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  1. Article ; Online: Zika virus infection in pregnant women and their children: A review.

    Marbán-Castro, Elena / Goncé, Anna / Fumadó, Victoria / Romero-Acevedo, Lucía / Bardají, Azucena

    European journal of obstetrics, gynecology, and reproductive biology

    2021  Volume 265, Page(s) 162–168

    Abstract: Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) transmitted primarily by Aedes mosquitoes. ZIKV can be transmitted to humans by non-vector borne mechanisms such as sexual intercourse, maternal-foetal transmission or blood transfusion. In 2015, ... ...

    Abstract Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) transmitted primarily by Aedes mosquitoes. ZIKV can be transmitted to humans by non-vector borne mechanisms such as sexual intercourse, maternal-foetal transmission or blood transfusion. In 2015, ZIKV emerged in the Americas, and spread to 87 countries and territories with autochthonous transmission, distributed across four of the six WHO regions. Most ZIKV infections in pregnancy are asymptomatic, but mother to child transmission of the virus can occur in 20 to 30% of cases and cause severe foetal and child defects. Children exposed to ZIKV while in utero might develop a pattern of structural anomalies and functional disabilities secondary to central nervous system damage, known as congenital Zika syndrome, and whose most common clinical feature is microcephaly. Normocephalic children born to mothers with ZIKV infection in pregnancy, and with no observable Zika-associated birth defects, may also present with later neurodevelopmental delay or post-natal microcephaly. Screening and detection of ZIKV infection in pregnancy is essential, because most women with ZIKV infection are asymptomatic and clinical manifestations are non-specific. However, the diagnosis of ZIKV infection poses multiple challenges due to limited resources and scarce laboratory capabilities in most affected areas, the narrow window of time that the virus persists in the bloodstream, the large proportion of asymptomatic infections, and the cross-reactivity with other flaviviruses such as Dengue virus (DENV). Molecular methods (RT-PCR) are the most reliable tool to confirm ZIKV infection, as serodiagnosis requires confirmation with neutralization tests in case of inconclusive or positive serology results. Prenatal ultrasound assessment is essential for monitoring foetal development and early detection of possible severe anomalies. A mid- and long-term follow-up of children exposed to ZIKV while in utero is necessary to promptly detect clinical manifestations of possible neurological impairment. Tweetable abstract: Zika virus infection during pregnancy is a cause of pregnancy loss and disability in children. Protection against mosquito bites, access to sexual and reproductive health services, prompt screening and detection of ZIKV infection in pregnancy, and prenatal ultrasound monitoring are key control strategies whilst a vaccine is not available.
    MeSH term(s) Animals ; Child ; Female ; Humans ; Infectious Disease Transmission, Vertical ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/epidemiology ; Pregnant Women ; Zika Virus ; Zika Virus Infection/complications ; Zika Virus Infection/diagnosis ; Zika Virus Infection/epidemiology
    Language English
    Publishing date 2021-07-09
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2021.07.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Association between soluble angiotensin-converting enzyme 2 in saliva and SARS-CoV-2 infection: a cross-sectional study.

    Bru, Samuel / Brotons, Pedro / Jordan, Iolanda / Alsina, Laia / Henares, Desiree / Carballar, Reyes / de Sevilla, Mariona Fernandez / Barrabeig, Irene / Fumado, Victoria / Baro, Bàrbara / Martínez-Láinez, Joan Marc / Garcia-Garcia, Juan J / Bassat, Quique / Balaguer, Albert / Clotet, Josep / Launes, Cristian / Muñoz-Almagro, Carmen

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 5985

    Abstract: This study aimed to investigate the association between saliva soluble angiotensin-converting enzyme 2 (sACE2) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adults. We selected a convenience sample of adults ... ...

