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  1. Article: Case report: Young-onset large vessel ischemic stroke due to hyperhomocysteinemia associated with the C677T polymorphism on

    Fukae, Jiro / Eguchi, Hiroto / Wada, Yoichi / Fuse, Atsuhito / Chishima, Rika / Nakatani, Mitsuyoshi / Nakajima, Asuka / Hattori, Nobutaka / Shimo, Yasushi

    Frontiers in neurology

    2023  Volume 14, Page(s) 1183306

    Abstract: Hyperhomocysteinemia is an important risk factor for cerebral infarction. Herein, we report on a 30-year-old man previously diagnosed with epilepsy who presented with right hemiplegia and total aphasia. Magnetic resonance imaging showed a fronto-temporal ...

    Abstract Hyperhomocysteinemia is an important risk factor for cerebral infarction. Herein, we report on a 30-year-old man previously diagnosed with epilepsy who presented with right hemiplegia and total aphasia. Magnetic resonance imaging showed a fronto-temporal ischemic lesion due to occlusion of the left middle cerebral artery. Clinical testing and imaging demonstrated that he had hyperhomocysteinemia induced by multiple factors including the C677T polymorphism on 5.10-methylenetetrahydrofolate reductase (
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1183306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Intrajejunal Infusion of Levodopa/Carbidopa for Advanced Parkinson's Disease: A Systematic Review.

    Tsunemi, Taiji / Oyama, Genko / Saiki, Shinji / Hatano, Taku / Fukae, Jiro / Shimo, Yasushi / Hattori, Nobutaka

    Movement disorders : official journal of the Movement Disorder Society

    2021  Volume 36, Issue 8, Page(s) 1759–1771

    Abstract: Advanced Parkinson's disease is inconsistently defined, and evidence is lacking in relation to device-aided therapies. To update existing reviews of intrajejunal infusion of levodopa/carbidopa (LCIG), we performed a literature search for relevant ... ...

    Abstract Advanced Parkinson's disease is inconsistently defined, and evidence is lacking in relation to device-aided therapies. To update existing reviews of intrajejunal infusion of levodopa/carbidopa (LCIG), we performed a literature search for relevant articles (to November 3, 2020) using PubMed supplemented by hand searching. Retrieved articles were categorized by relevance to identified research questions, including motor complications and symptoms; nonmotor symptoms; functioning, quality of life, and caregiver burden; optimal timing of treatment initiation and administration duration; discontinuation; and complications. Most eligible studies (n = 56) were open-label, observational studies including relatively small patient numbers. LCIG consistently reduces OFF time and increased ON time without troublesome dyskinesia with varying effects regarding ON time with troublesome dyskinesia and the possibility of diphasic dyskinesia. More recent evidence provides some increased support for the benefits of LCIG in relation to nonmotor symptoms, quality of life, activities of daily living, and reduced caregiver burden. Patient age does not appear to significantly impact the effectiveness of LCIG. Discontinuation rates with LCIG (~17%-26%) commonly relate to device-related issues, although the ability to easily discontinue LCIG may represent a potential benefit. LCIG may be a favorable option for patients with advanced Parkinson's disease who show predominant nonmotor symptoms and vulnerability to complications of other advanced therapy modalities. Larger, well-controlled studies, including precise investigation of cost effectiveness, would further assist treatment selection. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
    MeSH term(s) Activities of Daily Living ; Antiparkinson Agents ; Carbidopa ; Drug Combinations ; Gels ; Humans ; Levodopa/adverse effects ; Parkinson Disease/drug therapy ; Quality of Life
    Chemical Substances Antiparkinson Agents ; Drug Combinations ; Gels ; Levodopa (46627O600J) ; Carbidopa (MNX7R8C5VO)
    Language English
    Publishing date 2021-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.28595
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2555: Show issues Location:
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    Zs.MO 238: Show issues

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  3. Article: Two rare diseases, acute calcific retropharyngeal tendinitis, and crowned dens syndrome, mimicking meningitis: A case report.

