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  1. AU="G Chandana"
  2. AU="Boga, Narasimha Rao"
  3. AU="Borm, Frank J"
  4. AU="Nguyen L. Vuong"
  5. AU="Pozner, Jason N"
  6. AU="Vikash R. V. Tatayah"
  7. AU=Carneiro Flvia R.G.
  8. AU="Harrison, Tina"
  9. AU="Hanxin Lu"
  10. AU="Pinto, Bernardo I"
  11. AU=Marek Martin
  12. AU="Rachmilewitz, Eliezer"
  13. AU="Marc S Cortese"
  14. AU=Nguyen Quynh Huong

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  1. Artikel ; Online: Lipid Abnormalities in Tuberculosis Patients with Diabetes Mellitus

    Jyothi / G Chandana / BA Praveen Kumar

    Journal of Clinical and Diagnostic Research, Vol 16, Iss 2, Pp OC01-OC

    A Hospital-based Cross-sectional Study

    2022  Band 04

    Abstract: Introduction: Tuberculosis (TB) is a chronic infectious disease that also causes lipid abnormalities. Limited studies are focusing on metabolic abnormalities in TB patients with Diabetes Mellitus (DM). While studying lipid abnormalities in pulmonary TB ... ...

    Abstract Introduction: Tuberculosis (TB) is a chronic infectious disease that also causes lipid abnormalities. Limited studies are focusing on metabolic abnormalities in TB patients with Diabetes Mellitus (DM). While studying lipid abnormalities in pulmonary TB patients, there were no marked differences between serum levels of cholesterol, triglycerides, Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). However, it was suggested that increased levels of lipoprotein (a) in patients with pulmonary TB may be a risk for atherosclerosis. Aim: To study the lipid abnormalities in TB patients with DM. Materials and Methods: This cross-sectional study was conducted in Department of Pulmonary Medicine at a tertiary care teaching Institute {PES Institute of Medical Sciences and Research (PESIMSR} Andhra Pradesh, India, between October 2015 to March 2016 (six months). Four groups were made, Group I included 30 patients with TB and no DM, Group II included 25 patients with TB with DM, Group III had 30 patients with DM only and Group IV was control group with 30 healthy individuals. Lipid profile testing was done for all the participants and the values obtained were compared. Analysis of Variance (ANOVA) test was used to compare the means between the groups and KruskalWallis test when data did not follow the normal distribution. The p-value <0.05 was considered statistically significant. Results: Total 25 patients in group II had 18 males and seven females with mean age of 48.5±11.12 years. The total cholesterol, triglycerides, Very Low Density Lipoprotein (VLDL) was high in group III (176.33±43.35 mg/dL, 221.733±39.2 mg/dL, 34.8±17.81 mg/dL respectively). The HDL was lowest in group II (27.88±8.03 mg/dL). However, the LDL values showed no significant difference between the groups (p-value=0.162). group I had Low Body Mass Index (BMI) (18.61±3.6 kg/m2 ). The atherogenic index was high in group II especially in males. Conclusion: In patients with TB and DM, screening of lipid profile can provide markers of atherogenicity which may help to predict and prevent cardiovascular events. A good nutritious diet is recommended alongside chemotherapeutics in the treatment for TB patient’s management and their lipid profile status should be monitored while managing the patients.
    Schlagwörter atherogenesis ; cardiovascular risk ; metabolic abnormalities ; nutrition ; oxidative stress ; Medicine ; R
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag JCDR Research and Publications Private Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Buch ; Online: RAMAN

    Krishna, Adithya / Nudurupati, Srikanth Rohit / G, Chandana D / Dwivedi, Pritesh / van Schaik, André / Mehendale, Mahesh / Thakur, Chetan Singh

    A Re-configurable and Sparse tinyML Accelerator for Inference on Edge

    2023  

    Abstract: Deep Neural Network (DNN) based inference at the edge is challenging as these compute and data-intensive algorithms need to be implemented at low cost and low power while meeting the latency constraints of the target applications. Sparsity, in both ... ...

