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  1. Article ; Online: Design and synthesis of phenoxy methyl-oxadiazole compounds against Alzheimer's disease.

    Evren, Asaf E / Nuha, Demokrat / Özkan, Begüm N S / Kahraman, Çiğdem / Gönülalan, Ekrem M / Yurttaş, Leyla

    Archiv der Pharmazie

    2024  , Page(s) e2400115

    Abstract: This study examines the synthesis and evaluation of 11 newly developed compounds as potential anti-Alzheimer's agents that occur via cholinesterase and β-secretase inhibition. The compounds were tested for their inhibitory activity against ... ...

    Abstract This study examines the synthesis and evaluation of 11 newly developed compounds as potential anti-Alzheimer's agents that occur via cholinesterase and β-secretase inhibition. The compounds were tested for their inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) using the modified Ellman method. The results showed that several compounds exhibited significant inhibition of AChE, particularly compounds 6d, 7a, and 7e, which demonstrated high inhibitory activity at lower concentrations, with IC
    Language English
    Publishing date 2024-04-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 6381-2
    ISSN 1521-4184 ; 0365-6233 ; 1437-1014
    ISSN (online) 1521-4184
    ISSN 0365-6233 ; 1437-1014
    DOI 10.1002/ardp.202400115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.4: Show issues Location:
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  2. Article ; Conference proceedings: Sun Protection Factor (SPF) and antioxidant capacity of Lavandula angustifolia L.

    Gonulalan Ekrem, M / Ozenver, N / Demirezer, LO

    Planta Medica International Open

    2017  Volume 4, Issue S 01

    Event/congress GA 2017 - Book of Abstracts, Basel, Switzerland, 2017-09-03
    Language English
    Publishing date 2017-10-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ISSN 2509-6656 ; 2509-9264
    ISSN (online) 2509-6656
    ISSN 2509-9264
    DOI 10.1055/s-0037-1608454
    Database Thieme publisher's database

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  3. Article ; Conference proceedings: Does the parthenolide free Feverfew extract exhibit the similar effect as parthenolide containing extract?

    Gonulalan Ekrem, M / Uzun, M / Demirezer, LO

    Planta Medica International Open

    2017  Volume 4, Issue S 01

    Event/congress GA 2017 - Book of Abstracts, Basel, Switzerland, 2017-09-03
    Language English
    Publishing date 2017-10-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ISSN 2509-6656 ; 2509-9264
    ISSN (online) 2509-6656
    ISSN 2509-9264
    DOI 10.1055/s-0037-1608175
    Database Thieme publisher's database

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  4. Article ; Conference proceedings: Skin antiaging effect of Lavandula officinalis extract determining by Matrix Metalloproteinase-1 inhibition assay

    Gonulalan Ekrem, M / Uzun, M / Demirezer, LO

    Planta Medica International Open

    2017  Volume 4, Issue S 01

    Event/congress GA 2017 - Book of Abstracts, Basel, Switzerland, 2017-09-03
    Language English
    Publishing date 2017-10-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ISSN 2509-6656 ; 2509-9264
    ISSN (online) 2509-6656
    ISSN 2509-9264
    DOI 10.1055/s-0037-1608174
    Database Thieme publisher's database

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  5. Article ; Conference proceedings: Determination of Sun Protection Factor (SPF) and antioxidant capacity of Tanacetum parthenium

    Gonulalan Ekrem, M / Uzun, M / Ozenver, N / Demirezer, LO

    Planta Medica International Open

    2017  Volume 4, Issue S 01

    Event/congress GA 2017 - Book of Abstracts, Basel, Switzerland, 2017-09-03
    Language English
    Publishing date 2017-10-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ISSN 2509-6656 ; 2509-9264
    ISSN (online) 2509-6656
    ISSN 2509-9264
    DOI 10.1055/s-0037-1608176
    Database Thieme publisher's database

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    Kategorien

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  6. Article ; Online: Metabolomics and proteomics profiles of some medicinal plants and correlation with BDNF activity.

    Gonulalan, Ekrem M / Nemutlu, Emirhan / Bayazeid, Omer / Koçak, Engin / Yalçın, Funda N / Demirezer, L Omur

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2019  Volume 74, Page(s) 152920

    Abstract: Background: Identification of the low abundance of phytochemicals in plant extracts is very difficult. Pharmacological activity observed in such plants is not due to a single compound. In most cases, plant extracts show activity based on synergistic or ... ...

