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Article ; Online: Switching to Dolutegravir/lamivudine or Bictegravir/Emtricitabine/Tenofovir alafenamide. A comparative real-world study.

Knobel, Hernando / Cañas-Ruano, Esperanza / Guelar, Ana / Knobel, Pablo / Villar-García, Judit / González-Mena, Alicia / Canepa, Ceclia / Arrieta-Aldea, Itziar / Marcos, Augustin / Abalat-Torrres, Agustí / Güerri-Fernández, Roberto

HIV research & clinical practice

2023 Volume 24, Issue 1, Page(s) 2239564

Abstract: Background: This real-world study compared the safety and effectiveness of Dolutegravir/lamivudine (D/L) and Bictegravir/Emtricitabine/Tenefovir alafenamide (B/F/T) switch therapy regimens for people living with HIV (PLWH).: Methods: The ... ...

Abstract	Background: This real-world study compared the safety and effectiveness of Dolutegravir/lamivudine (D/L) and Bictegravir/Emtricitabine/Tenefovir alafenamide (B/F/T) switch therapy regimens for people living with HIV (PLWH). Methods: The retrospective study conducted from April 2019 to November 2022, included PLWH with < 50 copies/mL of HIV-RNA prior to recruitment who initiated either D/L or B/F/T switching therapy. The primary objective was to evaluate treatment discontinuation rates; safety and virologic outcomes were also evaluated. Results: 690 PLWH were included, 358 in the D/L and 332 in the B/F/T, and a median follow-up of 728 and 1013 days, respectively. The discontinuation proportions were 8.7% (31 participants, incidence rate of 4.44 per 100 PYFU in the D/L group and 15.3% (51 participants, incidence rate of 6.25 per 100 PYFU) in the B/F/T group. The adjusted hazard ratio for B/F/T discontinuation compared to D/L was 1.20 (95% CI: 0.71;2.0; Conclusions: Switching to either B/T/F or D/L treatment for PLWH was effective and well tolerated in this real-world study. Treatment discontinuation rates did not significantly differ between the two regimens.
MeSH term(s)	Humans ; Lamivudine/adverse effects ; HIV Infections/drug therapy ; Retrospective Studies ; Adenine ; Treatment Outcome ; Emtricitabine ; Drug Combinations ; Heterocyclic Compounds, 4 or More Rings/adverse effects
Chemical Substances	tenofovir alafenamide (EL9943AG5J) ; Lamivudine (2T8Q726O95) ; dolutegravir (DKO1W9H7M1) ; bictegravir (8GB79LOJ07) ; Adenine (JAC85A2161) ; Emtricitabine (G70B4ETF4S) ; Drug Combinations ; Heterocyclic Compounds, 4 or More Rings
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Journal Article
ISSN	2578-7470
ISSN (online)	2578-7470
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Article ; Online: Genetic characteristics involved in COVID-19 severity. The CARGENCORS case-control study and meta-analysis.

Journal of medical virology

2024 Volume 96, Issue 2, Page(s) e29404

Abstract: Pre-existing coronary artery disease (CAD), and thrombotic, inflammatory, or virus infectivity response phenomena have been associated with COVID-19 disease severity. However, the association of candidate single nucleotide variants (SNVs) related to ... ...

Abstract	Pre-existing coronary artery disease (CAD), and thrombotic, inflammatory, or virus infectivity response phenomena have been associated with COVID-19 disease severity. However, the association of candidate single nucleotide variants (SNVs) related to mechanisms of COVID-19 complications has been seldom analysed. Our aim was to test and validate the effect of candidate SNVs on COVID-19 severity. CARGENCORS (CARdiovascular GENetic risk score for Risk Stratification of patients positive for SARS-CoV-2 [COVID-19] virus) is an age- and sex-matched case-control study with 818 COVID-19 cases hospitalized with hypoxemia, and 1636 controls with COVID-19 treated at home. The association between severity and SNVs related to CAD (n = 32), inflammation (n = 19), thrombosis (n = 14), virus infectivity (n = 11), and two published to be related to COVID-19 severity was tested with adjusted logistic regression models. Two external independent cohorts were used for meta-analysis (SCOURGE and UK Biobank). After adjustment for potential confounders, 14 new SNVs were associated with COVID-19 severity in the CARGENCORS Study. These SNVs were related to CAD (n = 10), thrombosis (n = 2), and inflammation (n = 2). We also confirmed eight SNVs previously related to severe COVID-19 and virus infectivity. The meta-analysis showed five SNVs associated with severe COVID-19 in adjusted analyses (rs11385942, rs1561198, rs6632704, rs6629110, and rs12329760). We identified 14 novel SNVs and confirmed eight previously related to COVID-19 severity in the CARGENCORS data. In the meta-analysis, five SNVs were significantly associated to COVID-19 severity, one of them previously related to CAD.
MeSH term(s)	Humans ; COVID-19 ; Case-Control Studies ; SARS-CoV-2/genetics ; Coronary Artery Disease ; Inflammation ; Thrombosis
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29404
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Zs.A 1320: Show issues

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Article ; Online: Numbers Game and Immune Geography as Determinants of Coronavirus Pathogenicity.

