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Article ; Online: Infective endocarditis in patient with transposition of the great arteries with Rastelli repair.

Rojas-Martelo, Giovani Andres / Jiménez-Cauhe, Juan / Gómez-Ayerbe, Cristina

2019 Volume 154, Issue 10, Page(s) 421–422

Title translation	Endocarditis infecciosa en paciente con transposición de grandes arterias con reparación de Rastelli.
MeSH term(s)	Arterial Switch Operation ; Arteries ; Endocarditis/diagnosis ; Endocarditis/etiology ; Humans ; Infant ; Reoperation ; Transposition of Great Vessels/surgery
Language	Spanish
Publishing date	2019-06-03
Publishing country	Spain
Document type	Letter
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2019.04.015
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Article ; Online: Symtuza

Gómez Ayerbe, Cristina / Santos González, Jesús / Palacios Muñoz, Rosario

Enfermedades infecciosas y microbiologia clinica (English ed.)

2018 Volume 36 Suppl 2, Page(s) 17–21

Abstract: The management of HIV infection is based on the administration of lifelong antiretroviral therapy (ART). Single-tablet regimens (STR) reduce pill burden and maximise long-term adherence. Cobicistat-boosted darunavir with emtricitabine and tenofovir ... ...

Title translation	Symtuza
Abstract	The management of HIV infection is based on the administration of lifelong antiretroviral therapy (ART). Single-tablet regimens (STR) reduce pill burden and maximise long-term adherence. Cobicistat-boosted darunavir with emtricitabine and tenofovir alafenamide co-formulation (DRV/c/FTC/TAF), with trade name Symtuza
MeSH term(s)	Anti-HIV Agents/therapeutic use ; Darunavir/therapeutic use ; Drug Combinations ; HIV Infections/drug therapy ; Humans ; Tenofovir/therapeutic use ; Treatment Outcome
Chemical Substances	Anti-HIV Agents ; Drug Combinations ; symtuza ; Tenofovir (99YXE507IL) ; Darunavir (YO603Y8113)
Language	Spanish
Publishing date	2018-12-03
Document type	Journal Article
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/S0213-005X(18)30393-8
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Article ; Online: A Pandemic within Other Pandemics. When a Multiple Infection of a Host Occurs: SARS-CoV-2, HIV and

González-Domenech, Carmen María / Pérez-Hernández, Isabel / Gómez-Ayerbe, Cristina / Viciana Ramos, Isabel / Palacios-Muñoz, Rosario / Santos, Jesús

Viruses

2021 Volume 13, Issue 5

Abstract: By the middle of 2021, we are still immersed in the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The concurrence of this new pandemic in regions where human immunodeficiency ... ...

Abstract	By the middle of 2021, we are still immersed in the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The concurrence of this new pandemic in regions where human immunodeficiency virus (HIV) and tuberculosis (TB) infections possess the same epidemiological consideration, has arisen concerns about the prognosis, clinical management, symptomatology, and treatment of patients with triple infection. At the same time, healthcare services previously devoted to diagnosis and treatment of TB and HIV are being jeopardized by the urgent need of resources and attention for COVID-19 patients. The aim of this review was to collect any article considering the three conditions (HIV, TB, and SARS-CoV-2), included in PubMed/Medline and published in the English language since the beginning of the COVID-19 pandemic. We focused on detailed descriptions of the unusual cases describing the three co-infections. Eighty-four out of 184 publications retrieved met our inclusion criteria, but only three of them reported cases (five in total) with the three concomitant infections. The clinical evolution, management, and therapy of all of them were not different from mild/severe cases with exclusive COVID-19; the outcome was not worse either, with recovery for the five patients. Cases of patients with COVID-19 besides HIV and TB infections are scarce in literature, but studies deliberately embracing the triple infection as a priori inclusion criterion should be carried out in order to provide a complete understanding of joint influence.
MeSH term(s)	COVID-19/complications ; COVID-19/epidemiology ; Coinfection/epidemiology ; Diagnostic Tests, Routine ; HIV/pathogenicity ; HIV Infections/complications ; HIV Infections/epidemiology ; Humans ; Mycobacterium tuberculosis/pathogenicity ; Pandemics ; SARS-CoV-2/pathogenicity ; Tuberculosis/complications ; Tuberculosis/epidemiology
Language	English
Publishing date	2021-05-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13050931
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Article: A Pandemic within Other Pandemics. When a Multiple Infection of a Host Occurs: SARS-CoV-2, HIV and Mycobacterium tuberculosis

