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Article ; Online: HIV pre-exposure prophylaxis (PrEP) for transgender and nonbinary persons. Literature review and guidelines for professionals.

Kania, Zofia / Mijas, Magdalena / Grabski, Bartosz / Gąsiorowski, Jacek / Pliczko, Mateusz

2023 Volume 57, Issue 5, Page(s) 1023–1035

Abstract: Transgender and nonbinary (TG/NB) persons are listed as one of the key populations in the context of HIV, due to increased risk of HIV infection in this group. HIV prevention, which includes a variety of available methods, should therefore be included in ...

Title translation	Profilaktyka przedekspozycyjna HIV (PrEP) dla osób transpłciowych i niebinarnych. Przegląd piśmiennictwa i wskazówki dla praktyków.
Abstract	Transgender and nonbinary (TG/NB) persons are listed as one of the key populations in the context of HIV, due to increased risk of HIV infection in this group. HIV prevention, which includes a variety of available methods, should therefore be included in the comprehensive health care for TG/NB persons. One such method is the pre-exposure prophylaxis (PrEP), whose high effectiveness in preventing HIV transmission has already been demonstrated in numerous studies conducted in the cisgender population. However, the available empirical data on its use in TG/NB persons are limited in many respects. This issue is also practically absent in the Polish literature; as a consequence, there are significant gaps in recommendations for professionals involved i n the prevention of HIV among TG/NB persons and professionals involved in the comprehensive health care for TG/NB persons. This article 1) outlines the issue of the use of PrEP among TG/NB persons, including the associated challenges for professionals (specialising in physical, as well as mental health); 2) demonstrates the possible applicability of PrEP in TG/NB populations based on available research findings; 3) summarises good practices in counselling and PrEP-related psychoeducational activities, as part of the comprehensive health care for TG/NB individuals.
MeSH term(s)	Male ; Humans ; HIV Infections/prevention & control ; HIV Infections/epidemiology ; Transgender Persons/psychology ; Homosexuality, Male/psychology ; Pre-Exposure Prophylaxis/methods ; Anti-HIV Agents/therapeutic use
Chemical Substances	Anti-HIV Agents
Language	Polish
Publishing date	2023-10-31
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	415518-x
ISSN	2391-5854 ; 0033-2674
ISSN (online)	2391-5854
ISSN	0033-2674
DOI	10.12740/PP/OnlineFirst/144821
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Article: Prevalence and genotype distribution of human papillomavirus infection among HIV-infected men who have sex with men living in Lower Silesia, Poland.

Biała, Martyna / Zalewska, Małgorzata / Szetela, Bartosz / Gąsiorowski, Jacek / Leszczyszyn, Jarosław / Inglot, Małgorzata

Postepy dermatologii i alergologii

2022 Volume 39, Issue 6, Page(s) 1128–1133

Abstract: Introduction: Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide and is associated with the risk of anogenital and oropharyngeal cancers. Men who have sex with men (MSM) are at a high risk of HPV infection. However, ... ...

Abstract	Introduction: Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide and is associated with the risk of anogenital and oropharyngeal cancers. Men who have sex with men (MSM) are at a high risk of HPV infection. However, little up-to-date data are available regarding the prevalence of HIV and HPV co-infection in MSM in Poland. Aim: To evaluate the prevalence, genotype distribution and risk factors for HPV infection among HIV-positive MSM living in Lower Silesia. Material and methods: A total of 54 HIV-positive and 28 HIV-negative MSM participated in the study. The polymerase chain reaction was performed to detect HPV from oral and anal swabs. A self-applied written questionnaire was conducted to collect sociodemographic and behavioural data. Results: The prevalence rates of oral and anal HPV infection were higher in HIV-infected MSM than in HIV-negative MSM. Statistical analysis showed that the prevalence of high oncogenic genotypes, HPV 16 and HPV 18, at the anal site was significantly higher in patients with lower CD4 cell counts, in addition, HPV 18 infection was significantly more frequent in patients with higher levels of HIV RNA. Moreover, HPV 33 and HPV 52 at the anal site were significantly more common in patients with lower nadir CD4. Conclusions: This is the first report of HPV infection among Polish HIV-infected MSM. Our results show that HIV-related immunodeficiency is associated with a higher prevalence of high-risk HPV infections, therefore early detection of HIV infection and initiation of antiretroviral therapy might reduce the risk of HPV-related diseases.
Language	English
Publishing date	2022-12-22
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596142-1
ISSN	1642-395X
ISSN	1642-395X
DOI	10.5114/ada.2022.122607
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Article ; Online: Rapid Progression and Overlapping of Skin Eruptions in a Patient with Secondary and Tertiary Syphilis Coinfected with HIV.