Bocharov, Gennady / Casella, Valentina / Argilaguet, Jordi / Grebennikov, Dmitry / Güerri-Fernandez, Roberto / Ludewig, Burkhard / Meyerhans, Andreas

Frontiers in cellular and infection microbiology

2020 Volume 10, Page(s) 559209

MeSH term(s)	Animals ; Coronavirus/genetics ; Coronavirus/pathogenicity ; Coronavirus/physiology ; Coronavirus Infections/genetics ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Cytokines/genetics ; Cytokines/immunology ; Geography ; Humans ; Virulence
Chemical Substances	Cytokines
Keywords	covid19
Language	English
Publishing date	2020-10-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2020.559209
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Article ; Online: Hospital-at-Home Expands Hospital Capacity During COVID-19 Pandemic.

Nogués, Xavier / Sánchez-Martinez, Francisca / Castells, Xavier / Díez-Pérez, Adolfo / Sabaté, Rosa Ana / Petit, Irene / Brasé, Ariadna / Horcajada, Juan Pablo / Güerri-Fernández, Roberto / Pascual, Julio

Journal of the American Medical Directors Association

2021 Volume 22, Issue 5, Page(s) 939–942

Abstract: A Coronavirus Disease 2019 (COVID-19)-specific Hospital-at-Home was implemented in a 400-bed tertiary hospital in Barcelona, Spain. Senior or immune-compromised physicians oversaw patient care. The alternative to inpatient care more than doubled beds ... ...

Abstract	A Coronavirus Disease 2019 (COVID-19)-specific Hospital-at-Home was implemented in a 400-bed tertiary hospital in Barcelona, Spain. Senior or immune-compromised physicians oversaw patient care. The alternative to inpatient care more than doubled beds available for hospitalization and decreased the risk of transmission among patients and health care professionals. Mild cases from either the emergency department or after hospital discharge were deemed suitable for admission to the Hospital-at-Home. More than half of all patients had pneumonia. Standardized protocols and management criteria were provided. Only 6% of cases required referral for inpatient hospitalization. These results are promising and may provide valuable insight for centers undertaking Hospital-at-Home initiatives or in the case of new COVID-19 outbreaks.
MeSH term(s)	COVID-19 ; Humans ; Pandemics ; SARS-CoV-2 ; Spain/epidemiology ; Telemedicine ; Tertiary Care Centers
Language	English
Publishing date	2021-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171030-2
ISSN	1538-9375 ; 1525-8610
ISSN (online)	1538-9375
ISSN	1525-8610
DOI	10.1016/j.jamda.2021.01.077
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Zs.A 5971: Show issues

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Article ; Online: Is there a future for selective estrogen-receptor modulators in osteoporosis?

Güerri-Fernández, Roberto C / Diez-Perez, Adolfo

Therapeutic advances in musculoskeletal disease

2012 Volume 4, Issue 2, Page(s) 55–59

Language	English
Publishing date	2012-07-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2516075-8
ISSN	1759-7218 ; 1759-7218
ISSN (online)	1759-7218
ISSN	1759-7218
DOI	10.1177/1759720X11435677
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Article ; Online: Bone tissue quality in patients with monoclonal gammopathy of uncertain significance.

Orduna, Guillermina / Mellibovsky, Leonardo / Abella, Eugenia / Nogués, Xavier / Granero, Roser / García-Giralt, Natalia / Pineda-Moncusí, Marta / Güerri-Fernández, Roberto / Prieto-Alhambra, Daniel / Díez-Pérez, Adolfo

Journal of bone and mineral metabolism

2020 Volume 38, Issue 4, Page(s) 563–569

Abstract: Introduction: Monoclonal gammopathy of uncertain significance (MGUS) is highly prevalent in older adults and affects bone structure, with osteoporosis and increased risk of fractures in up to 14% of affected patients. Dual-energy X-ray absorptiometry ( ... ...