    Abstract This study aimed to investigate the association between saliva soluble angiotensin-converting enzyme 2 (sACE2) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adults. We selected a convenience sample of adults with post-acute SARS-CoV-2 infection and their household children living in quarantined family households of the metropolitan Barcelona region (Spain) during the spring 2020 pandemic national lockdown. Participants were tested for saliva sACE2 quantification by western blot and nasopharyngeal SARS-CoV-2 RT-PCR detection. A total of 161 saliva samples [82 (50.9%) from children; 79 (49.1%) from females] yielded valid western blot and RT-PCR results. Saliva sACE2 was detected in 79 (96.3%) children and 76 (96.2%) convalescent adults. Twenty (24.4%) children and 20 (25.3%) convalescent adults were positive for SARS-CoV-2 in nasopharynx by RT-PCR. SARS-CoV-2 RT-PCR-negative children had a significantly higher mean proportional level of saliva sACE2 (0.540 × 10
    MeSH term(s) Adult ; Child ; Female ; Humans ; Angiotensin-Converting Enzyme 2 ; Communicable Disease Control ; COVID-19/epidemiology ; Cross-Sectional Studies ; Nasopharynx ; Saliva ; SARS-CoV-2 ; Specimen Handling
    Chemical Substances ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; STAT3 protein, human
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-31911-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Perceptions of COVID-19 Maternal Vaccination among Pregnant Women and Healthcare Workers and Factors That Influence Vaccine Acceptance: A Cross-Sectional Study in Barcelona, Spain.

    Marbán-Castro, Elena / Nedic, Ivana / Ferrari, Mara / Crespo-Mirasol, Esther / Ferrer, Laia / Noya, Berta / Marin, Anna / Fumadó, Victoria / López, Marta / Menéndez, Clara / Martínez Bueno, Cristina / Llupià, Anna / Goncé, Anna / Bardají, Azucena

    Vaccines

    2022  Volume 10, Issue 11

    Abstract: COVID-19 is associated with poor maternal and pregnancy outcomes. COVID-19 vaccination is recommended in Spain, yet vaccination rates in pregnancy are suboptimal. This study investigates the perceptions of pregnant women and healthcare workers (HCW) ... ...

    Abstract COVID-19 is associated with poor maternal and pregnancy outcomes. COVID-19 vaccination is recommended in Spain, yet vaccination rates in pregnancy are suboptimal. This study investigates the perceptions of pregnant women and healthcare workers (HCW) regarding COVID-19 vaccination. A web-based cross-sectional quantitative study was conducted in 2021-2022 among 302 pregnant women and 309 HCWs in the Catalan public health system. Most pregnant women (83%) and HCWs (86%) were aware of COVID-19 maternal vaccines. The recommendation of the COVID-19 vaccination by an HCW was identified as the greatest facilitator for maternal vaccine uptake, while the fear of harming the foetus was the most significant barrier reported for rejecting vaccination. HCWs recognised they received limited information and training about COVID-19 vaccination in pregnancy, which hindered them from providing informed recommendations. This study highlights that information and education on COVID-19 vaccines to pregnant women and health professionals are pivotal to ensuring informed decision-making and increasing vaccine uptake.
    Language English
    Publishing date 2022-11-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10111930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19 and Africa: Surviving between a rock and a hard place.

    de Aranzabal, Maite / Fumadó, Victoria / Alegria, Iñaki / Rivera, Mercedes / Torre, Nuria / Guibert, Belen / Muñoz, María José / Moraleda, Cinta / Bassat, Quique

    Anales de pediatria

    2020  Volume 93, Issue 6, Page(s) 420.e1–420.e6

    Abstract: With over 575,000 deaths and about 13.3 million cases globally, the COVID-19 pandemic has had a terrible impact globally during the 6 months since cases were first detected in China. Conscious of the many challenges presented in settings with abundance ... ...

