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  1. Article: Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer.

    Cotino-Nájera, Sandra / Herrera, Luis A / Domínguez-Gómez, Guadalupe / Díaz-Chávez, José

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1287505

    Abstract: One of the primary diseases that cause death worldwide is cancer. Cancer cells can be intrinsically resistant or acquire resistance to therapies and drugs used for cancer treatment through multiple mechanisms of action that favor cell survival and ... ...

    Abstract One of the primary diseases that cause death worldwide is cancer. Cancer cells can be intrinsically resistant or acquire resistance to therapies and drugs used for cancer treatment through multiple mechanisms of action that favor cell survival and proliferation, becoming one of the leading causes of treatment failure against cancer. A promising strategy to overcome chemoresistance and radioresistance is the co-administration of anticancer agents and natural compounds with anticancer properties, such as the polyphenolic compound resveratrol (RSV). RSV has been reported to be able to sensitize cancer cells to chemotherapeutic agents and radiotherapy, promoting cancer cell death. This review describes the reported molecular mechanisms by which RSV sensitizes tumor cells to radiotherapy and chemotherapy treatment.
    Language English
    Publishing date 2023-11-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1287505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Residual Effects of Transgenic Cotton on the Intestinal Microbiota of

    Pérez-López, Javier / Alavez, Valeria / Cerritos, René / Andraca-Gómez, Guadalupe / Fornoni, Juan / Wegier, Ana

    Microorganisms

    2023  Volume 11, Issue 2

    Abstract: The interaction among plants, insects, and microbes (PIM) is a determinant factor for the assembly and functioning of natural and anthropic ecosystems. In agroecosystems, the relationships among PIM are based on the interacting taxa, environmental ... ...

    Abstract The interaction among plants, insects, and microbes (PIM) is a determinant factor for the assembly and functioning of natural and anthropic ecosystems. In agroecosystems, the relationships among PIM are based on the interacting taxa, environmental conditions, and agricultural management, including genetically modified (GM) organisms. Although evidence for the unintended effects of GM plants on non-target insects is increasingly robust, our knowledge remains limited regarding their impact on gut microbes and their repercussions on the host's ecology, especially in the wild. In this study, we compared the gut microbial community of
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11020261
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  3. Article ; Online: Climatic and soil characteristics account for the genetic structure of the invasive cactus moth

    Andraca-Gómez, Guadalupe / Ordano, Mariano / Lira-Noriega, Andrés / Osorio-Olvera, Luis / Domínguez, César A / Fornoni, Juan

    PeerJ

    2024  Volume 12, Page(s) e16861

    Abstract: Background: Knowledge of the physical and environmental conditions that may limit the migration of invasive species is crucial to assess the potential for expansion outside their native ranges. The cactus moth, : Methods: To further understand what ... ...

    Abstract Background: Knowledge of the physical and environmental conditions that may limit the migration of invasive species is crucial to assess the potential for expansion outside their native ranges. The cactus moth,
    Methods: To further understand what influences the distribution and genetic structure of this otherwise important threat to native and managed ecosystems, in the present study we combined ecological niche modeling and population genetic analyses to identify potential environmental barriers in the native region of Argentina. Samples were collected on the host with the wider distribution range,
    Results: Significant genetic structure was detected using 10 nuclear microsatellites and 24 sampling sites. At least six genetic groups delimited by mountain ranges, salt flats and wetlands were mainly located to the west of the Dry Chaco ecoregion. Niche modeling supports that this region has high environmental suitability where the upper soil temperature and humidity, soil carbon content and precipitation were the main environmental factors that explain the presence of the moth. Environmental filters such as the upper soil layer may be critical for pupal survival and consequently for the establishment of populations in new habitats, whereas the presence of available hosts is a necessary conditions for insect survival, upper soil and climatic characteristics will determine the opportunities for a successful establishment.
    MeSH term(s) Animals ; United States ; Moths/genetics ; Argentina ; Ecosystem ; Opuntia ; Brazil
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.16861
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  4. Article ; Online: Role of

    Vargas-Sierra, Orlando / Hernández-Juárez, Jennifer / Uc-Uc, Perla Yaceli / Herrera, Luis A / Domínguez-Gómez, Guadalupe / Gariglio, Patricio / Díaz-Chávez, José

    Frontiers in bioscience (Landmark edition)

    2024  Volume 29, Issue 1, Page(s) 16

    Abstract: Background: The : Methods: After ectopic expressing SLC5A8 in the HeLa cell line, we evaluated its effects on cell behavior both : Results: Overexpression of SLC5A8 in the HeLa cell line decreased its proliferation by arresting cancer cells in the ...

