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Article ; Online: Anticoagulation for Atrial Fibrillation in Patients With Cancer.

Yasui, Taku / Fujita, Masashi

Circulation journal : official journal of the Japanese Circulation Society

2021 Volume 86, Issue 2, Page(s) 211–212

MeSH term(s)	Anticoagulants/adverse effects ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Blood Coagulation ; Humans ; Neoplasms/complications ; Neoplasms/drug therapy
Chemical Substances	Anticoagulants
Language	English
Publishing date	2021-12-28
Publishing country	Japan
Document type	Editorial ; Comment
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.CJ-21-1003
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Ui IV Zs.74: Show issues

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Article ; Online: Early add-on use of belimumab as induction therapy for patients with childhood-onset systemic lupus erythematosus.

Hashimoto, Shun / Fujita, Masashi / Aizawa, Tomomi / Watanabe, Shojiro / Tsugawa, Koji / Tanaka, Hiroshi

Lupus

2024 Volume 33, Issue 5, Page(s) 543–544

MeSH term(s)	Humans ; Child ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/chemically induced ; Induction Chemotherapy ; Antibodies, Monoclonal, Humanized/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Treatment Outcome
Chemical Substances	belimumab (73B0K5S26A) ; Antibodies, Monoclonal, Humanized ; Immunosuppressive Agents
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Letter
ZDB-ID	1154407-7
ISSN	1477-0962 ; 0961-2033
ISSN (online)	1477-0962
ISSN	0961-2033
DOI	10.1177/09612033241238867
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Zs.A 3717: Show issues

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Article ; Online: A case of a newly developed complicated cystic lesion in the liver.

Hayashi, Manabu / Otsuka, Mitsuru / Fujita, Masashi / Abe, Kazumichi / Takahashi, Atsushi / Ohira, Hiromasa

Journal of medical ultrasonics (2001)

2024

Language	English
Publishing date	2024-05-02
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1396630-3
ISSN	1613-2254 ; 0287-0592 ; 1346-4523
ISSN (online)	1613-2254
ISSN	0287-0592 ; 1346-4523
DOI	10.1007/s10396-024-01464-6
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Zs.B 2695: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.B 2695 -Engl.Ausg.-: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article: Circulating myostatin levels as a prognostic biomarker in patients with acute liver failure and late-onset hepatic failure.

Hayashi, Manabu / Abe, Kazumichi / Sugaya, Tatsuro / Takahata, Yosuke / Fujita, Masashi / Takahashi, Atsushi / Ohira, Hiromasa

Hepatology research : the official journal of the Japan Society of Hepatology

2024

Abstract: Aim: Myostatin is a myokine involved in muscle mass regulation. The associations between circulating myostatin levels and clinical characteristics in patients with acute liver failure (ALF) and late-onset hepatic failure (LOHF) are unclear.: Methods: ...

Abstract	Aim: Myostatin is a myokine involved in muscle mass regulation. The associations between circulating myostatin levels and clinical characteristics in patients with acute liver failure (ALF) and late-onset hepatic failure (LOHF) are unclear. Methods: In this retrospective study, 51 patients with ALF or LOHF were included. Serum myostatin was measured using an enzyme-linked immunosorbent assay. Results: Myostatin levels were significantly lower in patients with ALF and LOHF than in controls (ALF/LOHF: 2522 pg/mL, controls: 3853 pg/mL, p = 0.003). The prevalence of low myostatin in deceased patients was significantly higher than that in spontaneous survivors and patients who underwent liver transplantation. Patients with low myostatin levels had a high incidence of complications. There was a positive correlation between the psoas muscle index and serum myostatin levels. Patients with low myostatin levels had shorter 1-year transplant-free survival and shorter 1-year overall survival than patients with high myostatin levels. Low serum myostatin levels were associated with poor prognosis independent of the Japanese scoring system for ALF ≥3, King's College criteria, or model for end-stage liver disease score >30.5. The combination of serum myostatin levels and prognostic models for ALF significantly stratified patients according to 1-year prognosis. Conclusions: Low serum myostatin levels were associated with a low psoas muscle index, complication rate, and poor prognosis in patients with ALF and LOHF. Assessment of circulating myostatin levels may improve the prediction of outcomes in patients with ALF and LOHF.
Language	English
Publishing date	2024-04-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1387041-5
ISSN	1386-6346 ; 0928-4346
ISSN	1386-6346 ; 0928-4346
DOI	10.1111/hepr.14051
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Zs.A 3826: Show issues