    Igami, Eriko / Fukae, Jiro / Kanazawa, Kazo / Fuse, Atsuhito / Nakajima, Asuka / Eguchi, Hiroto / Hattori, Nobutaka / Shimo, Yasushi

    Frontiers in neurology

    2022  Volume 13, Page(s) 946222

    Abstract: We report two rare cases. One involved acute calcific retropharyngeal tendinitis, an inflammatory condition of the longus colli tendon triggered by the deposition of calcium hydroxyapatite crystals. The other involved crowned dens syndrome, caused by ... ...

    Abstract We report two rare cases. One involved acute calcific retropharyngeal tendinitis, an inflammatory condition of the longus colli tendon triggered by the deposition of calcium hydroxyapatite crystals. The other involved crowned dens syndrome, caused by pseudogout of the atlantoaxial junction following deposition of calcium pyrophosphate dehydrate or calcium hydroxyapatite. Although these two diseases involve different mechanisms, the common symptoms of neck pain and fever resemble those of meningitis. Accurate diagnosis can thus be difficult without background knowledge of these conditions. Cerebrospinal fluid examination and cervical computed tomography are useful for distinguishing these pathologies from meningitis.
    Language English
    Publishing date 2022-10-21
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.946222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of Residual Drug in the Pharynx on the Delayed-On Phenomenon in Parkinson's Disease Patients.

    Fukae, Jiro / Fujioka, Shinsuke / Umemoto, George / Arahata, Hajime / Yanamoto, Shosaburo / Mishima, Takayasu / Tsuboi, Yoshio

    Movement disorders clinical practice

    2020  Volume 7, Issue 3, Page(s) 273–278

    Abstract: Background and objective: The delayed-on phenomenon (DOP) related to levodopa treatment frequently disturbs quality of life in advanced-stage Parkinson's disease (PD) patients. The objective of this study was to explore the impact of swallowing ... ...

    Abstract Background and objective: The delayed-on phenomenon (DOP) related to levodopa treatment frequently disturbs quality of life in advanced-stage Parkinson's disease (PD) patients. The objective of this study was to explore the impact of swallowing dysfunction on the development of DOP.
    Methods: Swallowing function was investigated by endoscopic evaluation in 11 PD patients with the DOP and 9 PD patients without the DOP during the
    Results: Residual drug was seen in the pharynx in six cases (30.0%). Pooling of saliva, delayed swallowing reflex, and residual drug were more frequent in the DOP group than in the group without the DOP (
    Conclusions: These results suggest that swallowing dysfunction leading to residual antiparkinsonian drug in the pharynx has substantial impacts on the DOP in PD patients.
    Language English
    Publishing date 2020-02-27
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.12908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Acute gastric dilatation is a potentially fatal complication in Parkinson's disease.

    Fukae, Jiro / Kano, Masayoshi / Nakajima, Asuka / Fuse, Atsuhito / Eguchi, Hiroto / Ashisawa, Karin / Takanashi, Masashi / Hattori, Nobutaka / Shimo, Yasushi

    Parkinsonism & related disorders

    2021  Volume 85, Page(s) 69–71

    MeSH term(s) Acute Disease ; Aged, 80 and over ; Fatal Outcome ; Gastric Dilatation/diagnosis ; Gastric Dilatation/etiology ; Gastroparesis/diagnosis ; Gastroparesis/etiology ; Humans ; Male ; Parkinson Disease/complications
    Language English
    Publishing date 2021-03-07
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2021.02.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4553: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 420: Show issues

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  6. Article ; Online: The Prevalence of Constipation and Irritable Bowel Syndrome in Parkinson's Disease Patients According to Rome III Diagnostic Criteria.

    Mishima, Takayasu / Fukae, Jiro / Fujioka, Shinsuke / Inoue, Kotoe / Tsuboi, Yoshio

    Journal of Parkinson's disease

    2017  Volume 7, Issue 2, Page(s) 353–357

    Abstract: Background: Gastrointestinal symptoms are one of the most common non-motor features of Parkinson's disease (PD). Recently, a report from Taiwan revealed that irritable bowel syndrome (IBS) may be associated with an increased risk of developing PD; ... ...

