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  1. Article: A Case of Persistent

    Sasano, Hiroshi / Yoshizawa, Toshihiro / Suzuki, Mai / Fukui, Yukiko / Arakawa, Ryutarou / Tamura, Naoto / Naito, Toshio

    Case reports in infectious diseases

    2022  Volume 2022, Page(s) 8725102

    Abstract: A 56-year-old woman with a history of connective tissue disease developed fever, ... ...

    Abstract A 56-year-old woman with a history of connective tissue disease developed fever, and
    Language English
    Publishing date 2022-03-12
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2627642-2
    ISSN 2090-6633 ; 2090-6625
    ISSN (online) 2090-6633
    ISSN 2090-6625
    DOI 10.1155/2022/8725102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Systemic Lupus Erythematosus Patient with Cutaneous

    Kim, Jonghun / Hasegawa, Toshio / Tada, Kurisu / Uehara, Yuki / Fukui, Yukiko / Nakamura, Ayako / Takei, Satomi / Mitarai, Satoshi / Aono, Akio / Ikeda, Shigaku

    Annals of dermatology

    2023  Volume 35, Issue Suppl 1, Page(s) S63–S66

    Abstract: A 38-year-old female with systemic lupus erythematosus (SLE) initiated belimumab treatment. One month later, she presented with a reddish painful swelling on her right lower leg. She was treated with ceftriaxone and vancomycin. However, novel ... ...

    Abstract A 38-year-old female with systemic lupus erythematosus (SLE) initiated belimumab treatment. One month later, she presented with a reddish painful swelling on her right lower leg. She was treated with ceftriaxone and vancomycin. However, novel erythematous papules and indurated nodules appeared on both her lower legs. Skin biopsy revealed microabscess formation with mixed cell granuloma surrounded by inflammatory cell infiltration within the dermis with subcutaneous fat tissue. A large number of acid-fast bacilli were observed with Ziehl-Neelsen staining. DNA sequencing of both the hsp65 and the 16S rRNA sequences showed a 100% match with the corresponding region of
    Language English
    Publishing date 2023-10-28
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 1012662-4
    ISSN 2005-3894 ; 1013-9087
    ISSN (online) 2005-3894
    ISSN 1013-9087
    DOI 10.5021/ad.21.077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2800: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Impact of the COVID-19 Pandemic on Initiation of Antibiotic Treatment After Performing a Blood Culture and Intervention by the Antimicrobial Stewardship Team.

    Kubota, Sanae / Sasano, Hiroshi / Suzuki, Mai / Fukui, Yukiko / Chonan, Masayoshi / Kawakami, Takaaki / Tabe, Yoko / Miida, Takashi / Kimura, Toshimi / Naito, Toshio

    International journal of general medicine

    2023  Volume 16, Page(s) 3713–3719

    Abstract: Purpose: Whether the coronavirus disease 2019 (COVID-19) pandemic had any effect on the time between blood culture collection and administration of antibiotics in the outpatient Department of Emergency Medicine in a single university hospital in Japan ... ...

    Abstract Purpose: Whether the coronavirus disease 2019 (COVID-19) pandemic had any effect on the time between blood culture collection and administration of antibiotics in the outpatient Department of Emergency Medicine in a single university hospital in Japan was investigated, and the intervention carried out by the antimicrobial stewardship team (AST) to promote the appropriate use of antibiotics was examined.
    Patients and methods: The monthly percentage of patients who visited the outpatient Department of Emergency Medicine between January 2019 and December 2021 and received an intravenous antibiotic within 3 hours of blood culture collection was calculated. The AST calculated a quality indicator (QI) based on the results of the investigation and started QI monitoring and hospital feedback.
    Results: From January 2020 to March 2021 (the third COVID-19 wave), the implementation rate of antibiotic administration within 3 hours after blood culture collection decreased as the COVID-19 pandemic spread, and the implementation rate tended to increase as the number of COVID-19-positive patients decreased. However, when the AST started monitoring and feedback from April 2021, although there was a temporary decline in the early stages of the fifth wave when the scale of infection was large, the implementation rate rose and was maintained by AST intervention. (the fourth and the fifth COVID-19 waves) (P<0.01). Also, the implementation rate was significantly lower during the COVID-19 pandemic than during the non- pandemic (P<0.05).
    Conclusion: The early COVID-19 pandemic may have affected the delay in time from blood culture collection to antibiotic administration. Later, in recurring COVID-19 pandemics, AST intervention eliminated this problem. When a bacterial infection such as sepsis is suspected, delayed treatment can be prevented by promptly collecting a blood culture, irrespective of concerns about COVID-19 infection. Calculating the QI may promote AST activities and the appropriate use of antibiotics.
    Language English
    Publishing date 2023-08-23
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S418558
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  4. Article ; Online: Isolation and identification of

