Article ; Online: Safety and Efficacy of Ceftaroline in Neonates With Staphylococcal Late-onset Sepsis: A Case Series Analysis.
The Pediatric infectious disease journal
2023 Volume 42, Issue 10, Page(s) 888–892
Abstract: Treatment of late-onset neonatal staphylococcal sepsis is sometimes challenging with feared side effects of vancomycin, increasing minimal inhibitory concentrations and questions about catheter management. In case of failure, ceftaroline was administered ...
| Abstract | Treatment of late-onset neonatal staphylococcal sepsis is sometimes challenging with feared side effects of vancomycin, increasing minimal inhibitory concentrations and questions about catheter management. In case of failure, ceftaroline was administered as a compassionate treatment in 16 infants (gestational age of less than 32 weeks and less than 28 postnatal days), whose first-line treatment failed. We report 11 successes and no severe adverse drug reactions. Larger data are required to confirm these encouraging results. |
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| MeSH term(s) | Infant, Newborn ; Infant ; Humans ; Anti-Bacterial Agents/adverse effects ; Staphylococcal Infections/drug therapy ; Vancomycin/adverse effects ; Bacteremia/drug therapy ; Neonatal Sepsis/drug therapy ; Sepsis/drug therapy ; Ceftaroline | |||||
| Chemical Substances | Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU) | |||||
| Language | English | |||||
| Publishing date | 2023-07-13 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 392481-6 | |||||
| ISSN | 1532-0987 ; 0891-3668 | |||||
| ISSN (online) | 1532-0987 | |||||
| ISSN | 0891-3668 | |||||
| DOI | 10.1097/INF.0000000000004023 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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