González-Domenech, Carmen María / Pérez-Hernández, Isabel / Gómez-Ayerbe, Cristina / Viciana Ramos, Isabel / Palacios-Muñoz, Rosario / Santos, Jesús

Viruses. 2021 May 17, v. 13, no. 5

2021

Abstract	By the middle of 2021, we are still immersed in the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The concurrence of this new pandemic in regions where human immunodeficiency virus (HIV) and tuberculosis (TB) infections possess the same epidemiological consideration, has arisen concerns about the prognosis, clinical management, symptomatology, and treatment of patients with triple infection. At the same time, healthcare services previously devoted to diagnosis and treatment of TB and HIV are being jeopardized by the urgent need of resources and attention for COVID-19 patients. The aim of this review was to collect any article considering the three conditions (HIV, TB, and SARS-CoV-2), included in PubMed/Medline and published in the English language since the beginning of the COVID-19 pandemic. We focused on detailed descriptions of the unusual cases describing the three co-infections. Eighty-four out of 184 publications retrieved met our inclusion criteria, but only three of them reported cases (five in total) with the three concomitant infections. The clinical evolution, management, and therapy of all of them were not different from mild/severe cases with exclusive COVID-19; the outcome was not worse either, with recovery for the five patients. Cases of patients with COVID-19 besides HIV and TB infections are scarce in literature, but studies deliberately embracing the triple infection as a priori inclusion criterion should be carried out in order to provide a complete understanding of joint influence.
Keywords	COVID-19 infection ; Human immunodeficiency virus ; Mycobacterium tuberculosis ; Severe acute respiratory syndrome coronavirus 2 ; disease course ; health services ; pandemic ; prognosis ; therapeutics ; tuberculosis
Language	English
Dates of publication	2021-0517
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v13050931
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Weight changes after first-line antiretroviral initiation in a cohort of HIV-positive patients in Southern Spain (CAPOTA study).

Gómez-Ayerbe, Cristina / Palacios, Rosario / Mayorga, Marisa / Navarrete, Miguel Nicolas / Ferra, Sergio / Ruiz, Inmaculada / Garcia, Coral / Castaño, Manuel / Merino, Dolores / Collado, Antonio / Hidalgo-Tenorio, Carmen / Delgado, Marcial / Rivero, Antonio / Santos, Jesús

International journal of STD & AIDS

2022 Volume 33, Issue 13, Page(s) 1119–1123

Abstract: Background: Obesity among persons living with HIV (PLWH) has increased and weight gain after antiretroviral therapy (ART) can lead to metabolic disorders and impact survival. Our objective was to analyze weight and metabolic changes in HIV näive ... ...

Abstract	Background: Obesity among persons living with HIV (PLWH) has increased and weight gain after antiretroviral therapy (ART) can lead to metabolic disorders and impact survival. Our objective was to analyze weight and metabolic changes in HIV näive patients after 48 weeks of ART. Methods: Observational, retrospective, multicentered cohort study comprising naïve-patients who started tenofovir alafenamide/emtricitabine/elvitegravir/cobicistat (TAF/FTC/EVG/c) or abacavir/lamivudine/dolutegravir (ABC/3TC/DTG), with no change in treatment for 48 weeks. Clinical and metabolic parameters were collected at baseline and week-48. Statistical program used was SPSS 21.0.0. Results: The study included 329 participants from 6 hospitals. Participants were 89% male and 10% had AIDS diagnosis. Median age was 35 (IQR 27-43) years. Median baseline CD4 count was 417 (IQR 250-569) cell/mm3 and HIV viral load 4.65 (IQR 4.21-5.18) log Conclusions: After ART initiation patients gain weight regardless of the regimen they take. Weight gain is associated with AIDS and the use of TAF/FTC/EVG/c.
MeSH term(s)	Humans ; Male ; Adult ; Female ; Lamivudine/therapeutic use ; Anti-HIV Agents/therapeutic use ; Cohort Studies ; Retrospective Studies ; Spain/epidemiology ; Overweight/drug therapy ; Acquired Immunodeficiency Syndrome/drug therapy ; Anti-Retroviral Agents/therapeutic use ; Emtricitabine/therapeutic use ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Weight Gain ; Obesity/epidemiology
Chemical Substances	Lamivudine (2T8Q726O95) ; Anti-HIV Agents ; Anti-Retroviral Agents ; Emtricitabine (G70B4ETF4S)
Language	English
Publishing date	2022-09-07
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/09564624221125356
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Zs.A 2829: Show issues