    Abstract Deep Neural Network (DNN) based inference at the edge is challenging as these compute and data-intensive algorithms need to be implemented at low cost and low power while meeting the latency constraints of the target applications. Sparsity, in both activations and weights inherent to DNNs, is a key knob to leverage. In this paper, we present RAMAN, a Re-configurable and spArse tinyML Accelerator for infereNce on edge, architected to exploit the sparsity to reduce area (storage), power as well as latency. RAMAN can be configured to support a wide range of DNN topologies - consisting of different convolution layer types and a range of layer parameters (feature-map size and the number of channels). RAMAN can also be configured to support accuracy vs power/latency tradeoffs using techniques deployed at compile-time and run-time. We present the salient features of the architecture, provide implementation results and compare the same with the state-of-the-art. RAMAN employs novel dataflow inspired by Gustavson's algorithm that has optimal input activation (IA) and output activation (OA) reuse to minimize memory access and the overall data movement cost. The dataflow allows RAMAN to locally reduce the partial sum (Psum) within a processing element array to eliminate the Psum writeback traffic. Additionally, we suggest a method to reduce peak activation memory by overlapping IA and OA on the same memory space, which can reduce storage requirements by up to 50%. RAMAN was implemented on a low-power and resource-constrained Efinix Ti60 FPGA with 37.2K LUTs and 8.6K register utilization. RAMAN processes all layers of the MobileNetV1 model at 98.47 GOp/s/W and the DS-CNN model at 79.68 GOp/s/W by leveraging both weight and activation sparsity.
    Schlagwörter Computer Science - Neural and Evolutionary Computing
    Thema/Rubrik (Code) 005
    Erscheinungsdatum 2023-06-10
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: An Overview of Psychological Analysis of Breast Cancer Patients undergoing Modified Radical Mastectomy and Breast Conservation Surgery and its impact on Objectified Body Consciousness at a Tertiary Care Cancer Centre in South India.

    Shekhar, Neha / Jaiswal, Richa / Joseph, Leesha / Jain, Shraddha / Jain, Salil / Kr, Ashwin / Yashas, Nitin / Fernandes, Aaron / G, Chandana / S, Vanitha / Reddy, Trupthi / Reddy, Lavanya / Kumar, Rohit

    Clinical breast cancer

    2023  Band 23, Heft 7, Seite(n) e394–e400

    Abstract: Background: Breast cancer is the most common cancer among females, and surgery plays a central role in its treatment. Surgical treatments may have a negative psychological impact on women's mental health regarding their body image. The purpose of this ... ...

    Abstract Background: Breast cancer is the most common cancer among females, and surgery plays a central role in its treatment. Surgical treatments may have a negative psychological impact on women's mental health regarding their body image. The purpose of this study was to compare the psychological health insights pertaining to objectified body consciousness scores before and after the surgery and also to observe whether these scores were comparable across the surgery types.
    Materials and methods: This retrospective analysis of prospectively maintained data included 706 breast carcinoma patients who underwent either Breast Conservation Surgery or Modified Radical Mastectomy at tertiary care Cancer Centre, between the years 2020 to 2021. A validated questionnaire of Objectified Body Consciousness was used to obtain responses at diagnosis and at 6 months postsurgery and final scores were calculated for both instances. Two sample t-tests/analysis of variance and Chi-square tests were used to compare continuous and categorical variables respectively.
    Results: Out of total 706 breast cancer patients, 402 patients underwent Breast Conservation Surgery and 304 underwent Modified radical mastectomy procedure. A statistically significant change was seen in the mean Objectified Body Consciousness Score (14.22 ± 15.44) for all patients when compared preoperatively(72.72 ± 11.38) and postoperatively(60.15 ± 17.58). This change was higher in the Modified Radical Mastectomy group(29.38 ± 11.53). Also, statistically significant rise in scores was seen with increasing age.
    Conclusion: We could affirmatively conclude in our study that younger breast cancer patients and all patients who underwent a Modified Radical Mastectomy, had more psychological apprehension with the body image postsurgery, signifying these groups should be encouraged by healthcare professionals to reach out for counselling at the earliest.
    Mesh-Begriff(e) Humans ; Female ; Mastectomy/methods ; Breast Neoplasms/surgery ; Breast Neoplasms/psychology ; Mastectomy, Modified Radical ; Retrospective Studies ; Consciousness ; Tertiary Healthcare ; India ; Mastectomy, Segmental/psychology
    Sprache Englisch
    Erscheinungsdatum 2023-06-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2106734-X
    ISSN 1938-0666 ; 1526-8209
    ISSN (online) 1938-0666
    ISSN 1526-8209
    DOI 10.1016/j.clbc.2023.05.017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Phytochemical investigation and evaluation of in vitro anti-inflammatory activity of Euphorbia hirta ethanol leaf and root extracts