    Abstract With over 575,000 deaths and about 13.3 million cases globally, the COVID-19 pandemic has had a terrible impact globally during the 6 months since cases were first detected in China. Conscious of the many challenges presented in settings with abundance of resources and with robust health systems, where mortality has been significant and transmission difficult to control, there was a logical concern to see how the virus could impact African countries, and their fragile and weak health systems. Such an anticipated "tsunami", with potentially devastating consequences, seems however to not have yet arrived, and African countries, albeit witnessing an increasing degree of autochthonous transmission, seem to this day relatively unaffected by the pandemic. In this article we review the current situation of the pandemic in the African continent, trying to understand the determinants of its slow progress.
    Keywords covid19
    Language English
    Publishing date 2020-11-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2830901-7
    ISSN 2341-2879 ; 2341-2879
    ISSN (online) 2341-2879
    ISSN 2341-2879
    DOI 10.1016/j.anpede.2020.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19 y África: sobreviviendo entre la espada y la pared.

    de Aranzabal, Maite / Fumadó, Victoria / Alegria, Iñaki / Rivera, Mercedes / Torre, Nuria / Guibert, Belen / Muñoz, María José / Moraleda, Cinta / Bassat, Quique

    Anales de pediatria

    2020  Volume 93, Issue 6, Page(s) 420.e1–420.e6

    Abstract: With over 575,000 deaths and about 13.3 million cases globally, the COVID-19 pandemic has had a terrible impact globally during the 6 months since cases were first detected in China. Conscious of the many challenges presented in settings with abundance ... ...

    Title translation COVID-19 and Africa: Surviving between a rock and a hard place.
    Abstract With over 575,000 deaths and about 13.3 million cases globally, the COVID-19 pandemic has had a terrible impact globally during the 6 months since cases were first detected in China. Conscious of the many challenges presented in settings with abundance of resources and with robust health systems, where mortality has been significant and transmission difficult to control, there was a logical concern to see how the virus could impact African countries, and their fragile and weak health systems. Such an anticipated "tsunami", with potentially devastating consequences, seems however to not have yet arrived, and African countries, albeit witnessing an increasing degree of autochthonous transmission, seem to this day relatively unaffected by the pandemic. In this article we review the current situation of the pandemic in the African continent, trying to understand the determinants of its slow progress.
    MeSH term(s) Africa/epidemiology ; COVID-19/epidemiology ; COVID-19/mortality ; COVID-19/transmission ; Delivery of Health Care/organization & administration ; Developing Countries ; Health Resources/statistics & numerical data ; Humans
    Keywords covid19
    Language Spanish
    Publishing date 2020-08-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2830901-7
    ISSN 2341-2879 ; 2341-2879
    ISSN (online) 2341-2879
    ISSN 2341-2879
    DOI 10.1016/j.anpedi.2020.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Safety and Acceptance of COVID-19 Vaccination After Multisystem Inflammatory Syndrome in Children (MIS-C) in Spain.

    Epalza, Cristina / Prieto-Tato, Luis / Pino, Rosa / Escartín-Paredes, Paula / Leoz, Inés / Grasa, Carlos / Vivanco-Allende, Ana / Rivière, Jacques G / Carrasco-Colom, Jaume / Villate, Olatz / Fumadó, Victoria / Hermoso-Ibañez, Concepción / Herrero, Blanca / Aguilera-Alonso, David / Tagarro, Alfredo / Moraleda, Cinta

    Journal of the Pediatric Infectious Diseases Society

    2022  Volume 11, Issue 10, Page(s) 471–473

    Abstract: In this cohort of 42 adolescents with a previous multisystem inflammatory syndrome (MIS-C) diagnosis, 32 (76.2%) were vaccinated with COVID-19 vaccines, with a low incidence of relevant adverse events. More importantly, no new MIS-C or myocarditis ... ...

