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  1. Article ; Online: Management of perioperative thromboprophylaxis for surgery following COVID-19: an expert-panel survey.

    Ferrandis, Raquel / Llau, Juan V / Afshari, Arash / Douketis, James D / Gómez-Luque, Aurelio / Samama, Charles-Marc

    British journal of anaesthesia

    2021  Volume 127, Issue 4, Page(s) e143–e145

    MeSH term(s) Anticoagulants/therapeutic use ; COVID-19/complications ; Humans ; Perioperative Care/methods ; SARS-CoV-2 ; Time ; Venous Thromboembolism/complications ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-07-09
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2021.06.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Breast Cancer and Anaesthesia: Genetic Influence.

    Raigon Ponferrada, Aida / Guerrero Orriach, Jose Luis / Molina Ruiz, Juan Carlos / Romero Molina, Salvador / Gómez Luque, Aurelio / Cruz Mañas, Jose

    International journal of molecular sciences

    2021  Volume 22, Issue 14

    Abstract: Breast cancer is the leading cause of mortality in women. It is a heterogeneous disease with a high degree of inter-subject variability even in patients with the same type of tumor, with individualized medicine having acquired significant relevance in ... ...

    Abstract Breast cancer is the leading cause of mortality in women. It is a heterogeneous disease with a high degree of inter-subject variability even in patients with the same type of tumor, with individualized medicine having acquired significant relevance in this field. The clinical and morphological heterogeneity of the different types of breast tumors has led to a diversity of staging and classification systems. Thus, these tumors show wide variability in genetic expression and prognostic biomarkers. Surgical treatment is essential in the management of these patients. However, the perioperative period has been found to significantly influence survival and cancer recurrence. There is growing interest in the pro-tumoral effect of different anaesthetic and analgesic agents used intraoperatively and their relationship with metastatic progression. There is cumulative evidence of the influence of anaesthetic techniques on the physiopathological mechanisms of survival and growth of the residual neoplastic cells released during surgery. Prospective randomized clinical trials are needed to obtain quality evidence on the relationship between cancer and anaesthesia. This document summarizes the evidence currently available about the effects of the anaesthetic agents and techniques used in primary cancer surgery and long-term oncologic outcomes, and the biomolecular mechanisms involved in their interaction.
    MeSH term(s) Anesthetics/adverse effects ; Animals ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Female ; Humans ; Neoplasm Recurrence, Local/chemically induced ; Neoplasm Recurrence, Local/genetics
    Chemical Substances Anesthetics
    Language English
    Publishing date 2021-07-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22147653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19: opening a new paradigm in thromboprophylaxis for critically ill patients?

    Ferrandis, Raquel / Llau, Juan V / Quintana, Manuel / Sierra, Pilar / Hidalgo, Francisco / Cassinello, Concepción / Gómez-Luque, Aurelio

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 332

    MeSH term(s) Anticoagulants/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Critical Illness ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; Pulmonary Embolism/complications ; Pulmonary Embolism/prevention & control ; SARS-CoV-2 ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants ; Heparin, Low-Molecular-Weight
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03052-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5517: Show issues Location:
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  4. Article: COVID-19: opening a new paradigm in thromboprophylaxis for critically ill patients?

    Ferrandis, Raquel / Llau, Juan V / Quintana, Manuel / Sierra, Pilar / Hidalgo, Francisco / Cassinello, Concepción / Gómez-Luque, Aurelio

    Crit Care

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #593537
    Database COVID19

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  5. Article ; Online: COVID-19

    Ferrandis, Raquel / Llau, Juan V. / Quintana, Manuel / Sierra, Pilar / Hidalgo, Francisco / Cassinello, Concepción / Gómez-Luque, Aurelio

    Critical care, 24(1):332

    opening a new paradigm in thromboprophylaxis for critically ill patients?

    2020  

    Keywords COVID-19 ; covid19
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: COVID-19

    Ferrandis, Raquel / Llau, Juan V. / Quintana, Manuel / Sierra, Pilar / Hidalgo, Francisco / Cassinello, Concepción / Gómez-Luque, Aurelio

    Critical Care

    opening a new paradigm in thromboprophylaxis for critically ill patients?

    2020  Volume 24, Issue 1

    Keywords Critical Care and Intensive Care Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2041406-7
    ISSN 1364-8535
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03052-9
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 5517: Show issues Location:
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  7. Article: The platelet of the patients with ischemic cardiopathy and cardiac valve disease showed a reduction of 8OH-DPAT binding sites.

    Bellido, Inmaculada / Delange, Laureano / Gomez-Luque, Aurelio

    Thrombosis research

    2008  Volume 121, Issue 4, Page(s) 555–565

    Abstract: Depression is prospectively associated with increased risk of coronary artery disease in individuals initially free of clinical cardiovascular disease probably by an increased platelet activity. The serotonergic receptors mainly implied in depression are ...

