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  1. Article ; Online: The Large American Liver Fluke ( Fascioloides magna )

    Ágnes Csivincsik / Tibor Halász / Gábor Nagy

    Parasitologia, Vol 3, Iss 4, Pp 300-

    A Survivor’s Journey through a Constantly Changing World

    2023  Volume 326

    Abstract: The large American liver fluke ( Fascioloides magna ) is considered an invasive trematode parasite in Europe. Its origin dates back before the Cretaceous-Paleogene Mass Extinction, after which it survived at least three population bottlenecks and ... ...

    Abstract The large American liver fluke ( Fascioloides magna ) is considered an invasive trematode parasite in Europe. Its origin dates back before the Cretaceous-Paleogene Mass Extinction, after which it survived at least three population bottlenecks and successful host switches before it arrived in Europe. The authors review the evolutionary history of F. magna , the distribution by its ancient proboscidean hosts, and the probable drivers of the switch to the white-tailed deer ( Odocoileus virginianus ). The review collects knowledge on the biology of intermediate hosts, which helps understand the factors that influence the epidemiology of F. magna in aquatic ecosystems. The authors demonstrate the adaptation potential of the parasite using data from both North American and European endemics. Finally, the study calls attention to the epidemiological risk of human-induced global change, with a special interest in the invasive snail species Pseudosuccinea columella .
    Keywords Fascioloides magna ; Proboscidea ; host switch ; bottleneck ; virulence ; Pseudosuccinea columella ; Infectious and parasitic diseases ; RC109-216 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Ion Channel Disturbances in Migraine Headache

    Eleonóra Spekker / Gábor Nagy-Grócz / László Vécsei

    International Journal of Molecular Sciences, Vol 24, Iss 23, p

    Exploring the Potential Role of the Kynurenine System in the Context of the Trigeminovascular System

    2023  Volume 16574

    Abstract: Migraine is a primary headache disorder, which is an enormous burden to the healthcare system. While some aspects of the pathomechanism of migraines remain unknown, the most accepted theory is that activation and sensitization of the trigeminovascular ... ...

    Abstract Migraine is a primary headache disorder, which is an enormous burden to the healthcare system. While some aspects of the pathomechanism of migraines remain unknown, the most accepted theory is that activation and sensitization of the trigeminovascular system are essential during migraine attacks. In recent decades, it has been suggested that ion channels may be important participants in the pathogenesis of migraine. Numerous ion channels are expressed in the peripheral and central nervous systems, including the trigeminovascular system, affecting neuron excitability, synaptic energy homeostasis, inflammatory signaling, and pain sensation. Dysfunction of ion channels could result in neuronal excitability and peripheral or central sensitization. This narrative review covers the current understanding of the biological mechanisms leading to activation and sensitization of the trigeminovascular pain pathway, with a focus on recent findings on ion channel activation and modulation. Furthermore, we focus on the kynurenine pathway since this system contains kynurenic acid, which is an endogenous glutamate receptor antagonist substance, and it has a role in migraine pathophysiology.
    Keywords migraine ; ion channels ; potassium channels ; ASICs ; purinerg system ; kynurenic system ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A Unique In Vitro Assay to Investigate ABCB4 Transport Function

    Csilla Temesszentandrási-Ambrus / Gábor Nagy / Annamária Bui / Zsuzsanna Gáborik

    International Journal of Molecular Sciences, Vol 24, Iss 4459, p

    2023  Volume 4459

    Abstract: ABCB4 is almost exclusively expressed in the liver, where it plays an essential role in bile formation by transporting phospholipids into the bile. ABCB4 polymorphisms and deficiencies in humans are associated with a wide spectrum of hepatobiliary ... ...

    Abstract ABCB4 is almost exclusively expressed in the liver, where it plays an essential role in bile formation by transporting phospholipids into the bile. ABCB4 polymorphisms and deficiencies in humans are associated with a wide spectrum of hepatobiliary disorders, attesting to its crucial physiological function. Inhibition of ABCB4 by drugs may lead to cholestasis and drug-induced liver injury (DILI), although compared with other drug transporters, there are only a few identified substrates and inhibitors of ABCB4. Since ABCB4 shares up to 76% identity and 86% similarity in the amino acid sequence with ABCB1, also known to have common drug substrates and inhibitors, we aimed to develop an ABCB4 expressing Abcb1-knockout MDCKII cell line for transcellular transport assays. This in vitro system allows the screening of ABCB4-specific drug substrates and inhibitors independently of ABCB1 activity. Abcb1KO-MDCKII-ABCB4 cells constitute a reproducible, conclusive, and easy to use assay to study drug interactions with digoxin as a substrate. Screening a set of drugs with different DILI outcomes proved that this assay is applicable to test ABCB4 inhibitory potency. Our results are consistent with prior findings concerning hepatotoxicity causality and provide new insights for identifying drugs as potential ABCB4 inhibitors and substrates.
    Keywords ABCB4 inhibitors ; MDR3 ; hepatotoxicity ; drug-induced liver injury ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 500
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Case report