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Article ; Online: Severe immunosuppression is related to poorer immunogenicity to SARS-CoV-2 vaccines among people living with HIV.

Corma-Gómez, Anaïs / Fernández-Fuertes, Marta / García, Estefanía / Fuentes-López, Ana / Gómez-Ayerbe, Cristina / Rivero-Juárez, Antonio / Domínguez, Carmen / Santos, Marta / Viñuela, Laura / Palacios, Rosario / Real, Luis M / Rivero, Antonio / Macías, Juan / Pineda, Juan A / García, Federico

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2022 Volume 28, Issue 11, Page(s) 1492–1498

Abstract: Objectives: The aim of this study was to assess the immunogenicity of SARS-CoV-2 available vaccines among people living with HIV (PLWH) after a complete vaccination scheme, and determine predictors of seroconversion.: Methods: This multicentre ... ...

Abstract	Objectives: The aim of this study was to assess the immunogenicity of SARS-CoV-2 available vaccines among people living with HIV (PLWH) after a complete vaccination scheme, and determine predictors of seroconversion. Methods: This multicentre prospective cohort study included 420 PLWH who had received a standard immunization, either with mRNA or adenoviral-vectored COVID-19 vaccines. Antibody response was evaluated within 1 to 2 months after the last dose of the vaccine with a quantitative determination of antitrimeric spike protein-specific IgG antibodies and IgG neutralizing antibodies. Results: Overall, 384 of 420 PLWH (91%) showed antibody response to vaccination. Seroconversion was observed in 308 of 326 individuals with cluster of differentiation 4 (CD4) counts ≥350 cells/mm Discussion: HIV-related immunosuppression impairs the antibody response to SARS-CoV-2 vaccines. Specific vaccination schemes should be urgently tailored in this setting, particularly in patients with CD4 cell counts <200 cells/μL. Adenoviral-vectored vaccines should be avoided in PLWH whenever possible.
MeSH term(s)	Humans ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; SARS-CoV-2 ; Prospective Studies ; Antibodies, Viral ; COVID-19/prevention & control ; Antibodies, Neutralizing ; Immunoglobulin G ; Immunosuppression Therapy ; Vaccination ; Immunologic Deficiency Syndromes ; HIV Infections ; RNA, Messenger
Chemical Substances	COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; Antibodies, Viral ; Antibodies, Neutralizing ; Immunoglobulin G ; RNA, Messenger ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-05-28
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2022.05.018
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 284: Show issues

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Article ; Online: Acute hepatitis C virus infection and direct-acting antiviral drugs: Perfect combination to eliminate the epidemic?

Gómez-Ayerbe, Cristina / Palacios, Rosario / Ríos, Maria J / Téllez, Francisco / Sayago, Carmen / Martín-Aspas, Andrés / Camacho, Angela / Muñoz, Leopoldo / Santos, Jesús

International journal of STD & AIDS

2021 Volume 32, Issue 13, Page(s) 1257–1260

Abstract: Early diagnosis and treatment of incident cases of hepatitis C virus (HCV) infection is fundamental to eliminate HCV in HIV-positive patients. From January 2016 to December 2019, we attended 40 episodes of acute HCV infection (AHC) in 35 subjects (9 ... ...

