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  1. Article ; Online: Nail Histomycology, Onychochromobiology, and Fungal Thigmatropism

    Gérald E. Piérard / Sébastien L. Piérard

    Open Access Journal of Science and Technology, Vol 4, Pp 1-

    2016  Volume 6

    Abstract: Background: Thigmotropism is a biologic feature coping with the directional growth of cells following topographical guidance cues. This mechanism is involved in the invasive phase of pathogen and opportunistic fungi. It was shown experimentally with ... ...

    Abstract Background: Thigmotropism is a biologic feature coping with the directional growth of cells following topographical guidance cues. This mechanism is involved in the invasive phase of pathogen and opportunistic fungi. It was shown experimentally with fungal hyphae of both dermatophytes and nondermatophyte molds, as well as with the mycelial phase of the dimorphic yeast Candida albicans. Objective: To revisit histomycology in onychomycoses of a diversity of fungal origins. Method: Histopathological section of nails plates were oriented parallel to the nail direction of growth. Result: Thigmotropism in part explains the patterns of orientations and shapes of fungi invading nail plates. It is probably influenced by onychochronobiology (speed of growth of the affected nails), and it governs various clinical presentations of onychomycoses.
    Keywords contact-sensing ; Histomycology ; Hyphal growth ; Fungus ; Onychomycosis ; Onychochronobiology ; Fungal nail infection ; Technology ; T ; Science ; Q
    Language English
    Publishing date 2016-09-01T00:00:00Z
    Publisher AgiAl Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Simulants of malignant melanoma

    Gérald E. Piérard / Claudine Piérard-Franchimont / Philippe Delvenne

    Oncology Reviews, Vol 9, Iss

    2015  Volume 1

    Abstract: During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN) of the skin. Beyond this clinical procedure, AMN histopathology remains mandatory for establishing their precise ... ...

    Abstract During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN) of the skin. Beyond this clinical procedure, AMN histopathology remains mandatory for establishing their precise diagnosis. Of note, panels of experts in AMN merely report moderate agreement in various puzzling cases. Divergences in opinion and misdiagnosis are likely increased when histopathological criteria are not fine-tuned and when facing a diversity of AMN types. Furthermore, some AMN have been differently named in the literature including atypical Spitz tumor, metastasizing Spitz tumor, borderline and intermediate melanocytic tumor, malignant Spitz nevus, pigmented epithelioid melanocytoma or animal-type melanoma. Some acronyms have been further suggested such as MELTUMP (after melanocytic tumor of uncertain malignant potential) and STUMP (after Spitzoid melanocytic tumor of uncertain malignant potential). In this review, such AMN at the exclusion of cutaneous malignant melanoma (MM) variants, are grouped under the tentative broad heading skin melanocytoma. Such set of AMN frequently follows an indolent course, although they exhibit atypical and sometimes worrisome patterns or cytological atypia. Rare cases of skin melanocytomas progress to loco regional clusters of lesions (agminate melanocytomas), and even to regional lymph nodes. At times, the distinction between a skin melanocytoma and MM remains puzzling. However, multipronged immunohistochemistry and emerging molecular biology help profiling any malignancy risk if present.
    Keywords Melanoma ; melanocytoma ; prognostic factor ; risk stratification ; Spitzoid tumor ; immunohistochemistry ; Other systems of medicine ; RZ201-999 ; Internal medicine ; RC31-1245
    Subject code 610
    Language English
    Publishing date 2015-08-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Skin Capacitance Mapping of Eccrine Sweat Gland Activity during Pregnancy

    Claudine Piérard-Franchimont / Trinh Hermanns-Lê / Gérald E. Piérard

    Open Access Journal of Science and Technology, Vol 4, Pp 1-

    2016  Volume 4

    Abstract: Skin capacitance mapping is a real-time non-invasive method useful in the assessment of eccrine gland activity. We presently revisit and explore the sweat gland production in pregnant women. Sprouts of sweat vapour are progressively increased during ... ...

    Abstract Skin capacitance mapping is a real-time non-invasive method useful in the assessment of eccrine gland activity. We presently revisit and explore the sweat gland production in pregnant women. Sprouts of sweat vapour are progressively increased during pregnancy by recruiting increasing numbers of active sweat pores. An overall moisturization of the stratum corneum ensues in absence of increased liquid sweat production. These aspects are conveniently assessed using skin capacitance mapping. The sweat duct opening could represent an increased way for percutaneous penetration of some xenobiotics during pregnancy.
    Keywords eccrine sweat gland ; skin capacitance mapping ; pregnancy ; imperceptible perspiration ; Technology ; T ; Science ; Q
    Language English
    Publishing date 2016-02-01T00:00:00Z
    Publisher AgiAl Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Alterations in Hair Follicle Dynamics in Women

    Claudine Piérard-Franchimont / Gérald E. Piérard

    BioMed Research International, Vol

    2013  Volume 2013

    Abstract: Endocrine changes supervening after parturition and menopause participate in the control of sebum production and hair growth modulation. The ensuing conditions include some peculiar aspects of hair loss (effluvium), alopecia, and facial hirsutism. The ... ...

