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  1. Article ; Online: Targeting metabolic-associated fatty liver disease in diabetic kidney disease: A call to action.

    Benlloch, Salvador / Moncho, Francesc / Górriz, Jose Luis

    Nefrologia

    2024  Volume 44, Issue 2, Page(s) 129–138

    Abstract: Nonalcoholic fatty liver disease or metabolic-associated fatty liver disease (MAFLD) is a common condicion with increasing prevalence and incidence, specially in patients with type 2 diabetes mellitus (T2DM). Both cardiovascular and renal disease are ... ...

    Abstract Nonalcoholic fatty liver disease or metabolic-associated fatty liver disease (MAFLD) is a common condicion with increasing prevalence and incidence, specially in patients with type 2 diabetes mellitus (T2DM). Both cardiovascular and renal disease are clearly increased in these patients, particularly in those with diabetic nephropathy. In the liver-heart-kidney-metabolic axis, the common pathophysiological basis of MAFLD, cardiovascular disease (CVD), chronic kidney disease (CKD), and T2DM is the same. The clinical relationship between all of them is clear and is multidirectional: MAFLD may precede the development of cardiovascular and renal disease, and may also worsen the prognosis of these complications once developed. In this review we emphasize the importance of targeting MAFLD in Diabetic kidney disease, with the goal of detecting high-risk patients in order to improve their prognosis.
    MeSH term(s) Humans ; Diabetic Nephropathies ; Non-alcoholic Fatty Liver Disease/complications ; Diabetes Mellitus, Type 2/complications ; Prognosis ; Cardiovascular Diseases/etiology ; Renal Insufficiency, Chronic/complications
    Language English
    Publishing date 2024-04-01
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefroe.2024.03.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comments on "Nonvalvular atrial fibrillation in patients undergoing chronic haemodialysis. Should dialysis patients with atrial fibrillation receive oral anticoagulation?"

    Cases, Aleix / Broseta, José Jesús / Rodriguez-Espinosa, Diana / Górriz, José Luis

    Nefrologia

    2023  Volume 43, Issue 1, Page(s) 148–150

    MeSH term(s) Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Renal Dialysis ; Anticoagulants/therapeutic use ; Risk Factors
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-04-04
    Publishing country Spain
    Document type Letter ; Comment
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefroe.2023.03.013
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  3. Article: Editorial: Management of Patients With Non-dialysis Dependent Chronic Kidney Disease (ND-CKD).

    Provenzano, Michele / Garofalo, Carlo / Gorriz, Jose Luis / Andreucci, Michele

    Frontiers in medicine

    2022  Volume 8, Page(s) 827245

    Language English
    Publishing date 2022-02-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.827245
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  4. Article ; Online: Detección de la enfermedad renal crónica mediante la determinación de filtrado glomerular estimado y albuminuria. ¿Estamos incumpliendo las recomendaciones de las guías?

    Górriz, Jose Luis / Puchades, Maria Jesús

    Semergen

    2018  Volume 44, Issue 2, Page(s) 79–81

    Title translation Detection of chronic kidney disease using estimated glomerular filtration and urine albumin: Are we complying with the recommendations of the guidelines?
    MeSH term(s) Albumins/analysis ; Albuminuria/diagnosis ; Glomerular Filtration Rate ; Humans ; Practice Guidelines as Topic ; Renal Insufficiency, Chronic/diagnosis ; Urinalysis/methods
    Chemical Substances Albumins
    Language Spanish
    Publishing date 2018-03-31
    Publishing country Spain
    Document type Journal Article
    ISSN 1578-8865
    ISSN (online) 1578-8865
    DOI 10.1016/j.semerg.2018.03.001
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  5. Article ; Online: Cardiorenal benefits of finerenone: protecting kidney and heart.

    González-Juanatey, José R / Górriz, Jose Luis / Ortiz, Alberto / Valle, Alfonso / Soler, Maria Jose / Facila, Lorenzo

    Annals of medicine

    2023  Volume 55, Issue 1, Page(s) 502–513

    Abstract: Persons with diabetes and chronic kidney disease (CKD) have a high residual risk of developing cardiovascular (CV) complications despite treatment with renin-angiotensin system blockers and sodium-glucose cotransporter type 2 inhibitors. Overactivation ... ...

