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Article ; Conference proceedings: Extended abstracts / 8th International Workshop on Microbeam Probes of Cellular Radiation Response

Furusawa, Yoshiya

Journal of radiation research 50 , Suppl. A, S. A82 - A125 : Ill., graph. Darst.

November 13 - 15, 2008, Chiba, Japan

2009

Event/congress	International Workshop on Microbeam Probes of Cellular Radiation Response (8, 2008, Chiba)
Author's details	co-presidents Yoshiya Furusawa
Collection	Journal of radiation research
Language	English
Publishing place	Chiba, 2009
Publishing country	Japan
Document type	Article ; Conference proceedings
HBZ-ID	HT016051249
Database	Catalogue ZB MED Medicine, Health

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Zs B 388 -50,Suppl.A-

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Article ; Online: Publication of JRR transfers to Oxford University Press (OUP).

Furusawa, Yoshiya

Journal of radiation research

2012 Volume 53, Issue 4, Page(s) 505

MeSH term(s)	Access to Information ; Japan ; Publishing ; Radiation Oncology/trends ; Radiology/trends
Language	English
Publishing date	2012-07-27
Publishing country	England
Document type	Editorial
ZDB-ID	603983-2
ISSN	1349-9157 ; 0449-3060
ISSN (online)	1349-9157
ISSN	0449-3060
DOI	10.1093/jrr/rrs040
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Article ; Online: Identification and characterization of inheritable structural variations induced by ion beam radiations in rice.

Zheng, Yunchao / Li, Shan / Huang, Jianzhong / Fu, Haowei / Zhou, Libin / Furusawa, Yoshiya / Shu, Qingyao

Mutation research

2021 Volume 823, Page(s) 111757

Abstract: High energy ion beams are effective physical mutagens for mutation induction in plants. Due to their high linear energy transfer (LET) property, they are known to generate single nucleotide variations (SNVs) and insertion/deletions (InDels, <50 bp) as ... ...

Abstract	High energy ion beams are effective physical mutagens for mutation induction in plants. Due to their high linear energy transfer (LET) property, they are known to generate single nucleotide variations (SNVs) and insertion/deletions (InDels, <50 bp) as well as structural variations (SVs). However, due to the technical difficulties to identify SVs, studies on ion beam induced SVs by genome sequencing have so far been limited in numbers and inadequate in nature, and knowledge of SVs is scarce with regards to their characteristics. In the present study, we identified and validated SVs in six M
MeSH term(s)	Argon/chemistry ; Carbon/chemistry ; Chromosome Aberrations/radiation effects ; DNA Transposable Elements ; Genome, Plant/radiation effects ; Heavy Ions ; Heterozygote ; Homologous Recombination ; Homozygote ; Mutagenesis ; Mutation ; Neon/chemistry ; Oryza/genetics ; Oryza/radiation effects ; Pilot Projects ; Radiation, Ionizing ; Tandem Repeat Sequences
Chemical Substances	DNA Transposable Elements ; Neon (4VB4Y46AHD) ; Argon (67XQY1V3KH) ; Carbon (7440-44-0)
Language	English
Publishing date	2021-06-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	206607-5
ISSN	1873-135X ; 1383-5718 ; 0027-5107 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
ISSN (online)	1873-135X
ISSN	1383-5718 ; 0027-5107 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
DOI	10.1016/j.mrfmmm.2021.111757
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Article ; Online: The Potential Application of Heavy Ion Beams in the Treatment of Arrhythmia: The Role of Radiation-Induced Modulation of Connexin43 and the Sympathetic Nervous System.

Amino, Mari / Yoshioka, Koichiro / Kamada, Tadashi / Furusawa, Yoshiya

International journal of particle therapy

2018 Volume 5, Issue 1, Page(s) 140–150

Abstract: It has been known that heart disease-such as myocardial infarction (MI), cardiac hypertrophy, or heart failure-alters the molecular structure and function of the gap junction, which can lead to an abnormal heart rhythm. Radiation has been shown to ... ...