Szetela, Bartosz / Gasiorowski, Jacek

AIDS research and human retroviruses

2016 Volume 32, Issue 9, Page(s) 874–875

Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article
ZDB-ID	639130-8
ISSN	1931-8405 ; 0889-2229
ISSN (online)	1931-8405
ISSN	0889-2229
DOI	10.1089/AID.2015.0321
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Article: Assessment of dietary habits and lifestyle among people with HIV.

Duda, Paweł / Knysz, Brygida / Gąsiorowski, Jacek / Szetela, Bartosz / Piotrowska, Ewa / Bronkowska, Monika

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

2021 Volume 29, Issue 12, Page(s) 1459–1467

Abstract: Background: The aim of this study was to determine the consumption of specific food groups by people with HIV and to determine the quality of their diets.: Objectives: To assess the relationship between selected eating habits and lifestyles of people ...

Abstract	Background: The aim of this study was to determine the consumption of specific food groups by people with HIV and to determine the quality of their diets. Objectives: To assess the relationship between selected eating habits and lifestyles of people infected with HIV. The research was conducted at the HIV/AIDS Preventative and Therapeutic Clinic of the Infectious Disease Prevention and Therapy Center at Wrocław Health Center (SPZOZ Wrocław), Poland. Material and methods: The study was conducted in 2019 among 31 patients of a counselling center in Wrocław. To determine the frequency of food consumption and eating habits, the KomPAN® questionnaire, prepared by employees of the Polish Academy of Sciences, was used. Results: All study participants were characterized by a small degree of unhealthy features in their diets; 87% of the respondents also demonstrated a small degree of healthy features in their diets, although the responses they gave showed that they assessed their nutritional knowledge and diet highly. Consumption of sweet snacks and adding salt to cooked meals were prevalent. The respondents took part in moderate physical activity and rarely consumed highly processed fast food products, though they ate fish and legumes - an important part of the diet - with similar frequency. Conclusions: More attention should be given to the nutritional issues of patients treated for HIV, and emphasis should be placed on promoting healthy eating habits among this population. In the scientific literature, few such studies are available that address issues related to the diet of HIV-infected people.
MeSH term(s)	Diet ; Feeding Behavior ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Humans ; Life Style ; Poland ; Surveys and Questionnaires
Language	English
Publishing date	2021-01-03
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2270257-X
ISSN	1899-5276 ; 1230-025X
ISSN	1899-5276 ; 1230-025X
DOI	10.17219/acem/128234
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Article: Making HIV clinic appointments for clients with positive HIV results at testing sites can improve referral rates.

Szetela, Bartosz / Łapiński, Łukasz / Gasiorowski, Jacek / Knysz, Brygida

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

2018 Volume 28, Issue 1, Page(s) 121–124

Abstract: Background: The percentage of people living with undiagnosed HIV infection remains very high in Poland and exceeds 50% - one of the highest rates in Europe. At the same time, the number of HIV tests performed by medical doctors per 1000 inhabitants is ... ...

