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Article ; Online: Evidence of Acute Tissue Edema after Cryoballoon Ablation for Atrial Fibrillation.

Fukuda, Koji

2019 Volume 60, Issue 3, Page(s) 497–498

Language	English
Publishing date	2019-07-05
Publishing country	Japan
Document type	Editorial ; Published Erratum
ZDB-ID	2187806-7
ISSN	1349-3299 ; 1349-2365
ISSN (online)	1349-3299
ISSN	1349-2365
DOI	10.1536/ihj.19-163
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Zs.A 211: Show issues

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Article ; Online: Educators' Psychosocial Burdens Due to the COVID-19 Pandemic and Predictive Factors: A Cross-Sectional Survey of the Relationship with Sense of Coherence and Social Capital.

Fukuda, Yasue / Fukuda, Koji

International journal of environmental research and public health

2022 Volume 19, Issue 4

Abstract: This study aims to identify the social and psychological burdens placed on educators during the third wave of the COVID-19 pandemic in Japan and to propose an optimal form of support. We investigated educators' perceptions of psychological and ... ...

Abstract	This study aims to identify the social and psychological burdens placed on educators during the third wave of the COVID-19 pandemic in Japan and to propose an optimal form of support. We investigated educators' perceptions of psychological and socioeconomic anxieties and burdens, sense of coherence, and social capital using a questionnaire survey of 1000 educators in January 2021. Multivariate regression analyses were conducted to analyze the associations between the variables. Results: Approximately 80% of the respondents considered COVID-19 a formidable, life-threatening illness. Our results revealed that the higher the social capital, the greater the fear of COVID-19, and the higher the sense of coherence, the lower this fear. Conclusions: The anxiety burden of implementing infection prevention was higher than the anxiety burden associated with distance learning. The predictive factors for educators' perceptions of burden included sense of coherence, gender, and age. Our findings suggest the importance of having the government and educational institutions provide multidimensional assistance that matches educators' individual characteristics.
MeSH term(s)	COVID-19/epidemiology ; Cross-Sectional Studies ; Humans ; Pandemics ; SARS-CoV-2 ; Sense of Coherence ; Social Capital
Language	English
Publishing date	2022-02-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19042134
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Article ; Online: Recognition of types and frequency of incidental findings in cancer staging CT should be essential for future artificial intelligence development.

Konno, Motoko / Anbai, Akira / Fukuda, Koji / Mori, Naoko

Clinical imaging

2023 Volume 99, Page(s) 31–32

MeSH term(s)	Humans ; Neoplasm Staging ; Artificial Intelligence ; Incidental Findings ; Tomography, X-Ray Computed ; Retrospective Studies ; Neoplasms/diagnostic imaging
Language	English
Publishing date	2023-04-08
Publishing country	United States
Document type	Letter
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2023.04.005
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Zs.A 1469: Show issues

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Article ; Online: Knowledge and preventive actions toward COVID-19, vaccination intent, and health literacy among educators in Japan: An online survey.

Fukuda, Yasue / Ando, Shuji / Fukuda, Koji

PloS one

2021 Volume 16, Issue 9, Page(s) e0257552

Abstract: Countermeasures against the spread of COVID-19 have become an urgent issue in educational settings, where many group activities are necessary. Educators are key to preventing the spread of COVID-19 in educational settings. Infection prevention behavior ... ...