Abstract	It has been known that heart disease-such as myocardial infarction (MI), cardiac hypertrophy, or heart failure-alters the molecular structure and function of the gap junction, which can lead to an abnormal heart rhythm. Radiation has been shown to modulate intercellular communication in the skin and lungs by increasing connexin43 (Cx43) expression. Understanding how Cx43 upregulation is induced in a diseased heart can help provide a new perspective to radiation therapy for arrhythmias. In a recent study with rabbits after MI, carbon ions were accelerated to 290 MeV/u and extracted in the air; a biologically (cell kill) uniform 6-cm spread-out Bragg peak beam was generated, and beam tissue depth was set to 30 mm with energy degraders to the depth position. Targeted heavy ion irradiation (THIR) with 15 Gy to the left ventricle increased Cx43 expression, improved conductivity, decreased the spatial heterogeneity of repolarization, and reduced the vulnerability of rabbit hearts to ventricular arrhythmias after MI. In clinically normal rabbits, THIR > = 10 Gy caused a significant dose-dependent increase of Cx43 protein and messenger RNA 2 weeks after irradiation. The left (irradiated) and right (nonirradiated) ventricles exhibited circumferential upregulation of Cx43 lasting for at least 1 year. There were no significant changes in electrocardiograms and echocardiograms, indicating no apparent injury for 1 year. A single exposure of 135 MeV/u THIR with 15 Gy to a dog heart attenuated vulnerability to ventricular arrhythmia after the induction of MI for at least 1 year through the modulation of Cx43 expression. This long-lasting remodeling effect on gap junctions may lay the groundwork to novel therapies against life-threatening ventricular arrhythmias in structural heart disease. To date, there have been few investigations into the effects of carbon-ion irradiation on electrophysiological properties in the human heart. Patients with mediastinum cancer were investigated for 5 years after treatment that included irradiation to the heart, and investigators found that carbon-ion beam irradiation to the heart is not immediately cardiotoxic and demonstrates consistent signals of arrhythmia reduction. Its practical application in non-cancer treatment, such as in arrhythmia treatment, is highly anticipated.
Language	English
Publishing date	2018-09-21
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2331-5180
ISSN (online)	2331-5180
DOI	10.14338/IJPT-18-00022.1
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Article: Mutagenic Effect of Three Ion Beams on Rice and Identification of Heritable Mutations by Whole Genome Sequencing.

Zheng, Yunchao / Li, Shan / Huang, Jianzhong / Fu, Haowei / Zhou, Libin / Furusawa, Yoshiya / Shu, Qingyao

Plants (Basel, Switzerland)

2020 Volume 9, Issue 5

Abstract: High-energy ion beams are known to be an effective and unique type of physical mutagen in plants. However, no study on the mutagenic effect of argon (Ar) ion beam radiation on rice has been reported. Genome-wide studies on induced mutations are important ...

Abstract	High-energy ion beams are known to be an effective and unique type of physical mutagen in plants. However, no study on the mutagenic effect of argon (Ar) ion beam radiation on rice has been reported. Genome-wide studies on induced mutations are important to comprehend their characteristics for establishing knowledge-based protocols for mutation induction and breeding, which are still very limited in rice. The present study aimed to investigate the mutagenic effect of three ion beams, i.e., Ar, carbon (C) and neon (Ne) on rice and identify and characterize heritable induced mutations by the whole genome sequencing of six M
Language	English
Publishing date	2020-04-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants9050551
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Article ; Online: Scaling parameter of the lethal effect of mammalian cells based on radiation-induced OH radicals: effectiveness of direct action in radiation therapy.

Kusumoto, Tamon / Ogawara, Ryo / Igawa, Kazuyo / Baba, Kentaro / Konishi, Teruaki / Furusawa, Yoshiya / Kodaira, Satoshi

Journal of radiation research

2020 Volume 62, Issue 1, Page(s) 86–93

Abstract: We have been studying the effectiveness of direct action, which induces clustered DNA damage leading to cell killing, relative to indirect action. Here a new criterion Direct Ation-Based Biological Effectiveness (DABBLE) is proposed to understand the ... ...