    Abstract Background: Identification of the low abundance of phytochemicals in plant extracts is very difficult. Pharmacological activity observed in such plants is not due to a single compound. In most cases, plant extracts show activity based on synergistic or antagonistic effects. Therefore, the idea of a holistic approach is more rational.
    Purpose: This study was planned to compare the metabolomics and proteomics profiles of Valeriana officinalis L. (Valerianaceae), Melissa officinalis L. (Lamiaceae), Hypericum perforatum L. (Hypericaceae) and Passiflora incarnata L. (Passifloraceae) used in sedative anxiolytic and sleep disorders. Integrated omics analyses were used to provide a better understanding of the effect of plant extracts on the brain-derived neurotrophic factor (BDNF) expression levels on the SH-SY5Y cell line by a holistic approach.
    Methods: Metabolomic profiling of the plants was performed using the GC-MS and LC-qTOF-MS systems, and the proteomics analysis using the LC-qTOF-MS system after trypsin digestion. The Human BDNF Quantikine ELISA kit was utilized to test BDNF expression activity on the SH-SY5Y cell line.
    Results: The investigated plant extracts showed a significant increase in BDNF expression (p < 0.05). M. officinalis was found as the most active extract. According to the correlation analyses between BDNF activity and metabolomics or proteomics level, 94 metabolites had a positive correlation while 23 metabolites had a highly negative correlation; those for proteins are 24 and 6, respectively.
    Conclusion: The multivariate data analysis revealed a similar metabolomics profile of H. perforatum and P. incarnata, which also had a similar activity profile. Remarkably, all the primary metabolites belonging to the Krebs Cycle (citric acid, fumaric acid, succinic acid, pyruvic acid, malic acid and citramalic acid, an analog of malic acid) were positively correlated with BDNF activity. Secondary metabolites with a high BDNF expression belonged to flavonoids, xanthone, coumarines, tannin, naphtalenes, terpenoids and carotenoid skeleton. Two proteins from the cytochrome P450 family (P450 71B11 and P450 94B3) were positively correlated with BDNF activity. Employing omics technologies in the plant research area will offer a better understanding of the role of plant extracts and may lead to the discovery of new compounds with specific activity.
    MeSH term(s) Brain-Derived Neurotrophic Factor/metabolism ; Chromatography, Liquid ; Drug Evaluation, Preclinical/methods ; Flavonoids/analysis ; Flavonoids/pharmacology ; Gas Chromatography-Mass Spectrometry ; Humans ; Hypericum/chemistry ; Mass Spectrometry ; Metabolomics/methods ; Passiflora/chemistry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plants, Medicinal/chemistry ; Plants, Medicinal/metabolism ; Proteomics/methods ; Secondary Metabolism ; Terpenes/analysis ; Terpenes/pharmacology ; Valerian/chemistry
    Chemical Substances Brain-Derived Neurotrophic Factor ; Flavonoids ; Plant Extracts ; Terpenes ; BDNF protein, human (7171WSG8A2)
    Language English
    Publishing date 2019-04-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2019.152920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4115: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Metabolomics and proteomics profiles of some medicinal plants and correlation with BDNF activity

    Gonulalan, Ekrem M / Bayazeid, Omer / Demirezer, L. Omur / Koçak, Engin / Nemutlu, Emirhan / Yalçın, Funda N

    Phytomedicine. 2019 Apr. 03,

    2019  

    Abstract: Identification of the low abundance of phytochemicals in plant extracts is very difficult. Pharmacological activity observed in such plants is not due to a single compound. In most cases, plant extracts show activity based on synergistic or antagonistic ... ...

    Abstract Identification of the low abundance of phytochemicals in plant extracts is very difficult. Pharmacological activity observed in such plants is not due to a single compound. In most cases, plant extracts show activity based on synergistic or antagonistic effects. Therefore, the idea of a holistic approach is more rational.This study was planned to compare the metabolomics and proteomics profiles of Valeriana officinalis L. (Valerianaceae), Melissa officinalis L. (Lamiaceae), Hypericum perforatum L. (Hypericaceae) and Passiflora incarnata L. (Passifloraceae) used in sedative anxiolytic and sleep disorders. Integrated omics analyses were used to provide a better understanding of the effect of plant extracts on the brain-derived neurotrophic factor (BDNF) expression levels on the SH-SY5Y cell line by a holistic approach.Metabolomic profiling of the plants was performed using the GC–MS and LC-qTOF-MS systems, and the proteomics analysis using the LC-qTOF-MS system after trypsin digestion. The Human BDNF Quantikine ELISA kit was utilized to test BDNF expression activity on the SH-SY5Y cell line.The investigated plant extracts showed a significant increase in BDNF expression (p < 0.05). M. officinalis was found as the most active extract. According to the correlation analyses between BDNF activity and metabolomics or proteomics level, 94 metabolites had a positive correlation while 23 metabolites had a highly negative correlation; those for proteins are 24 and 6, respectively.The multivariate data analysis revealed a similar metabolomics profile of H. perforatum and P. incarnata, which also had a similar activity profile. Remarkably, all the primary metabolites belonging to the Krebs Cycle (citric acid, fumaric acid, succinic acid, pyruvic acid, malic acid and citramalic acid, an analog of malic acid) were positively correlated with BDNF activity. Secondary metabolites with a high BDNF expression belonged to flavonoids, xanthone, coumarines, tannin, naphtalenes, terpenoids and carotenoid skeleton. Two proteins from the cytochrome P450 family (P450 71B11 and P450 94B3) were positively correlated with BDNF activity. Employing omics technologies in the plant research area will offer a better understanding of the role of plant extracts and may lead to the discovery of new compounds with specific activity.
    Keywords carotenoids ; cell lines ; citric acid ; cytochrome P-450 ; enzyme-linked immunosorbent assay ; flavonoids ; fumaric acid ; gas chromatography-mass spectrometry ; humans ; Hypericum perforatum ; malic acid ; medicinal plants ; medicinal properties ; Melissa officinalis ; metabolomics ; multivariate analysis ; Passiflora incarnata ; plant extracts ; proteomics ; pyruvic acid ; secondary metabolites ; sedatives ; sleep disorders ; succinic acid ; tranquilizers ; tricarboxylic acid cycle ; trypsin ; Valeriana officinalis ; xanthone
    Language English
    Dates of publication 2019-0403
    Publishing place Elsevier GmbH
    Document type Article
    Note Pre-press version
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2019.152920
    Database NAL-Catalogue (AGRICOLA)

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4115: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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