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  1. Article ; Online: Drosophila Genetics: Analysis of Tissue Growth in Adult Tissues.

    Fulford, Alexander D / Ribeiro, Paulo S

    Methods in molecular biology (Clifton, N.J.)

    2018  Volume 1893, Page(s) 43–51

    Abstract: Drosophila melanogaster has been widely used in the study of developmental growth control and has been instrumental in the discovery and delineation of many signalling pathways that contribute to this growth, in particular the Hippo pathway. Quantitative ...

    Abstract Drosophila melanogaster has been widely used in the study of developmental growth control and has been instrumental in the discovery and delineation of many signalling pathways that contribute to this growth, in particular the Hippo pathway. Quantitative analysis of adult tissue size has remained a vital tool in the study of tissue growth. This chapter will describe how to dissect, image, and quantify two tissues commonly used to measure growth, the Drosophila wing and eye.
    MeSH term(s) Animals ; Drosophila/genetics ; Drosophila/growth & development ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Eye/cytology ; Eye/metabolism ; Female ; Genetic Association Studies ; Life Cycle Stages ; Microscopy ; Wings, Animal/anatomy & histology ; Wings, Animal/metabolism
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2018-12-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-8910-2_3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fat/Dachsous family cadherins in cell and tissue organisation.

    Fulford, Alexander D / McNeill, Helen

    Current opinion in cell biology

    2019  Volume 62, Page(s) 96–103

    Abstract: Precisely controlled organisation at the cellular and tissue level is crucial to establish and maintain complex organisms. The atypical cadherins Fat (Ft), Fat2 and Dachsous (Ds) contribute to this organisation by regulating growth and planar cell ... ...

    Abstract Precisely controlled organisation at the cellular and tissue level is crucial to establish and maintain complex organisms. The atypical cadherins Fat (Ft), Fat2 and Dachsous (Ds) contribute to this organisation by regulating growth and planar cell polarity. Here we describe the recent advances in understanding how these large cadherins coordinate these processes, and discuss additional progress extending their function in regulation of microtubules, migration and disease.
    MeSH term(s) Animals ; Cadherins/metabolism ; Cadherins/physiology ; Cell Polarity/physiology ; Drosophila Proteins/physiology
    Chemical Substances Cadherins ; Drosophila Proteins ; ds protein, Drosophila ; kug protein, Drosophila
    Language English
    Publishing date 2019-11-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2019.10.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2963: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Fat regulates expression of four-jointed reporters in vivo through a 20 bp element independently of the Hippo pathway.

    Arbouzova, Natalia I / Fulford, Alexander D / Zhang, Hongtao / McNeill, Helen

    Developmental biology

    2019  Volume 450, Issue 1, Page(s) 23–33

    Abstract: Development of an organism requires accurate coordination between the growth of a tissue and orientation of cells within the tissue. The large cadherin Fat has been shown to play a role in both of these processes. Fat is involved in the establishment of ... ...

    Abstract Development of an organism requires accurate coordination between the growth of a tissue and orientation of cells within the tissue. The large cadherin Fat has been shown to play a role in both of these processes. Fat is involved in the establishment of planar cell polarity and regulates growth through the Hippo pathway, a developmental cascade that controls proliferation and apoptosis. Both Fat and the Hippo pathway are known to regulate transcription of four-jointed, although the nature of this regulation is unknown. In this study, we test whether Fat affects four-jointed transcription via or independently of Hippo pathway. Our analysis of the four-jointed regulatory region reveals a 1.2 kb element that functions as an enhancer for graded expression of Four-jointed in the eye imaginal disc. Within this enhancer element, we identify a 20 bp fragment that is critical for regulation by Fat but not by Hippo. Our findings suggest that Fat and the Hippo pathway control four-jointed expression independently of each other and none of the transcription factors known to function downstream of the Hippo pathway are required to regulate four-jointed expression through the 1.2 kb element.
    MeSH term(s) Animals ; Cell Adhesion Molecules/genetics ; Cell Adhesion Molecules/metabolism ; Drosophila Proteins/biosynthesis ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Enhancer Elements, Genetic ; Gene Expression Regulation, Developmental ; Genes, Reporter ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Membrane Glycoproteins/biosynthesis ; Membrane Glycoproteins/genetics ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction ; Transcription, Genetic
    Chemical Substances Cell Adhesion Molecules ; Drosophila Proteins ; Intracellular Signaling Peptides and Proteins ; Membrane Glycoproteins ; fj protein, Drosophila ; ft protein, Drosophila ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; hpo protein, Drosophila (EC 2.7.11.1)
    Language English
    Publishing date 2019-03-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2019.03.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 508: Show issues Location:
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  4. Article ; Online: Expanded directly binds conserved regions of Fat to restrain growth via the Hippo pathway.

