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Article ; Online: Assessment of Internet Available Patient Information on Chronic Pancreatitis Using the Ensuring Quality Information for Patients Tool: A Systematic Search and Evaluation.

Staubli, Sebastian M / Ghani, Shahi / Walker, Harriet Louise / Fusai, Giuseppe K / Raptis, Dimitri A

2023 Volume 42, Issue 1, Page(s) 70–77

Abstract: Introduction: Chronic pancreatitis (CP) is a relevant chronic medical problem whereby delayed presentation and poor patient understanding can cause adverse effects. Quality of patient information available on the internet about CP is not known.: ... ...

Abstract	Introduction: Chronic pancreatitis (CP) is a relevant chronic medical problem whereby delayed presentation and poor patient understanding can cause adverse effects. Quality of patient information available on the internet about CP is not known. Methods: A systematic review of the information about CP available online using the search term "chronic pancreatitis" in using the search engine Google has been conducted. The quality of the top 100 websites returned from this search term was analysed using the validated Ensuring Quality Information for Patients (EQIP) tool (maximum score 36). Additional items were included in the website analysis specific to CP. Results: In total, 45 websites were eligible for analysis. The median EQIP score of the websites was 16 (interquartile range 12-19.5). The majority of websites originated from the USA and the United Kingdom with 31 and 11 websites, respectively. Provision of additional information was inconsistent, with most websites covering information regarding aetiology and advocating alcohol and tobacco cessation, but only few reporting on more complex issues. Conclusion: Internet available information about CP is of limited quality. There is an immediate need for high quality, patient targeted, and informative literature accessible on the internet about this topic.
Language	English
Publishing date	2023-11-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	632798-9
ISSN	1421-9875 ; 0257-2753
ISSN (online)	1421-9875
ISSN	0257-2753
DOI	10.1159/000535073
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Article ; Online: Role of circulating exosomal biomarkers and their diagnostic accuracy in pancreatic cancer.

Sha, Menazir / Kunduzi, Basir / Froghi, Saied / Quaglia, Alberto / Davidson, Brian / Fusai, Giuseppe K

JGH open : an open access journal of gastroenterology and hepatology

2022 Volume 7, Issue 1, Page(s) 30–39

Abstract: Background and aim: New biomarkers have the potential to facilitate early diagnosis of pancreatic cancer (PC). Circulating exosomes are cell-derived protein complexes containing RNA that can be used as indicators of cancer development. The aim of this ... ...

Abstract	Background and aim: New biomarkers have the potential to facilitate early diagnosis of pancreatic cancer (PC). Circulating exosomes are cell-derived protein complexes containing RNA that can be used as indicators of cancer development. The aim of this review is to evaluate the current literature involving PC patient groups for highly accurate exosomal biomarkers. Methods: The literature search followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Eight-hundred and seventy-five studies were identified across various databases (Ovid MEDLINE, Embase, and Cochrane) published between 2009 and 2020. Nine studies fulfilled the inclusion criteria: human PC patients, diagnosis as outcome of interest, serum biomarker of exosomal content, reporting of diagnostic values, and disease progress. Area under the curve (AUC) of the exosomal biomarker was compared against that of CA19-9. Results: Nine papers were reviewed for relevant outcomes based on the inclusion criteria. These studies involved 565 participants (331 PC, 234 controls; male/female ratio 1.21; mean age 64.1). Tumor staging was reported in all studies, with 45.6% of PC patients diagnosed with early-stage PC (T1-2). The mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1) and GPC 1 reported the highest performing sensitivity and specificity at 100% each. The microRNA panel (miR-10b, miR-21, miR-30c, miR-181a, and miR-let7a), mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1), and GPC 1 showed a perfect AUC of 1.0. Five studies compared the AUC of the exosomal biomarker against CA19-9, each being superior to that of CA19-9. Conclusion: The potential of exosomal biomarkers remains promising in PC diagnosis. Standardization of future studies will allow for larger comparative analyses and overcoming contrasting findings.
Language	English
Publishing date	2022-11-25
Publishing country	Australia
Document type	Journal Article
ISSN	2397-9070
ISSN (online)	2397-9070
DOI	10.1002/jgh3.12848
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Article ; Online: Assessing the Impact of Primary Tumour Location on Survival After Resection of Colorectal Liver Metastases: A Propensity Weighted Retrospective Cohort Study.

Borakati, Aditya / Froghi, Farid / Shetye, Alysha / Fusai, Giuseppe K / Davidson, Brian R / Mirnezami, Reza

World journal of surgery

2022 Volume 46, Issue 7, Page(s) 1734–1755

Abstract: Background: Right-sided colonic tumours appear to have poorer survival after resection of colorectal liver metastases, although this may be confounded by various factors including advanced stage and emergency presentation.: Methods: Medical records ... ...