Abstract	Early diagnosis and treatment of incident cases of hepatitis C virus (HCV) infection is fundamental to eliminate HCV in HIV-positive patients. From January 2016 to December 2019, we attended 40 episodes of acute HCV infection (AHC) in 35 subjects (9 reinfections) who were coinfected with HIV. The patients were treated with direct-acting antiviral agents (DAAs) in seven hospitals in Andalusia, Spain. All were men who have sex with men (MSM), mean age was 42.9 (±8.3) years and median time of HIV infection was 46.6 months (IQR: 20.4-67.2). All received antiretroviral therapy and had undetectable HIV viral load (except 2 with 65 and 68 copies/mL); median CD4 count was 632 cells/mm
MeSH term(s)	Adult ; Antiviral Agents/therapeutic use ; Coinfection/drug therapy ; Epidemics ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Hepacivirus/genetics ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Hepatitis C, Chronic/drug therapy ; Homosexuality, Male ; Humans ; Male ; Sexual and Gender Minorities
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-07-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/09564624211033756
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Zs.A 2829: Show issues

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Article ; Online: Long or complicated mpox in patients with uncontrolled HIV infection.

Corma-Gómez, Anaïs / Cabello, Alfonso / Orviz, Eva / Morante-Ruiz, Miguel / Ayerdi, Oskar / Al-Hayani, Aws / Muñoz-Gómez, Ana / Santos, Ignacio De Los / Gómez-Ayerbe, Cristina / Rodrigo, David / Riestra, Sandra De la Rosa / Reus-Bañuls, Sergio / Silva-Klug, Ana / Galindo, María José / Santos, Marta / Serrano-Fuentes, Miriam / Faro-Míguez, Naya / Pérez-Camacho, Inés / Corona-Mata, Diana /

Morano, Luis / López-Ruz, Miguel Ángel / Montero, Marta / Anaya-Baz, Blanca / Merino, Dolores / Castillo-Navarro, Antonia / Pineda, Juan A / Macías, Juan

Journal of medical virology

2024 Volume 96, Issue 3, Page(s) e29511

Abstract: To date, former research about the impact of HIV infection on mpox poor outcomes is still limited and controversial. Therefore, the aim of this study was to assess the impact of HIV on the clinical course of mpox, in a large population of patients from ... ...

Abstract	To date, former research about the impact of HIV infection on mpox poor outcomes is still limited and controversial. Therefore, the aim of this study was to assess the impact of HIV on the clinical course of mpox, in a large population of patients from Spain. Nationwide case-series study. Patients from 18 Spanish hospitals, with PCR-confirmed mpox from April 27, 2022 to June 30, 2023 were included in this study. The main outcome was the development of long or complicated (LC) mpox, defined as: (i) duration of the clinical course ≥ 28 days, or; (ii) disseminated disease, or: (iii) emergence of severe complications. One thousand eight hundred twenty-three individuals were included. Seven hundred eighty-six (43%) were people living with HIV (PLWH), of whom 11 (1%) had a CD4 cell count < 200 cells/mm
MeSH term(s)	Humans ; HIV Infections ; Mpox (monkeypox) ; CD4 Lymphocyte Count ; Disease Progression ; RNA
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29511
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Zs.A 1320: Show issues

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Article ; Online: Brief Report: Patients' Experiences and Opinions After Desimplification of Their Single-Tablet Regimens for the Treatment of HIV Infection: A Survey in a Multicentre Cohort.

Suárez-García, Inés / Ruiz-Algueró, Marta / Alejos, Belén / García-Yubero, Cristina / Belza, Mª José / Espacio, Ramón / Hernández, Juanse / Muñoz Sánchez, Josefa / Garaialde, Ainhoa / Alonso Socas, María Del Mar / Alcaraz, Antonia / Pierola Ruiz de Galarreta, Beatriz / Martínez Madrid, Onofre Juan / Gutiérrez Cuéllar, Isabel / Gómez-Ayerbe, Cristina / Olalla, Julián / Jarrín, Inma

Journal of acquired immune deficiency syndromes (1999)

2022 Volume 90, Issue 1, Page(s) 62–68

Abstract: Objectives: The aims of this study were to describe patients' experiences after single-tablet regimen (STR) desimplification and its impact on self-reported treatment adherence and quality of life.: Methods: We performed a survey among all patients ... ...