Abstract	Background: The percentage of people living with undiagnosed HIV infection remains very high in Poland and exceeds 50% - one of the highest rates in Europe. At the same time, the number of HIV tests performed by medical doctors per 1000 inhabitants is the lowest in Europe. Thus, every effort should be made to keep diagnosed patients in care. However, a number of patients are lost to care (LTC), with the percentage depending on the testing modality used (voluntary counseling and testing sites - VCTs, private laboratories, medical clinics, clubs) and communication skills of persons giving the results. Until now, there was only 1 prospective study in Poland that looked into the problem of continuum of care. Objectives: The objective of the study was to assess VCT clients' willingness to accept help with making the first appointment at a local HIV clinic after receiving positive results and the percentage of patients getting into care at the clinic after referral. Material and methods: Referral efficacy analysis between 2010 and 2014 was a joint venture between VCT site and the largest HIV clinic in Wrocław. Every patient diagnosed with HIV infection was offered personal help with making the first appointment at the HIV clinic. Later, it was assessed whether the first visit actually took place. Results: All the patients who collected their positive results came for their first visit at the HIV clinic with a referral rate reaching 100%, falling to 97.1% only in 2013. Most visits took place during 1-2 weeks. Conclusions: Patients were willing to use counselors' help with making appointments at the HIV clinic, which in turn increased referral rates and numbers of patients retained in care.
MeSH term(s)	Continuity of Patient Care ; Counseling/organization & administration ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Humans ; Point-of-Care Testing ; Poland/epidemiology ; Prevalence ; Referral and Consultation/statistics & numerical data ; Voluntary Programs
Language	English
Publishing date	2018-11-08
Publishing country	Poland
Document type	Evaluation Studies ; Journal Article
ZDB-ID	2270257-X
ISSN	1899-5276 ; 1230-025X
ISSN	1899-5276 ; 1230-025X
DOI	10.17219/acem/91064
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Article ; Online: Deep vein thrombosis of the lower limbs in intravenous drug users.

Kwiatkowska, Wiesława / Knysz, Brygida / Gąsiorowski, Jacek / Witkiewicz, Wojciech

Postepy higieny i medycyny doswiadczalnej (Online)

2015 Volume 69, Page(s) 510–520

Abstract: Background: Addiction to intravenously administered drugs has been a serious epidemiological problem for years. Among the related health complications, deep vein thrombosis (DVT) is one of the most important. This paper provides an illustrative ... ...

Abstract	Background: Addiction to intravenously administered drugs has been a serious epidemiological problem for years. Among the related health complications, deep vein thrombosis (DVT) is one of the most important. This paper provides an illustrative presentation of DVT in intravenous drug users (IDUs), HIV-positive subjects among them. Methods: We searched PubMed, Ovid Journals, Scopus, ScienceDirect, Cochrane Library, Google Scholar and references from articles obtained. The main terms used to identify appropriate studies of DVT in IDUs were 'intravenous drug users', 'substance-related disorders' and 'deep vein thrombosis'. Results: No guidelines exist for DVT in intravenous drug users. As many as 47.6% of IDUs report having suffered from DVT. IDUs may constitute approx. 50% of patients under 40 years of age with DVT, this being promoted by multiple vein punctures, groin injections, lack of sterility, insoluble microparticles and other factors. The clinical appearance is more complex than in the general population, which also makes prognosis more difficult. HIV infection can worsen DVT. It often appears as proximal iliofemoral thrombosis, accompanied by local and general complications. Ultrasound with a compression test is an objective method of choice, but must often be complemented with computed tomography. Antithrombotic therapy in IDUs needs to be applied individually. The optimal method is supervised therapy at addiction treatment services. Conclusions: Individual and public preventive measures, among them locally prepared guidelines for DVT in IDUs, may be the most important processes capable of effectively reducing the morbidity of septic and non-septic DVT.
MeSH term(s)	Adult ; Drug Users/statistics & numerical data ; Female ; HIV Infections/etiology ; Humans ; Lower Extremity ; Male ; Substance Abuse, Intravenous/complications ; Substance Abuse, Intravenous/epidemiology ; Venous Thrombosis/epidemiology ; Venous Thrombosis/etiology
Language	English
Publishing date	2015-04-22
Publishing country	Poland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	418865-2
ISSN	1732-2693 ; 0032-5449
ISSN (online)	1732-2693
ISSN	0032-5449
DOI	10.5604/17322693.1150215
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Article: Characterization of local electrochemical doping of high performance conjugated polymer for photovoltaics using scanning droplet cell microscopy.

