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  1. Article ; Online: Salvia rosmarinus: a possible role in unmet therapeutic needs in the prevention and care of immunological disorders.

    Furci, Fabiana / Cicero, Nicola / Allegra, Alessandro / Gangemi, Sebastiano

    Natural product research

    2024  , Page(s) 1–5

    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2024.2338815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Microbiota, Diet and Acute Leukaemia: Tips and Tricks on Their Possible Connections.

    Furci, Fabiana / Cicero, Nicola / Allegra, Alessandro / Gangemi, Sebastiano

    Nutrients

    2023  Volume 15, Issue 19

    Abstract: Acute leukaemia is probably one of the most recurrent cancers in children and younger adults, with an incidence of acute lymphoblastic leukaemia in 80% of cases and an incidence of acute myeloid leukaemia in 15% of cases. Yet, while incidence is common ... ...

    Abstract Acute leukaemia is probably one of the most recurrent cancers in children and younger adults, with an incidence of acute lymphoblastic leukaemia in 80% of cases and an incidence of acute myeloid leukaemia in 15% of cases. Yet, while incidence is common in children and adolescents, acute leukaemia is a rare disease whose aetiology still requires further analysis. Many studies have investigated the aetiology of acute leukaemia, reporting that the formation of gut microbiota may be modified by the start and development of many diseases. Considering that in patients affected by acute lymphoblastic leukaemia, there is an inherent disequilibrium in the gut microbiota before treatment compared with healthy patients, increasing evidence shows how dysbiosis of the gut microbiota provokes an inflammatory immune response, contributing to the development of cancer. Our analysis suggeststhe key role of gut microbiota in the modulation of the efficacy of leukaemia treatment as well as in the progress of many cancers, such as acute leukaemia. Therefore, in this paper, we present an examination of information found in literature regarding the role of dietary factors and gut microbiota alterations in the development of leukaemia and suggest possible future preventive and therapeutic strategies.
    MeSH term(s) Child ; Adult ; Adolescent ; Humans ; Neoplasm Recurrence, Local ; Microbiota ; Diet/adverse effects ; Leukemia, Myeloid, Acute/etiology ; Dysbiosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/etiology
    Language English
    Publishing date 2023-10-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15194253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Anaphylaxis due to antiallergic and antiasthmatic biologics.

    Furci, Fabiana / Luxi, Nicoletta / Senna, Gianenrico / Trifirò, Gianluca

    Current opinion in allergy and clinical immunology

    2023  Volume 23, Issue 5, Page(s) 364–369

    Abstract: Purpose of review: To provide a better understanding of the risk of anaphylaxis due to antiallergic and antiasthmatic biologics through an analysis of data reported in literature and in clinical trials, and by conducting a retrospective descriptive ... ...

    Abstract Purpose of review: To provide a better understanding of the risk of anaphylaxis due to antiallergic and antiasthmatic biologics through an analysis of data reported in literature and in clinical trials, and by conducting a retrospective descriptive analysis of individual case safety reports on VigiBase, the WHO International Pharmacovigilance database.
    Recent findings: Analysis of the data, as described, demonstrated safety of the antiallergic and antiasthmatic biologics with a low incidence of anaphylaxis.
    Summary: Biologic therapies have revolutionized the treatment of many diseases, such as atopic dermatitis, nasal polyps, spontaneous chronic urticarial and severe asthma with a precise immunological action, in the sphere of precision medicine.Albeit these drugs are generally well tolerated, generating real-world evidence is crucial to re-evaluate clinically relevant adverse events, such as anaphylaxis, allowing to confirm their safety profile in particular in special populations such as paediatric patients.
    MeSH term(s) Humans ; Child ; Anaphylaxis/chemically induced ; Anaphylaxis/drug therapy ; Biological Products/adverse effects ; Anti-Asthmatic Agents ; Anti-Allergic Agents ; Retrospective Studies
    Chemical Substances Biological Products ; Anti-Asthmatic Agents ; Anti-Allergic Agents
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0000000000000937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Plant Food Allergy Improvement after Grass Pollen Sublingual Immunotherapy: A Case Series.