    Abstract Depression is prospectively associated with increased risk of coronary artery disease in individuals initially free of clinical cardiovascular disease probably by an increased platelet activity. The serotonergic receptors mainly implied in depression are 5-HT1A and 5-HT2 receptors. Activation of 5HT2 receptor induces platelet aggregation. Drugs with 5-HT1A receptor agonist and 5-HT2A receptor antagonist effects reduced the receptor-mediated platelet aggregation. There are only indirect data about 5-HT1A receptors presence in platelet membranes, thus our aims were to study the characteristics of the platelet membranes 5-HT1A binding sites of both healthy volunteers and patients with cardiac valve disease and ischemic cardiopathy. The bound of the 5-HT1A selective agonist 3H-8OH-DPAT to the platelet membranes 5-HT1A binding sites of patients with cardiac valve disease and ischemic cardiopathy were compared with a control group of healthy voluntaries using radioligand binding methods. The patients with cardiovascular disease showed a reduction (-50.40%) (p<0.01) of the 3H-8OH-DPAT bound to the platelet membranes 5-HT1A receptors (1.652+/-0.79 fmol/mg protein) with respect to the control group (3.331+/-0.16 fmol/mg protein). 3H-8OH-DPAT binding to human platelet membranes is saturable, of high affinity, and seems selective for 5-HT1A receptors, and similar to that described in animal brain and in other human cells. Patients with ischemic cardiopathy and cardiac valve disease showed a reduction of the 8OH-DPAT bound to the platelet membranes. Taken together, these findings suggest that the 8OH-DPAT bound to the human platelet membranes is modulated by modifications produced by cardiovascular disease conditions.
    MeSH term(s) 8-Hydroxy-2-(di-n-propylamino)tetralin/metabolism ; Adult ; Aged ; Binding Sites ; Blood Platelets/metabolism ; Female ; Heart Valve Diseases/blood ; Humans ; Male ; Middle Aged ; Myocardial Ischemia/blood ; Platelet Aggregation ; Receptor, Serotonin, 5-HT1A/blood ; Serotonin Uptake Inhibitors/pharmacology
    Chemical Substances Serotonin Uptake Inhibitors ; Receptor, Serotonin, 5-HT1A (112692-38-3) ; 8-Hydroxy-2-(di-n-propylamino)tetralin (78950-78-4)
    Language English
    Publishing date 2008
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2007.06.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 863: Show issues Location:
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  8. Article ; Online: Prevention of the renarrowing of coronary arteries using drug-eluting stents in the perioperative period: an update.

    Llau, Juan V / Ferrandis, Raquel / Sierra, Pilar / Gómez-Luque, Aurelio

    Vascular health and risk management

    2010  Volume 6, Page(s) 855–867

    Abstract: The management of patients scheduled for surgery with a coronary stent, and receiving 1 or more antiplatelet drugs, has many controversies. The premature discontinuation of antiplatelet drugs substantially increases the risk of stent thrombosis (ST), ... ...

    Abstract The management of patients scheduled for surgery with a coronary stent, and receiving 1 or more antiplatelet drugs, has many controversies. The premature discontinuation of antiplatelet drugs substantially increases the risk of stent thrombosis (ST), myocardial infarction, and cardiac death, and surgery under an altered platelet function could also lead to an increased risk of bleeding in the perioperative period. Because of the conflict in the recommendations, this article reviews the current antiplatelet protocols after positioning a coronary stent, the evidence of increased risk of ST associated with the withdrawal of antiplatelet drugs and increased bleeding risk associated with its maintenance, the different perioperative antiplatelet protocols when patients are scheduled for surgery or need an urgent operation, and the therapeutic options if excessive bleeding occurs.
    MeSH term(s) Aspirin/therapeutic use ; Blood Loss, Surgical/prevention & control ; Clopidogrel ; Coronary Thrombosis/prevention & control ; Coronary Vessels/drug effects ; Coronary Vessels/physiopathology ; Coronary Vessels/surgery ; Drug-Eluting Stents/adverse effects ; Humans ; Myocardial Revascularization/adverse effects ; Myocardial Revascularization/instrumentation ; Myocardial Revascularization/methods ; Perioperative Care/methods ; Perioperative Period ; Piperazines/therapeutic use ; Platelet Aggregation Inhibitors/therapeutic use ; Prasugrel Hydrochloride ; Thiophenes/therapeutic use ; Ticlopidine/analogs & derivatives ; Ticlopidine/therapeutic use
    Chemical Substances Piperazines ; Platelet Aggregation Inhibitors ; Thiophenes ; Clopidogrel (A74586SNO7) ; Prasugrel Hydrochloride (G89JQ59I13) ; Ticlopidine (OM90ZUW7M1) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2010-10-05
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2186568-1
    ISSN 1178-2048 ; 1176-6344
    ISSN (online) 1178-2048
    ISSN 1176-6344
    DOI 10.2147/VHRM.S7402
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    Zs.A 6066: Show issues Location:
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  9. Article ; Online: "Patient blood management" in orthopaedic surgery.

    Canillas, Fernando / Gómez-Ramírez, Susana / García-Erce, José Antonio / Pavía-Molina, José / Gómez-Luque, Aurelio / Muñoz, Manuel

    Revista espanola de cirugia ortopedica y traumatologia

    2015  Volume 59, Issue 3, Page(s) 137–149

    Abstract: Orthopaedic and trauma surgical procedures (OTS) can lead to significant blood losses and acute postoperative anaemia, which in many cases requires allogeneic blood transfusions (ABT). The clinical, economic and logistical disadvantages of ABT have ... ...