Abstract	Objectives: The aims of this study were to describe patients' experiences after single-tablet regimen (STR) desimplification and its impact on self-reported treatment adherence and quality of life. Methods: We performed a survey among all patients from the multicenter cohort of the Spanish HIV/AIDS Network who had desimplified the STRs dolutegravir/abacavir/lamivudine (DGT/ABC/3TC) or rilpivirine/tenofovir disoproxil fumarate/emtricitabine to their separate components (DTG + generic ABC/3TC or RPV + generic TDF/FTC) between December 2016 and November 2018. Results: Among 216 patients who fulfilled inclusion criteria, 138 (63.9%) completed the questionnaire. Most of the patients (78.3%) knew what generic drugs are, only 8.7% believed that treatment with 2 pills is less effective than treatment with an STR, and 67.4% agreed that it is reasonable to take 2 pills instead of 1 for HIV treatment to decrease costs for the health care system. After desimplification, 13.0% of the patients stated they had more secondary effects, 8.0% had forgotten one or more doses more frequently than before, and 10.9% had sometimes forgotten to take 1 pill, but not the other. A proportion of 30.4% reported not being happy to take more pills a day, and 10.1% experienced a worse quality of life after the treatment desimplification. Conclusions: After STR desimplification, most of the patients had a fair knowledge about generic antiretrovirals, and they agreed to desimplify their STR to decrease costs. Although almost a third of the respondents were not happy to take 2 pills a day, only a minority reported worse adherence or quality of life.
MeSH term(s)	Anti-HIV Agents/therapeutic use ; Drug Combinations ; Emtricitabine/therapeutic use ; HIV Infections/drug therapy ; Humans ; Lamivudine/therapeutic use ; Quality of Life ; Surveys and Questionnaires ; Tablets ; Tenofovir/therapeutic use
Chemical Substances	Anti-HIV Agents ; Drug Combinations ; Tablets ; Lamivudine (2T8Q726O95) ; Tenofovir (99YXE507IL) ; Emtricitabine (G70B4ETF4S)
Language	English
Publishing date	2022-01-28
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000002923
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Zs.A 2442: Show issues

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Article ; Online: Role of previous systemic antibiotic therapy on the probability of recurrence after an initial episode of

Merchante, Nicolás / Herrero, Rocío / Valverde-Fredet, María Dolores / Rodríguez-Fernández, Miguel / Pinagorte, Héctor / Martínez-Marcos, Francisco J / Gil-Anguita, Concepción / García-López, María / Tasias Pitarch, María / Abril López De Medrano, Vicente / Navarrete Lorite, Miguel Nicolás / Gómez-Ayerbe, Cristina / León, Eva / González-De La Aleja, Pilar / Ruiz Castillo, Ana / Aller, Ana I / Rodríguez, Juan Carlos / Ternero Fonseca, Julia / Corzo, Juan E /

Naranjo Pérez, Alberto / Trigo-Rodríguez, Marta / Merino, Esperanza

JAC-antimicrobial resistance

2023 Volume 5, Issue 2, Page(s) dlad033

Abstract: Objectives: To investigate the role of previous antibiotic therapy in the risk of recurrence after a : Methods: Multicentre observational study. Patients with a CDI episode achieving clinical cure with oral vancomycin and followed up 8 weeks were ... ...

Abstract	Objectives: To investigate the role of previous antibiotic therapy in the risk of recurrence after a Methods: Multicentre observational study. Patients with a CDI episode achieving clinical cure with oral vancomycin and followed up 8 weeks were included. Previous antibiotic exposure up to 90 days was collected. Multivariate analysis of predictors of recurrence adjusted by the propensity score (PS) of being previously treated with each non-CDI antibiotic was performed. Results: Two hundred and forty-one patients were included; 216 (90%) had received systemic antibiotics. Fifty-three patients (22%) had a CDI recurrence. Rates of recurrence were lower in those treated with piperacillin/tazobactam in the last month when compared with those not receiving piperacillin/tazobactam [3 (7%) versus 50 (25%); Conclusions: Recent use of piperacillin/tazobactam might be associated with a lower risk of CDI recurrence, while recent use of cephalosporins might promote an increased risk. These findings should be considered when treating hospitalized patients.
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article
ISSN	2632-1823
ISSN (online)	2632-1823
DOI	10.1093/jacamr/dlad033
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