    Furci, Fabiana / Ricciardi, Luisa

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 11

    Abstract: Background: Cross-reactivity between pollens and plant food has been widely described. Pollen extract subcutaneous immunotherapy in patients with pollens and plant food allergy has been shown to improve tolerance not only to inhalant allergens but also ... ...

    Abstract Background: Cross-reactivity between pollens and plant food has been widely described. Pollen extract subcutaneous immunotherapy in patients with pollens and plant food allergy has been shown to improve tolerance not only to inhalant allergens but also to reduce symptoms in patients with various food allergies.
    Methods: We retrospectively report our experience with 15 female patients with a positive history for moderate, persistent allergic rhinitis due to grass pollen and oropharyngeal symptoms after ingestion of different plant food. These patients followed a five-grass pollen sublingual tablet immunotherapy for three years in a discontinuous pre-co-seasonal scheme.
    Results: All 15 patients treated with the 5-grass pollen sublingual tablet immunotherapy, taken once daily for 3 years on a 7-month course, showed improved ocular/nasal symptoms, with a reduction in the use of symptomatic drugs (e.g., nasal corticosteroids and H1 antihistamines). After the first seven-month course of immunotherapy, all patients declared a good tolerance to the intake of fruits and vegetables, and in particular, good tolerance to the offending foods.
    Conclusions: In conclusion, we have observed improvement of both respiratory and plant food allergies after sublingual immunotherapy (SLIT) with a five-grass pollen tablet.
    Language English
    Publishing date 2021-10-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10111412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Plant Food Allergy Improvement after Grass Pollen Sublingual Immunotherapy: A Case Series

    Furci, Fabiana / Ricciardi, Luisa

    Pathogens. 2021 Oct. 30, v. 10, no. 11

    2021  

    Abstract: Background: Cross-reactivity between pollens and plant food has been widely described. Pollen extract subcutaneous immunotherapy in patients with pollens and plant food allergy has been shown to improve tolerance not only to inhalant allergens but also ... ...

    Abstract Background: Cross-reactivity between pollens and plant food has been widely described. Pollen extract subcutaneous immunotherapy in patients with pollens and plant food allergy has been shown to improve tolerance not only to inhalant allergens but also to reduce symptoms in patients with various food allergies. Methods: We retrospectively report our experience with 15 female patients with a positive history for moderate, persistent allergic rhinitis due to grass pollen and oropharyngeal symptoms after ingestion of different plant food. These patients followed a five-grass pollen sublingual tablet immunotherapy for three years in a discontinuous pre-co-seasonal scheme. Results: All 15 patients treated with the 5-grass pollen sublingual tablet immunotherapy, taken once daily for 3 years on a 7-month course, showed improved ocular/nasal symptoms, with a reduction in the use of symptomatic drugs (e.g., nasal corticosteroids and H1 antihistamines). After the first seven-month course of immunotherapy, all patients declared a good tolerance to the intake of fruits and vegetables, and in particular, good tolerance to the offending foods. Conclusions: In conclusion, we have observed improvement of both respiratory and plant food allergies after sublingual immunotherapy (SLIT) with a five-grass pollen tablet.
    Keywords adrenal cortex hormones ; allergic rhinitis ; cross reaction ; females ; food allergies ; grasses ; immunotherapy ; ingestion ; nose ; pollen
    Language English
    Dates of publication 2021-1030
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10111412
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: The intriguing possibility of using probiotics in allergen-specific immunotherapy.

    Furci, Fabiana / Caminati, Marco / Crisafulli, Ernesto / Senna, Gianenrico / Gangemi, Sebastiano

    The World Allergy Organization journal

    2023  Volume 16, Issue 2, Page(s) 100751

    Abstract: Allergen immunotherapy (AIT) can be considered the etiological therapy for allergic rhinitis and hymenoptera venom allergy. Its role is increasingly emerging in the context of IgE mediated food allergy, where the achievement of tolerance, or the ... ...