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Article ; Online: Combination of psoas muscle mass index and neutrophil-to-lymphocyte ratio as a noninvasive prognostic marker in hepatocellular carcinoma patients undergoing radiofrequency ablation.

Hayashi, Manabu / Abe, Kazumichi / Fujita, Masashi / Takahashi, Atsushi / Ohira, Hiromasa

European journal of gastroenterology & hepatology

2023 Volume 35, Issue 5, Page(s) 568–574

Abstract: Aim: The psoas muscle index (PMI) and neutrophil-to-lymphocyte ratio (NLR) have been reported as useful noninvasive prognostic markers in patients with hepatocellular carcinoma (HCC). The usefulness of the combination of the PMI and NLR as a prognostic ... ...

Abstract	Aim: The psoas muscle index (PMI) and neutrophil-to-lymphocyte ratio (NLR) have been reported as useful noninvasive prognostic markers in patients with hepatocellular carcinoma (HCC). The usefulness of the combination of the PMI and NLR as a prognostic marker in HCC patients undergoing radiofrequency ablation (RFA) is unclear. Methods: We retrospectively analyzed the PMI and NLR in 112 patients undergoing RFA, including 40 patients aged 75 years and older (36%). The influence of the PMI and NLR on disease-free survival and overall survival (OS) was analyzed. Results: There were 66 patients with high PMI and low NLR values (58%), 36 patients with a low PMI or high NLR value (32%), and 10 patients with low PMI and high NLR values (9%). The combination of the PMI and NLR did not show a significant association with the disease-free survival rate. For patients aged ≥75 years, those with both low PMI and high NLR values showed significantly shorter OS periods (log-rank: P < 0.001). In the multivariate analysis, the combination of a low PMI value and high NLR value was significantly associated with shorter survival periods (hazard ratio: 19.72; 95% confidence interval, 4.933-78.8; P < 0.001). Conclusion: In this study, the combination of PMI and NLR was associated with prognosis in patients with early HCC and preserved liver function. The combination of the PMI and NLR may be a useful and noninvasive prognostic marker in HCC patients aged 75 years and older, as well as in younger patients.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Neutrophils/pathology ; Liver Neoplasms/pathology ; Prognosis ; Retrospective Studies ; Psoas Muscles/diagnostic imaging ; Psoas Muscles/pathology ; Lymphocytes ; Radiofrequency Ablation
Language	English
Publishing date	2023-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000002532
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Zs.A 2932: Show issues

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Article ; Online: Changes in platelet levels and prognosis in patients with acute liver failure and late-onset hepatic failure.

Hayashi, Manabu / Fujita, Masashi / Abe, Kazumichi / Takahashi, Atsushi / Ohira, Hiromasa

Medicine

2022 Volume 101, Issue 48, Page(s) e31438

Abstract: The therapeutic strategies for acute liver failure (ALF) and late-onset hepatic failure (LOHF) still have room for improvement. Recent studies have reported an association between platelets and the pathophysiology of ALF. In this study, we investigated ... ...