    Abstract In this cohort of 42 adolescents with a previous multisystem inflammatory syndrome (MIS-C) diagnosis, 32 (76.2%) were vaccinated with COVID-19 vaccines, with a low incidence of relevant adverse events. More importantly, no new MIS-C or myocarditis occurred after a median of 10 weeks (range 5.3-19.7) post-vaccination.
    MeSH term(s) Adolescent ; Child ; Humans ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Spain/epidemiology ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-07-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piac076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: "Maternal Vaccination Greatly Depends on Your Trust in the Healthcare System": A Qualitative Study on the Acceptability of Maternal Vaccines among Pregnant Women and Healthcare Workers in Barcelona, Spain.

    Marín-Cos, Anna / Marbán-Castro, Elena / Nedic, Ivana / Ferrari, Mara / Crespo-Mirasol, Esther / Ventura, Laia Ferrer / Zamora, Berta Noya / Fumadó, Victoria / Menéndez, Clara / Martínez Bueno, Cristina / Llupià, Anna / López, Marta / Goncé, Anna / Bardají, Azucena

    Vaccines

    2022  Volume 10, Issue 12

    Abstract: The World Health Organization (WHO) identified vaccine hesitancy as one of the top 10 threats to global health in 2019. Health promotion and education have been seen to improve knowledge and uptake of vaccinations in pregnancy. This qualitative study was ...

    Abstract The World Health Organization (WHO) identified vaccine hesitancy as one of the top 10 threats to global health in 2019. Health promotion and education have been seen to improve knowledge and uptake of vaccinations in pregnancy. This qualitative study was conducted based on phenomenology, a methodological approach to understand first-hand experiences, and grounded theory, an inductive approach to analyse data, where theoretical generalisations emerge. Data were collected through semi-structured interviews with pregnant women attending antenatal care services and healthcare workers (HCWs) in Barcelona, Spain. Interviews were audio-recorded, transcribed, and coded, and notes were taken. Inductive thematic analysis was performed, and data were manually coded. Pertussis was reported as the most trusted vaccine among pregnant women due to its long-standing background as a recommended vaccine in pregnancy. The influenza vaccine was regarded as less important since it was perceived to cause mild disease. The COVID-19 vaccine was the least trustworthy for pregnant women due to uncertainties about effectiveness, health effects in the mid- and long-term, the fast development of the vaccine mRNA technology, and the perceptions of limited data on vaccine safety. However, the necessity to be vaccinated was justified by pregnant women due to the exceptional circumstances of the COVID-19 pandemic. The recommendations provided by HCW and the established relationship between the HCW, particularly midwives, and pregnant women were the main factors affecting decision-making. The role of mass media was perceived as key to helping provide reliable messages about the need for vaccines during pregnancy. Overall, vaccines administered during pregnancy were perceived as great tools associated with better health and improved quality of life. Pregnancy was envisioned as a vulnerable period in women's lives that required risk-benefits assessments for decision-making about maternal vaccinations. A holistic approach involving the community and society was considered crucial for health education regarding maternal vaccines in support of the work conducted by HCWs.
    Language English
    Publishing date 2022-11-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10122015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Acute and long-term immune responses to SARS-CoV-2 infection in unvaccinated children and young adults with inborn errors of immunity.

    García-García, Ana / Fortuny, Claudia / Fumadó, Victoria / Jordan, Iolanda / Ruiz-López, Laura / González-Navarro, Europa Azucena / Egri, Natalia / Esteve-Solé, Ana / Luo, Yiyi / Vlagea, Alexandru / Cabedo, Manel Monsonís / Launes, Cristian / Soler, Aleix / Codina, Anna / Juan, Manel / Pascal, Mariona / Deyà-Martínez, Angela / Alsina, Laia

    Frontiers in immunology

    2023  Volume 14, Page(s) 1084630

    Abstract: Purpose: To describe SARS-CoV-2 infection outcome in unvaccinated children and young adults with inborn errors of immunity (IEI) and to compare their specific acute and long-term immune responses with a sex-, age-, and severity-matched healthy ... ...