    Abstract Background: Gastrointestinal symptoms are one of the most common non-motor features of Parkinson's disease (PD). Recently, a report from Taiwan revealed that irritable bowel syndrome (IBS) may be associated with an increased risk of developing PD; however, the prevalence of IBS in PD patients has not been fully evaluated. Rome III criteria are widely assessed with a questionnaire to determine functional gastrointestinal disorders.
    Objective: We assessed the prevalence of constipation and IBS in PD patients in our cohort using Rome III criteria.
    Methods: Between October 2014 and April 2015, 118 patients with PD were treated at Fukuoka University Hospital and were enrolled in this study. Rome III criteria were used to diagnose constipation and IBS.
    Results: Constipation and IBS were detected in 32 (27.1%) and 20 patients (17.0%), respectively. The most common symptom related to constipation was straining during defecation (77.1%). Among constipation symptoms, patients' self-awareness of constipation was mostly related to straining during defecation (odds ratio 5.27, 95% confidence interval 1.475-18.811). The number of constipation symptoms was correlated with the severity of the Hoehn-Yahr Stage (p < 0.05) and total levodopa equivalent dose (p < 0.05).
    Conclusions: This is the first report to investigate the prevalence of IBS in PD patients with Rome III criteria. We found a higher prevalence of IBS compared with the general population. The prevalence of constipation based on Rome III criteria was much lower than that reported in previous studies. Further studies are warranted to evaluate gastrointestinal symptoms in PD patients using comparable questionnaires.
    Language English
    Publishing date 2017
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2620609-2
    ISSN 1877-718X ; 1877-7171
    ISSN (online) 1877-718X
    ISSN 1877-7171
    DOI 10.3233/JPD-160982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6964: Show issues Location:
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  7. Article: Herpes Zoster Radiculomyelitis With Aquaporin-4 Antibodies: A Case Report and Literature Review.

    Eguchi, Hiroto / Takeshige, Haruka / Nakajima, Sho / Kanou, Masayoshi / Nakajima, Asuka / Fuse, Atsuto / Fukae, Jiro / Miwa, Hideto / Shimo, Yasushi

    Frontiers in neurology

    2020  Volume 11, Page(s) 585303

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2020-11-23
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2020.585303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Myasthenia Gravis with Anti-Muscle-Specific Tyrosine Kinase Antibody during Pregnancy and Risk of Neonatal Myasthenia Gravis: A Case Report and Review of the Literature.

    Inoue, Ken-Ichi / Tsugawa, Jun / Fukae, Jiro / Fukuhara, Kosuke / Kawano, Hiroyasu / Fujioka, Shinsuke / Tsuboi, Yoshio

    Case reports in neurology

    2020  Volume 12, Issue 1, Page(s) 114–120

    Abstract: A 31-year-old woman presented with a nasal voice, dysarthria, and upper limb weakness during her first pregnancy. Soon after delivery of her first baby, her symptoms disappeared. At the age of 34 years, during her second pregnancy, her nasal voice re- ... ...

    Abstract A 31-year-old woman presented with a nasal voice, dysarthria, and upper limb weakness during her first pregnancy. Soon after delivery of her first baby, her symptoms disappeared. At the age of 34 years, during her second pregnancy, her nasal voice re-appeared. After delivery of the second baby, her nasal voice worsened, and bilateral eyelid ptosis and easy fatigability were also evident. She was referred to our hospital. Because of her myasthenic symptoms and anti-muscle-specific tyrosine kinase (MuSK) antibody (Ab)-positive status, she was diagnosed as having myasthenia gravis (MG). Her symptoms were worse than those in her first pregnancy. She was treated with oral steroid and double filtration plasmapheresis. After initiation of treatment, her myasthenic symptoms improved completely. In addition, her baby developed transient neonatal MG (TNMG) on the fourth day after birth and then gradually recovered over 30 days. It should be noted that symptoms of patients with anti-MuSK Ab-positive MG (MuSK-MG) can deteriorate during pregnancy, and the babies delivered of patients with MuSK-MG have a high probability of developing TNMG.
    Language English
    Publishing date 2020-03-17
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2505302-4
    ISSN 1662-680X
    ISSN 1662-680X
    DOI 10.1159/000506189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Modeling Parkinson's Disease and Atypical Parkinsonian Syndromes Using Induced Pluripotent Stem Cells.

