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  1. AU="Gönen, Murat"
  2. AU="Soliman, Essam S"
  3. AU="Poenisch, Falk"
  4. AU="Ng C."
  5. AU="Cabaton, Nicolas J"

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  1. Article ; Online: Electromyographic evaluation of the effectiveness of electroacupuncture in experimental damage of nervus radialis and nervus ulnaris in rabbits

    Polat Eren / Gunay Cihan / Kavakli Ahmet / Gonen Murat

    Veterinarski Glasnik, Vol 77, Iss 1, Pp 69-

    2023  Volume 79

    Abstract: Many different acupuncture points and techniques have been used in the treatment of peripheral nerve injuries. It is known that alternative and complementary medicine techniques have become popular in the treatment of nerve damage in recent years. In ... ...

    Abstract Many different acupuncture points and techniques have been used in the treatment of peripheral nerve injuries. It is known that alternative and complementary medicine techniques have become popular in the treatment of nerve damage in recent years. In this study, it was aimed to investigate the effectiveness of electroacupuncture in acute and chronic radial and ulnar nerve injuries. Electromyographic measurements were made to evaluate the effectiveness of electroacupuncture. In the study, the rabbits were divided into four groups namely acute nerve injury (ANI) group, chronic nerve injury (CNI) group, positive control (PC) group and negative control (NC) group. In the ANI, CNI and PC groups, damage was created on the nervus radialis and nervus ulnaris by applying pressure for 60 seconds using a hemostatic forceps under anesthesia. No damage was created in the NC group. Fifteen sessions of electroacupuncture were applied to the rabbits in the ANI, CNI, and NC groups every other day using LI-4, LI-10, LR-3, and ST-36 electroacupuncture points. Electroacupuncture was not applied to the rabbits in the PC group. Electromyographic examinations of both forelimbs of rabbits were performed during electroacupuncture applications. In the study, rabbits in the ANI group were measured at first amplitudes of 9.78 ± 1.66, and final amplitudes of 18.94 ± 1.83 (p ˂ 0.01). Rabbits in the CNI group were measured at first amplitudes of 11.34 ± 1.52, and final amplitudes of 16.03 ± 1.35 ( p ˂ 0.01). However, no statistically significant difference was found between the first and last latency values for both groups of rabbits. As a result, it was determined that electroacupuncture is an effective treatment method for both acute and chronic nerve injuries, as well as being more effective in acute cases than in chronic cases.
    Keywords electroacupuncture ; electromyography ; rabbit ; nerve ; injury ; Veterinary medicine ; SF600-1100
    Subject code 630
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Faculty of Veterinary Medicine, Belgrade
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Flow volume measurement of arterial venous and cerebrospinal fluid in patients with multiple sclerosis.

    Aglamis, Serpil / Gönen, Murat

    Arquivos de neuro-psiquiatria

    2022  Volume 80, Issue 7, Page(s) 706–711

    Abstract: Background: Multiple sclerosis (MS) is usually described as an autoimmune disease, although the exact mechanism of the disease remains unknown. There have been studies reporting that venous flow abnormalities may be involved in the pathogenesis of MS or ...

    Title translation Medição do volume de fluxo do líquido cefalorraquidiano e venoso arterial em pacientes com esclerose múltipla.
    Abstract Background: Multiple sclerosis (MS) is usually described as an autoimmune disease, although the exact mechanism of the disease remains unknown. There have been studies reporting that venous flow abnormalities may be involved in the pathogenesis of MS or many of the associated clinical manifestations.
    Objective: The aim of this study was to evaluate flow volumes of the middle cerebral artery (MCA), transverse sinus (TS), and cerebral aqueduct using phase contrast magnetic resonance imaging (PC-MRI) in relapsing-remitting MS patients and a control group.
    Methods: We included 34 patients diagnosed by the McDonald criteria, revised in 2017, as well as 15 healthy controls matched by age and sex. The MRI scans were performed using a 1.5-T superconducting scanner. Axial T1-weighted, T2-weighted, and PC-MRI sequences were performed for the quantitative investigation of flow volume measurements. Quantitative analyses of flows were performed using flow analyses program PC-MRI angiography software. A circular region of interest was placed manually into the cerebral aqueduct, bilateral MCA, and TS.
    Results: Flow volumes of the cerebral aqueduct and MCA were not statistically significant between the MS and control groups. The flow volumes of the TS for the patient group were lower than those of the control group, and this difference was statistically significant.
    Conclusions: A reduced TS flow volume in MS patients was noted in the present study when compared with the control group, suggesting a relation between venous pathologies and MS. Further studies are needed to understand whether this relation is causal or epiphenomenal.
    MeSH term(s) Cerebral Aqueduct/diagnostic imaging ; Cerebral Aqueduct/pathology ; Cerebrospinal Fluid ; Humans ; Magnetic Resonance Imaging/methods ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/pathology ; Multiple Sclerosis, Relapsing-Remitting/diagnostic imaging
    Language English
    Publishing date 2022-09-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 418916-4
    ISSN 1678-4227 ; 0004-282X
    ISSN (online) 1678-4227
    ISSN 0004-282X
    DOI 10.1055/s-0042-1755276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A retroperitoneal myopericytoma: The first case located at the retroperitoneal area and not originate from the kidneys.

