari / Kondo, Hiroyo / Fujino, Hidemi

Journal of medical ultrasonics (2001)

2022 Volume 49, Issue 2, Page(s) 125–132

Abstract: Purpose: Ultrasound (US) has been reported to improve the permeability of cell membranes to pharmaceuticals by causing cavitation. Astaxanthin (AX) potently terminates the induction of inflammation, but it has low oral bioavailability, which limits its ... ...

Abstract	Purpose: Ultrasound (US) has been reported to improve the permeability of cell membranes to pharmaceuticals by causing cavitation. Astaxanthin (AX) potently terminates the induction of inflammation, but it has low oral bioavailability, which limits its incorporation in local cells and organs and its therapeutic potential. In this study, we aimed to investigate the contribution of US to AX incorporation to compensate for the limited incorporation of AX, and regulation of the pro-inflammatory factor interleukin-1β (IL-1β) by AX. Methods: Murine bone marrow-derived macrophages were stimulated by lipopolysaccharide (LPS). After 2 h, cells were treated with 10 μM AX and/or pulsed high-intensity US irradiation. The cells were then incubated for another 3 h and harvested. AX incorporation in cells was measured by absorbance, and the expression of IL-1β was measured by qPCR. All values are expressed as means ± standard error of the mean. Results: The combination of AX and US significantly increased AX incorporation in cells compared to AX alone (p < 0.05). In addition, this combination further suppressed the expression of IL-1β compared to AX alone (p < 0.05). Conclusion: Pulsed high-intensity US irradiation combined with AX treatment promoted AX incorporation in cells and enhanced the anti-inflammatory effect on macrophages.
MeSH term(s)	Animals ; Humans ; Inflammation/diagnostic imaging ; Lipopolysaccharides/metabolism ; Lipopolysaccharides/pharmacology ; Macrophages/metabolism ; Mice ; Xanthophylls/metabolism ; Xanthophylls/pharmacology ; Xanthophylls/therapeutic use
Chemical Substances	Lipopolysaccharides ; Xanthophylls ; astaxanthine (8XPW32PR7I)
Language	English
Publishing date	2022-01-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1396630-3
ISSN	1613-2254 ; 0287-0592 ; 1346-4523
ISSN (online)	1613-2254
ISSN	0287-0592 ; 1346-4523
DOI	10.1007/s10396-022-01189-4
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Article ; Online: Alternating current electromagnetic field exposure lessens intramyocellular lipid accumulation due to high-fat feeding via enhanced lipid metabolism in mice.

Nakanishi, Ryosuke / Tanaka, Masayuki / Nisa, Badur Un / Shimizu, Sayaka / Hirabayashi, Takumi / Tanaka, Minoru / Maeshige, Noriaki / Roy, Roland R / Fujino, Hidemi

PloS one

2023 Volume 18, Issue 11, Page(s) e0289086

Abstract: Long-term high-fat feeding results in intramyocellular lipid accumulation, leading to insulin resistance. Intramyocellular lipid accumulation is related to an energy imbalance between excess fat intake and fatty acid consumption. Alternating current ... ...

Abstract	Long-term high-fat feeding results in intramyocellular lipid accumulation, leading to insulin resistance. Intramyocellular lipid accumulation is related to an energy imbalance between excess fat intake and fatty acid consumption. Alternating current electromagnetic field exposure has been shown to enhance mitochondrial metabolism in the liver and sperm. Therefore, we hypothesized that alternating current electromagnetic field exposure would ameliorate high-fat diet-induced intramyocellular lipid accumulation via activation of fatty acid consumption. C57BL/6J mice were either fed a normal diet (ND), a normal diet and exposed to an alternating current electromagnetic field (ND+EMF), a high-fat diet (HFD), or a high-fat diet and exposed to an alternating current electromagnetic field (HFD+EMF). Electromagnetic field exposure was administered 8 hrs/day for 16 weeks using an alternating current electromagnetic field device (max.180 mT, Hokoen, Utatsu, Japan). Tibialis anterior muscles were collected for measurement of intramyocellular lipids, AMPK phosphorylation, FAT/CD-36, and carnitine palmitoyltransferase (CPT)-1b protein expression levels. Intramyocellular lipid levels were lower in the HFD + EMF than in the HFD group. The levels of AMPK phosphorylation, FAT/CD-36, and CPT-1b protein levels were higher in the HFD + EMF than in the HFD group. These results indicate that alternating current electromagnetic field exposure decreases intramyocellular lipid accumulation via increased fat consumption.
MeSH term(s)	Mice ; Male ; Animals ; Lipid Metabolism ; AMP-Activated Protein Kinases/metabolism ; Electromagnetic Fields ; Mice, Inbred C57BL ; Semen/metabolism ; Diet, High-Fat/adverse effects ; Fatty Acids/metabolism ; Liver/metabolism
Chemical Substances	AMP-Activated Protein Kinases (EC 2.7.11.31) ; Fatty Acids
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0289086
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