Abstract	The therapeutic strategies for acute liver failure (ALF) and late-onset hepatic failure (LOHF) still have room for improvement. Recent studies have reported an association between platelets and the pathophysiology of ALF. In this study, we investigated changes in platelet levels and clinical findings in ALF and LOHF patients. We retrospectively investigated the clinical data of 62 patients with ALF and LOHF. We analyzed the association between changes in platelet levels for 7 days after admission and the prognosis in patients with ALF and LOHF. The factors associated with changes in platelet levels were also analyzed. The platelet levels on days 1, 3, and 7 were significantly lower in the patients who died or underwent liver transplantation than in the spontaneous survivors. Administration of recombinant thrombomodulin was associated with spontaneous survival. The platelet levels in patients who met the King's College Hospital Criteria or the Japanese scoring system (JSS) for ALF ≥ 4 were significantly decreased 7 days after admission. The area under the receiver operating characteristic curve (AUROC) of a JSS score of 3 for predicting low platelet levels on day 7 was 0.903. Decreased platelet levels were associated with poor prognosis in patients with ALF and LOHF. The patients with low platelet levels and JSS scores on admission showed a high AUROC for predicting low platelet levels on day 7. Decreased platelet levels after admission may be a simple prognostic marker in ALF and LOHF patients.
MeSH term(s)	Humans ; Retrospective Studies ; Liver Failure ; Liver Failure, Acute
Language	English
Publishing date	2022-12-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000031438
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Article ; Online: Bacillus cereus Sepsis in a Patient with Severe Alcoholic Hepatitis: A Case Report.

Suto, Kazuto / Hayashi, Manabu / Fujita, Masashi / Abe, Kazumichi / Takahashi, Atsushi / Ohira, Hiromasa

Internal medicine (Tokyo, Japan)

2023

Abstract: A 57-year-old woman with a liver injury was referred to our hospital. She had a history of heavy alcohol consumption and had developed severe alcoholic hepatitis. Blood cultures revealed bacteremia caused by Bacillus cereus. The patient was treated with ... ...

Abstract	A 57-year-old woman with a liver injury was referred to our hospital. She had a history of heavy alcohol consumption and had developed severe alcoholic hepatitis. Blood cultures revealed bacteremia caused by Bacillus cereus. The patient was treated with short-term steroid therapy for liver injury and vancomycin administration for B. cereus sepsis, which led to recovery. The findings in the present case suggest the need for empirical therapy with vancomycin in patients with severe alcoholic hepatitis and suspected B. cereus infection.
Language	English
Publishing date	2023-11-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2553-23
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Article ; Online: Influence of serum Gas6 levels on prognosis in patients with hepatocellular carcinoma.

Hayashi, Manabu / Abe, Kazumichi / Sugaya, Tatsuro / Takahata, Yosuke / Fujita, Masashi / Takahashi, Atsushi / Ohira, Hiromasa

Japanese journal of clinical oncology

2023 Volume 54, Issue 1, Page(s) 62–69

Abstract: Objective: The prediction of prognosis in hepatocellular carcinoma patients is important for switching treatment. The association between circulating growth arrest-specific 6 levels and prognosis in hepatocellular carcinoma patients is unknown.: ... ...

Abstract	Objective: The prediction of prognosis in hepatocellular carcinoma patients is important for switching treatment. The association between circulating growth arrest-specific 6 levels and prognosis in hepatocellular carcinoma patients is unknown. Methods: We retrospectively analysed the association between serum growth arrest-specific 6 levels and clinical findings in 132 patients with hepatocellular carcinoma. Serum growth arrest-specific 6 levels were measured using enzyme-linked immunosorbent assay. Results: Amongst 132 patients, the Barcelona Clinic Liver Cancer stage was classified as 0, A, B, C and D in 19, 48, 41, 18 and 6 patients, respectively. Serum growth arrest-specific 6 levels in hepatocellular carcinoma patients were higher than those in healthy controls (28.4 ng/mL vs. 19.6 ng/mL, P < 0.001), and growth arrest-specific 6 levels were positively correlated with soluble Axl levels. In the entire cohort, high growth arrest-specific 6 levels were associated with a shorter survival period (hazard ratio: 1.78 per 20 ng/mL, 95% confidence interval: 1.01-3.16, P = 0.045). In early and intermediate-stage hepatocellular carcinoma patients treated with transcatheter arterial chemoembolization (n = 59), we determined a cut-off value of 36.4 ng/mL based on the receiver operating characteristic curve to predict death within 3 years, and high growth arrest-specific 6 levels were associated with a high cumulative incidence of portal vein tumour thrombosis (Gray's test: P = 0.010) and shorter overall survival (log-rank: P = 0.005). Conclusions: Serum growth arrest-specific 6 levels were associated with prognosis in hepatocellular carcinoma patients. In early and intermediate-stage hepatocellular carcinoma patients who underwent transcatheter arterial chemoembolization, high growth arrest-specific 6 levels were associated with a high incidence of portal vein tumour thrombosis. Circulating growth arrest-specific 6 levels may be a useful prognostic marker in hepatocellular carcinoma patients.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Chemoembolization, Therapeutic/adverse effects ; Liver Neoplasms/pathology ; Portal Vein/pathology ; Prognosis ; Retrospective Studies ; Treatment Outcome ; Venous Thrombosis/complications ; Venous Thrombosis/therapy
Chemical Substances	growth arrest-specific protein 6
Language	English
Publishing date	2023-10-06
Publishing country	England
Document type	Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyad132
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Article ; Online: Aseptic meningitis as initial presentation of subclinical Sjögren's syndrome: Could the cerebrospinal fluid anti-Ro/SSA and anti-La/SSB antibody system be the culprit?