Abstract	Background: Right-sided colonic tumours appear to have poorer survival after resection of colorectal liver metastases, although this may be confounded by various factors including advanced stage and emergency presentation. Methods: Medical records of consecutive patients undergoing resection of colorectal liver metastases at a single centre from 2008 to 2015 were retrospectively reviewed. Cases were categorised by primary tumour location (right colon, left colon, rectum). Each primary location was weighted using propensity scores to balance covariates, including staging and mode of presentation. Cox regression was then applied to derive multivariable hazard ratios (HR) of survival after liver resection. Primary outcomes were 10-year overall survival (OS) and 5-year disease-free survival (DFS) after liver resection based on PTL. Results: 414 patients were included in the analysis. Left colonic tumours were significantly associated with higher rates of bilobar liver metastasis (36.2% vs. 20.1% and 30.1%) and larger maximum size of liver metastases compared with rectal and right-sided tumours, respectively. There was no difference in rates of extra-hepatic metastases, recurrence in the liver after resection or RAS, BRAF or p53 mutational status. After propensity weighting and Cox-regression, right-sided tumours were independently associated with significantly reduced 10 year OS (HR 1.56, 95% CI 1.03-2.36, p = 0.04) but not 5 year DFS (HR 1.36, 95% CI 0.89-2.08, p = 0.15). Conclusions: Compared with left colonic and rectal tumours, right-sided colonic tumours are independently associated with inferior OS after resection of CRLM. This is despite higher rates of bilobar liver metastases and larger metastases with left-sided tumours.
MeSH term(s)	Colonic Neoplasms/surgery ; Colorectal Neoplasms/pathology ; Hepatectomy ; Humans ; Liver Neoplasms/secondary ; Prognosis ; Retrospective Studies
Language	English
Publishing date	2022-03-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-022-06514-z
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Article ; Online: Author Correction: Management of patients at the hepatopancreatobiliary unit of a London teaching hospital during the COVID-19 pandemic.

Staubli, Sebastian M / Raptis, Dimitri A / Ghani, Shahi / Davidson, Brian R / Fusai, Giuseppe K / Imber, Charles / Iype, Sateesh / Nasralla, David / Pissanou, Theodora / Rahman, Sakhawat / Sharma, Dinesh / Tinguely, Pascale / Haddad, Fares / Dodd, Miranda / Dann, Chris / Walker, David / Pollok, Joerg-Matthias

Scientific reports

2023 Volume 13, Issue 1, Page(s) 17549

Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-44594-6
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Article ; Online: Management of patients at the hepatopancreatobiliary unit of a London teaching hospital during the COVID-19 pandemic.

Scientific reports

2023 Volume 13, Issue 1, Page(s) 13432

Abstract: To mitigate COVID-19-related shortage of treatment capacity, the hepatopancreatobiliary (HPB) unit of the Royal Free Hospital London (RFHL) transferred its practice to independent hospitals in Central London through the North Central London Cancer ... ...

Abstract	To mitigate COVID-19-related shortage of treatment capacity, the hepatopancreatobiliary (HPB) unit of the Royal Free Hospital London (RFHL) transferred its practice to independent hospitals in Central London through the North Central London Cancer Alliance. The aim of this study was to critically assess this strategy and evaluate perioperative outcomes. Prospectively collected data were reviewed on all patients who were treated under the RFHL HPB unit in six hospitals between November 2020 and October 2021. A total of 1541 patients were included, as follows: 1246 (81%) at the RFHL, 41 (3%) at the Chase Farm Hospital, 23 (2%) at the Whittington Hospital, 207 (13%) at the Princess Grace Hospital, 12 (1%) at the Wellington Hospital and 12 (1%) at the Lister Hospital, Chelsea. Across all institutions, overall complication rate were 40%, major complication (Clavien-Dindo grade ≥ 3a) rate were 11% and mortality rates were 1.4%, respectively. In COVID-19-positive patients (n = 28), compared with negative patients, complication rate and mortality rates were increased tenfold. Outsourcing HPB patients, including their specialist care, to surrounding institutions was safe and ensured ongoing treatment with comparable outcomes among the institutions during the COVID-19 pandemic. Due to the lack of direct comparison with a non-pandemic cohort, these results can strictly only be applied within a pandemic setting.
MeSH term(s)	Humans ; London/epidemiology ; Pandemics ; COVID-19/epidemiology ; Hospitals, Teaching ; Data Collection
Language	English
Publishing date	2023-08-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-40264-9
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Article: Performance and Safety of EUS Ablation Techniques for Pancreatic Cystic Lesions: A Systematic Review and Meta-Analysis.

