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  1. Article ; Online: Experimental Study on Strength and Permeability Characteristics of Cemented Rock-Tailings Backfill

    Huafu Qiu / Fushun Zhang / Weibo Sun / Lang Liu / Yujiao Zhao / Chao Huan

    Frontiers in Earth Science, Vol

    2022  Volume 10

    Abstract: To study the strength and permeability characteristics of cemented tailings backfill with different cement–sand ratios and different waste rock contents, uniaxial compression strength test and permeability test were carried out respectively. The porosity ...

    Abstract To study the strength and permeability characteristics of cemented tailings backfill with different cement–sand ratios and different waste rock contents, uniaxial compression strength test and permeability test were carried out respectively. The porosity of cemented tailings backfills after solidification was observed by scanning electron microscope. The effects of cement–sand ratio and waste rock content on the internal porosity and overall permeability of cemented tailings backfill were studied. The test results showed that the cement–sand ratio and waste rock content have certain effects on the strength and permeability of the backfill body. When the cement–sand ratio was fixed, the uniaxial compressive strength and permeability of the backfill body increased first and then decreased with the increase of waste rock content. When the waste rock content was 10%, the uniaxial compressive strength of the backfill body reached the maximum, and when the waste rock content was 30%, the permeability reached the maximum. Due to the increase of the area of waste rock particles in the cross-section, the area of gas passing rapidly decreased, resulting in the decrease of the permeability growth rate. When the waste stone content was fixed, with the decrease of cement–sand ratio, due to the decrease of cementitious materials, more micro-cracks were produced in the curing process of backfill body, resulting in the decrease of uniaxial compressive strength and the increase of permeability.
    Keywords cemented tailings backfill ; waste rock ; uniaxial compression strength ; permeability ; scanning electron microscope ; Science ; Q
    Subject code 690
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Influence of Mindfulness and Relaxation on Treatment of Essential Hypertension

    Fushun Zhang / Yuanyuan Zhang / Nan Jiang / Qiao Zhai / Juanjuan Hu / Jing Feng

    Journal of Healthcare Engineering, Vol

    Meta-Analysis

    2021  Volume 2021

    Abstract: Background. Some studies published previously have shown a strong correlation between hypertension and psychological nature including impulsion emotion or mindfulness and relaxation temperament, among which mindfulness and relaxation temperament might ... ...

    Abstract Background. Some studies published previously have shown a strong correlation between hypertension and psychological nature including impulsion emotion or mindfulness and relaxation temperament, among which mindfulness and relaxation temperament might have a benign influence on blood pressure, ameliorating the hypertension. However, the conclusion was not confirmed. Objective. The meta-analysis was performed to investigate the influence of mindfulness and relaxation on essential hypertension interventions and confirm the effects. Methods. Systematic searches were conducted in common English and Chinese electronic databases (i.e., PubMed/MEDLINE, EMBASE, Web of Science, CINAHL, PsycINFO, Cochrane Library, and Chinese Biomedical Literature Database) from 1980 to 2020. A meta-analysis including 5 studies was performed using Rev Man 5.4.1 software to estimate the influence of mindfulness and relaxation on blood pressure, ameliorating the hypertension. Publication bias and heterogeneity of samples were tested using a funnel plot. Studies were analyzed using either a random-effect model or a fixed-effect model. Results. All the 5 studies investigated the influence of mindfulness and relaxation on diastolic and systolic blood pressure, with total 205 participants in the control group and 204 in the intervention group. The random-effects model (REM) was used to calculate the pooled effect for mindfulness and relaxation on diastolic blood pressure (I2 = 0%, t2 = 0.000, P=0.41). The random pooled effect size (MD) was 0.30 (95% CI = −0.81–1.42, P=0.59). REM was used to calculate the pooled effect for mindfulness and relaxation on systolic blood pressure (I2 = 49%, t2 = 3.05, P=0.10). The random pooled effect size (MD) was −1.05 (95% CI = −3.29–1.18, P=0.36). The results of this meta-analysis were influenced by publication bias to some degree. Conclusion. All the results showed less influence of mindfulness and relaxation might act on diastolic or systolic blood pressure, when mindfulness and relaxation are used to intervene in treating CVD and hypertension.
    Keywords Medicine (General) ; R5-920 ; Medical technology ; R855-855.5
    Subject code 796
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A paralogous pair of mammalian host restriction factors form a critical host barrier against poxvirus infection.

    Xiangzhi Meng / Fushun Zhang / Bo Yan / Chuanping Si / Hiroaki Honda / Akiko Nagamachi / Lu-Zhe Sun / Yan Xiang

    PLoS Pathogens, Vol 14, Iss 2, p e

    2018  Volume 1006884

    Abstract: Host restriction factors constitute a formidable barrier for viral replication to which many viruses have evolved counter-measures. Human SAMD9, a tumor suppressor and a restriction factor for poxviruses in cell lines, is antagonized by two classes of ... ...