    Ozkent, Mehmet Serkan / Günler, Tugba / Gönen, Murat

    Indian journal of pathology & microbiology

    2023  Volume 66, Issue 2, Page(s) 369–371

    Abstract: A 25-year-old woman had a mass of approximately 65 cm × 33 cm × 102 cm, located in the left paraaortic area on CT scan. It was diagnosed as retroperitoneal malignant neoplasm on imaging. Afterward, open retroperitoneal tumor excision was performed. At ... ...

    Abstract A 25-year-old woman had a mass of approximately 65 cm × 33 cm × 102 cm, located in the left paraaortic area on CT scan. It was diagnosed as retroperitoneal malignant neoplasm on imaging. Afterward, open retroperitoneal tumor excision was performed. At laparotomy, the mass was carefully dissected from the ureter, renal artery, and aorta and excised as en-bloc. The pathological result was "myopericytoma." Histologically, the pathological findings characterized a pericytic neoplasm characterized by a perivascular growth of myoid tumor cells. In addition, there were uniform, oval-shaped cells with eosinophilic cytoplasm arranged in short fascicles around blood vessels. The cytologic atypia and mitoses were absent. There are many different tumors in the retroperitoneal area. Most of these lesions are malign nature. Nevertheless, for each benign and malign neoplasm, the preoperative imaging method is generally similar. This present case showed the significant findings of myopericytoma, a benign pathology located in the retroperitoneal area.
    MeSH term(s) Female ; Humans ; Adult ; Myopericytoma/pathology ; Kidney/diagnostic imaging ; Kidney/pathology ; Diagnosis, Differential ; Retroperitoneal Neoplasms/diagnostic imaging ; Retroperitoneal Neoplasms/surgery
    Language English
    Publishing date 2023-04-18
    Publishing country India
    Document type Case Reports
    ZDB-ID 197621-7
    ISSN 0974-5130 ; 0377-4929
    ISSN (online) 0974-5130
    ISSN 0377-4929
    DOI 10.4103/ijpm.ijpm_403_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Large vessel occlusion detection by non-contrast CT using artificial ıntelligence.

    Aytaç, Emrah / Gönen, Murat / Tatli, Sinan / Balgetir, Ferhat / Dogan, Sengul / Tuncer, Turker

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2024  

    Abstract: Introduction: Computer vision models have been used to diagnose some disorders using computer tomography (CT) and magnetic resonance (MR) images. In this work, our objective is to detect large and small brain vessel occlusion using a deep feature ... ...

    Abstract Introduction: Computer vision models have been used to diagnose some disorders using computer tomography (CT) and magnetic resonance (MR) images. In this work, our objective is to detect large and small brain vessel occlusion using a deep feature engineering model in acute of ischemic stroke.
    Methods: We use our dataset. which contains 324 patient's CT images with two classes; these classes are large and small brain vessel occlusion. We divided the collected image into horizontal and vertical patches. Then, pretrained AlexNet was utilized to extract deep features. Here, fc6 and fc7 (sixth and seventh fully connected layers) layers have been used to extract deep features from the created patches. The generated features from patches have been concatenated/merged to generate the final feature vector. In order to select the best combination from the generated final feature vector, an iterative selector (iterative neighborhood component analysis-INCA) has been used, and this selector has chosen 43 features. These 43 features have been used for classification. In the last phase, we used a kNN classifier with tenfold cross-validation.
    Results: By using 43 features and a kNN classifier, our AlexNet-based deep feature engineering model surprisingly attained 100% classification accuracy.
    Conclusion: The obtained perfect classification performance clearly demonstrated that our proposal could separate large and small brain vessel occlusion detection in non-contrast CT images. In this aspect, this model can assist neurology experts with the early recanalization chance.
    Language English
    Publishing date 2024-04-15
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-024-07522-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Flow volume measurement of arterial venous and cerebrospinal fluid in patients with multiple sclerosis

    Aglamis, Serpil / Gönen, Murat

    Arquivos de Neuro-Psiquiatria

    2022  Volume 80, Issue 07, Page(s) 706–711

    Abstract: Background: Multiple sclerosis (MS) is usually described as an autoimmune disease, although the exact mechanism of the disease remains unknown. There have been studies reporting that venous flow abnormalities may be involved in the pathogenesis of MS or ...