Papaefthymiou, Apostolis / Johnson, Gavin J / Maida, Marcello / Gkolfakis, Paraskevas / Ramai, Daryl / Facciorusso, Antonio / Arvanitakis, Marianna / Ney, Alexander / Fusai, Giuseppe K / Saftoiu, Adrian / Tabacelia, Daniela / Phillpotts, Simon / Chapman, Michael H / Webster, George J / Pereira, Stephen P

Cancers

2023 Volume 15, Issue 9

Abstract: Background: Pancreatic cystic lesions (PCL) represent an increasingly diagnosed condition with significant burden to patients' lives and medical resources. Endoscopic ultrasound (EUS) ablation techniques have been utilized to treat focal pancreatic ... ...

Abstract	Background: Pancreatic cystic lesions (PCL) represent an increasingly diagnosed condition with significant burden to patients' lives and medical resources. Endoscopic ultrasound (EUS) ablation techniques have been utilized to treat focal pancreatic lesions. This systematic review with meta-analysis aims to assess the efficacy of EUS ablation on PCL in terms of complete or partial response and safety. Methods: A systematic search in Medline, Cochrane and Scopus databases was performed in April 2023 for studies assessing the performance of the various EUS ablation techniques. The primary outcome was complete cyst resolution, defined as cyst disappearance in follow-up imaging. Secondary outcomes included partial resolution (reduction in PCL size), and adverse events rate. A subgroup analysis was planned to evaluate the impact of the available ablation techniques (ethanol, ethanol/paclitaxel, radiofrequency ablation (RFA), and lauromacrogol) on the results. Meta-analyses using a random effects model were conducted and the results were reported as percentages with 95% confidence intervals (95%CI). Results: Fifteen studies (840 patients) were eligible for analysis. Complete cyst resolution after EUS ablation was achieved in 44% of cases (95%CI: 31-57; 352/767; I Conclusion: EUS ablation of pancreatic cysts provides acceptable rates of complete resolution and a low incidence of severe adverse events, with chemoablative agents yielding higher performance rates.
Language	English
Publishing date	2023-05-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15092627
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Article ; Online: Role of colectomy in preventing recurrent primary sclerosing cholangitis in liver transplant recipients.

Buchholz, Bettina M / Lykoudis, Panagis M / Ravikumar, Reena / Pollok, Joerg M / Fusai, Giuseppe K

World journal of gastroenterology

2018 Volume 24, Issue 28, Page(s) 3171–3180

Abstract: Aim: To study the published evidence on the impact of colectomy in preventing recurrent primary sclerosing cholangitis (rPSC).: Methods: An unrestricted systematic literature search in PubMed, EMBASE, Medline OvidSP, ISI Web of Science, Lista (EBSCO) ...

Abstract	Aim: To study the published evidence on the impact of colectomy in preventing recurrent primary sclerosing cholangitis (rPSC). Methods: An unrestricted systematic literature search in PubMed, EMBASE, Medline OvidSP, ISI Web of Science, Lista (EBSCO) and the Cochrane library was performed on clinical studies investigating colectomy in liver transplantation (LT) recipients with and without rPSC in the liver allograft. Study quality was evaluated according to a modification of the methodological index for non-randomized studies (MINORS) criteria. Primary endpoints were the impact of presence, timing and type of colectomy on rPSC. Overall presence of inflammatory bowel disease (IBD), time of IBD diagnosis, posttransplant IBD and immunosuppressive regimen were investigated as secondary outcome. Results: The literature search yielded a total of 180 publications. No randomized controlled trial was identified. Six retrospective studies met the inclusion criteria of which 5 studies were graded as high quality articles. Reporting of IBD was heterogenous but in four publications, either inflammatory bowel disease, ulcerative colitis or in particular active colitis post-LT significantly increased the risk of rPSC. The presence of an intact ( Conclusion: The data favours a protective role of pre-/peri-LT colectomy in rPSC but the current evidence is not strong enough to recommend routine colectomy for rPSC prevention.
MeSH term(s)	Cholangitis, Sclerosing/etiology ; Cholangitis, Sclerosing/pathology ; Cholangitis, Sclerosing/prevention & control ; Colectomy ; Colon/microbiology ; Cyclosporine/therapeutic use ; Dysbiosis/complications ; Dysbiosis/epidemiology ; Dysbiosis/microbiology ; Dysbiosis/surgery ; Gastrointestinal Microbiome ; Humans ; Immunosuppressive Agents/therapeutic use ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/epidemiology ; Inflammatory Bowel Diseases/microbiology ; Inflammatory Bowel Diseases/surgery ; Liver Transplantation/adverse effects ; Perioperative Care/methods ; Risk Assessment ; Risk Factors ; Secondary Prevention/methods ; Tacrolimus/therapeutic use ; Treatment Outcome
Chemical Substances	Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D) ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2018-07-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v24.i28.3171
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Article ; Online: The Value of Textbook Outcome in Benchmarking Pancreatoduodenectomy for Nonfunctioning Pancreatic Neuroendocrine Tumors.

