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  1. Article ; Online: Phytotoxins produced by plant pathogenic Streptomyces species.

    Bignell, D R D / Fyans, J K / Cheng, Z

    Journal of applied microbiology

    2014  Volume 116, Issue 2, Page(s) 223–235

    Abstract: Streptomyces is a large genus consisting of soil-dwelling, filamentous bacteria that are best known for their capability of producing a vast array of medically and agriculturally useful secondary metabolites. In addition, a small number of Streptomyces ... ...

    Abstract Streptomyces is a large genus consisting of soil-dwelling, filamentous bacteria that are best known for their capability of producing a vast array of medically and agriculturally useful secondary metabolites. In addition, a small number of Streptomyces spp. are capable of colonizing and infecting the underground portions of living plants and causing economically important crop diseases such as potato common scab (CS). Research into the mechanisms of Streptomyces plant pathogenicity has led to the identification and characterization of several phytotoxic secondary metabolites that are known or suspected of contributing to diseases in various plants. The best characterized are the thaxtomin phytotoxins, which play a critical role in the development of CS, acid scab and soil rot of sweet potato. In addition, the best-characterized CS-causing pathogen, Streptomyces scabies, produces a molecule that is predicted to resemble the Pseudomonas syringae coronatine phytotoxin and which contributes to seedling disease symptom development. Other Streptomyces phytotoxic secondary metabolites that have been identified include concanamycins, FD-891 and borrelidin. Furthermore, there is evidence that additional, unknown metabolites may participate in Streptomyces plant pathogenicity. Such revelations have implications for the rational development of better management procedures for controlling CS and other Streptomyces plant diseases.
    MeSH term(s) Bacterial Toxins/chemistry ; Bacterial Toxins/metabolism ; Fatty Alcohols/chemistry ; Fatty Alcohols/metabolism ; Indoles/chemistry ; Indoles/metabolism ; Ipomoea batatas/microbiology ; Macrolides/chemistry ; Macrolides/metabolism ; Multigene Family ; Piperazines/chemistry ; Piperazines/metabolism ; Plant Diseases/microbiology ; Soil Microbiology ; Solanum tuberosum/microbiology ; Streptomyces/genetics ; Streptomyces/metabolism ; Streptomyces/pathogenicity
    Chemical Substances Bacterial Toxins ; Fatty Alcohols ; Indoles ; Macrolides ; Piperazines ; thaxtomin C ; thaxtomine A (122380-18-1) ; FD 891 (142383-53-7) ; borrelidin (7184-60-3) ; concanamycin A (80890-47-7) ; concanamycin B (81552-33-2)
    Language English
    Publishing date 2014-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1358023-1
    ISSN 1365-2672 ; 1364-5072
    ISSN (online) 1365-2672
    ISSN 1364-5072
    DOI 10.1111/jam.12369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 259: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Recent advances in engineering nonribosomal peptide assembly lines

    Winn, M / Fyans, J. K / Zhuo, Y / Micklefield, J

    Natural product reports. 2016 Feb. 4, v. 33, no. 2

    2016  

    Abstract: Covering: up to July 2015 Nonribosomal peptides are amongst the most widespread and structurally diverse secondary metabolites in nature with many possessing bioactivity that can be exploited for therapeutic applications. Due to the major challenges ... ...

    Abstract Covering: up to July 2015 Nonribosomal peptides are amongst the most widespread and structurally diverse secondary metabolites in nature with many possessing bioactivity that can be exploited for therapeutic applications. Due to the major challenges associated with total- and semi-synthesis, bioengineering approaches have been developed to increase yields and generate modified peptides with improved physicochemical properties or altered bioactivity. Here we review the major advances that have been made over the last decade in engineering the biosynthesis of nonribosomal peptides. Structural diversity has been introduced by the modification of enzymes required for the supply of precursors or by heterologous expression of tailoring enzymes. The modularity of nonribosomal peptide synthetase (NRPS) assembly lines further supports module or domain swapping methodologies to achieve changes in the amino acid sequence of nonribosomal peptides. We also review the new synthetic biology technologies promising to speed up the process, enabling the creation and optimisation of many more assembly lines for heterologous expression, offering new opportunities for engineering the biosynthesis of novel nonribosomal peptides.
    Keywords amino acid sequences ; bioactive properties ; biosynthesis ; enzymes ; heterologous gene expression ; nonribosomal peptides ; physicochemical properties ; synthetic biology ; therapeutics
    Language English
    Dates of publication 2016-0204
    Size p. 317-347.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2002546-4
    ISSN 1460-4752 ; 0265-0568
    ISSN (online) 1460-4752
    ISSN 0265-0568
    DOI 10.1039/c5np00099h
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Recent advances in engineering nonribosomal peptide assembly lines.

    Winn, M / Fyans, J K / Zhuo, Y / Micklefield, J

    Natural product reports

    2015  Volume 33, Issue 2, Page(s) 317–347

    Abstract: Nonribosomal peptides are amongst the most widespread and structurally diverse secondary metabolites in nature with many possessing bioactivity that can be exploited for therapeutic applications. Due to the major challenges associated with total- and ... ...