Gasiorowski, Jacek / Mardare, Andrei Ionut / Sariciftci, Niyazi Serdar / Hassel, Achim Walter

Electrochimica acta

2015 Volume 113, Page(s) 834–839

Abstract: The electrochemical oxidation of a next generation low bandgap high performance photovoltaic material namely poly[4,8-bis-substituted-benzo[1,2-b:4,5-b0]dithiophene-2,6-diyl-alt-4-substituted-thieno[3,4-b] thiophene-2,6-diyl] (PBDTTT-c) thin film was ... ...

Abstract	The electrochemical oxidation of a next generation low bandgap high performance photovoltaic material namely poly[4,8-bis-substituted-benzo[1,2-b:4,5-b0]dithiophene-2,6-diyl-alt-4-substituted-thieno[3,4-b] thiophene-2,6-diyl] (PBDTTT-c) thin film was investigated using a scanning droplet cell microscope. Cyclic voltammetry was used for the basic characterization of the oxidation/doping of PBDTTT-c. Application of the different final potentials during the electrochemical study provides a close look to the oxidation kinetics. The electrical properties of both doped and undoped PBDTTT-c were analyzed in situ by electrochemical impedance spectroscopy giving the possibility to correlate the changes in the doping level with the subsequent changes in the resistance and capacitance. As a result one oxidation peak was found during the cyclic voltammetry and in potentiostatic measurements. From Mott-Schottky analysis a donor concentration of 2.3 × 10
Language	English
Publishing date	2015-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1483548-4
ISSN	0013-4686
ISSN	0013-4686
DOI	10.1016/j.electacta.2013.07.050
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Article: Electrochemical characterization of sub-micro-gram amounts of organic semiconductors using scanning droplet cell microscopy.

Gasiorowski, Jacek / Mardare, Andrei I / Sariciftci, Niyazi S / Hassel, Achim Walter

Journal of electroanalytical chemistry (Lausanne, Switzerland)

2014 Volume 691, Issue 100, Page(s) 77–82

Abstract: Scanning droplet cell microscopy (SDCM) uses a very small electrolyte droplet at the tip of a capillary which comes in contact with the working electrode. This method is particularly interesting for studies on organic semiconductors since it provides ... ...

Abstract	Scanning droplet cell microscopy (SDCM) uses a very small electrolyte droplet at the tip of a capillary which comes in contact with the working electrode. This method is particularly interesting for studies on organic semiconductors since it provides localized electrochemical investigations with high reproducibility. One clear advantage of applying SDCM is represented by the very small amounts of material necessary (less than 1 mg). Organic materials can be investigated quickly and inexpensively in electrochemical studies with a high throughput. In the present study, thin layers of poly(3-hexylthiophene) (P3HT), which is one of the most often used material for organic solar cells, were deposited on ITO/glass as working electrodes in SDCM studies. The redox reactions in 0.1 M tetra(n-butyl)ammonium hexafluorophosphate (TBAPF
Language	English
Publishing date	2014-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1491150-4
ISSN	1873-2569 ; 1572-6657 ; 0368-1874 ; 0022-0728
ISSN (online)	1873-2569
ISSN	1572-6657 ; 0368-1874 ; 0022-0728
DOI	10.1016/j.jelechem.2012.11.008
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Article ; Online: Czynniki wpływające na zakaźność HIV.

Gąsiorowski, Jacek / Łapiński, Łukasz / Knysz, Brygida

Postepy higieny i medycyny doswiadczalnej (Online)

2011 Volume 65, Page(s) 190–194

Abstract: To date it has been impossible to establish borderline physical conditions which prevent HIV from infecting human cells. Full inactivation of the virus is not necessary to lose its capacity for infection--often damage of the mechanisms concerning e.g. ... ...