    Fulford, Alexander D / Enderle, Leonie / Rusch, Jannette / Hodzic, Didier / Holder, Maxine V / Earl, Alex / Oh, Robin Hyunseo / Tapon, Nicolas / McNeill, Helen

    The Journal of cell biology

    2023  Volume 222, Issue 5

    Abstract: The Hippo pathway is a conserved and critical regulator of tissue growth. The FERM protein Expanded is a key signaling hub that promotes activation of the Hippo pathway, thereby inhibiting the transcriptional co-activator Yorkie. Previous work identified ...

    Abstract The Hippo pathway is a conserved and critical regulator of tissue growth. The FERM protein Expanded is a key signaling hub that promotes activation of the Hippo pathway, thereby inhibiting the transcriptional co-activator Yorkie. Previous work identified the polarity determinant Crumbs as a primary regulator of Expanded. Here, we show that the giant cadherin Fat also regulates Expanded directly and independently of Crumbs. We show that direct binding between Expanded and a highly conserved region of the Fat cytoplasmic domain recruits Expanded to the apicolateral junctional zone and stabilizes Expanded. In vivo deletion of Expanded binding regions in Fat causes loss of apical Expanded and promotes tissue overgrowth. Unexpectedly, we find Fat can bind its ligand Dachsous via interactions of their cytoplasmic domains, in addition to the known extracellular interactions. Importantly, Expanded is stabilized by Fat independently of Dachsous binding. These data provide new mechanistic insights into how Fat regulates Expanded, and how Hippo signaling is regulated during organ growth.
    MeSH term(s) Animals ; Drosophila melanogaster/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Hippo Signaling Pathway ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Transcription Factors/metabolism ; Cell Adhesion Molecules/genetics ; Cell Adhesion Molecules/metabolism
    Chemical Substances Drosophila Proteins ; Intracellular Signaling Peptides and Proteins ; Membrane Proteins ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Transcription Factors ; ft protein, Drosophila ; crb protein, Drosophila ; Cell Adhesion Molecules ; ex protein, Drosophila
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202204059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.190: Show issues Location:
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  5. Article: Fat regulates expression of four-jointed reporters in vivo through a 20 bp element independently of the Hippo pathway

    Arbouzova, Natalia I / Fulford, Alexander D / Zhang, Hongtao / McNeill, Helen

    Developmental biology. 2019 June 01, v. 450, no. 1

    2019  

    Abstract: Development of an organism requires accurate coordination between the growth of a tissue and orientation of cells within the tissue. The large cadherin Fat has been shown to play a role in both of these processes. Fat is involved in the establishment of ... ...