Abstract	We have been studying the effectiveness of direct action, which induces clustered DNA damage leading to cell killing, relative to indirect action. Here a new criterion Direct Ation-Based Biological Effectiveness (DABBLE) is proposed to understand the contribution of direct action for cell killing induced by C ions. DABBLE is defined as the ratio of direct action to indirect action. To derive this ratio, we describe survival curves of mammalian cells as a function of the number of OH radicals produced 1 ps and 100 ns after irradiation, instead of the absorbed dose. By comparing values on the vertical axis of the survival curves at a certain number of OH radicals produced, we successfully discriminate the contribution of direct action induced by C ions from that of indirect action. DABBLE increases monotonically with increasing linear energy transfer (LET) up to 140 keV/μm and then drops, when the survival curves are described by the number of OH radicals 1 ps after irradiation. The trend of DABBLE is in agreement with that of relative biological effectiveness (RBE) of indirect action. In comparison, the value of DABBLE increases monotonically with LET, when the survival curves are described by the number of OH radicals 100 ns after irradiation. This finding implies that the effectiveness of C ion therapy for cancer depends on the contribution of direct action and we can follow the contribution of direct action over time in the chemical phase.
MeSH term(s)	Animals ; Carbon ; Cell Survival/radiation effects ; Hydroxyl Radical/metabolism ; Linear Energy Transfer ; Mammals/metabolism ; Radiotherapy ; Relative Biological Effectiveness ; X-Rays
Chemical Substances	Hydroxyl Radical (3352-57-6) ; Carbon (7440-44-0)
Language	English
Publishing date	2020-12-14
Publishing country	England
Document type	Journal Article
ZDB-ID	603983-2
ISSN	1349-9157 ; 0449-3060
ISSN (online)	1349-9157
ISSN	0449-3060
DOI	10.1093/jrr/rraa111
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Article ; Online: Combination of agents modifying effects in hadrontherapy: modelization of the role of HO° free radicals.

Usami, Noriko / Hirayama, Ryoichi / Kobayashi, Katsumi / Furusawa, Yoshiya / Le Sech, Claude

International journal of radiation biology

2020 Volume 96, Issue 5, Page(s) 622–627

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Betamethasone/pharmacology ; Deoxyglucose/pharmacology ; HeLa Cells ; Humans ; Hydroxyl Radical ; Linear Energy Transfer ; Models, Theoretical ; Platinum Compounds/pharmacology ; Proton Therapy ; Radiation-Sensitizing Agents/pharmacology
Chemical Substances	Platinum Compounds ; Radiation-Sensitizing Agents ; Hydroxyl Radical (3352-57-6) ; Betamethasone (9842X06Q6M) ; Deoxyglucose (9G2MP84A8W)
Language	English
Publishing date	2020-02-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3065-x
ISSN	1362-3095 ; 0020-7616 ; 0955-3002
ISSN (online)	1362-3095
ISSN	0020-7616 ; 0955-3002
DOI	10.1080/09553002.2020.1721594
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Article ; Online: Biological effects of carbon ion beams with various LETs on budding yeast Saccharomyces cerevisiae.

Matuo, Youichirou / Izumi, Yoshinobu / Furusawa, Yoshiya / Shimizu, Kikuo

Mutation research

2017 Volume 810, Page(s) 45–51

Abstract: It has been established that irradiation with higher linear energy transfer (LET) increases lethality and mutagenicity more than that with lower LET. However, the characteristics specific to carbon ion beam have not yet been elucidated. Yeast cells were ... ...

Abstract	It has been established that irradiation with higher linear energy transfer (LET) increases lethality and mutagenicity more than that with lower LET. However, the characteristics specific to carbon ion beam have not yet been elucidated. Yeast cells were irradiated with carbon ions with an LET of 13 or 50keV/μm, and cell survival and mutation frequency were analyzed. The results, combined with our previous findings for ions with an LET of 107keV/μm, demonstrated that, in conjunction with an increase in LET, cell survival decreased, while mutation frequency increased. This indicates that a carbon ion beam with a higher LET is more mutagenic than one with a lower LET.
MeSH term(s)	Carbon ; Cell Survival/radiation effects ; Dose-Response Relationship, Radiation ; Heavy Ion Radiotherapy ; Heavy Ions ; Linear Energy Transfer ; Mutagenesis/radiation effects ; Mutation Rate ; Saccharomyces cerevisiae/radiation effects
Chemical Substances	Carbon (7440-44-0)
Language	English
Publishing date	2017-11-07
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	206607-5
ISSN	1873-135X ; 1383-5718 ; 0027-5107 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
ISSN (online)	1873-135X
ISSN	1383-5718 ; 0027-5107 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
DOI	10.1016/j.mrfmmm.2017.10.003
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Article ; Online: Misrepair of DNA double-strand breaks after exposure to heavy-ion beams causes a peak in the LET-RBE relationship with respect to cell killing in DT40 cells.

Aoki-Nakano, Mizuho / Furusawa, Yoshiya

Journal of radiation research

2013 Volume 54, Issue 6, Page(s) 1029–1035

Abstract: To determine the radiobiological mechanisms underlying relative biological effectiveness (RBE) and the repair efficiencies of DNA double-strand breaks (DSBs) as a function of linear energy transfer (LET), we exposed cells of the chicken B-lymphocyte cell ...