    Kuntal Das / Syed Mohammed Basheeruddin Asdaq / M. Saifulla Khan / S. Amrutha / Abdulhakeem Alamri / Majid Alhomrani / Walaa F. Alsanie / Aparana Bhaskar / G. Chandana shree / P. Harshitha

    Journal of King Saud University: Science, Vol 34, Iss 7, Pp 102261- (2022)

    A comparative study

    2022  

    Abstract: Background: Inflammation is an unpleasant complex biological condition that is with macrophages, leucocytes, and even mast cells. Many marketed effective chemical anti-inflammatory drugs are available but due to many disadvantages people are relying on ... ...

    Abstract Background: Inflammation is an unpleasant complex biological condition that is with macrophages, leucocytes, and even mast cells. Many marketed effective chemical anti-inflammatory drugs are available but due to many disadvantages people are relying on the herbals with low health risk and toxicity. Objective: The research was performed to carryout the phytochemical investigation and explore the in vitro anti-inflammatory activities of leaf and roots extracts of Euphorbia hirta (EH). Methodology: Dried EH parts (viz. leaf and roots) were extracted with ethanol solvent using Soxhlet method and preliminary screened for presence of various phytochemicals. The extracts were also further tested for total alkaloids, flavonoids, and phenolics. After that, anti-inflammatory activity was measured in vitro using albumin denaturation, anti-proteinase, and anti-lipoxygenase activities against conventional anti-inflammatory agent, aspirin (100 g/ml). Finally, a correlation study was generated from the results for presence of the amount of flavonoid and phenolics in connection to the activity. Results: The result revealed the yield was higher in ethanol root extract (48.2 g) than leaf extract. Bioactive compounds alkaloids, glycosides, flavonoids, tannins, and phenolics were reported in leaf and root extracts. Further, the number of total flavonoids and phenolics showed higher in ethanolic leaf extracts (87.53 mg QE/g and 143.20 mg GAE/g). Total alkaloids content was higher in ethanolic root extracts (13.01 mg atropine/g). Ethanol EH leaf extract exhibited significant anti-inflammatory activity than root by inhibiting albumin denaturation, proteinase, and the lipoxygenase activities with 87.51 %, and 51.2 % followed by 97.30 %, and 54.21 % followed by 94.43 % and 48.21 % respectively at 100 µg/ml concentration. Conclusion: The results affirmed that ethanol EH leaf extract showed better anti-inflammatory activity than root extracts when evaluated with three different in vitro models and the dose dependency activity was recorded.
    Schlagwörter Euphorbia hirta ; Phytochemicals ; Albumin denaturation ; Anti-proteinase ; Anti-lipoxygenase ; Science (General) ; Q1-390
    Thema/Rubrik (Code) 580
    Sprache Englisch
    Erscheinungsdatum 2022-10-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Over-the-counter self-medication leading to intracranial hypertension in a young lady

    A M Ramana Reddy / L K Prashanth / G G Sharat Kumar / G Chandana / Rakesh Jadav

    Journal of Neurosciences in Rural Practice, Vol 5, Iss 4, Pp 384-

    2014  Band 386

    Abstract: Intracranial hypertension (idiopathic-IIH and secondary) is a potentially treatable condition. Although various factors such as female gender and obesity, certain drugs have been implicated as risk factors for IIH, there remains a lack of clarity in the ... ...

    Abstract Intracranial hypertension (idiopathic-IIH and secondary) is a potentially treatable condition. Although various factors such as female gender and obesity, certain drugs have been implicated as risk factors for IIH, there remains a lack of clarity in the exact causal-effect relationship. In India, self-medication by obtaining drugs over the counter due to lack of adequate drug regulation and ignorance of the public is a very common practice with a potential for severe adverse effects. We present a case of a young lady who has developed intracranial hypertension possibly due to self-medication with steroids and cyproheptadine, obtained over the counter.
    Schlagwörter Cyproheptadine ; dexamethasone ; idiopathic intracranial hypertension (IIH) ; intracranial hypertension ; steroid withdrawal ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2014-01-01T00:00:00Z
    Verlag Wolters Kluwer Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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