    Abstract Persons with diabetes and chronic kidney disease (CKD) have a high residual risk of developing cardiovascular (CV) complications despite treatment with renin-angiotensin system blockers and sodium-glucose cotransporter type 2 inhibitors. Overactivation of mineralocorticoid receptors plays a key role in the progression of renal and CV disease, mainly by promoting inflammation and fibrosis. Finerenone is a nonsteroidal selective mineralocorticoid antagonist. Recent clinical trials, such as FIDELIO-DKD and FIGARO-DKD and the combined analysis FIDELITY have demonstrated that finerenone decreases albuminuria, risk of CKD progression, and CV risk in subjects with type 2 diabetes (T2D) and CKD. As a result, finerenone should thus be considered as part of a holistic approach to kidney and CV risk in persons with T2D and CKD. In this narrative review, the impact of finerenone treatment on the CV system in persons with type 2 diabetes and CKD is analyzed from a practical point of view.Key messages:Despite inhibition of renin-angiotensin system and sodium-glucose cotransporter type 2, persons with type 2 diabetes (T2D) and chronic kidney disease (CKD) remain on high cardiovascular (CV) residual risk.Overactivation of mineralocorticoid receptors plays a key role in the progression of renal and CV disease, mainly by promoting inflammation and fibrosis that is not targeted by traditional treatments.Finerenone is a nonsteroidal selective mineralocorticoid antagonist that decreases not only albuminuria, but also the risk of CKD progression, and CV risk in subjects with T2D and CKD.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Receptors, Mineralocorticoid/therapeutic use ; Albuminuria/complications ; Diabetic Nephropathies/complications ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Cardiovascular Diseases/prevention & control ; Cardiovascular Diseases/complications ; Kidney ; Fibrosis ; Inflammation/drug therapy ; Glucose ; Sodium/therapeutic use
    Chemical Substances Mineralocorticoid Receptor Antagonists ; Receptors, Mineralocorticoid ; finerenone ; Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2023.2171110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Finerenone: towards a holistic therapeutic approach to patients with diabetic kidney disease.

    Górriz, Jose Luis / González-Juanatey, José Ramón / Facila, Lorenzo / Soler, Maria Jose / Valle, Alfonso / Ortiz, Alberto

    Nefrologia

    2023  Volume 43, Issue 4, Page(s) 386–398

    Abstract: Despite current treatments, which include renin angiotensin system blockers and SGLT2 inhibitors, the risk of progression of kidney disease among patients with diabetes and chronic kidney disease (CKD) remains unacceptably high. The pathogenesis of CKD ... ...

    Abstract Despite current treatments, which include renin angiotensin system blockers and SGLT2 inhibitors, the risk of progression of kidney disease among patients with diabetes and chronic kidney disease (CKD) remains unacceptably high. The pathogenesis of CKD in patients with diabetes is complex and includes hemodynamic and metabolic factors, as well as inflammation and fibrosis. Finerenone is a highly selective nonsteroidal mineralocorticoid antagonist that, in contrast to current therapies, may directly reduce inflammation and fibrosis, thus adding value in the management of these patients. In fact, finerenone decreases albuminuria and slows CKD progression in persons with diabetes. We now review the mechanisms of action of finerenone, the results of recent clinical trials, and the integration of the kidney and cardiovascular protection afforded by finerenone in the routine care of patients with diabetes and CKD.
    MeSH term(s) Humans ; Diabetic Nephropathies/drug therapy ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Inflammation ; Fibrosis ; Diabetes Mellitus
    Chemical Substances finerenone
    Language English
    Publishing date 2023-10-08
    Publishing country Spain
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefroe.2023.09.002
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  7. Article ; Online: Reticulocyte hemoglobin content and iron therapy in chronic kidney disease: Reply of the Anemia group of the Spanish Society of Nephrology.

    Cases, Aleix / de Sequera, Patricia / Quiroga, Borja / Puchades, Maria Jesús / Martin-Rodriguez, Leyre / Gorriz, José Luis / Portolés, José

    Nefrologia

    2023  Volume 43, Issue 5, Page(s) 651–652

    MeSH term(s) Humans ; Reticulocytes ; Nephrology ; Anemia/drug therapy ; Anemia/etiology ; Hemoglobins ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy ; Iron/therapeutic use
    Chemical Substances Hemoglobins ; Iron (E1UOL152H7)
    Language English
    Publishing date 2023-11-06
    Publishing country Spain
    Document type Letter ; Comment
    ZDB-ID 2837917-2
    ISSN 2013-2514 ; 2013-2514
    ISSN (online) 2013-2514
    ISSN 2013-2514
    DOI 10.1016/j.nefroe.2021.06.012
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  8. Article ; Online: Urinary cell cycle arrest biomarkers and diuretic efficiency in acute heart failure.