Abstract	To determine the radiobiological mechanisms underlying relative biological effectiveness (RBE) and the repair efficiencies of DNA double-strand breaks (DSBs) as a function of linear energy transfer (LET), we exposed cells of the chicken B-lymphocyte cell line DT40 and its DSB repair pathway-deficient derivatives to heavy-ion beams produced at the Heavy-Ion Medical Accelerator in Chiba (HIMAC) at the National Institute of Radiological Sciences (NIRS), Chiba, Japan. The relationship between LET and cell lethality was investigated in the DNA DSB repair gene knockouts Ku70(-/-), Rad54(-/-), and Ku70(-/-)Rad54(-/-), and in the wild-type cells. We found that cell-cycle stage and activity of the DNA DSB repair pathways influence LET-mediated biological effects. An expected LET-RBE relationship was observed in the cells capable of DNA repair, but no peak was found in the RBE with respect to cell survival in the Ku70(-/-)Rad54(-/-) cells or in Ku70(-/-) cells in the G1 and early S cell-cycle phases (when no sister chromatids were present and homologous recombination could not occur). These findings suggest that the peak in RBE is caused by deficient repair of the DNA DSBs.
MeSH term(s)	Animals ; Apoptosis/genetics ; Apoptosis/radiation effects ; Cell Line, Tumor ; Chickens ; Chromosome Aberrations/radiation effects ; DNA Breaks, Double-Stranded/radiation effects ; DNA Repair/genetics ; DNA Repair/radiation effects ; Dose-Response Relationship, Radiation ; Heavy Ions ; Linear Energy Transfer/genetics ; Linear Energy Transfer/radiation effects ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/pathology ; Radiation Dosage ; Relative Biological Effectiveness
Language	English
Publishing date	2013-05-30
Publishing country	England
Document type	Journal Article
ZDB-ID	603983-2
ISSN	1349-9157 ; 0449-3060
ISSN (online)	1349-9157
ISSN	0449-3060
DOI	10.1093/jrr/rrt064
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Article ; Online: Cell survival fraction estimation based on the probability densities of domain and cell nucleus specific energies using improved microdosimetric kinetic models.

Sato, Tatsuhiko / Furusawa, Yoshiya

Radiation research

2012 Volume 178, Issue 4, Page(s) 341–356

Abstract: Estimation of the survival fractions of cells irradiated with various particles over a wide linear energy transfer (LET) range is of great importance in the treatment planning of charged-particle therapy. Two computational models were developed for ... ...

Abstract	Estimation of the survival fractions of cells irradiated with various particles over a wide linear energy transfer (LET) range is of great importance in the treatment planning of charged-particle therapy. Two computational models were developed for estimating survival fractions based on the concept of the microdosimetric kinetic model. They were designated as the double-stochastic microdosimetric kinetic and stochastic microdosimetric kinetic models. The former model takes into account the stochastic natures of both domain and cell nucleus specific energies, whereas the latter model represents the stochastic nature of domain specific energy by its approximated mean value and variance to reduce the computational time. The probability densities of the domain and cell nucleus specific energies are the fundamental quantities for expressing survival fractions in these models. These densities are calculated using the microdosimetric and LET-estimator functions implemented in the Particle and Heavy Ion Transport code System (PHITS) in combination with the convolution or database method. Both the double-stochastic microdosimetric kinetic and stochastic microdosimetric kinetic models can reproduce the measured survival fractions for high-LET and high-dose irradiations, whereas a previously proposed microdosimetric kinetic model predicts lower values for these fractions, mainly due to intrinsic ignorance of the stochastic nature of cell nucleus specific energies in the calculation. The models we developed should contribute to a better understanding of the mechanism of cell inactivation, as well as improve the accuracy of treatment planning of charged-particle therapy.
MeSH term(s)	Cell Nucleus/radiation effects ; Cell Survival/radiation effects ; Humans ; Kinetics ; Linear Energy Transfer ; Probability ; Radiometry/methods ; Relative Biological Effectiveness ; Salivary Glands/radiation effects
Language	English
Publishing date	2012-08-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80322-4
ISSN	1938-5404 ; 0033-7587
ISSN (online)	1938-5404
ISSN	0033-7587
DOI	10.1667/rr2842.1
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