    Abstract Host restriction factors constitute a formidable barrier for viral replication to which many viruses have evolved counter-measures. Human SAMD9, a tumor suppressor and a restriction factor for poxviruses in cell lines, is antagonized by two classes of poxvirus proteins, represented by vaccinia virus (VACV) K1 and C7. A paralog of SAMD9, SAMD9L, is also encoded by some mammals, while only one of two paralogs is retained by others. Here, we show that SAMD9L functions similarly to SAMD9 as a restriction factor and that the two paralogs form a critical host barrier that poxviruses must overcome to establish infection. In mice, which naturally lack SAMD9, overcoming SAMD9L restriction with viral inhibitors is essential for poxvirus replication and pathogenesis. While a VACV deleted of both K1 and C7 (vK1L-C7L-) was restricted by mouse cells and highly attenuated in mice, its replication and virulence were completely restored in SAMD9L-/- mice. In humans, both SAMD9 and SAMD9L are poxvirus restriction factors, although the latter requires interferon induction in many cell types. While knockout of SAMD9 with Crispr-Cas9 was sufficient for abolishing the restriction for vK1L-C7L- in many human cells, knockout of both paralogs was required for abolishing the restriction in interferon-treated cells. Both paralogs are antagonized by VACV K1, C7 and C7 homologs from diverse mammalian poxviruses, but mouse SAMD9L is resistant to the C7 homolog encoded by a group of poxviruses with a narrow host range in ruminants, indicating that host species-specific difference in SAMD9/SAMD9L genes serves as a barrier for cross-species poxvirus transmission.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Subject code 572
    Language English
    Publishing date 2018-02-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Sensing and signaling of immunogenic extracellular RNAs restrain group 2 innate lymphoid cell-driven acute lung inflammation and airway hyperresponsiveness.

    Li She / Hamad H Alanazi / Liping Yan / Edward G Brooks / Peter H Dube / Yan Xiang / Fushun Zhang / Yilun Sun / Yong Liu / Xin Zhang / Xiao-Dong Li

    PLoS ONE, Vol 15, Iss 7, p e

    2020  Volume 0236744

    Abstract: Repeated exposures to environmental allergens in susceptible individuals drive the development of type 2 inflammatory conditions such as asthma, which have been traditionally considered to be mainly mediated by Th2 cells. However, emerging evidence ... ...

    Abstract Repeated exposures to environmental allergens in susceptible individuals drive the development of type 2 inflammatory conditions such as asthma, which have been traditionally considered to be mainly mediated by Th2 cells. However, emerging evidence suggest that a new innate cell type, group 2 innate lymphoid cells (ILC2), plays a central role in initiating and amplifying a type 2 response, even in the absence of adaptive immunity. At present, the regulatory mechanisms for controlling ILC2 activation remain poorly understood. Here we report that respiratory delivery of immunogenic extracellular RNA (exRNAs) derived from RNA- and DNA-virus infected cells, was able to activate a protective response against acute type 2 lung immunopathology and airway hyperresponsiveness (AHR) induced by IL-33 and a fungal allergen, A. flavus, in mice. Mechanistically, we found that the innate immune responses triggered by exRNAs had a potent suppressive effect in vivo on the proliferation and function of ILC2 without the involvement of adaptive immunity. We further provided the loss-of-function genetic evidence that the TLR3- and MAVS-mediated signaling axis is essential for the inhibitory effects of exRNAs in mouse lungs. Thus, our results indicate that the host detection of extracellular immunostimulatory RNAs generated during respiratory viral infections have an important function in the regulation of ILC2-driven acute lung inflammation.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610 ; 570
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Discovery of SARS-CoV‑2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay

    Chunlong Ma / Michael Dominic Sacco / Zilei Xia / George Lambrinidis / Julia Alma Townsend / Yanmei Hu / Xiangzhi Meng / Tommy Szeto / Mandy Ba / Xiujun Zhang / Maura Gongora / Fushun Zhang / Michael Thomas Marty / Yan Xiang / Antonios Kolocouris / Yu Chen / Jun Wang

    ACS Central Science, Vol 7, Iss 7, Pp 1245-

    2021  Volume 1260

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Critical epitopes in the nucleocapsid protein of SFTS virus recognized by a panel of SFTS patients derived human monoclonal antibodies.

    Li Yu / Li Zhang / Lina Sun / Jing Lu / Wei Wu / Chuan Li / Quanfu Zhang / Fushun Zhang / Cong Jin / Xianjun Wang / Zhenqiang Bi / Dexin Li / Mifang Liang

    PLoS ONE, Vol 7, Iss 6, p e

    2012  Volume 38291

    Abstract: BACKGROUND: SFTS virus (SFTSV) is a newly discovered pathogen to cause severe fever with thrombocytopenia syndrome (SFTS) in human. Successful control of SFTSV epidemic requires better understanding of the antigen target in humoral immune responses to ... ...

    Abstract BACKGROUND: SFTS virus (SFTSV) is a newly discovered pathogen to cause severe fever with thrombocytopenia syndrome (SFTS) in human. Successful control of SFTSV epidemic requires better understanding of the antigen target in humoral immune responses to the new bunyavirus infection. METHODOLOGY/PRINCIPAL FINDINGS: We have generated a combinatorial Fab antibody phage library from two SFTS patients recovered from SFTSV infection. To date, 94 unique human antibodies have been generated and characterized from over 1200 Fab antibody clones obtained by screening the library with SFTS purified virions. All those monoclonal antibodies (MAbs) recognized the nucleocapsid (N) protein of SFTSV while none of them were reactive to the viral glycoproteins Gn or Gc. Furthermore, over screening 1000 mouse monoclonal antibody clones derived from SFTSV virions immunization, 462 clones reacted with N protein, while only 16 clones were reactive to glycoprotein. Furthermore, epitope mapping of SFTSV N protein was performed through molecular simulation, site mutation and competitive ELISA, and we found that at least 4 distinct antigenic epitopes within N protein were recognized by those human and mouse MAbs, in particular mutation of Glu10 to Ala10 abolished or significantly reduced the binding activity of nearly most SFTS patients derived MAbs. CONCLUSIONS/SIGNIFICANCE: The large number of human recombinant MAbs derived from SFTS patients recognized the viral N protein indicated the important role of the N protein in humoral responses to SFTSV infection, and the critical epitopes we defined in this study provided molecular basis for detection and diagnosis of SFTSV infection.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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