Title translation	Influence of different physical conditions on HIV infectivity.
Abstract	To date it has been impossible to establish borderline physical conditions which prevent HIV from infecting human cells. Full inactivation of the virus is not necessary to lose its capacity for infection--often damage of the mechanisms concerning e.g. HIV entry into the cell or integration with host DNA is sufficient. The presence of HIV RNA in a sample under certain conditions does not mean that the virions are infectious. Viral infectivity under certain conditions depends on temperature, humidity, sunlight, atmospheric pressure, pH of the environment, disinfectants, coagulation inhibitors, and the kind and amount of infectious biological material, especially HIV viremia in it. At present the influence of high temperature on HIV infectivity, inactivation or HIV RNA level is the best known phenomenon, while the influence of low temperature on the above parameters has been examined in less detail. In the paper the authors present the influence of various parameters on HIV infectivity, especially temperature variation.
MeSH term(s)	HIV/pathogenicity ; HIV Infections/prevention & control ; Humans ; Risk Factors ; Temperature
Language	Polish
Publishing date	2011-03-25
Publishing country	Poland
Document type	English Abstract ; Journal Article
ZDB-ID	418865-2
ISSN	1732-2693 ; 0032-5449
ISSN (online)	1732-2693
ISSN	0032-5449
DOI	10.5604/17322693.936097
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Article ; Online: Efficacy and safety of nucleoside-sparing regimen based on raltegravir and ritonavir-boosted darunavir in HIV-1-infected treatment-experienced patients.

Jabłonowska, Elżbieta / Pulik, Piotr / Kalinowska, Anna / Gąsiorowski, Jacek / Parczewski, Miłosz / Bociąga-Jasik, Monika / Pulik, Łukasz / Siwak, Ewa / Wójcik, Kamila

Journal of medical virology

2017 Volume 89, Issue 12, Page(s) 2122–2129

Abstract: Aim: To assess the efficacy and tolerability of dual therapy containing raltegravir (RAL) and ritonavir boosted darunavir (DRV/r) in HIV-1-infected treatment-experienced patients.: Method: Retrospective analysis of 81 HIV-1-infected treatment- ... ...

Abstract	Aim: To assess the efficacy and tolerability of dual therapy containing raltegravir (RAL) and ritonavir boosted darunavir (DRV/r) in HIV-1-infected treatment-experienced patients. Method: Retrospective analysis of 81 HIV-1-infected treatment-experienced patients (56 male and 25 female, 5 Polish centers) who switched to RAL/DRV/r. Results: The main reasons for the introduction of dual therapy were renal dysfunction (16/81 patients-19.8%) and virologic failure on previous regimens (15/81 patients-18.5%). At 48 weeks the treatment was continued in 58/81 (71.6% of patients). In three patients the therapy was discontinued because of virologic failure. However, no mutations to DRV or integrase inhibitors (InI) were detected. At 48 weeks of treatment CD4 Conclusions: Dual therapy was effective and safe for the vast majority of antiretroviral-experienced subjects. Such therapy can be recommended especially for patients with renal impairment or NRTIs intolerance.
MeSH term(s)	Adult ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/adverse effects ; Anti-HIV Agents/therapeutic use ; CD4 Lymphocyte Count ; Darunavir/administration & dosage ; Darunavir/adverse effects ; Darunavir/therapeutic use ; Drug Therapy, Combination ; Female ; HIV Infections/drug therapy ; HIV Infections/virology ; HIV Protease Inhibitors/administration & dosage ; HIV Protease Inhibitors/adverse effects ; HIV Protease Inhibitors/therapeutic use ; HIV-1/drug effects ; Humans ; Kidney/drug effects ; Male ; Middle Aged ; Proteinuria/etiology ; RNA, Viral ; Raltegravir Potassium/administration & dosage ; Raltegravir Potassium/adverse effects ; Raltegravir Potassium/therapeutic use ; Retrospective Studies ; Viral Load/drug effects
Chemical Substances	Anti-HIV Agents ; HIV Protease Inhibitors ; RNA, Viral ; Raltegravir Potassium (43Y000U234) ; Darunavir (YO603Y8113)
Language	English
Publishing date	2017-08-31
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.24826
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