    Abstract Background: Multiple sclerosis (MS) is usually described as an autoimmune disease, although the exact mechanism of the disease remains unknown. There have been studies reporting that venous flow abnormalities may be involved in the pathogenesis of MS or many of the associated clinical manifestations.
    Objective: The aim of this study was to evaluate flow volumes of the middle cerebral artery (MCA), transverse sinus (TS), and cerebral aqueduct using phase contrast magnetic resonance imaging (PC-MRI) in relapsing-remitting MS patients and a control group.
    Methods: We included 34 patients diagnosed by the McDonald criteria, revised in 2017, as well as 15 healthy controls matched by age and sex. The MRI scans were performed using a 1.5-T superconducting scanner. Axial T1-weighted, T2-weighted, and PC-MRI sequences were performed for the quantitative investigation of flow volume measurements. Quantitative analyses of flows were performed using flow analyses program PC-MRI angiography software. A circular region of interest was placed manually into the cerebral aqueduct, bilateral MCA, and TS.
    Results: Flow volumes of the cerebral aqueduct and MCA were not statistically significant between the MS and control groups. The flow volumes of the TS for the patient group were lower than those of the control group, and this difference was statistically significant.
    Conclusions: A reduced TS flow volume in MS patients was noted in the present study when compared with the control group, suggesting a relation between venous pathologies and MS. Further studies are needed to understand whether this relation is causal or epiphenomenal.
    Keywords Multiple Sclerosis ; Magnetic Resonance Imaging ; Middle Cerebral Artery ; Transverse Sinuses ; Esclerose Múltipla ; Imagem de Ressonância Magnética ; Artéria Cerebral Média ; Seios Transversos
    Language English
    Publishing date 2022-07-01
    Publisher Thieme Revinter Publicações Ltda.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 418916-4
    ISSN 1678-4227 ; 0004-282X
    ISSN (online) 1678-4227
    ISSN 0004-282X
    DOI 10.1055/s-0042-1755276
    Database Thieme publisher's database

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  6. Article ; Online: Epileptic olfactory auras: a clinical spectrum.

    Taşcı, İrem / Balgetir, Ferhat / Müngen, Bülent / Gönen, Murat

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2021  Volume 42, Issue 8, Page(s) 3397–3401

    Abstract: Objective: To investigate the relative frequency of olfactory aura in a large number of patients with focal epilepsy, and examine the full clinical spectrum of epileptic olfactory auras (OAs) and their relationship to hemispheric lateralization and ... ...

    Abstract Objective: To investigate the relative frequency of olfactory aura in a large number of patients with focal epilepsy, and examine the full clinical spectrum of epileptic olfactory auras (OAs) and their relationship to hemispheric lateralization and localization of epileptogenic focus.
    Methods: This retrospective study was based on the medical records of 1384 patients with focal epilepsy. Of these, 71 (5.1%) patients were present with OAs, comprising 25 (35.2%) men and 46 (64.8%) women with a mean age of 35.43 ± 12.89 years. These 71 patients were classified according to the clinical features of the OAs, and the electroencephalography and magnetic resonance imaging findings were examined.
    Results: The relative frequency of OAs was 5.1% in the focal epileptic patients. The clinical spectrum of OAs in our cases was outlined as follows, complex OAs and elementary OAs. Elementary OAs were divided into three subgroups: elementary neutral OAs, elementary unpleasant OAs, and elementary pleasant OAs. In our cases, there was no difference between the right and left hemispheres in terms of lateralization of the epileptogenic focus. In all the 71 patients, the epileptogenic zone was most commonly localized in the temporal lobe (n = 58; 81.7%).
    Conclusions: The relative frequency of OAs in focal epilepsies is likely to be found higher than expected. Elementary OAs occur much more frequently than complex OAs. Among the elementary OAs, elementary unpleasant OAs and elementary neutral OAs are the most common types, whereas elementary pleasant OAs are extremely rare.
    MeSH term(s) Adult ; Electroencephalography ; Epilepsies, Partial ; Epilepsy/diagnostic imaging ; Epilepsy/epidemiology ; Epilepsy, Temporal Lobe ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Retrospective Studies ; Temporal Lobe ; Young Adult
    Language English
    Publishing date 2021-01-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-020-04999-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Long-term clinical course and prognosis of hot water epilepsy: 15-Year follow-up.