    Abstract Purpose: To describe SARS-CoV-2 infection outcome in unvaccinated children and young adults with inborn errors of immunity (IEI) and to compare their specific acute and long-term immune responses with a sex-, age-, and severity-matched healthy population (HC).
    Methods: Unvaccinated IEI patients up to 22 years old infected with SARS-CoV-2 were recruited along with a cohort of HC. SARS-CoV-2 serology and ELISpot were performed in the acute phase of infection (up to 6 weeks) and at 3, 6, 9, and 12 months.
    Results: Twenty-five IEI patients (median age 14.3 years, min.-max. range 4.5-22.8; 15/25 males; syndromic combined immunodeficiencies: 48.0%, antibody deficiencies: 16.0%) and 17 HC (median age 15.3 years, min.-max. range 5.4-20.0; 6/17 males, 35.3%) were included. Pneumonia occurred in 4/25 IEI patients. In the acute phase SARS-CoV-2 specific immunoglobulins were positive in all HC but in only half of IEI in whom it could be measured (n=17/25): IgG
    Conclusions: Our IEI pediatric cohort had a higher COVID-19 pneumonia rate than the general age-range population, with lower humoral and cellular responses in the acute phase (even lower compared to the reported IEI serological response after SARS-CoV-2 vaccination), and weaker humoral responses at 6 months after infection compared with HC.
    MeSH term(s) Male ; Humans ; Child ; Young Adult ; Adolescent ; COVID-19 ; SARS-CoV-2 ; COVID-19 Vaccines ; Immunoglobulin M ; Primary Immunodeficiency Diseases ; Immunity ; Immunoglobulin A ; Immunoglobulin G
    Chemical Substances COVID-19 Vaccines ; Immunoglobulin M ; Immunoglobulin A ; Immunoglobulin G
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1084630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Travel-associated extensively drug-resistant typhoid fever: a case series to inform management in non-endemic regions.

    Posen, H Joshua / Wong, Waison / Farrar, Daniel S / Campigotto, Aaron / Chan, Tiffany / Barker, Kevin R / Hagmann, Stefan H F / Ryan, Edward T / LaRocque, Regina C / Earl, Ashlee M / Worby, Colin J / Castelli, Francesco / Fumadó, Victoria Pérez / Britton, Philip N / Libman, Michael / Hamer, Davidson H / Morris, Shaun K

    Journal of travel medicine

    2022  Volume 30, Issue 1

    Abstract: Background: Extensively drug-resistant (XDR) typhoid fever is a threat to travelers to Pakistan. We describe a multicontinental case series of travel-acquired XDR typhoid fever to demonstrate the global spread of the problem and encourage preventive ... ...

    Abstract Background: Extensively drug-resistant (XDR) typhoid fever is a threat to travelers to Pakistan. We describe a multicontinental case series of travel-acquired XDR typhoid fever to demonstrate the global spread of the problem and encourage preventive interventions as well as appropriate empiric antimicrobial use.
    Methods: Cases were extracted from the GeoSentinel database, microbiologic laboratory records of two large hospitals in Toronto, Canada, and by invitation to TropNet sites. All isolates were confirmed XDR Salmonella enterica serovar Typhi (Salmonella typhi), with resistance to ampicillin, ceftriaxone, ciprofloxacin and trimethoprim-sulfamethoxazole.
    Results: Seventeen cases were identified in Canada (10), USA (2), Spain (2), Italy (1), Australia (1) and Norway (1). Patients under 18 years represented 71% (12/17) of cases, and all patients travelled to Pakistan to visit friends or relatives. Only one patient is known to have been vaccinated. Predominant symptoms were fever, abdominal pain, vomiting and diarrhoea. Antimicrobial therapy was started on Day 1 of presentation in 75% (12/16) of patients, and transition to a carbapenem or azithromycin occurred a median of 2 days after blood culture was drawn. Antimicrobial susceptibilities were consistent with the XDR S. typhi phenotype, and whole genome sequencing on three isolates confirmed their belonging to the XDR variant of the H58 clade.
    Conclusions: XDR typhoid fever is a particular risk for travelers to Pakistan, and empiric use of a carbapenem or azithromycin should be considered. Pre-travel typhoid vaccination and counseling are necessary and urgent interventions, especially for visiting friends and relatives travelers. Ongoing sentinel surveillance of XDR typhoid fever is needed to understand changing epidemiology.
    MeSH term(s) Humans ; Typhoid Fever/epidemiology ; Travel ; Azithromycin ; Anti-Bacterial Agents ; Salmonella typhi ; Anti-Infective Agents ; Carbapenems ; Pakistan/epidemiology
    Chemical Substances Azithromycin (83905-01-5) ; Anti-Bacterial Agents ; Anti-Infective Agents ; Carbapenems
    Language English
    Publishing date 2022-07-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taac086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Impact of COVID-19 Lockdown on the Nasopharyngeal Microbiota of Children and Adults Self-Confined at Home