Kurotaki, Keigo / Fujita, Masashi / Aizawa, Tomomi / Tsugawa, Koji / Tanaka, Hiroshi

Modern rheumatology case reports

2022 Volume 6, Issue 2, Page(s) 217–219

Abstract: Aseptic meningitis sometimes occurs as a consequence of central nervous system (CNS) involvement in patients with primary Sjögren's syndrome (SS), even in paediatric-onset cases. However, little information is available regarding the pathological role of ...

Abstract	Aseptic meningitis sometimes occurs as a consequence of central nervous system (CNS) involvement in patients with primary Sjögren's syndrome (SS), even in paediatric-onset cases. However, little information is available regarding the pathological role of CSF anti-Ro/SSA and anti-La/SSB antibodies in the CNS involvement in patients with primary SS. We experienced an 18-year-old adolescent female with a 7-year history of suspicion of subclinical SS who subsequently developed aseptic meningitis as an initial presentation of probable SS. Her CSF exhibited marked elevation of anti-Ro/SSA and anti-La/SSB antibodies. When compared to her CSF IgG/serum IgG ratio (0.0058), her CSF/serum ratios of anti-Ro/SSA and anti-La/SSB antibody titres were higher (0.448 and 0.068, respectively; these were 77.5 and 11.7 times higher than that of IgG, respectively), suggesting that regional production of these antibodies was attributable, at least partly, to the development of meningitis. After the initiation of prednisolone treatment, her clinical manifestations promptly subsided. Since the clinical and pathological roles of the Ro/SSA antibody system in several autoimmune conditions have been postulated, our clinical observation may add novel insight to this theory.
MeSH term(s)	Adolescent ; Autoimmune Diseases ; Child ; Female ; Humans ; Immunoglobulin G ; Meningitis, Aseptic/diagnosis ; Meningitis, Aseptic/etiology ; Sjogren's Syndrome/complications ; Sjogren's Syndrome/diagnosis
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2022-04-26
Publishing country	England
Document type	Journal Article ; Case Reports
ISSN	2472-5625
ISSN (online)	2472-5625
DOI	10.1093/mrcr/rxac011
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Article ; Online: Be aware of severe juvenile chronic iridocyclitis without evidence of arthritis: Juvenile chronic iridocyclitis revisited.

Tokutake, Haruka / Hashimoto, Shun / Fujita, Masashi / Tsugawa, Koji / Terui, Kiminori / Kudo, Asaka / Tanaka, Hiroshi

International journal of rheumatic diseases

2023 Volume 27, Issue 1, Page(s) e14913

MeSH term(s)	Humans ; Iridocyclitis/diagnosis ; Iridocyclitis/drug therapy ; Arthritis, Juvenile
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Letter
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.14913
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