Abstract	Introduction: Monoclonal gammopathy of uncertain significance (MGUS) is highly prevalent in older adults and affects bone structure, with osteoporosis and increased risk of fractures in up to 14% of affected patients. Dual-energy X-ray absorptiometry (DXA), the standard technique for diagnosing osteoporosis, is ineffective to reveal microstructure and bone quality in this disease. Materials and methods: We conducted a cross-sectional study of patients with MGUS, recruited consecutively from the Hematology and Internal Medicine Departments of Hospital del Mar, Barcelona, between January 2011 and January 2018. Medical records, clinical results and spinal X-ray images were collected. Bone mineral density (BMD) at hip and spine was measured by DXA and Bone Material Strength index (BMSi) by impact microindentation on the tibial mid-shaft. Results: Thirty-nine patients with MGUS and 65 age-matched controls without previous fractures were included. In the MGUS group, 11 (28.2%) patients had prevalent fractures, nearly half of them vertebral (n = 5, 45.45%). Compared to controls, MGUS patients had significantly lower BMSi, a mean (SD) of 70.72 (9.70) vs. 78.29 (8.70), p = 0.001, and lower spinal BMD values (0.900 [0.159] vs. 1.003 [0.168], respectively, p = 0.012), but no significant differences at femoral neck and total hip. No association was observed between BMSi and DXA. Bone remodeling markers (procollagen type-1 N propeptide, bone-alkaline phosphatase and C-terminal telopeptide of type I collagen) did not differ between the two groups. Conclusions: Spinal BMD and mechanical properties of bone tissue, as measured by impact microindentation, were impaired in patients with MGUS. These changes in bone tissue mechanical resistance were independent of DXA levels.
MeSH term(s)	Aged ; Body Mass Index ; Bone Density ; Bone and Bones/physiopathology ; Case-Control Studies ; Female ; Humans ; Male ; Monoclonal Gammopathy of Undetermined Significance/physiopathology
Language	English
Publishing date	2020-01-23
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1295123-7
ISSN	1435-5604 ; 0914-8779
ISSN (online)	1435-5604
ISSN	0914-8779
DOI	10.1007/s00774-020-01084-3
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Zs.A 4894: Show issues

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Article: Impact of a Nosocomial COVID-19 Outbreak on a Non-COVID-19 Nephrology Ward during the First Wave of the Pandemic in Spain.

Montero, María Milagro / Hidalgo López, Carlota / López Montesinos, Inmaculada / Sorli, Luisa / Barrufet Gonzalez, Cristina / Villar-García, Judith / Güerri-Fernández, Roberto / Herranz, Milagros / Crespo, Marta / Arenas Jiménez, María Dolores / Pascual, Julio / González Juanes, Cristina / Horcajada, Juan P

Antibiotics (Basel, Switzerland)

2021 Volume 10, Issue 6

Abstract: Introduction: The aim of this study was to analyze a nosocomial coronavirus disease 2019 (COVID-19) outbreak that occurred on a polyvalent non-COVID-19 ward at a tertiary care university hospital in Spain during the first wave of the pandemic and to ... ...

Abstract	Introduction: The aim of this study was to analyze a nosocomial coronavirus disease 2019 (COVID-19) outbreak that occurred on a polyvalent non-COVID-19 ward at a tertiary care university hospital in Spain during the first wave of the pandemic and to describe the containment measures taken. The outbreak affected healthcare workers (HCWs) and kidney disease patients including transplant patients and those requiring maintenance hemodialysis. Methods: The outbreak investigation and report were conducted in accordance with the Orion statement guidelines. Results: In this study, 15 cases of COVID-19 affecting 10 patients and 5 HCWs were identified on a ward with 31 beds and 43 HCWs. The patients had tested negative for severe acute respiratory syndrome coronavirus 2 infection on admission. One of the HCWs was identified as the probable index case. Five patients died (mortality rate, 50%). They were all elderly and had significant comorbidities. The infection control measures taken included the transfer of infected patients to COVID-19 isolation wards, implementation of universal preventive measures, weekly PCR testing of patients and HCWs linked to the ward, training of HCWs on infection control and prevention measures, and enhancement of cleaning and disinfection. The outbreak was contained in 2 weeks, and no new cases occurred. Conclusion: Nosocomial COVID-19 outbreaks can have high attack rates involving both patients and HCWs and carry a high risk of patient mortality. Hospitals need to implement effective infection prevention and control strategies to prevent nosocomial COVID-19 spread.
Language	English
Publishing date	2021-05-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics10060619
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Article: Aminoglycoside or Polymyxin Monotherapy for Treating Complicated Urinary Tract Infections Caused by Extensively Drug-Resistant Pseudomonas aeruginosa: A Propensity Score-Adjusted and Matched Cohort Study.