    Núñez-Marín, Gonzalo / Romero-González, Gregorio / Bover, Jordi / Górriz, Jose Luis / Bayés-Genís, Antoni / Sanchis, Juan / Núñez, Julio / de la Espriella, Rafael

    Cardiorenal medicine

    2024  

    Abstract: Introduction This study aimed to evaluate the association between the NephroCheck ® Test AKIRisk® Score, diuretic efficiency (DE) and the odds of worsening kidney function (WKF) within the first 72 hours of admission in patients hospitalized for acute ... ...

    Abstract Introduction This study aimed to evaluate the association between the NephroCheck ® Test AKIRisk® Score, diuretic efficiency (DE) and the odds of worsening kidney function (WKF) within the first 72 hours of admission in patients hospitalized for acute heart failure (AHF). Methods The study prospectively enrolled 125 patients admitted with AHF. NephroCheck ® Test was obtained within the first 24 of admission. DE was defined as net fluid urine output per 40 mg of furosemide equivalents. Results The median AKIRisk® Score was 0.11 (IQR 0.06-0.34) and 38 (30.4%) patients had an AKIRisk® Score >0.3. The median cumulative DE at 72 hours was 1963 mL (IQR 1317-3239 ml). At 72 hours, a total of 10 (8%) patients developed an absolute increase in sCr ≥0.5 mg/dL (WKF). In a multivariate setting, there was an inverse association between the AKIRisk® Score and DE within the first 72 hours. In fact, the highest the AKIRisk® Score (centered at 0.3) the higher the likelihood of poor diuretic efficiency (below the median) and WKF at 72 hours (Odds Ratio [OR] 2.04; 95%; CI 1.02-4.07; p=0.043, and OR 3.31, 95% CI 1.30-8.43; p = 0.012, respectively). Conclusion In patients with AHF, a higher NephroCheck ® AKIRisk® score is associated with poorer DE and a higher risk of WKF at 72 hours. Further research is needed to confirm the role of urinary cell cycle arrest biomarkers in the AHF scenario.
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2595659-0
    ISSN 1664-5502 ; 1664-3828
    ISSN (online) 1664-5502
    ISSN 1664-3828
    DOI 10.1159/000538774
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  9. Article ; Online: Corrigendum to "Review of the renal endpoints used in cardiovascular safety clinical trials in type 2 diabetes mellitus patients and their importance in primary care" [Primary Care Diabetes 13 (6) (2019) 485-494].

    Górriz, Jose Luis / Cos Claramunt, Francesc Xavier / Duque, Natalia / Matali, Arantxa

    Primary care diabetes

    2020  Volume 14, Issue 2, Page(s) 186–187

    Language English
    Publishing date 2020-02-14
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 2273997-X
    ISSN 1878-0210 ; 1751-9918
    ISSN (online) 1878-0210
    ISSN 1751-9918
    DOI 10.1016/j.pcd.2020.01.001
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  10. Article: Use of Circular RNAs in Diagnosis, Prognosis and Therapeutics of Renal Cell Carcinoma.

    Osca-Verdegal, Rebeca / Beltrán-García, Jesús / Górriz, José Luis / Martínez Jabaloyas, José María / Pallardó, Federico V / García-Giménez, José Luis

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 879814

    Abstract: Renal cell carcinoma is the most common type of kidney cancer, representing 90% of kidney cancer diagnoses, and the deadliest urological cancer. While the incidence and mortality rates by renal cell carcinoma are higher in men compared to women, in both ... ...

    Abstract Renal cell carcinoma is the most common type of kidney cancer, representing 90% of kidney cancer diagnoses, and the deadliest urological cancer. While the incidence and mortality rates by renal cell carcinoma are higher in men compared to women, in both sexes the clinical characteristics are the same, and usually unspecific, thereby hindering and delaying the diagnostic process and increasing the metastatic potential. Regarding treatment, surgical resection remains the main therapeutic strategy. However, even after radical nephrectomy, metastasis may still occur in some patients, with most metastatic renal cell carcinomas being resistant to chemotherapy and radiotherapy. Therefore, the identification of new biomarkers to help clinicians in the early detection, and treatment of renal cell carcinoma is essential. In this review, we describe circRNAs related to renal cell carcinoma processes reported to date and propose the use of some in therapeutic strategies for renal cell carcinoma treatment.
    Language English
    Publishing date 2022-06-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.879814
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