    László Lehner / Kálmán Czeibert / Péter Csébi / Kristóf Diószegi / Gábor Nagy

    Frontiers in Veterinary Science, Vol

    Intraventricular tumor removal using transcallosal approach and follow-up in three dogs

    2023  Volume 10

    Abstract: This case series describes the surgical removal of lateral ventricular tumors using a transcallosal approach, long-term follow-up, and magnetic resonance imaging (MRI) results of 3 dogs. Two tumors were benign choroid plexus tumors (CPT). One was a grade ...

    Abstract This case series describes the surgical removal of lateral ventricular tumors using a transcallosal approach, long-term follow-up, and magnetic resonance imaging (MRI) results of 3 dogs. Two tumors were benign choroid plexus tumors (CPT). One was a grade 2 astrocytoma. Complete tumor removal was achieved using the transcallosal approach. All dogs had ventriculomegaly which remained static or progressed during the follow-up period. All dogs had epileptic seizures before the surgical procedure which persisted despite tumor removal. One dog with CPT was alive after 3 years and 5 months and had minor focal seizures every 3–4 months. No other clinical signs were observed. The second dog with CPT was neurologically free for 17 months after the surgical procedure but died due to acute-onset therapy-resistant generalized epileptic seizures. The third dog with intraventricular astrocytoma experienced epileptic seizures 2 and 4 months after the surgical procedure. The second event was therapy-resistant which led to death.
    Keywords transcallosal ; dog ; lateral ventricle ; choroid plexus tumor ; surgery ; craniotomy ; Veterinary medicine ; SF600-1100
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Dysregulated miRNA and mRNA Expression Affect Overlapping Pathways in a Huntington’s Disease Model

    Nóra Zsindely / Gábor Nagy / Fruzsina Siági / Anita Farkas / László Bodai

    International Journal of Molecular Sciences, Vol 24, Iss 11942, p

    2023  Volume 11942

    Abstract: Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in the Huntingtin gene. Transcriptional dysregulation is one of the main cellular processes affected by mutant Huntingtin (mHtt). In ... ...

    Abstract Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in the Huntingtin gene. Transcriptional dysregulation is one of the main cellular processes affected by mutant Huntingtin (mHtt). In this study, we investigate the alterations in miRNA and mRNA expression levels in a Drosophila model of HD by RNA sequencing and assess the functional effects of misregulated miRNAs in vivo. We found that in head samples of HD flies, the level of 32 miRNAs changed significantly; half of these were upregulated, while the other half were downregulated. After comparing miRNA and mRNA expression data, we discovered similarities in the impacted molecular pathways. Additionally, we observed that the putative targets of almost all dysregulated miRNAs were overrepresented among the upregulated mRNAs. We tested the effects of overexpression of five misregulated miRNAs in the HD model and found that while mir-10 and mir-219 enhanced, mir-137, mir-305, and mir-1010 ameliorated mHtt-induced phenotypes. Based on our results, we propose that while altered expression of mir-10, mir-137, and mir-1010 might be part of HD pathology, the upregulation of mir-305 might serve as a compensatory mechanism as a response to mHtt-induced transcriptional dysregulation.
    Keywords Huntington’s disease ; neurodegeneration ; miRNA ; transcriptomics ; transcription ; Drosophila ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 500
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Evaluation of a Phytogenic Feed Supplement Containing Carvacrol and Limonene on Sheep Performance and Parasitological Status on a Hungarian Milking Sheep Farm

    Éva Varga-Visi / Gábor Nagy / Ágnes Csivincsik / Tamás Tóth

    Veterinary Sciences, Vol 10, Iss 369, p

    2023  Volume 369

    Abstract: There is currently worldwide interest in phytogenic feed supplements (PFSs) because they can lead to improved animal production. The scope of the present study was to observe the impact of a feed supplement containing carvacrol (CAR) and limonene (LIM) ... ...

