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  1. Article ; Online: Detection of Pathogens in Cerebrospinal Fluid With the BIOFIRE Blood Culture Identification 2 Panel in Two Neonates With Healthcare-associated Central Nervous System Infections.

    Guner Ozenen, Gizem / Ayhan, Fahri Yuce / Kacar, Pelin / Gulderen, Mustafa / Yangin Ergon, Ezgi / Ergun, Deniz / Ozbay, Tezcan / Bayram, Arzu / Ozbakır, Hincal / Devrim, Ilker

    The Pediatric infectious disease journal

    2024  Volume 43, Issue 3, Page(s) e117–e118

    MeSH term(s) Infant, Newborn ; Humans ; Blood Culture ; Central Nervous System ; Bacteria/genetics ; Central Nervous System Infections/diagnosis ; Multiplex Polymerase Chain Reaction
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000004200
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  2. Article ; Online: Comparative Analysis of Pediatric Brucellosis Cases With and Without Bacteremia.

    Yılmaz Çelebi, Miray / Böncüoğlu, Elif / Kıymet, Elif / Şahinkaya, Şahika / Cem, Ela / Gülderen, Mustafa / Kaçar, Pelin / Özdağ, Eda / Akaslan Kara, Aybüke / Güner Özenen, Gizem / Sorguç, Yelda / Ayhan, Fahri Yüce / Apa, Hurşit / Bayram, Süleyman Nuri / Devrim, İlker

    Vector borne and zoonotic diseases (Larchmont, N.Y.)

    2024  

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2047199-3
    ISSN 1557-7759 ; 1530-3667
    ISSN (online) 1557-7759
    ISSN 1530-3667
    DOI 10.1089/vbz.2023.0080
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  3. Article ; Online: Rehospitalization indications of children hospitalized for COVID-19 infections after discharge: Should we suspect long COVID?

    Cem, Ela / Kıymet, Elif / Böncüoğlu, Elif / Şahinkaya, Şahika / Çelebi, Miray Yılmaz / Gülderen, Mustafa / Kara, Aybüke Akaslan / Özenen, Gizem Güner / Bayram, Nuri / Devrim, İlker

    The Turkish journal of pediatrics

    2023  Volume 65, Issue 4, Page(s) 583–591

    Abstract: Background: Complications that may develop in children after coronavirus disease 2019 (COVID-19) infections are unknown. The `Long COVID` syndrome is a new process that can also be identified in children. Therefore, in this study, the conditions that ... ...

    Abstract Background: Complications that may develop in children after coronavirus disease 2019 (COVID-19) infections are unknown. The `Long COVID` syndrome is a new process that can also be identified in children. Therefore, in this study, the conditions that may develop in children after COVID-19 infection were discussed, and the indications for rehospitalizations were reviewed.
    Methods: This retrospective cohort study was conducted in a tertiary children`s hospital in İzmir, Türkiye. All children who were rehospitalized in the study center after discharge, and the indications for readmissions were screened.
    Results: Since the beginning of the pandemic, 777 children with COVID-19 infection were hospitalized, including 98 (12.6%) cases rehospitalized for any indication. Fifty-five (56.1%) patients were male, and 43 (43.9%) were female. The mean age of the study population was 79.3±63.5 months (1 month to 17 years). Among these 98 patients, 76 (77.6%) were rehospitalized because of the presence of their primary underlying disease, nonspecific infectious diseases unrelated to COVID-19, and the need to perform certain surgical procedures. The remaining 22 (22.4%) patients presented with symptoms such as fatigue, fever, abdominal pain, and myalgia after the COVID-19 infection. No other underlying cause was detected in approximately one-third of the patients, whose manifestations were found to be consistent with long COVID syndrome.
    Conclusions: The findings of acute COVID-19 infection are well characterized, but there is still limited data on its long-term outcomes. The majority of the study population that had no underlying disease were thought to have complications from the COVID-19 infection. Therefore, although the incidence rate of long COVID syndrome in childhood has not been revealed so far, it should be kept in mind among relevant differential diagnoses.
    MeSH term(s) Humans ; Child ; Female ; Male ; Post-Acute COVID-19 Syndrome ; COVID-19/complications ; Patient Readmission ; Patient Discharge ; Retrospective Studies
    Language English
    Publishing date 2023-09-04
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 123487-0
    ISSN 2791-6421 ; 0041-4301
    ISSN (online) 2791-6421
    ISSN 0041-4301
    DOI 10.24953/turkjped.2022.829
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  4. Article ; Online: The impact of the BIOFIRE

    Devrim, Ilker / Ayhan, Fahri Yuce / Kacar, Pelin / Guner Ozenen, Gizem / Bayram, Arzu / Ergun, Deniz / Ozbakır, Hincal / Gulderen, Mustafa / Yilmaz Celebi, Miray / Ozer, Arife / Akaslan Kara, Aybüke / Bayram, Nuri

    European journal of pediatrics

    2023  Volume 183, Issue 3, Page(s) 1353–1360

    Abstract: This study aimed to assess the therapeutic effects of implementing the ... ...