    Abstract Nonribosomal peptides are amongst the most widespread and structurally diverse secondary metabolites in nature with many possessing bioactivity that can be exploited for therapeutic applications. Due to the major challenges associated with total- and semi-synthesis, bioengineering approaches have been developed to increase yields and generate modified peptides with improved physicochemical properties or altered bioactivity. Here we review the major advances that have been made over the last decade in engineering the biosynthesis of nonribosomal peptides. Structural diversity has been introduced by the modification of enzymes required for the supply of precursors or by heterologous expression of tailoring enzymes. The modularity of nonribosomal peptide synthetase (NRPS) assembly lines further supports module or domain swapping methodologies to achieve changes in the amino acid sequence of nonribosomal peptides. We also review the new synthetic biology technologies promising to speed up the process, enabling the creation and optimisation of many more assembly lines for heterologous expression, offering new opportunities for engineering the biosynthesis of novel nonribosomal peptides.
    MeSH term(s) Amino Acid Sequence ; Models, Molecular ; Molecular Structure ; Peptide Synthases/metabolism ; Peptides/chemistry
    Chemical Substances Peptides ; Peptide Synthases (EC 6.3.2.-) ; non-ribosomal peptide synthase (EC 6.3.2.-)
    Language English
    Publishing date 2015-11-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2002546-4
    ISSN 1460-4752 ; 0265-0568
    ISSN (online) 1460-4752
    ISSN 0265-0568
    DOI 10.1039/c5np00099h
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Phytotoxins produced by plant pathogenic Streptomyces species

    Bignell, D.R.D / Fyans, J.K / Cheng, Z

    Journal of applied microbiology. 2014 Feb., v. 116, no. 2

    2014  

    Abstract: Streptomyces is a large genus consisting of soil‐dwelling, filamentous bacteria that are best known for their capability of producing a vast array of medically and agriculturally useful secondary metabolites. In addition, a small number of Streptomyces ... ...

    Abstract Streptomyces is a large genus consisting of soil‐dwelling, filamentous bacteria that are best known for their capability of producing a vast array of medically and agriculturally useful secondary metabolites. In addition, a small number of Streptomyces spp. are capable of colonizing and infecting the underground portions of living plants and causing economically important crop diseases such as potato common scab (CS). Research into the mechanisms of Streptomyces plant pathogenicity has led to the identification and characterization of several phytotoxic secondary metabolites that are known or suspected of contributing to diseases in various plants. The best characterized are the thaxtomin phytotoxins, which play a critical role in the development of CS, acid scab and soil rot of sweet potato. In addition, the best‐characterized CS‐causing pathogen, Streptomyces scabies, produces a molecule that is predicted to resemble the Pseudomonas syringae coronatine phytotoxin and which contributes to seedling disease symptom development. Other Streptomyces phytotoxic secondary metabolites that have been identified include concanamycins, FD‐891 and borrelidin. Furthermore, there is evidence that additional, unknown metabolites may participate in Streptomyces plant pathogenicity. Such revelations have implications for the rational development of better management procedures for controlling CS and other Streptomyces plant diseases.
    Keywords Pseudomonas syringae ; Streptomyces scabiei ; bacteria ; pathogenicity ; pathogens ; phytotoxicity ; phytotoxins ; plant diseases and disorders ; potatoes ; secondary metabolites ; seedlings ; soil ; sweet potatoes
    Language English
    Dates of publication 2014-02
    Size p. 223-235.
    Publishing place Blackwell Science
    Document type Article
    ZDB-ID 1358023-1
    ISSN 1364-5072
    ISSN 1364-5072
    DOI 10.1111/jam.12369
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 259: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Phytotoxins produced by plant pathogenic Streptomyces species

    Bignell, D.R.D. / Fyans, J.K. / Cheng, Z.

    Journal of applied microbiology

    Volume v. 116,, Issue no. 2

    Abstract: Streptomyces is a large genus consisting of soil‐dwelling, filamentous bacteria that are best known for their capability of producing a vast array of medically and agriculturally useful secondary metabolites. In addition, a small number of Streptomyces ... ...

    Abstract Streptomyces is a large genus consisting of soil‐dwelling, filamentous bacteria that are best known for their capability of producing a vast array of medically and agriculturally useful secondary metabolites. In addition, a small number of Streptomyces spp. are capable of colonizing and infecting the underground portions of living plants and causing economically important crop diseases such as potato common scab (CS). Research into the mechanisms of Streptomyces plant pathogenicity has led to the identification and characterization of several phytotoxic secondary metabolites that are known or suspected of contributing to diseases in various plants. The best characterized are the thaxtomin phytotoxins, which play a critical role in the development of CS, acid scab and soil rot of sweet potato. In addition, the best‐characterized CS‐causing pathogen, Streptomyces scabies, produces a molecule that is predicted to resemble the Pseudomonas syringae coronatine phytotoxin and which contributes to seedling disease symptom development. Other Streptomyces phytotoxic secondary metabolites that have been identified include concanamycins, FD‐891 and borrelidin. Furthermore, there is evidence that additional, unknown metabolites may participate in Streptomyces plant pathogenicity. Such revelations have implications for the rational development of better management procedures for controlling CS and other Streptomyces plant diseases.
    Keywords Streptomyces scabiei ; secondary metabolites ; potatoes ; phytotoxins ; pathogenicity ; pathogens ; seedlings ; plant diseases and disorders ; phytotoxicity ; bacteria ; sweet potatoes ; Pseudomonas syringae ; soil
    Language English
    Document type Article
    ISSN 1364-5072
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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    Kategorien

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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