    Takei, Satomi / Teramoto, Kanae / Fujimura, Junya / Fujiwara, Megumi / Suzuki, Mai / Fukui, Yukiko / Sekiguchi, Yuji / Kawakami, Takaaki / Chonan, Masayoshi / Wakita, Mitsuru / Horiuchi, Yuki / Miida, Takashi / Naito, Toshio / Kirikae, Teruo / Tada, Tatsuya / Tabe, Yoko

    Frontiers in cellular and infection microbiology

    2024  Volume 14, Page(s) 1361432

    Abstract: ... ...

    Abstract Wickerhamiella
    MeSH term(s) Female ; Humans ; Child ; Antifungal Agents/pharmacology ; Blood Culture ; Micafungin ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Microbial Sensitivity Tests ; Candida ; Saccharomycetales
    Chemical Substances Antifungal Agents ; Micafungin (R10H71BSWG)
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2024.1361432
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  5. Article: Successful Treatment of a Case of Metallo-Beta-Lactamase-Producing

    Koishi, Noriko / Sasano, Hiroshi / Yoshizawa, Toshihiro / Shikuri, Mika / Matsumoto, Hiroshi / Suzuki, Mai / Fukui, Yukiko / Chonan, Masayoshi / Kimura, Toshimi / Ichida, Hirofumi / Saiura, Akio / Naito, Toshio

    Case reports in infectious diseases

    2023  Volume 2023, Page(s) 5574769

    Abstract: An 80-year-old woman underwent pancreatoduodenectomy. Post-operation, she experienced a fever, and a culture of blood revealed metallo-beta-lactamase- ... ...

    Abstract An 80-year-old woman underwent pancreatoduodenectomy. Post-operation, she experienced a fever, and a culture of blood revealed metallo-beta-lactamase-producing
    Language English
    Publishing date 2023-04-07
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2627642-2
    ISSN 2090-6633 ; 2090-6625
    ISSN (online) 2090-6633
    ISSN 2090-6625
    DOI 10.1155/2023/5574769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A preliminary analysis of the performance of a targeted HIV electronic medical records alert system: A single hospital experience.

    Naito, Toshio / Endo, Kanako / Fukushima, Shinichi / Suzuki, Mai / Fukui, Yukiko / Saita, Mizue / Yokokawa, Hirohide

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2020  Volume 27, Issue 1, Page(s) 123–125

    Abstract: Early treatment of HIV relies on a timely detection of the infection, but many people living with HIV/AIDS are unaware of their infection. In the current study, we applied an electronic medical records (EMR)-based alert system flagging high-risk patients ...

    Abstract Early treatment of HIV relies on a timely detection of the infection, but many people living with HIV/AIDS are unaware of their infection. In the current study, we applied an electronic medical records (EMR)-based alert system flagging high-risk patients previously diagnosed with infections of syphilis, hepatitis A virus, hepatitis B virus, and/or hepatitis C virus, and those aged 20-50 years with a prior diagnosis of shingles. During the study period (April to October 2019), a total of 47 individuals among 22,264 patients visiting our department were identified as having high-risk of carrying HIV, and 14 of these individuals underwent HIV testing. Two males aged below 65 years with a previous diagnosis of syphilis were subsequently tested positive for HIV. This preliminary analysis of the EMR alert system facilitated the identification of high-risk people possibly carrying HIV, but the test rate remains to be improved.
    MeSH term(s) Electronic Health Records ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; Hepatitis B ; Hepatitis C ; Hospitals ; Humans ; Male ; Syphilis/diagnosis
    Language English
    Publishing date 2020-09-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2020.09.009
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5236: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Time-series blood cytokine profiles correlate with treatment responses in triple-negative breast cancer patients.