    Rocafort, Muntsa / Henares, Desiree / Brotons, Pedro / Launes, Cristian / Fernandez de Sevilla, Mariona / Fumado, Victoria / Barrabeig, Irene / Arias, Sara / Redin, Alba / Ponomarenko, Julia / Mele, Maria / Millat-Martinez, Pere / Claverol, Joana / Balanza, Nuria / Mira, Alex / Garcia-Garcia, Juan J. / Bassat, Quique / Jordan, Iolanda / Muñoz-Almagro, Carmen

    Viruses. 2022 July 12, v. 14, no. 7

    2022  

    Abstract: The increased incidence of COVID-19 cases and deaths in Spain in March 2020 led to the declaration by the Spanish government of a state of emergency imposing strict confinement measures on the population. The objective of this study was to characterize ... ...

    Abstract The increased incidence of COVID-19 cases and deaths in Spain in March 2020 led to the declaration by the Spanish government of a state of emergency imposing strict confinement measures on the population. The objective of this study was to characterize the nasopharyngeal microbiota of children and adults and its relation to SARS-CoV-2 infection and COVID-19 severity during the pandemic lockdown in Spain. This cross-sectional study included family households located in metropolitan Barcelona, Spain, with one adult with a previous confirmed COVID-19 episode and one or more exposed co-habiting child contacts. Nasopharyngeal swabs were used to determine SARS-CoV-2 infection status, characterize the nasopharyngeal microbiota and determine common respiratory DNA/RNA viral co-infections. A total of 173 adult cases and 470 exposed children were included. Overall, a predominance of Corynebacterium and Dolosigranulum and a limited abundance of common pathobionts including Haemophilus and Streptococcus were found both among adults and children. Children with current SARS-CoV-2 infection presented higher bacterial richness and increased Fusobacterium, Streptococcus and Prevotella abundance than non-infected children. Among adults, persistent SARS-CoV-2 RNA was associated with an increased abundance of an unclassified member of the Actinomycetales order. COVID-19 severity was associated with increased Staphylococcus and reduced Dolosigranulum abundance. The stringent COVID-19 lockdown in Spain had a significant impact on the nasopharyngeal microbiota of children, reflected in the limited abundance of common respiratory pathobionts and the predominance of Corynebacterium, regardless of SARS-CoV-2 detection. COVID-19 severity in adults was associated with decreased nasopharynx levels of healthy commensal bacteria.
    Keywords COVID-19 infection ; Corynebacterium ; DNA ; Dolosigranulum ; Fusobacterium ; Haemophilus ; Prevotella ; RNA ; Severe acute respiratory syndrome coronavirus 2 ; Staphylococcus ; Streptococcus ; adults ; children ; cross-sectional studies ; nasopharynx ; pandemic ; Spain
    Language English
    Dates of publication 2022-0712
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14071521
    Database NAL-Catalogue (AGRICOLA)

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