    Abstract Development of an organism requires accurate coordination between the growth of a tissue and orientation of cells within the tissue. The large cadherin Fat has been shown to play a role in both of these processes. Fat is involved in the establishment of planar cell polarity and regulates growth through the Hippo pathway, a developmental cascade that controls proliferation and apoptosis. Both Fat and the Hippo pathway are known to regulate transcription of four-jointed, although the nature of this regulation is unknown. In this study, we test whether Fat affects four-jointed transcription via or independently of Hippo pathway. Our analysis of the four-jointed regulatory region reveals a 1.2 kb element that functions as an enhancer for graded expression of Four-jointed in the eye imaginal disc. Within this enhancer element, we identify a 20 bp fragment that is critical for regulation by Fat but not by Hippo. Our findings suggest that Fat and the Hippo pathway control four-jointed expression independently of each other and none of the transcription factors known to function downstream of the Hippo pathway are required to regulate four-jointed expression through the 1.2 kb element.
    Keywords apoptosis ; cadherins ; cell polarity ; enhancer elements ; eyes ; transcription factors
    Language English
    Dates of publication 2019-0601
    Size p. 23-33.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2019.03.004
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    In stock of ZB MED Bonn / Germany

    Z 76/715: Show issues

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  6. Article ; Online: Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation.

    Fulford, Alexander D / Holder, Maxine V / Frith, David / Snijders, Ambrosius P / Tapon, Nicolas / Ribeiro, Paulo S

    eLife

    2019  Volume 8

    Abstract: Hippo signalling integrates diverse stimuli related to epithelial architecture to regulate tissue growth and cell fate decisions. The Hippo kinase cascade represses the growth-promoting transcription co-activator Yorkie. The FERM protein Expanded is one ... ...

    Abstract Hippo signalling integrates diverse stimuli related to epithelial architecture to regulate tissue growth and cell fate decisions. The Hippo kinase cascade represses the growth-promoting transcription co-activator Yorkie. The FERM protein Expanded is one of the main upstream Hippo signalling regulators in
    MeSH term(s) Animals ; Casein Kinase I/metabolism ; Cell Cycle Proteins/metabolism ; Drosophila ; Drosophila Proteins/metabolism ; Gene Expression Regulation ; Membrane Proteins/metabolism ; Phosphorylation ; Protein Binding ; Protein Interaction Maps ; Protein Processing, Post-Translational ; Proteolysis ; Ubiquitin-Protein Ligases/metabolism ; beta-Transducin Repeat-Containing Proteins/metabolism
    Chemical Substances Cell Cycle Proteins ; Drosophila Proteins ; Membrane Proteins ; beta-Transducin Repeat-Containing Proteins ; crb protein, Drosophila ; ex protein, Drosophila ; slmb protein, Drosophila ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Casein Kinase I (EC 2.7.11.1)
    Language English
    Publishing date 2019-09-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.46592
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  7. Article ; Online: Prp8 regulates oncogene-induced hyperplastic growth in

    Fernández-Espartero, Cecilia H / Rizzo, Alberto / Fulford, Alexander D / Falo-Sanjuan, Julia / Goutte-Gattat, Damien / Ribeiro, Paulo S

    Development (Cambridge, England)

    2018  Volume 145, Issue 22

    Abstract: Although developmental signalling pathways control tumourigenic growth, the cellular mechanisms that abnormally proliferating cells rely on are still largely unknown. ...

    Abstract Although developmental signalling pathways control tumourigenic growth, the cellular mechanisms that abnormally proliferating cells rely on are still largely unknown.
    MeSH term(s) Actins/metabolism ; Animals ; Carcinogenesis ; Cell Death ; Cell Differentiation ; Cell Polarity ; Cell Proliferation ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; Eye/growth & development ; Eye/metabolism ; Gastrointestinal Tract/metabolism ; Gastrointestinal Tract/pathology ; Gene Knockdown Techniques ; Hyperplasia ; Neoplasm Invasiveness ; Neoplasms/metabolism ; Neoplasms/pathology ; Oncogenes ; Organ Specificity ; Phenotype ; RNA Interference ; RNA Splicing Factors/metabolism ; ras Proteins/metabolism
    Chemical Substances Actins ; Drosophila Proteins ; Prp8 protein, Drosophila ; RNA Splicing Factors ; ras Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2018-11-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.162156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ub I Zs.183: Show issues Location:
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