Partelli, Stefano / Fermi, Francesca / Fusai, Giuseppe K / Tamburrino, Domenico / Lykoudis, Panagis / Beghdadi, Nassiba / Dokmak, Safi / Wiese, Dominik / Landoni, Luca / Reich, Federico / Busch, O R C / Napoli, Niccolò / Jang, Jin-Young / Kwon, Wooil / Armstrong, Thomas / Allen, Peter J / He, Jin / Javed, Ammar / Sauvanet, Alain /

Bartsch, Detlef K / Salvia, Roberto / van Dijkum, E J M Nieveen / Besselink, Mark G / Boggi, Ugo / Kim, Sun-Whe / Wolfgang, Christofer L / Falconi, Massimo

Annals of surgical oncology

2024

Abstract: Background: Textbook outcome (TO) is a composite variable that can define the quality of pancreatic surgery. The aim of this study is to evaluate TO after pancreatoduodenectomy (PD) for nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs).: ... ...

Abstract	Background: Textbook outcome (TO) is a composite variable that can define the quality of pancreatic surgery. The aim of this study is to evaluate TO after pancreatoduodenectomy (PD) for nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs). Patients and methods: All patients who underwent PD for NF-PanNETs (2007-2016) in different centers were included in this retrospective study. TO was defined as the absence of severe postoperative complications and mortality, length of hospital stay ≤ 19 days, R0 resection, and at least 12 lymph nodes harvested. Results: Overall, 477 patients were included. The TO rate was 32%. Tumor size [odds ratio (OR) 1.696; p = 0.013], a minimally invasive approach (OR 12.896; p = 0.001), and surgical volume (OR 2.062; p = 0.023) were independent predictors of TO. The annual frequency of PDs increased over time as well as the overall rate of TO. At a median follow-up of 44 months, patients who achieved TO had similar disease-free (p = 0.487) and overall survival (p = 0.433) rates compared with patients who did not achieve TO. TO rate in patients with NF-PanNET > 2 cm was 35% versus 27% in patients with NF-PanNET ≤ 2 cm (p = 0.044). Considering only NF-PanNETs > 2 cm, patients with TO and those without TO had comparable 5-year overall survival rates (p = 0.766) CONCLUSIONS: TO is achieved in one-third of patients after PD for NF-PanNETs and is not associated with a benefit in terms of long-term survival.
Language	English
Publishing date	2024-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-024-15114-1
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Article ; Online: ASO Visual Abstract: The Value of Textbook Outcome in Benchmarking Pancreatoduodenectomy for Nonfunctioning Pancreatic Neuroendocrine Tumors.

Bartsch, Detlef K / Salvia, Roberto / van Dijkum, E J M Nieveen / Besselink, M G / Boggi, Ugo / Kim, Sun-Whe / Wolfgang, Christofer L / Falconi, Massimo

Annals of surgical oncology

2024

Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-024-15190-3
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Article ; Online: Treatment challenges in and outside a specialist network setting: Pancreatic neuroendocrine tumours.

Lykoudis, Panagis M / Partelli, Stefano / Muffatti, Francesca / Caplin, Martyn / Falconi, Massimo / Fusai, Giuseppe K

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2017 Volume 45, Issue 1, Page(s) 46–51

Abstract: Pancreatic Neuroendocrine Neoplasms comprise a group of rare tumours with special biology, an often indolent behaviour and particular diagnostic and therapeutic requirements. The specialized biochemical tests and radiological investigations, the ... ...

Abstract	Pancreatic Neuroendocrine Neoplasms comprise a group of rare tumours with special biology, an often indolent behaviour and particular diagnostic and therapeutic requirements. The specialized biochemical tests and radiological investigations, the complexity of surgical options and the variety of medical treatments that require individual tailoring, mandate a multidisciplinary approach that can be optimally achieved through an organized network. The present study describes currents concepts in the management of these tumours as well as an insight into the challenges of delivering the pathway in and outside a Network.
MeSH term(s)	Delivery of Health Care/organization & administration ; Humans ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/therapy ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/therapy ; Patient Care Team ; Precision Medicine ; Rare Diseases/therapy ; Survival Rate
Language	English
Publishing date	2017-10-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2017.08.019
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