Abstract	Countermeasures against the spread of COVID-19 have become an urgent issue in educational settings, where many group activities are necessary. Educators are key to preventing the spread of COVID-19 in educational settings. Infection prevention behavior requires comprehensive and complex measures such as self-restraint. disinfection care, hand washing, wearing masks and recommendation and implementation of vaccination. Improvement in the knowledge, skills, and preventive actions of educators vis-à-vis COVID-19 could allow for the continued provision of educational services while ensuring safety in educational settings. Therefore, the objective of this study was to explore the knowledge and preventive actions of educators regarding COVID-19 and vaccination awareness to provide appropriate support for educators. The study used data collected from 1,000 Japanese educators in January 2021 when the third wave of viral infections spread. Online surveys and multivariate linear regression analysis were used to determine age and whether respondents were being cared for by a doctor. We investigated the effects of factors on educators' willingness to be vaccinated and changes in their behavior. This study found that factors such as age, gender, whether a respondent was under a physician's care, and health literacy, affected the willingness of educators to receive vaccinations and engage in preventive actions. The study also suggests that the reliability of national government public relations efforts is lower than the reliability of local government public relations and that of information from family physicians, pharmacies, and mass media. It is therefore necessary to reexamine how information is disseminated by the national government and to increase the degree of trust in that information among the public. The findings of the study also revealed the importance of improving the provision of appropriate information and health literacy for the behavior of educators, not only during the initial outbreak, but also during the subsequent period of pandemic life.
MeSH term(s)	Adult ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/virology ; Female ; Health Education ; Health Knowledge, Attitudes, Practice ; Health Literacy ; Humans ; Internet ; Japan ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; Pandemics/prevention & control ; Reproducibility of Results ; SARS-CoV-2/physiology ; Surveys and Questionnaires ; Vaccination ; Young Adult
Language	English
Publishing date	2021-09-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0257552
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Article ; Online: Corrigendum to "Oncostatin M mediates cardioprotection via angiogenesis in ischemic heart disease" [Am. Heart J. Plus Cardiol. Res. Pract. vol. 35, 2023, 100331].

Ikeda, Shohei / Sato, Koichi / Takeda, Morihiko / Shinozaki, Mariko / Miki, Keita / Hirano, Michinori / Fukuda, Koji / Shiba, Nobuyuki

American heart journal plus : cardiology research and practice

2024 Volume 40, Page(s) 100385

Abstract: This corrects the article DOI: 10.1016/j.ahjo.2023.100331.]. ...

Abstract	[This corrects the article DOI: 10.1016/j.ahjo.2023.100331.].
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Published Erratum
ISSN	2666-6022
ISSN (online)	2666-6022
DOI	10.1016/j.ahjo.2024.100385
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Article ; Online: LIGHT regulated gene expression in rheumatoid synovial fibroblasts.

Fukuda, Koji / Miura, Yasushi / Maeda, Toshihisa / Hayashi, Shinya / Kikuchi, Kenichi / Takashima, Yoshinori / Matsumoto, Tomoyuki / Kuroda, Ryosuke

Molecular biology reports

2024 Volume 51, Issue 1, Page(s) 356

Abstract: Background: Synovial hyperplasia caused by rheumatoid arthritis (RA), an autoimmune inflammatory disease, leads to the destruction of the articular cartilage and bone. A member of the tumor necrosis factor superfamily, Lymphotoxin-related inducible ... ...

Abstract	Background: Synovial hyperplasia caused by rheumatoid arthritis (RA), an autoimmune inflammatory disease, leads to the destruction of the articular cartilage and bone. A member of the tumor necrosis factor superfamily, Lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells (LIGHT) has been shown to correlate with the pathogenesis of RA. Methods: We used cDNA microarray analysis to compare the expression of genes in rheumatoid fibroblast-like synoviocytes with and without LIGHT stimulation. Results: Significant changes in gene expression (P-values < 0.05 and fold change ≥ 2.0) were associated mainly with biological function categories of glycoprotein, glycosylation site as N-linked, plasma membrane part, integral to plasma membrane, intrinsic to plasma membrane, signal, plasma membrane, signal peptide, alternative splicing, and topological domain as extracellular. Conclusions: Our results indicate that LIGHT may regulate the expression in RA-FLS of genes which are important in the differentiation of several cell types and in cellular functions.
MeSH term(s)	Humans ; Synovial Membrane/metabolism ; Arthritis, Rheumatoid/metabolism ; Synoviocytes/metabolism ; Fibroblasts/metabolism ; Glycoproteins/genetics ; Gene Expression ; Cells, Cultured
Chemical Substances	Glycoproteins
Language	English
Publishing date	2024-02-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-024-09311-0
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Zs.A 1140: Show issues

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Article ; Online: Association between albumin-bilirubin grade and plasma trough concentrations of regorafenib and its metabolites M-2 and M-5 at steady-state in Japanese patients.