    Saldajeno, Don Pietro / Kawaoka, Shinpei / Masuda, Norikazu / Tanaka, Sunao / Bando, Hiroko / Nishimura, Tomomi / Kadoya, Takayuki / Yamanaka, Takashi / Imoto, Shigeru / Velaga, Ravindranath M / Tamura, Nobuko / Aruga, Tomoyuki / Ikeda, Kazushi / Fukui, Yukiko / Maeshima, Yurina / Takada, Masahiro / Suzuki, Eiji / Ueno, Takayuki / Ogawa, Seishi /
    Haga, Hironori / Ohno, Shinji / Morita, Satoshi / Kawaguchi, Kosuke / Toi, Masakazu

    British journal of cancer

    2024  Volume 130, Issue 6, Page(s) 1023–1035

    Abstract: Background: Triple-negative breast cancer (TNBC) is the most heterogeneous breast cancer subtype. Partly due to its heterogeneity, it is currently challenging to stratify TNBC patients and predict treatment outcomes.: Methods: In this study, we ... ...

    Abstract Background: Triple-negative breast cancer (TNBC) is the most heterogeneous breast cancer subtype. Partly due to its heterogeneity, it is currently challenging to stratify TNBC patients and predict treatment outcomes.
    Methods: In this study, we examined blood cytokine profiles of TNBC patients throughout treatments (pre-treatment, during chemotherapy, pre-surgery, and 1 year after the surgery in a total of 294 samples). We analyzed the obtained cytokine datasets using weighted correlation network analyses, protein-protein interaction analyses, and logistic regression analyses.
    Results: We identified five cytokines that correlate with good clinical outcomes: interleukin (IL)-1α, TNF-related apoptosis-inducing ligand (TRAIL), Stem Cell Factor (SCF), Chemokine ligand 5 (CCL5 also known as RANTES), and IL-16. The expression of these cytokines was decreased during chemotherapy and then restored after the treatment. Importantly, patients with good clinical outcomes had constitutively high expression of these cytokines during treatments. Protein-protein interaction analyses implicated that these five cytokines promote an immune response. Logistic regression analyses revealed that IL-1α and TRAIL expression levels at pre-treatment could predict treatment outcomes in our cohort.
    Conclusion: We concluded that time-series cytokine profiles in breast cancer patients may be useful for understanding immune cell activity during treatment and for predicting treatment outcomes, supporting precision medicine.
    Trial registration: The study has been registered with the University Hospital Medical Information Network Clinical Trials Registry ( http://www.umin.ac.jp/ctr/index-j.htm ) with the unique trial number UMIN000023162. The association Japan Breast Cancer Research Group trial number is JBCRG-22. The clinical outcome of the JBCRG-22 study was published in Breast Cancer Research and Treatment on 25 March 2021. https://doi.org/10.1007/s10549-021-06184-w .
    MeSH term(s) Humans ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/metabolism ; Cytokines/metabolism ; Chemokines ; Treatment Outcome ; Japan
    Chemical Substances Cytokines ; Chemokines
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-023-02527-0
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.142: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Long-term outcomes of incidental gallbladder carcinoma without additional resection: A single institution experiment.

    Sugiyama, Tomohiro / Makino, Kenta / Fukui, Yukiko / Kinoshita, Hiromitsu / Miki, Akira / Uchida, Shigeki / Tsubono, Michihiko / Adachi, Yasushi

    Molecular and clinical oncology

    2020  Volume 13, Issue 2, Page(s) 216–220

    Abstract: Incidental gallbladder carcinoma (IGC), defined as unexpected malignancy identified in the surgical gallbladder specimen of a cholecystectomy performed for a benign diagnosis, can be difficult to suspect preoperatively. Furthermore, there are valid ... ...