López Montesinos, Inmaculada / Gómez-Zorrilla, Silvia / Palacios-Baena, Zaira Raquel / Prim, Nuria / Echeverria-Esnal, Daniel / Gracia, María Pilar / Montero, María Milagro / Durán-Jordà, Xavier / Sendra, Elena / Sorli, Luisa / Guerri-Fernandez, Roberto / Padilla, Eduardo / Grau, Santiago / Horcajada, Juan Pablo

Infectious diseases and therapy

2021 Volume 11, Issue 1, Page(s) 335–350

Abstract: Introduction: Extensively drug-resistant (XDR) Pseudomonas aeruginosa (PA) infections are difficult to treat. We aimed to compare aminoglycosides or polymyxin monotherapy versus other antibiotic regimens (carbapenems, aztreonam, ceftazidime, cefepime, ... ...

Abstract	Introduction: Extensively drug-resistant (XDR) Pseudomonas aeruginosa (PA) infections are difficult to treat. We aimed to compare aminoglycosides or polymyxin monotherapy versus other antibiotic regimens (carbapenems, aztreonam, ceftazidime, cefepime, ceftolozane-tazobactam, or ceftazidime-avibactam) in complicated urinary tract infections (cUTI) caused by XDR-PA. Methods: Study performed at a tertiary-care hospital from 2010 to 2019. All consecutive adult patients with XDR-PA urine cultures and diagnosed with cUTI were retrospectively reviewed. XDR phenotype was defined according to Magiorakos et al. A propensity score was used as a covariate in multivariate analyses and for matching. Primary outcome was early clinical failure and at end of treatment (EOT). Main secondary outcomes were 30- and 90-day mortality, microbiological clearance, and antibiotic-related side effects. Results: Of the 465 episodes screened, 101 were included, 48% were treated with aminoglycoside or colistin monotherapy. Most XDR-PA were susceptible to colistin (100%) and amikacin (43%). Patients treated with antibiotic regimens other than aminoglycosides or polymyxin monotherapy were more likely to have hematologic malignancy (p < 0.001), higher SOFA score (p = 0.048), and bacteremia (p = 0.003). In multivariate models adjusted by propensity score, aminoglycoside or colistin monotherapy was not associated with worse outcomes. After propensity score matching, 28 episodes in each treatment group were matched. Adjusted ORs (95% CI) for early clinical failure and at EOT with aminoglycosides or polymyxin monotherapy were 0.53 (0.18-1.58) and 1.29 (0.34-4.83), respectively. Aminoglycoside or colistin monotherapy was not associated with higher 30-day (HR 0.93, 95% CI 0.17-5.08) or 90-day mortality (HR 0.68, 95% CI 0.20-2.31), nor with absence of microbiological clearance (OR 0.72, 95% CI 0.33-1.58). No statistically significant differences were found in terms of nephrotoxicity. Clostridioides difficile infection was observed only in the "other antibiotic regimens" group (n = 6, 11.3%). Conclusions: Aminoglycosides or polymyxin monotherapy showed good efficacy and safety profile in treating cUTI caused by XDR-PA. These results may be useful for antibiotic stewardship activities.
Language	English
Publishing date	2021-12-03
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2701611-0
ISSN	2193-6382 ; 2193-8229
ISSN (online)	2193-6382
ISSN	2193-8229
DOI	10.1007/s40121-021-00570-z
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Article ; Online: Brief Research Report: Anti-SARS-CoV-2 Immunity in Long Lasting Responders to Cancer Immunotherapy Through mRNA-Based COVID-19 Vaccination.

Sisteré-Oró, Marta / Wortmann, Diana D J / Andrade, Naína / Aguilar, Andres / Mayo de Las Casas, Clara / Casabal, Florencia Garcia / Torres, Susana / Bona Salinas, Eduardo / Raventos Soler, Laura / Arcas, Andrea / Esparre, Carlos / Garcia, Beatriz / Valarezo, Joselyn / Rosell, Rafael / Güerri-Fernandez, Roberto / Gonzalez-Cao, Maria / Meyerhans, Andreas

Frontiers in immunology

2022 Volume 13, Page(s) 908108

Abstract: Cancer patients (CPs) have been identified as particularly vulnerable to SARS-CoV-2 infection, and therefore are a priority group for receiving COVID-19 vaccination. From the patients with advanced solid tumors, about 20% respond very efficiently to ... ...