Fujita, Kazuma / Taguchi, Daiki / Fukuda, Koji / Yoshida, Taichi / Shimazu, Kazuhiro / Shinozaki, Hanae / Shibata, Hiroyuki / Miura, Masatomo

Investigational new drugs

2024

Abstract: The aim of the present study was to determine whether the trough plasma concentrations ( ... ...

Abstract	The aim of the present study was to determine whether the trough plasma concentrations (C
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	604895-x
ISSN	1573-0646 ; 0167-6997
ISSN (online)	1573-0646
ISSN	0167-6997
DOI	10.1007/s10637-024-01429-z
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Zs.A 1823: Show issues

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Article ; Online: Parents' attitudes towards and perceptions of involving minors in medical research from the Japanese perspective.

Fukuda, Yasue / Fukuda, Koji

BMC medical ethics

2018 Volume 19, Issue 1, Page(s) 91

Abstract: Background: Children's intentions should be respected. Parents are the key persons involved in decision-making related to their children. In Japan, the appropriate ages and standards for a child's consent and assent, approval, and decision-making are ... ...

Abstract	Background: Children's intentions should be respected. Parents are the key persons involved in decision-making related to their children. In Japan, the appropriate ages and standards for a child's consent and assent, approval, and decision-making are not clearly defined, which makes the process of obtaining consent and assent for clinical research complex. The purpose of this paper is as follows: to understand the attitudes and motives of parents concerning children's participation in medical research and the factors influencing their decision-making. We also sought to clarify who has the right to be involved in decisions regarding children's participation in research. Methods: A semi-structured Internet survey on parents' opinions and attitudes and preferences concerning medical research involvement was conducted. Children were divided into three age groups (6-10-year-olds, 11-14-year-olds, and 15-18-year-olds), with three illness severity categories. Possible correlations between the number of children, children's ages, parents' educational levels, and parents' attitudes were examined. Results: Among the participants, 42.3% recognized the term "informed consent." The proportion of participants who understood "informed consent" increased with educational level. Four out of five participants did not know, or had not heard of, the term "informed assent." Furthermore, the percentage of those who understood the term "informed assent" increased with academic level. Participants generally believed in prioritizing parents' opinions over children's, and that parents and children would ideally reach a joint decision. Although many parents favored collaborative decision-making, they also wanted their own will reflected in the decision and felt they should receive important information before their children do. Decision-making was affected by the condition's severity and prognosis. This indicates that most Japanese parents believe that their children have the right to know their disease name and treatment; nonetheless, they should be protected. Parents' values and judgments regarding medical intervention involving their children varied. Conclusions: Children's ability to consent to treatment and research believed to be in their best interests should be assessed appropriately. They should be permitted to provide consent or assent, and their views should be respected. Involving children in decision-making fosters more open communication and transparency between medical professionals, parents, and children.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Attitude to Health ; Biomedical Research/ethics ; Child ; Decision Making/ethics ; Educational Status ; Female ; Humans ; Informed Consent/ethics ; Informed Consent/psychology ; Informed Consent By Minors/ethics ; Informed Consent By Minors/psychology ; Japan ; Male ; Middle Aged ; Parents/psychology ; Surveys and Questionnaires
Language	English
Publishing date	2018-11-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041552-7
ISSN	1472-6939 ; 1472-6939
ISSN (online)	1472-6939
ISSN	1472-6939
DOI	10.1186/s12910-018-0330-1
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Article ; Online: Clinical response of pancreatic cancer bearing a germline BRCA2 p.I3169M fs*48 variant for platinum-based drug and PARP inhibitor.

Akahira, Risa / Fukuda, Koji / Shimazu, Kazuhiro / Yoshida, Taichi / Taguchi, Daiki / Shinozaki, Hanae / Nanjyo, Hiroshi / Shibata, Hiroyuki

Japanese journal of clinical oncology

2023 Volume 54, Issue 2, Page(s) 201–205

Abstract: Pancreatic cancer is a malignancy with a high mortality rate, accounting for 37 000 people annually in Japan. It is rarely diagnosed in a resectable state, and effective medicines for its advanced stage are scarce. Some pancreatic cancer is hereditary, ... ...