    Balgetir, Ferhat / Gönen, Murat / Müngen, Eren / Berilgen, Ayşe / Müngen, Bülent

    Epilepsy & behavior : E&B

    2022  Volume 129, Page(s) 108607

    Abstract: Objective: Hot water epilepsy (HWE) is a type of reflex epilepsy triggered by bathing with hot water. Hot water epilepsy is generally considered as a self-limiting benign disease although its long-term course and prognosis remains unknown. In this study, ...

    Abstract Objective: Hot water epilepsy (HWE) is a type of reflex epilepsy triggered by bathing with hot water. Hot water epilepsy is generally considered as a self-limiting benign disease although its long-term course and prognosis remains unknown. In this study, we aimed to determine the long-term clinical course and prognosis of hot water epilepsy and possible factors affecting them.
    Methods: The diagnosis of HWE was made based on the clinical history obtained from patients and their first degree relatives witnessing to the seizures and video recordings of seizures if available; then, the type of seizure was identified. Good prognosis was defined as patients whose seizures were controlled with or without preventive measures and who did not require antiepileptic treatment. The poor prognosis was defined as patients whose seizures continued despite preventive measures and required antiepileptic treatment.
    Results: The study included 50 (31 male and 19 female) patients with a mean follow-up of 17.63 ± 10.46 (median, 15.0) years. The age at onset of seizure was 14.52 ± 12.71 (median: 10.0) years. There were 38 (76%) patients in the good prognosis group. 18 (36%) of them achieved complete remission, who did not require preventive measures. In the remaining 20 (40%) patients, seizures could be controlled with only preventive measures. Seizures could be controlled with antiepileptic treatment in only 1 (2%) of 12 (24%) patients in the poor prognosis group. A significant relationship was found between the frequency of hot water seizures (HWSs) and poor prognosis (p = 0.019), as well as the presence of spontaneous seizures outside of bathing and poor prognosis (p = 0.000).
    Significance: Hot water epilepsy, as previously known, is not a self-limiting benign disease. Approximately ¾ of the cases have a good prognosis, but the rest are in the case of chronic epilepsy. The low response rate to antiepileptics' treatment suggests that the pathogenesis of the HWE may differ from other epilepsies.
    MeSH term(s) Anticonvulsants/therapeutic use ; Electroencephalography/adverse effects ; Epilepsy, Reflex/diagnosis ; Epilepsy, Reflex/etiology ; Epilepsy, Reflex/therapy ; Female ; Follow-Up Studies ; Hot Temperature ; Humans ; Male ; Prognosis ; Water
    Chemical Substances Anticonvulsants ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2022.108607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Acute Rhinosinusitis as an Infrequent Cause of Symptomatic Cluster Headache: Report of Seven Cases.

    Balgetir, Ferhat / Avcı, Deniz / Gönen, Murat / Taşcı, İrem

    Journal of oral & facial pain and headache

    2019  Volume 33, Issue 4, Page(s) 408–412

    Abstract: Cluster headache (CH) is a primary headache disorder characterized by unilateral headache attacks lasting 15 to 180 minutes, occurring between two and eight times a day, and accompanied by autonomic symptoms ipsilateral to the pain. However, cases of ... ...

    Abstract Cluster headache (CH) is a primary headache disorder characterized by unilateral headache attacks lasting 15 to 180 minutes, occurring between two and eight times a day, and accompanied by autonomic symptoms ipsilateral to the pain. However, cases of symptomatic CH that occur secondary to an underlying structural pathology have also been reported in the literature. In this report, seven patients are presented who were admitted with signs of CH and diagnosed with acute rhinosinusitis depending on extensive clinical and radiologic examinations. Symptomatic CH, though rarely reported in the literature compared to CH, should be kept in mind in patients presenting with the first attack of CH. Moreover, in such patients, whether the pain becomes worse when bending forward and becomes sensitive on palpation should be questioned, and a radiologic work-up should be performed to rule out secondary causes such as rhinosinusitis. In the present cases, the resolution of CH attacks with acute sinusitis therapy confirmed the diagnosis.
    MeSH term(s) Acute Disease ; Cluster Headache ; Headache ; Humans ; Pain ; Sinusitis
    Language English
    Publishing date 2019-06-24
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2762048-7
    ISSN 2333-0376 ; 2333-0384
    ISSN (online) 2333-0376
    ISSN 2333-0384
    DOI 10.11607/ofph.2175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The relationship between saphenofemoral junction insufficiency and varicocele.