    Abstract There is currently worldwide interest in phytogenic feed supplements (PFSs) because they can lead to improved animal production. The scope of the present study was to observe the impact of a feed supplement containing carvacrol (CAR) and limonene (LIM) on the performance and parasitological status of sheep. The feed supplement decreased the plasma levels of β-hydroxybutyrate ( p < 0.001), triglycerides ( p = 0.014), nonesterified fatty acids ( p = 0.021), and fructosamine ( p = 0.002) in lactating ewes after 42 days of supplementation, while the average live weight ( p = 0.002) and average daily weight gain ( p = 0.001) of their twin suckling lambs increased significantly by the end of the study. In another experiment, fattening lambs fed the same supplement showed a decrease in fecal egg number of gastrointestinal nematodes ( p = 0.02) but no differences in live weight, average daily gain, or mean number of Haemonchus contortus nematodes in the abomasum. The results highlighted that the inclusion of carvacrol and limonene in the feed of lactating ewes effectively increased the weight gain of the suckling lambs, presumably due to the ewes’ improved energy, but further studies are needed to elucidate the effects of carvacrol and limonene against gastrointestinal parasites.
    Keywords carvacrol ; limonene ; sheep ; performance ; Haemonchus contortus ; plant extract ; Veterinary medicine ; SF600-1100
    Subject code 630
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The golden jackal (Canis aureus) and the African swine fever pandemic

    Péter Kemenszky / Ferenc Jánoska / Gábor Nagy / Ágnes Csivincsik

    Veterinary Medicine and Science, Vol 8, Iss 1, Pp 97-

    Its role is controversial but not negligible (a diet analysis study)

    2022  Volume 103

    Abstract: Abstract Background In Europe, the African swine fever (ASF) pandemic mostly affects the environmental domain of health, which is a strongly human‐impacted ecosystem. However, the current control strategies focus solely on the wild boar and tend to ... ...

    Abstract Abstract Background In Europe, the African swine fever (ASF) pandemic mostly affects the environmental domain of health, which is a strongly human‐impacted ecosystem. However, the current control strategies focus solely on the wild boar and tend to disregard other epidemiologically relevant elements of the ecosystem. Objectives This study investigated the potential impact of the golden jackal on the surveillance effort and disease transmission. Methods For this reason, the authors analysed the content of 277 stomachs of this canid species within its westernmost inhabitant population, in order to determine the amount of suid remains, disposed. Results The findings confirmed that in a densely populated wild boar habitat, the main diet component of jackals was wild boar all the year round. The jackals disposed of 0.3–0.6 kg/km2/day offals that potentially contained suid remains. On the other hand, the scavenging activity removed the most important target objects on which the passive surveillance of ASF should be based. Conclusions This study cannot determine whether canid scavengers positively or negatively influence the control efforts; however, the impact of the jackal should not be disregarded. The results warn the necessity of a multidisciplinary approach to complex epidemiological situations within different ecosystems.
    Keywords African swine fever ; diet analysis ; golden jackal ; One Health ; wild boar ; Veterinary medicine ; SF600-1100
    Subject code 630
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The Evaluation of Syngas Loss from Disposable Syringe Sampling System

    Gábor NAGY / Mária AMBRUS

    Journal of the Turkish Chemical Society, Section A: Chemistry, Vol 7, Iss 2, Pp 441-

    A Case Study

    2020  Volume 448

    Abstract: The main advantage of standard gas sampling methods is their capability to keep a consistent gas composition from sampling till analysis. On the other hand, the disadvantages include the price and possible fragility of the sampling equipment, and the ... ...

    Abstract The main advantage of standard gas sampling methods is their capability to keep a consistent gas composition from sampling till analysis. On the other hand, the disadvantages include the price and possible fragility of the sampling equipment, and the speed of sampling. Thus, a new tool was required that should have low cost, could be used for fast sampling and during fieldwork. Disposable plastic syringes fulfil all these requirements with the additional advantage that they can be used multiple times to take gas samples. With the utilisation of 3-way stopcocks, a filter media and a butterfly needle, a simple but efficient sampling system was prepared. Even though the holding time of certain components is not as high as it is for a standard sample holder, the precise analysis of the gas samples is possible. Syringes have been successfully utilised in the field of applied pyrolysis, for small and pilot scale experiments, and can even be used in industrial environment.
    Keywords gas sampling method ; syngas ; gc ; disposable syringe ; Chemistry ; QD1-999
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Turkish Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: International workshop on metropolitan regions

    Gábor Nagy

    Hungarian Geographical Bulletin, Vol 62, Iss 2, Pp 226-

    Cluj-Napoca, 9-10 Nov. 2012

    2013  Volume 230

    Abstract: ...

    Abstract -
    Keywords Geography (General) ; G1-922
    Language English
    Publishing date 2013-07-01T00:00:00Z
    Publisher Research Centre for Astronomy and Earth Sciences, Hungarian Academy of Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Book Reviews

    Ildikó Egyed / Zsuzsanna Zsibók / Gábor Nagy / Lidia Groeger

    European Spatial Research and Policy, Vol 28, Iss 2, Pp 297-

    2021  Volume 306

    Keywords Social Sciences ; H ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Lodz University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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