Abstract	Pancreatic cancer is a malignancy with a high mortality rate, accounting for 37 000 people annually in Japan. It is rarely diagnosed in a resectable state, and effective medicines for its advanced stage are scarce. Some pancreatic cancer is hereditary, and ~10% have germline mutations of Breast cancer 1/2 (BRCA1/2). BRCA1/2 are key molecules involved in homologous recombination to repair DNA double-strand break. Platinum-based drugs and poly Adenosine diphosphate ribose (ADP) ribose polymerase inhibitors that induce synthetic lethality would be theoretically effective in patients with loss-of-function mutations in BRCA1/2. Strictly speaking, some discrepancy between the pathogenicity of BRCA1/2 and their drug sensitivity might be expected. Hence, we report that platinum-based anticancer agents and poly ADP ribose polymerase inhibitors were effective against pancreatic cancer bearing BRCA2 p.I3169M fs*48.
MeSH term(s)	Humans ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Antineoplastic Agents ; Germ-Line Mutation ; Pancreatic Neoplasms ; Germ Cells
Chemical Substances	Poly(ADP-ribose) Polymerase Inhibitors ; BRCA1 protein, human ; BRCA1 Protein ; BRCA2 protein, human ; BRCA2 Protein ; Antineoplastic Agents
Language	English
Publishing date	2023-11-11
Publishing country	England
Document type	Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyad157
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Zs.A 1298: Show issues

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Article ; Online: Takotsubo syndrome associated with coronary microvascular dysfunction: A case study.

Ikeda, Shohei / Takeda, Morihiko / Sato, Koichi / Shinozaki, Mariko / Watanabe, Satomi / Miki, Keita / Hirano, Michinori / Fukuda, Koji / Shiba, Nobuyuki

Journal of cardiology cases

2023 Volume 29, Issue 3, Page(s) 124–127

Abstract: The patient, a 68-year-old man, presented to our emergency room with chest pain, prompting an emergency cardiac catheterization due to elevated cardiac troponin-I levels. While no obvious coronary artery stenosis was found, there was evidence of apical ... ...

Abstract	The patient, a 68-year-old man, presented to our emergency room with chest pain, prompting an emergency cardiac catheterization due to elevated cardiac troponin-I levels. While no obvious coronary artery stenosis was found, there was evidence of apical ballooning wall motion in the left ventricle, leading to a diagnosis of takotsubo syndrome. Three months later, he occasionally experienced chest pain at rest, prompting us to conduct another cardiac catheterization. Left ventriculography showed normal contraction. Suddenly, he experienced chest pain accompanied by ST elevation, which occurred spontaneously. Subsequently, slow-flow phenomenon was observed in the intermediate part of left anterior descending artery (LAD). We promptly administered nitroglycerin to alleviate the symptoms. Following the diagnosis of coronary microvascular dysfunction (CMD), he started calcium-channel blocker therapy and remained asymptomatic. One year later, we re-performed cardiac catheterization to further explore his condition. Acetylcholine provocation test was performed, which showed no epicardial coronary spasm. However, lactic acid elevation was observed in the coronary sinus blood sample. Additionally, a coronary physiological measurement in the LAD revealed a high index of microcirculatory resistance and low coronary flow reserve. Based on this series of clinical events, we inferred a significant contribution of CMD to the patient's condition. Learning objective: Coronary microvascular dysfunction (CMD) is increasingly recognized as an important cardiovascular disease, leading to myocardial ischemia, which is occasionally associated with takotsubo syndrome (TTS). In this report, we present a case of spontaneous CMD associated with TTS. This case emphasizes the significance of accurate diagnosis and appropriate treatment, highlighting the importance of recognizing CMD in patients with TTS.
Language	English
Publishing date	2023-12-07
Publishing country	Japan
Document type	Case Reports
ISSN	1878-5409
ISSN (online)	1878-5409
DOI	10.1016/j.jccase.2023.11.005
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