    Abstract Endocrine changes supervening after parturition and menopause participate in the control of sebum production and hair growth modulation. The ensuing conditions include some peculiar aspects of hair loss (effluvium), alopecia, and facial hirsutism. The hair cycling is of major clinical relevance because most hair growth disorders result from disturbances in this chronobiological feature. Of note, any correlation between a biologic abnormality and hair cycling disturbance does not prove a relationship of causality. The proportion of postmenopausal women is rising in the overall population. Therefore, the prevalence of these hair follicle disturbances is globally on the rise. Current therapies aim at correcting the underlying hormonal imbalances, and at improving the overall cosmetic appearance. However, in absence of pathogenic diagnosis and causality criteria, chances are low that a treatment given by the whims of fate will adequately control hair effluvium. The risk and frequency of therapeutic inertia are further increased. When the hair loss is not controlled and/or compensated by growth of new hairs, several clinical aspects of alopecia inexorably develop. Currently, there is little evidence supporting any specific treatment for these endocrine hair disorders in post-partum and postmenopausal women. Current hair treatment strategies are symptomatic and nonspecific so current researchers aim at developing new, targeted methods.
    Keywords Medicine ; R
    Subject code 660
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Ipilimumab, a Promising Immunotherapy with Increased Overall Survival in Metastatic Melanoma?

    Gérald E. Piérard / François Aubin / Philippe Humbert

    Dermatology Research and Practice, Vol

    2012  Volume 2012

    Keywords Dermatology ; RL1-803 ; Medicine ; R ; DOAJ:Dermatology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Tracking and Treating Malignant Melanoma Metastases

    Gérald E. Piérard / Philippe Humbert / Pascale Quatresooz

    Dermatology Research and Practice, Vol

    2012  Volume 2012

    Keywords Dermatology ; RL1-803 ; Medicine ; R ; DOAJ:Dermatology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The Skin Ivory Spot. A Possible Indicator for Skinfield Photo-Carcinogenesis in Recreational Sunbed Addicts

    Claudine Piérard-Franchimont / Gérald E. Piérard / Pascale Quatresooz

    International Journal of Environmental Research and Public Health, Vol 9, Iss 2, Pp 362-

    2012  Volume 369

    Abstract: Introduction: For a decade or so, artificial sources of restricted light wavelengths, particularly sunbeds, have progressively gained popularity among adolescents and young adults. Warnings were raised focusing on the risk of accelerated photoaging and ... ...

    Abstract Introduction: For a decade or so, artificial sources of restricted light wavelengths, particularly sunbeds, have progressively gained popularity among adolescents and young adults. Warnings were raised focusing on the risk of accelerated photoaging and photocarcinogenesis. The ULEV (ultraviolet light-enhanced visualization) method is a convenient noninvasive way identifying subtle pigmentary changes presenting as a mottled subclinical melanoderma (MSM). Of note, rare spotty amelanotic macules presenting as skin ivory spots (SIS) was reported on any part of the body. Subjects and method: This work is the first attempt at evaluating the changes in the MSM and SIS spots developed on the skin of 33 phototype III young women designated as avid users involved in frequent exposures to sunshine and sunbeds for lifestyle purposes for a duration of at least 120 months. Results: MSM was markedly heterogeneous and was distinctly obvious in the majority of adepts of frequent natural and artificial photoexposures. SIS was particularly developed in subjects presenting with severe MSM patterns. Discussion: MSM and SIS are more severe in subjects frequently exposed to sunbeds and sun exposures. These signs possibly represent a risk marker for field photocarcinogenesis.
    Keywords carcinoma ; melanin ; melanocyte ; ULEV method ; ultraviolet light ; sunbed ; field photocarcinogenesis ; Medicine ; R
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Ustekinumab Biotherapy and Real-Time Psoriasis Capacitance Mapping

    Claudine Piérard-Franchimont / Gérald E. Piérard

    Journal of Biomedicine and Biotechnology, Vol

    A Pilot Study

    2012  Volume 2012

    Abstract: In recent years, the treatment of moderate to severe psoriasis has benefited from the development of targeted biologicals. Assessing this new class of drugs calls for precise modalities of severity/improvement ratings of the disease. Bioengineering- ... ...

    Abstract In recent years, the treatment of moderate to severe psoriasis has benefited from the development of targeted biologicals. Assessing this new class of drugs calls for precise modalities of severity/improvement ratings of the disease. Bioengineering-driven dermometrology aims at improving objective and quantitative assessments of disease severity and treatment efficacy. Skin capacitance mapping/imaging is one of those emerging methods. Among its clinical applications, psoriasis capacitance mapping (PCM) was introduced in order to assess both skin scaliness and water trapping inside the stratum corneum (inflammatory serum deposits) on lesional skin. PCM was used for assessing the therapeutic effects of ustekinumab on target lesions of 5 psoriatic patients. The reduction in the inflammatory dampness of the stratum corneum was conveniently seen after a 1-month ustekinumab treatment. The present pilot study suggests that PCM could be used as a fast and convenient method for assessing the anti-inflammatory efficacy of ustekinumab and other biotherapies.
    Keywords Biotechnology ; TP248.13-248.65 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Thigmotropism of Malignant Melanoma Cells

    Gérald E. Piérard / Fanchon Noël / Claudine Piérard-Franchimont / Pascale Quatresooz

    Dermatology Research and Practice, Vol

    2012  Volume 2012

    Keywords Dermatology ; RL1-803 ; Medicine ; R ; DOAJ:Dermatology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Women's Skin throughout Lifetime

    Gérald E. Piérard / Corinne Charlier / Philippe Delvenne / Philippe Humbert / Claudine Piérard-Franchimont

    BioMed Research International, Vol

    2014  Volume 2014

    Keywords Medicine ; R
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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