    Abstract Background: The
    Methods: After ectopic expressing SLC5A8 in the HeLa cell line, we evaluated its effects on cell behavior both
    Results: Overexpression of SLC5A8 in the HeLa cell line decreased its proliferation by arresting cancer cells in the G1 phase and inhibiting cellular migration. Furthermore, we observed that pyruvate increased the SLC5A8 effect, inducing S-phase arrest and inhibiting the entry into mitosis. SLC5A8 decreased tumor growth in xenograft transplants, significantly reducing the volume and tumor weight at 35 days of analysis.
    Conclusions: In summary, our results indicate that
    MeSH term(s) Female ; Humans ; Cell Line, Tumor ; Genes, Tumor Suppressor ; HeLa Cells ; Monocarboxylic Acid Transporters/genetics ; Pyruvic Acid ; Uterine Cervical Neoplasms/genetics ; Animals
    Chemical Substances Monocarboxylic Acid Transporters ; Pyruvic Acid (8558G7RUTR) ; SLC5A8 protein, human
    Language English
    Publishing date 2024-01-29
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2901016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editorial: Advances in wild type and mutant p53 research in cancer.

    Hernández-de la Cruz, Olga N / Domínguez-Gómez, Guadalupe / Deb, Moonmoon / Díaz-Chávez, José

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 1064280

    Language English
    Publishing date 2022-11-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.1064280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: PaSTe. Blockade of the Lipid Phenotype of Prostate Cancer as Metabolic Therapy: A Theoretical Proposal.

    Romo-Perez, Adriana / Domínguez-Gómez, Guadalupe / Chávez-Blanco, Alma / González-Fierro, Aurora / Correa-Basurto, José / Dueñas-González, Alfonso

    Current medicinal chemistry

    2023  

    Abstract: Background: Prostate cancer is the most frequently diagnosed malignancy in 112 countries and is the leading cause of death in eighteen. In addition to continuing research on prevention and early diagnosis, improving treatments and making them more ... ...

    Abstract Background: Prostate cancer is the most frequently diagnosed malignancy in 112 countries and is the leading cause of death in eighteen. In addition to continuing research on prevention and early diagnosis, improving treatments and making them more affordable is imperative. In this sense, the therapeutic repurposing of low-cost and widely available drugs could reduce global mortality from this disease. The malignant metabolic phenotype is becoming increasingly important due to its therapeutic implications. Cancer generally is characterized by hyperactivation of glycolysis, glutaminolysis, and fatty acid synthesis. However, prostate cancer is particularly lipidic; it exhibits increased activity in the pathways for synthesizing fatty acids, cholesterol, and fatty acid oxidation (FAO).
    Objective: Based on a literature review, we propose the PaSTe regimen (Pantoprazole, Simvastatin, Trimetazidine) as a metabolic therapy for prostate cancer. Pantoprazole and simvastatin inhibit the enzymes fatty acid synthase (FASN) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), therefore, blocking the synthesis of fatty acids and cholesterol, respectively. In contrast, trimetazidine inhibits the enzyme 3-b-Ketoacyl-CoA thiolase (3-KAT), an enzyme that catalyzes the oxidation of fatty acids (FAO). It is known that the pharmacological or genetic depletion of any of these enzymes has antitumor effects in prostatic cancer.
    Results: Based on this information, we hypothesize that the PaSTe regimen will have increased antitumor effects and may impede the metabolic reprogramming shift. Existing knowledge shows that enzyme inhibition occurs at molar concentrations achieved in plasma at standard doses of these drugs.
    Conclusion: We conclude that this regimen deserves to be preclinically evaluated because of its clinical potential for the treatment of prostate cancer.
    Language English
    Publishing date 2023-06-07
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867330666230607104441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Does Therapeutic Repurposing in Cancer Meet the Expectations of Having Drugs at a Lower Price?

    Gonzalez-Fierro, Aurora / Romo-Pérez, Adriana / Chávez-Blanco, Alma / Dominguez-Gomez, Guadalupe / Duenas-Gonzalez, Alfonso

    Clinical drug investigation

    2023  Volume 43, Issue 4, Page(s) 227–239

    Abstract: Therapeutic repurposing emerged as an alternative to the traditional drug discovery and development model (DDD) of new molecular entities (NMEs). It was anticipated that by being faster, safer, and cheaper, the development would result in lower-cost ... ...