    Abstract This study aimed to assess the therapeutic effects of implementing the BioFire
    MeSH term(s) Child ; Humans ; Infant ; Bacteremia/diagnosis ; Blood Culture ; Retrospective Studies ; Cross-Sectional Studies ; Sepsis/diagnosis ; Sepsis/drug therapy ; Anti-Infective Agents/therapeutic use ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Infective Agents ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-12-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-023-05381-7
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  5. Article ; Online: Do not Miss the Diagnosis of Bacterial Sepsis in Infants With COVID-19.

    Böncüoğlu, Elif / Kiymet, Elif / Yilmaz Çelebi, Miray / Cem, Ela / Gülderen, Mustafa / Şahinkaya, Şahika / Bayram, Nuri / Devrim, İlker

    The Pediatric infectious disease journal

    2021  Volume 41, Issue 1, Page(s) e31–e32

    MeSH term(s) Bacterial Infections ; COVID-19 ; Humans ; Infant ; SARS-CoV-2 ; Sepsis/diagnosis
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003351
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  6. Article ; Online: Did Hospitalization Age Decrease in Children in the Omicron (B.1.1.529) Era?

    Böncüoğlu, Elif / Kiymet, Elif / Şahinkaya, Şahika / Cem, Ela / Yilmaz Çelebi, Miray / Gülderen, Mustafa / Kaçar, Pelin / Güner Özenen, Gizem / Akaslan Kara, Aybüke / Bayram, Nuri / Devrim, İlker

    The Pediatric infectious disease journal

    2022  Volume 41, Issue 9, Page(s) e403

    MeSH term(s) Child ; Hospitalization ; Humans
    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Letter
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003600
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  7. Article ; Online: Readmission reasons of pediatric patients diagnosed with multisystem inflammatory syndrome after discharge.

    Cem, Ela / Kıymet, Elif / Böncüoğlu, Elif / Şahinkaya, Şahika / Yılmaz Çelebi, Miray / Gülderen, Mustafa / Akaslan Kara, Aybüke / Meşe, Timur / Ağin, Hasan / Bayram, Nuri / Devrim, İlker

    Archives of rheumatology

    2022  Volume 38, Issue 2, Page(s) 315–321

    Abstract: Objectives: There is no clear information in the literature about causes of reactivation of multisystem inflammatory syndrome in children (MIS-C) or indications for readmissions for MIS-C after discharge; as a result, the conditions that may develop ... ...

    Abstract Objectives: There is no clear information in the literature about causes of reactivation of multisystem inflammatory syndrome in children (MIS-C) or indications for readmissions for MIS-C after discharge; as a result, the conditions that may develop after infection in children with MIS-C were discussed, and the reasons for hospitalization were screened.
    Patients and methods: This single-center retrospective study was conducted with 95 patients (65 males, 30 females; mean age: 92.8±55.5 months; range, 5 to 17 months) between November 11, 2020, and December 30, 2021. Children who were rehospitalized in the study center after their discharge with the diagnosis of MIS-C were included in the study, and the indications for readmissions were evaluated.
    Results: During the study period, six (6.3%) patients (4 males, 2 females; median age: 114.5 months [interquartile range: 122 months]) had to be rehospitalized. Four of these patients had an underlying disease, while the other two were previously healthy children. Fever was the most common reason for readmissions in half of the patients, while the remaining patients were readmitted with the indications of myocarditis, pneumonia, and posttraumatic pain syndrome.
    Conclusion: Although no evidence for the reactivation of MIS-C was detected in patients in the literature, it should also be emphasized that close follow-up of these patients is a must, considering possible cardiac complications.
    Language English
    Publishing date 2022-10-21
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 3012972-2
    ISSN 2618-6500 ; 2148-5046
    ISSN (online) 2618-6500
    ISSN 2148-5046
    DOI 10.46497/ArchRheumatol.2023.9605
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  8. Article ; Online: Which Findings Make multisystem Inflammatory Syndrome in Children Different from the Pre-Pandemic Kawasaki Disease?

    Cem, Ela / Böncüoğlu, Elif / Kıymet, Elif / Şahinkaya, Şahika / Yılmaz Çelebi, Miray / Gülderen, Mustafa / Kaçar, Pelin / Akaslan Kara, Aybüke / Aydın, Ayşenur / Murat, Mehmet / Yılmazer, Murat Muhtar / Bayram, Nuri / Devrim, İlker

    Pediatric cardiology

    2022  Volume 44, Issue 2, Page(s) 424–432

    Abstract: Multisystem Inflammatory Syndrome in Children associated with COVID-19 infection attracted attention because some features overlapped with Kawasaki disease. And due to these overlapping features with Kawasaki disease, it has become difficult to diagnose ... ...