    Abstract Allergen immunotherapy (AIT) can be considered the etiological therapy for allergic rhinitis and hymenoptera venom allergy. Its role is increasingly emerging in the context of IgE mediated food allergy, where the achievement of tolerance, or the permanent resolution of an allergy, represents the optimal goal of AIT. AIT treatment, indicated in adults and children with allergic rhinitis, has a preventative effect on the development of asthma and can also be used when asthma is associated to rhinitis; however, it is not the first choice for treatment of isolated asthma. While knowledge on immunological mechanisms, efficacy, and safety of AIT is known, an intriguing line of investigation has arisen on how the action of AIT is modulated by the use of probiotics, starting from awareness that the microbiome is altered in allergic conditions: the use of probiotics in inducing the stimulation of innate immunity via toll-like receptor activation, thus acting as adjuvants in AIT, is hereby examined. Therefore, by analyzing literature on AIT and probiotics, we intend to draw attention to how the role and use of AIT are emerging as being increasingly important for both the short- and long-term management of allergic diseases and how recourse probiotics may represent an additional therapeutic strategy to modulate the effectiveness of AIT. However, further investigations are needed to better identify which probiotics to use, the dosage, and the optimal duration to obtain correct immunomodulation, and how to best customize their use, including a "AIT + probiotics" strategy in the field of precision medicine.
    Language English
    Publishing date 2023-02-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2581968-9
    ISSN 1939-4551
    ISSN 1939-4551
    DOI 10.1016/j.waojou.2023.100751
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  7. Article: Upsides and downsides of a telecounselling model of integrated asthma management between general practitioners and specialists.

    Furci, Fabiana / Caminati, Marco / Genovese, Sara / Gangemi, Sebastiano / Senna, Gianenrico

    Clinical and translational allergy

    2022  Volume 12, Issue 2, Page(s) e12088

    Abstract: Background: Asthma control, one of the most important goals in the management of asthmatic patients, requires good adherence to guidelines and support at a territorial level, in particular on the part of general practitioners (GPs). A territorial ... ...

    Abstract Background: Asthma control, one of the most important goals in the management of asthmatic patients, requires good adherence to guidelines and support at a territorial level, in particular on the part of general practitioners (GPs). A territorial hospital alliance can become a strength in asthma management, where control by GPs can also be carried out through a spirometric examination.
    Methods: The realisation of a telecounselling model management of asthma between GPs and specialists was the aim of this study, to understand how to obtain good asthma control. A specific digital platform, the PneumoApp platform, was used for the insertion of clinical data and flow volume (F-V) curves, performed in asthmatic patients by GPs, and for the subsequent evaluation of these data by specialists.
    Results: GPs have shown to be able to perform a check-up of respiratory function well using a portable spirometer, but the analysis of the collected data showed that GP assessment of the severity level of asthma is incorrect in patients with moderate-severe asthma.
    Conclusions: The effectiveness of a telecounselling collaboration between hospital and territory in the management of asthma patients can be improved by greater diffusion of the use of Global Initiative for Asthma (GINA) guidelines at a local level.
    Language English
    Publishing date 2022-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2630865-4
    ISSN 2045-7022
    ISSN 2045-7022
    DOI 10.1002/clt2.12088
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  8. Article: The potential protective role of corticosteroid therapy in patients with asthma and COPD against COVID-19.

    Furci, Fabiana / Caminati, Marco / Senna, Gianenrico / Gangemi, Sebastiano

    Clinical and molecular allergy : CMA

    2021  Volume 19, Issue 1, Page(s) 19

    Abstract: Background: The observation of patients hospitalized for coronavirus disease (COVID-19) led us to note a lower prevalence of patients affected by chronic respiratory disease, in particular asthmatic patients, compared to the general population. ... ...