    Abstract Orthopaedic and trauma surgical procedures (OTS) can lead to significant blood losses and acute postoperative anaemia, which in many cases requires allogeneic blood transfusions (ABT). The clinical, economic and logistical disadvantages of ABT have promoted the development of multidisciplinary and multimodal programs generically known as Patient Blood Management (PBM) programs, which have as their objective to reduce or eliminate the need for ABT and improve clinical outcomes. These programs are supported by the implementation of four groups of perioperative measures: (1) use of restrictive transfusion criteria; (2) stimulation of erythropoiesis; (3) reduction of bleeding; and (4) autologous blood transfusion. In this article, a review is presented of the effectiveness, safety and recommendations of applicable strategies in OTS, as well as the barriers and requirements to the development and implementation of PBM programs in this surgical specialty.
    MeSH term(s) Blood Loss, Surgical/prevention & control ; Blood Transfusion, Autologous ; Bloodless Medical and Surgical Procedures/methods ; Hematinics/therapeutic use ; Humans ; Orthopedic Procedures ; Perioperative Care/methods ; Practice Guidelines as Topic
    Chemical Substances Hematinics
    Language Spanish
    Publishing date 2015-05
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 2417057-4
    ISSN 1988-8856 ; 1888-4415
    ISSN (online) 1988-8856
    ISSN 1888-4415
    DOI 10.1016/j.recot.2014.11.005
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  10. Article ; Online: Recomendaciones de consenso SEDAR-SEMICYUC sobre el manejo de las alteraciones de la hemostasia en los pacientes graves con infección por COVID-19

    Llau, Juan V. / Ferrandis, Raquel / Sierra, Pilar / Hidalgo, Francisco / Cassinello, Concepción / Gómez-Luque, Aurelio / Quintana, Manuel / Amezaga, Rocio / Gero, María / Serrano, Ainhoa / Marcos, Pilar

    Rev Esp Anestesiol Reanim

    Abstract: Resumen La infección por el coronavirus SARS-CoV-2, causante de la enfermedad denominada COVID-19, provoca alteraciones fundamentalmente en el sistema respiratorio. En los pacientes graves, con frecuencia la enfermedad evoluciona a un síndrome de distrés ...

    Abstract Resumen La infección por el coronavirus SARS-CoV-2, causante de la enfermedad denominada COVID-19, provoca alteraciones fundamentalmente en el sistema respiratorio. En los pacientes graves, con frecuencia la enfermedad evoluciona a un síndrome de distrés respiratorio agudo que puede predisponer a los pacientes a un estado de hipercoagulabilidad, con trombosis tanto a nivel venoso como arterial. Esta predisposición presenta una fisiopatología multifactorial, relacionada tanto con la hipoxia como con el grave proceso inflamatorio ligado a esta patología, además de los factores trombóticos adicionales presentes en muchos de los pacientes. Ante la necesidad de optimizar el manejo de la hipercoagulabilidad, los grupos de trabajo de las Sociedades Científicas de Anestesiología-Reanimación y Terapéutica del Dolor (SEDAR) y de Medicina Intensiva, Crítica y de Unidades Coronarias (SEMICYUC), han desarrollado un consenso para establecer unas pautas de actuación frente a las alteraciones de la hemostasia observadas en los pacientes graves con infección por COVID-19. Estas recomendaciones incluyen la profilaxis de la enfermedad tromboembólica venosa en pacientes graves y en el periparto, el manejo de los pacientes en tratamiento crónico con fármacos antiagregantes o anticoagulantes, de las complicaciones hemorrágicas en la evolución de la enfermedad y de la interpretación de las alteraciones generales de la hemostasia. Abstract The infection by the coronavirus SARS-CoV-2, which causes the disease called COVID-19, mainly causes alterations in the respiratory system. In severely ill patients, the disease often evolves into an acute respiratory distress syndrome that can predispose patients to a state of hypercoagulability, with thrombosis at both venous and arterial levels. This predisposition presents a multifactorial physiopathology, related to hypoxia as well as to the severe inflammatory process linked to this pathology, including the additional thrombotic factors present in many of the patients. In view of the need to optimise the management of hypercoagulability, the working groups of the Scientific Societies of Anaesthesiology-Resuscitation and Pain Therapy (SEDAR) and of Intensive, Critical Care Medicine and Coronary Units (SEMICYUC) have developed a consensus to establish guidelines for actions to be taken against alterations in haemostasis observed in severely ill patients with COVID-19 infection. These recommendations include prophylaxis of venous thromboembolic disease in these patients, and in the peripartum, management of patients on long-term antiplatelet or anticoagulant treatment, bleeding complications in the course of the disease, and the interpretation of general alterations in haemostasis.
    Keywords covid19
    Publisher Elsevier; PMC; WHO
    Document type Article ; Online
    Note WHO #Covidence: #343496
    DOI 10.1016/j.redar.2020.05.007
    Database COVID19

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