    Abstract Multisystem Inflammatory Syndrome in Children associated with COVID-19 infection attracted attention because some features overlapped with Kawasaki disease. And due to these overlapping features with Kawasaki disease, it has become difficult to diagnose both disorders. Therefore, this study focused on the differences between the patients diagnosed with MIS-C after COVID-19 and Kawasaki patients analyzed, particularly during the pre-pandemic period. In this way, it is aimed to reduce the dilemmas experienced in Diagnosis. In this descriptive study, 98 patients diagnosed with MIS-C throughout the pandemic were compared to 37 patients diagnosed with Kawasaki Disease during the pre-pandemic period.The patients in the MIS-C group were older children and clinically suffered from more headaches, vomiting, diarrhea, abdominal pain, and chest pain than Kawasaki patients. Signs of shock such as hypotension and tachycardia were more remarkable. Also, myocarditis and mitral regurgitation were detected at a higher rate in the MIS-C group. Besides, in the laboratory, lymphopenia, hypoalbuminemia, and creatinine elevation were more apparent.In conclusion, our present study findings support that although the MIS-C and Kawasaki share common features, they present with different clinical and laboratory features. And these differences are thought to be supportive in treatment and patient management.
    MeSH term(s) Child ; Humans ; Adolescent ; COVID-19 ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Mucocutaneous Lymph Node Syndrome/epidemiology ; Pandemics ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/epidemiology
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-022-02961-6
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  9. Article ; Online: The Evaluation of Troponin I Levels and Myocarditis in Children with COVID-19: A Pediatric Single-Center Experience.

    Guner Ozenen, Gizem / Akaslan Kara, Aybuke / Kiymet, Elif / Boncuoglu, Elif / Sahinkaya, Sahika / Cem, Ela / Yilmaz Celebi, Miray / Kacar, Pelin / Gulderen, Mustafa / Uras, Meltem / Yılmazer, Murat Muhtar / Murat, Mehmet / Mese, Timur / Agin, Hasan / Bayram, Nuri / Devrim, İlker

    Pediatric cardiology

    2022  Volume 44, Issue 4, Page(s) 873–881

    Abstract: Children with COVID-19 usually show milder symptoms than adults; however, a minority of them may have cardiac involvement. We aimed to identify the role of troponin I levels that may predict early cardiac involvement in children with COVID-19. A single- ... ...

    Abstract Children with COVID-19 usually show milder symptoms than adults; however, a minority of them may have cardiac involvement. We aimed to identify the role of troponin I levels that may predict early cardiac involvement in children with COVID-19. A single-center retrospective study was conducted to evaluate hospitalized children diagnosed with COVID-19 between March 11, 2020, and December 31, 2021. Patients with available troponin I levels and with no known cardiac disease were included. During the study period, 412 children with COVID-19 who had troponin I levels on admission were identified. Troponin levels were elevated in 7 (1.7%) patients and were normal in 395 (98.3%) patients. The median age of patients with elevated troponin levels was 4 (min. 2-max. 144) months, which was statistically lower than the age of patients with normal troponin levels (P = 0.035). All the patients with elevated troponin levels had tachycardia. Out of 7 patients with high troponin levels, 3 (42.9%) of them were admitted to the pediatric intensive care unit (PICU), 2 (28.6%) required oxygen support, and 1 (14.3%) required a mechanical ventilator. Patients with elevated troponin levels had a statistically longer hospital stay (P < 0.001). Neutropenia, tachycardia, PICU admission, oxygen support, and mechanical ventilation were statistically more common in patients with elevated troponin levels (P values were 0.033, 0.020, < 0.001, 0.050, and < 0.001, respectively). Electrocardiography (ECG) and echocardiography (ECHO) were performed on all patients with elevated troponin levels, and 6 (85.8%) patients were diagnosed with myocarditis. The ECG and ECHO have been performed in 58 (14.3%) out of 405 patients with normal troponin levels. Two (3.5%) patients had negative T waves on ECG, and all ECHOs were normal. Our results suggest that elevated troponin I levels in children with COVID-19 can be used to evaluate cardiac involvement and decide the need for further pediatric cardiologist evaluation.
    MeSH term(s) Adult ; Humans ; Child ; Troponin I ; COVID-19 ; Retrospective Studies ; Myocarditis/diagnosis ; Oxygen
    Chemical Substances Troponin I ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-10-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-022-03017-5
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