    Abstract Background: The observation of patients hospitalized for coronavirus disease (COVID-19) led us to note a lower prevalence of patients affected by chronic respiratory disease, in particular asthmatic patients, compared to the general population. Therefore, the aim of this paper is to evaluate the possible protective role of corticosteroid therapy in patients with chronic lung disease, regarding the risk of contracting severe COVID-19.
    Main body: SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) receptors to enter the cells. Considering the high number of these receptors in patients affected by asthma and chronic obstructive pulmonary disease (COPD), the evidence that these patients do not have a high risk of hospitalization for COVID-19 needs further study to understand what the possible protective "factors" are in these patients. In particular, the finding in some studies of reduced coronavirus replication in cell lines treated with steroids, molecules commonly used for treating chronic lung diseases, needs further attention.
    Short conclusion: The hypothesis that corticosteroids, commonly used in treating airways diseases, might modify the severity of SARS-CoV-2 disease has become a key point and a possible predictive factor of a positive outcome of COVID-19 in patients treated everyday with these molecules.
    Language English
    Publishing date 2021-11-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2126317-6
    ISSN 1476-7961
    ISSN 1476-7961
    DOI 10.1186/s12948-021-00159-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Air Pollution and microRNAs: The Role of Association in Airway Inflammation.

    Furci, Fabiana / Allegra, Alessandro / Tonacci, Alessandro / Isola, Stefania / Senna, Gianenrico / Pioggia, Giovanni / Gangemi, Sebastiano

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 6

    Abstract: Air pollution exposure plays a key role in the alteration of gene expression profiles, which can be regulated by microRNAs, inducing the development of various diseases. Moreover, there is also evidence of sensitivity of miRNAs to environmental factors, ... ...

    Abstract Air pollution exposure plays a key role in the alteration of gene expression profiles, which can be regulated by microRNAs, inducing the development of various diseases. Moreover, there is also evidence of sensitivity of miRNAs to environmental factors, including tobacco smoke. Various diseases are related to specific microRNA signatures, suggesting their potential role in pathophysiological processes; considering their association with environmental pollutants, they could become novel biomarkers of exposure. Therefore, the aim of the present work is to analyse data reported in the literature on the role of environmental stressors on microRNA alterations and, in particular, to identify specific alterations that might be related to the development of airway diseases so as to propose future preventive, diagnostic, and therapeutic strategies.
    Language English
    Publishing date 2023-06-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13061375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Uncontrolled Asthma: Unmet Needs in the Management of Patients.

    Caminati, Marco / Vaia, Rachele / Furci, Fabiana / Guarnieri, Gabriella / Senna, Gianenrico

    Journal of asthma and allergy

    2021  Volume 14, Page(s) 457–466

    Abstract: The recent scientific research has provided clinicians with the tools for substantially upgrading the standard of care in the field of bronchial asthma. Nevertheless, satisfactory asthma control still remains an unmet need worldwide. Identifying the ... ...

    Abstract The recent scientific research has provided clinicians with the tools for substantially upgrading the standard of care in the field of bronchial asthma. Nevertheless, satisfactory asthma control still remains an unmet need worldwide. Identifying the major determinants of poor control in different asthma severity levels represents the first step towards the improvement of the overall patients' management. The present review aims to provide an overview of the main unmet needs in asthma control and of the potential tools for overcoming the issue. Implementing a personalized medicine approach is essential, not only in terms of pharmacological treatments, biologic drugs or sophisticated biomarkers. In fact, exploring the complex profile of each patient, from his inflammation phenotype to his preferences and expectations, may help in filling the gap between the big potential of currently available treatments and the overall unsatisfactory asthma control. Telemedicine and e-health technologies may provide a strategy to both optimize disease assessment on a regular basis and enhance patients' empowerment in managing their asthma. Increasing patients' awareness as well as the physicians' knowledge about asthma phenotypes and treatment options besides corticosteroid probably represent the key and more difficult goals of all the players involved in asthma management at every level.
    Language English
    Publishing date 2021-05-03
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494877-9
    ISSN 1178-6965
    ISSN 1178-6965
    DOI 10.2147/JAA.S260604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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