    Mishima, Takayasu / Fujioka, Shinsuke / Fukae, Jiro / Yuasa-Kawada, Junichi / Tsuboi, Yoshio

    International journal of molecular sciences

    2018  Volume 19, Issue 12

    Abstract: Parkinson's disease (PD) and atypical parkinsonian syndromes are age-dependent multifactorial neurodegenerative diseases, which are clinically characterized by bradykinesia, tremor, muscle rigidity and postural instability. Although these diseases share ... ...

    Abstract Parkinson's disease (PD) and atypical parkinsonian syndromes are age-dependent multifactorial neurodegenerative diseases, which are clinically characterized by bradykinesia, tremor, muscle rigidity and postural instability. Although these diseases share several common clinical phenotypes, their pathophysiological aspects vary among the disease categories. Extensive animal-based approaches, as well as postmortem studies, have provided important insights into the disease mechanisms and potential therapeutic targets. However, the exact pathological mechanisms triggering such diseases still remain elusive. Furthermore, the effects of drugs observed in animal models are not always reproduced in human clinical trials. By using induced pluripotent stem cell (iPSC) technology, it has become possible to establish patient-specific iPSCs from their somatic cells and to effectively differentiate these iPSCs into different types of neurons, reproducing some key aspects of the disease phenotypes in vitro. In this review, we summarize recent findings from iPSC-based modeling of PD and several atypical parkinsonian syndromes including multiple system atrophy, frontotemporal dementia and parkinsonism linked to chromosome 17 and Perry syndrome. Furthermore, we discuss future challenges and prospects for modeling and understanding PD and atypical parkinsonian syndromes.
    MeSH term(s) Aging/pathology ; Animals ; Cell- and Tissue-Based Therapy ; Gene Editing ; Humans ; Induced Pluripotent Stem Cells/pathology ; Models, Biological ; Parkinson Disease/pathology
    Language English
    Publishing date 2018-12-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19123870
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  10. Article ; Online: Longstanding IgG4-related Ophthalmic Disease Dramatically Improved after Steroid Therapy.

    Hirata, Yoko / Fukae, Jiro / Nishida, Akihiro / Fujioka, Shinsuke / Hamasaki, Mokoto / Nonokuma, Masanari / Tsuboi, Yoshio

    Internal medicine (Tokyo, Japan)

    2018  Volume 57, Issue 19, Page(s) 2879–2883

    Abstract: A 61-year-old man was admitted to our hospital because of decreased visual acuity. On admission, he had marked blepharoedema, conjunctival injection, exophthalmos, diplopia, and blurred vision. He also had bronchial asthma and urinary retention requiring ...

    Abstract A 61-year-old man was admitted to our hospital because of decreased visual acuity. On admission, he had marked blepharoedema, conjunctival injection, exophthalmos, diplopia, and blurred vision. He also had bronchial asthma and urinary retention requiring urethral catheterization. His serum immunoglobulin (Ig) G4 level was elevated to 1,830 U/mL. Fluorodeoxyglucose-positron emission tomography revealed an abnormal uptake in multiple organs. A histopathological examination of the salivary gland revealed IgG4-positive plasma cell infiltration, leading to a diagnosis of IgG4-related ophthalmic disease. After initiating steroid therapy, his longstanding ophthalmic, respiratory, and urinary symptoms dramatically improved. In IgG4-related disease, steroid therapy should be considered even if patients have longstanding symptoms.
    MeSH term(s) Eye Diseases/diagnosis ; Eye Diseases/etiology ; Eye Diseases/therapy ; Glucocorticoids/therapeutic use ; Humans ; Immunoglobulin G/metabolism ; Immunoglobulin G4-Related Disease/diagnosis ; Immunoglobulin G4-Related Disease/etiology ; Immunoglobulin G4-Related Disease/therapy ; Male ; Middle Aged ; Positron-Emission Tomography ; Prednisolone/therapeutic use ; Salivary Glands/metabolism
    Chemical Substances Glucocorticoids ; Immunoglobulin G ; Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2018-05-18
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.0300-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 240: Show issues Location:
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