    Alkan, Ender / Inal, Hasan Ali / Gonen, Murat / Tolu, Ismet

    Andrologia

    2020  Volume 52, Issue 11, Page(s) e13820

    Abstract: The aim of the study was to investigate whether or not there is a significant relationship between varicocele and SFJ insufficiency. This study included 200 men with (study group) and 200 men without (control group) primary varicocele which was initially ...

    Abstract The aim of the study was to investigate whether or not there is a significant relationship between varicocele and SFJ insufficiency. This study included 200 men with (study group) and 200 men without (control group) primary varicocele which was initially diagnosed by observation during the Valsalva manoeuver. Subsequently, scrotal and lower extremity venous Doppler ultrasonography (USG) was performed by a senior radiologist, and participants with testicular veins >3.0 mm in diameter and reverse blood flow were determined to have varicocele. SFJ insufficiency was defined as retrograde flow in the SFJ of longer than 0.5 s. Retrograde venous flow in the pampiniform plexus was determined 3.5% (study) versus 0.0% (control) and 77.0% (study) versus 0.0% (control) in the right testis and left testis, respectively, and bilaterally at 11.5% (study) versus 0.0% (control). The presence of SFJ insufficiency was also found to be higher in the study group than in the control group (unilaterally: 26.0% versus 15.0%; bilaterally: 14.0% versus 5.0%). The current study demonstrates a statistically significant relationship between varicocele and SFJ insufficiency and supports the argument that varicocele is not a local disease and may be attributable to a systemic vascular insufficiency. Additional studies with larger series are needed to further elucidate this topic.
    MeSH term(s) Femoral Vein/diagnostic imaging ; Humans ; Male ; Spermatic Cord/diagnostic imaging ; Testis/diagnostic imaging ; Ultrasonography, Doppler, Color ; Varicocele/diagnostic imaging ; Varicose Veins ; Venous Insufficiency/complications ; Venous Insufficiency/diagnostic imaging
    Language English
    Publishing date 2020-09-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 7280-1
    ISSN 1439-0272 ; 0303-4569
    ISSN (online) 1439-0272
    ISSN 0303-4569
    DOI 10.1111/and.13820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Increased serum chemerin levels associated with carotid intima-media thickness.

    Demir, Caner Feyzi / Ataş, İklimya Nimet / Balgetir, Ferhat / Artaş, Hakan / Gönen, Murat / Aydin, Süleyman

    Arquivos de neuro-psiquiatria

    2021  Volume 79, Issue 3, Page(s) 189–194

    Abstract: Background: Elevated levels of chemerin can predict future ischemic cerebrovascular disease. Although chemerin is thought to play a role in atherosclerotic inflammation, whether circulating chemerin levels are associated with the severity of ... ...

    Abstract Background: Elevated levels of chemerin can predict future ischemic cerebrovascular disease. Although chemerin is thought to play a role in atherosclerotic inflammation, whether circulating chemerin levels are associated with the severity of atherosclerosis remains to be determined.
    Objectives: Through the use of carotid Doppler ultrasonography, our aim in this study was to investigate the relationships of serum chemerin levels with carotid intima-media thickness (CIMT) as an indicator of generalized atherosclerosis.
    Methods: This study compared 40 patients with ischemic stroke and 40 healthy subjects. Measurements were made at end-diastole using color Doppler ultrasonography (CDUS) after a 5-min rest interval in a quiet and dark room. CIMT was defined as the distance between the innermost edge of the luminal echo to the innermost edge of the media/adventitia echo. CIMT was measured in the posterior wall of both common carotid arteries within 1 cm proximally to the bulbus. Three measurements were made on both sides and the average measurement was taken as the CIMT. Serum chemerin levels were determined in all patients and healthy subjects.
    Results: Serum chemerin levels were significantly higher in the patient group than in the control group (p=0.004). Serum chemerin levels were positively correlated with CIMT (p<0.05). There was a significant difference between the groups with regard to CIMT (p<0.001).
    Conclusion: Elevated serum chemerin levels appear to be associated with CIMT, thus suggesting that a link exists between chemerin and atherosclerotic ischemic cerebrovascular disease.
    MeSH term(s) Atherosclerosis ; Carotid Arteries/diagnostic imaging ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery, Common/diagnostic imaging ; Carotid Intima-Media Thickness ; Chemokines/blood ; Humans ; Risk Factors ; Ultrasonography
    Chemical Substances Chemokines ; RARRES2 protein, human
    Language English
    Publishing date 2021-04-22
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 418916-4
    ISSN 1678-4227 ; 0004-282X
    ISSN (online) 1678-4227
    ISSN 0004-282X
    DOI 10.1590/0004-282X-ANP-2020-0195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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