Abstract	Cancer patients (CPs) have been identified as particularly vulnerable to SARS-CoV-2 infection, and therefore are a priority group for receiving COVID-19 vaccination. From the patients with advanced solid tumors, about 20% respond very efficiently to immunotherapy with anti-PD1/PD-L1 antibodies and achieve long lasting cancer responses. It is unclear whether an efficient cancer-specific immune response may also correlate with an efficient response upon COVID-19 vaccination. Here, we explored the antiviral immune response to the mRNA-based COVID-19 vaccine BNT162b2 in a group of 11 long-lasting cancer immunotherapy responders. We analysed the development of SARS-CoV-2-specific IgG serum antibodies, virus neutralizing capacities and T cell responses. Control groups included patients treated with adjuvant cancer immunotherapy (IMT, cohort B), CPs not treated with immunotherapy (no-IMT, cohort C) and healthy controls (cohort A). The median ELISA IgG titers significantly increased after the prime-boost COVID vaccine regimen in all cohorts (Cohort A: pre-vaccine = 900 (100-2700), 3 weeks (w) post-boost = 24300 (2700-72900); Cohort B: pre-vaccine = 300 (100-2700), 3 w post-boost = 8100 (300-72900); Cohort C: pre-vaccine = 500 (100-2700), 3 w post-boost = 24300 (300-72900)). However, at the 3 w post-prime time-point, only the healthy control group showed a statistically significant increase in antibody levels (Cohort A = 8100 (900-8100); Cohort B = 900 (300-8100); Cohort C = 900 (300-8100)) (P < 0.05). Strikingly, while all healthy controls generated high-level antibody responses after the complete prime-boost regimen (Cohort A = 15/15 (100%), not all CPs behaved alike [Cohort B= 12/14 (84'6%); Cohort C= 5/6 (83%)]. Their responses, including those of the long-lasting immunotherapy responders, were more variable (Cohort A: 3 w post-boost (median nAb titers = 95.32 (84.09-96.93), median Spike-specific IFN-γ response = 64 (24-150); Cohort B: 3 w post-boost (median nAb titers = 85.62 (8.22-97.19), median Spike-specific IFN-γ response (28 (1-372); Cohort C: 3 w post-boost (median nAb titers = 95.87 (11.8-97.3), median Spike-specific IFN-γ response = 67 (20-84)). Two long-lasting cancer responders did not respond properly to the prime-boost vaccination and did not generate S-specific IgGs, neutralizing antibodies or virus-specific T cells, although their cancer immune control persisted for years. Thus, although mRNA-based vaccines can induce both antibody and T cell responses in CPs, the immune response to COVID vaccination is independent of the capacity to develop an efficient anti-cancer immune response to anti PD-1/PD-L1 antibodies.
MeSH term(s)	B7-H1 Antigen ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Humans ; Immunoglobulin G ; Immunotherapy ; Neoplasms/therapy ; Research Report ; SARS-CoV-2/immunology ; Vaccination ; Viral Vaccines ; mRNA Vaccines/immunology
Chemical Substances	B7-H1 Antigen ; COVID-19 Vaccines ; Immunoglobulin G ; Viral Vaccines ; mRNA Vaccines ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-07-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.908108
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Article ; Online: 52-year-old man with recurrent urinary tract infection, Munchausen's syndrome.

Herrera, Sabina / Corzo, Patricia / Oliverò, Ruperto-Carlos / Zabalza, Ana / Güerri-Fernández, Roberto Carlos

Enfermedades infecciosas y microbiologia clinica

2015 Volume 33, Issue 7, Page(s) 501

MeSH term(s)	Abdominal Pain ; Electronic Health Records ; Emergency Service, Hospital ; Health Services Misuse ; Humans ; Male ; Medical Record Linkage ; Middle Aged ; Munchausen Syndrome/diagnosis ; Patient Dropouts ; Patient Readmission ; Salivary alpha-Amylases/analysis ; Sputum/enzymology ; Sputum/microbiology ; Urinalysis ; Urinary Tract Infections ; Viridans Streptococci/isolation & purification
Chemical Substances	Salivary alpha-Amylases (EC 3.2.1.1)
Language	English
Publishing date	2015-08
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	1070941-1
ISSN	1578-1852 ; 0213-005X
ISSN (online)	1578-1852
ISSN	0213-005X
DOI	10.1016/j.eimc.2014.11.002
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