    Abstract Therapeutic repurposing emerged as an alternative to the traditional drug discovery and development model (DDD) of new molecular entities (NMEs). It was anticipated that by being faster, safer, and cheaper, the development would result in lower-cost drugs. As defined in this work, a repurposed cancer drug is one approved by a health regulatory authority against a non-cancer indication that then gains new approval for cancer. With this definition, only three drugs are repurposed for cancer: Bacillus Calmette-Guerin (BCG) vaccine (superficial bladder cancer, thalidomide [multiple myeloma], and propranolol [infantile hemangioma]). Each of these has a different history regarding price and affordability, and it is not yet possible to generalize the impact of drug repurposing on the final price to the patient. However, the development, including the price, does not differ significantly from an NME. For the end consumer, the product's price is unrelated to whether it followed the classical development or repurposing. Economic constraints for clinical development, and drug prescription biases for repurposing drugs, are barriers yet to be overcome. The affordability of cancer drugs is a complex issue that varies from country to country. Many alternatives for having affordable drugs have been put forward, however these measures have thus far failed and are, at best, palliative. There are no immediate solutions to the problem of access to cancer drugs. It is necessary to critically analyze the impact of the current drug development model and be creative in implementing new models that genuinely benefit society.
    MeSH term(s) Humans ; Drug Repositioning ; Motivation ; Antineoplastic Agents/therapeutic use ; Urinary Bladder Neoplasms/drug therapy ; BCG Vaccine/therapeutic use
    Chemical Substances Antineoplastic Agents ; BCG Vaccine
    Language English
    Publishing date 2023-03-08
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1220136-4
    ISSN 1179-1918 ; 0114-2402 ; 1173-2563
    ISSN (online) 1179-1918
    ISSN 0114-2402 ; 1173-2563
    DOI 10.1007/s40261-023-01251-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2807: Show issues Location:
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  8. Article ; Online: Selection of clinically relevant drug concentrations for in vitro studies of candidates drugs for cancer repurposing: a proposal.

    Robles-Bañuelos, Benjamin / Romo-Perez, Adriana / Dominguez-Gomez, Guadalupe / Chavez-Blanco, Alma / Gonzalez-Fierro, Aurora / Duenas-Gonzalez, Alfonso

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

    2023  Volume 26, Issue 5, Page(s) 1077–1088

    Abstract: Drug repurposing of widely prescribed patent-off and cheap drugs may provide affordable drugs for cancer treatment. Nevertheless, many preclinical studies of cancer drug repurposing candidates use in vitro drug concentrations too high to have clinical ... ...

    Abstract Drug repurposing of widely prescribed patent-off and cheap drugs may provide affordable drugs for cancer treatment. Nevertheless, many preclinical studies of cancer drug repurposing candidates use in vitro drug concentrations too high to have clinical relevance. Hence, preclinical studies must use clinically achievable drug concentrations. In this work, several FDA-approved cancer drugs are analyzed regarding the correlation between the drug inhibitory concentrations 50% (IC
    MeSH term(s) Humans ; Drug Repositioning ; Neoplasms/drug therapy ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2023-12-08
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2397359-6
    ISSN 1699-3055 ; 1699-048X
    ISSN (online) 1699-3055
    ISSN 1699-048X
    DOI 10.1007/s12094-023-03352-w
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    Zs.A 6644: Show issues Location:
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  9. Article ; Online: Analyzing left-truncated and right-censored infectious disease cohort data with interval-censored infection onset.

    Pak, Daewoo / Liu, Jun / Ning, Jing / Gómez, Guadalupe / Shen, Yu

    Statistics in medicine

    2020  Volume 40, Issue 2, Page(s) 287–298

    Abstract: In an infectious disease cohort study, individuals who have been infected with a pathogen are often recruited for follow up. The period between infection and the onset of symptomatic disease, referred to as the incubation period, is of interest because ... ...

    Abstract In an infectious disease cohort study, individuals who have been infected with a pathogen are often recruited for follow up. The period between infection and the onset of symptomatic disease, referred to as the incubation period, is of interest because of its importance on disease surveillance and control. However, the incubation period is often difficult to ascertain due to the uncertainty associated with asymptomatic infection onset time. An additional complication is that the observed infected subjects are likely to have longer incubation periods due to the prevalent sampling. In this article, we demonstrate how to estimate the distribution of the incubation period with the uncertain infection onset, subject to left-truncation and right-censoring. We employ a family of sufficiently general parametric models, the generalized odds-rate class of regression models, for the underlying incubation period and its correlation with covariates. In simulation studies, we assess the finite sample performance of the model fitting and hazard function estimation. The proposed method is illustrated on data from the HIV/AIDS study on injection drug users admitted to a detoxification program in Badalona, Spain.
    MeSH term(s) Acquired Immunodeficiency Syndrome ; Cohort Studies ; Computer Simulation ; Humans ; Research Design ; Spain
    Language English
    Publishing date 2020-10-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.8774
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    Zs.A 1756: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: Comments on 'Use of composite endpoints in clinical trials' by Abdul J. Sankoh, Haihong Li and Ralph B. D'Agostino, Sr.

    Gómez, Guadalupe / Gómez-Mateu, Moisés

    Statistics in medicine

    2016  Volume 35, Issue 2, Page(s) 317–318

    MeSH term(s) Clinical Trials as Topic/methods ; Drug Evaluation/methods ; Endpoint Determination/methods ; Humans
    Language English
    Publishing date 2016-01-30
    Publishing country England
    Document type Comment ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.6483
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1756: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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