    Abstract Incidental gallbladder carcinoma (IGC), defined as unexpected malignancy identified in the surgical gallbladder specimen of a cholecystectomy performed for a benign diagnosis, can be difficult to suspect preoperatively. Furthermore, there are valid clinical reasons to defer reoperation for additional resection, particularly in elderly patients. The present study aimed to determine the long-term outcomes and prognostic factors associated with recurrence in patients with IGC. The medical records of 678 patients who underwent cholecystectomy at Toyooka Hospital between September 2011 and November 2017 were reviewed. The cases identified to be IGC were retrospectively analyzed to determine patient and histopathological characteristics, surgical details, long-term outcomes and factors associated with cancer recurrence. A total of 22 patients were diagnosed with gallbladder carcinoma following cholecystectomy by histopathological examination, and 12 of these were identified to be IGC. The median age was 80 years (range 70-89 years). Although 6 of the 12 patients with IGC had stage pT2 or pT3 tumors, only 1 patient underwent additional resection. Recurrence occurred in 3 of the 8 patients who did not undergo additional resection and were available for long-term follow-up. Recurrence was not associated with the extent of tumor invasion but may be associated with other histopathological findings, preoperative treatment history and risk factors for recurrence. Furthermore, long-term survival was observed in patients with pT2 and pT3 tumors who did not undergo additional resection. Recurrence was not associated with the extent of tumor invasion but may be associated with other histopathological findings, preoperative treatment history, and risk factors for recurrence. Furthermore, long-term survival was observed in patients with pT2 and pT3 tumors who did not undergo additional resection. Even if it is a progressive IGC case, appropriate preoperative treatment or cholecystectomy without persistence of the carcinoma cell, based on a preoperative image evaluation and a postoperative histopathological examination, may greatly influence the long-term prognosis of IGC.
    Language English
    Publishing date 2020-06-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2796865-0
    ISSN 2049-9469 ; 2049-9450
    ISSN (online) 2049-9469
    ISSN 2049-9450
    DOI 10.3892/mco.2020.2054
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  9. Article ; Online: Granulocyte-colony-stimulating factor-producing metaplastic carcinoma of the breast with significant elevation of serum interleukin-17 and vascular endothelial growth factor levels.

    Fukui, Yukiko / Kawashima, Masahiro / Kawaguchi, Kosuke / Takeuchi, Megumi / Hirata, Masahiro / Kataoka, Tatsuki R / Sakurai, Takaki / Kataoka, Masako / Kanao, Shotaro / Nakamoto, Yuji / Hirata, Kimiko / Yoshimura, Michio / Yoshikawa, Katsuhiro / Ishiguro, Hiroshi / Toi, Masakazu

    International cancer conference journal

    2018  Volume 7, Issue 3, Page(s) 107–113

    Abstract: Granulocyte-colony-stimulating factor (G-CSF) production in carcinomas is associated with a very aggressive phenotype. Interleukin (IL)-17 secreted from tumor-infiltrating lymphocytes induces the production of G-CSF and vascular endothelial growth factor ...

    Abstract Granulocyte-colony-stimulating factor (G-CSF) production in carcinomas is associated with a very aggressive phenotype. Interleukin (IL)-17 secreted from tumor-infiltrating lymphocytes induces the production of G-CSF and vascular endothelial growth factor (VEGF) in cancer tissue. We present a case of a G-CSF-producing metaplastic breast carcinoma (MpBC) accompanied by systemic elevation of IL-17 and VEGF levels. A 56-year-old woman presented with a rapidly growing tumor measuring > 10 cm in her left breast. Core needle biopsy confirmed the diagnosis as MpBC with triple-negative features. Diffuse fluorodeoxyglucose uptake in the long bones and marked leukocytosis suggested that the G-CSF was produced by the primary tumor, which showed upregulated G-CSF mRNA and protein levels. Multiplex cytokine assessment identified increased serum IL-17, VEGF, and G-CSF levels. After radical mastectomy and skin grafting, the leukocyte count and serum G-CSF, IL-17, and VEGF levels were normalized. She underwent postmastectomy radiotherapy (50 Gy/25 Fr) and adjuvant chemotherapy (90 mg/m
    Language English
    Publishing date 2018-06-01
    Publishing country Singapore
    Document type Case Reports
    ISSN 2192-3183
    ISSN (online) 2192-3183
    DOI 10.1007/s13691-018-0330-5
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