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  1. Article ; Online: Functional assessment in endometrial and cervical cancer: diffusion and perfusion, two captivating tools for radiologists.

    De Muzio, F / Fusco, R / Simonetti, I / Grassi, F / Grassi, R / Brunese, M C / Ravo, L / Maggialetti, N / D'Aniello, R / Greco, F / Gabelloni, M / Granata, V

    European review for medical and pharmacological sciences

    2023  Volume 27, Issue 16, Page(s) 7793–7810

    Abstract: Uterine cervical and endometrial cancers are two major gynecological malignancies, affecting women's health worldwide. Magnetic resonance imaging (MRI) is appropriate for evaluating malignant disease, thanks to the excellent soft tissue contrast and ... ...

    Abstract Uterine cervical and endometrial cancers are two major gynecological malignancies, affecting women's health worldwide. Magnetic resonance imaging (MRI) is appropriate for evaluating malignant disease, thanks to the excellent soft tissue contrast and multiplanar imaging ability. Recently, functional MR techniques, namely diffusion-weighted imaging (DWI) and dynamic contrast-enhanced imaging (DCE), have proved to be a precious support not only in cancer diagnosis but also in disease staging, in the therapy planning, in monitoring response to treatment and during long-term recurrence surveillance. In the field of gynecologic oncology, the European Society of Urogenital Radiology (ESUR) recommends DWI and dynamic contrast-enhanced imaging (DCE-MRI) for local staging of endometrial and cervical cancer, but the potential application of functional imaging in all different aspects of patient management seems very promising. The aim of this article is to summarize the existing literature, providing a comprehensive update on the role of functional MRI in endometrial and cervical cancer.
    MeSH term(s) Female ; Humans ; Uterine Cervical Neoplasms/diagnostic imaging ; Perfusion ; Uterus ; Radiologists ; Endometrial Neoplasms/diagnostic imaging
    Language English
    Publishing date 2023-09-05
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202308_33435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma?

    Ibrahim, Firuz / Gabelloni, Michela / Faggioni, Lorenzo / Padma, Subramanyam / Visakh, Arun R / Cioni, Dania / Neri, Emanuele

    Journal of personalized medicine

    2023  Volume 13, Issue 3

    Abstract: Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. We aimed to compare the performance of ... ...

    Abstract Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. We aimed to compare the performance of SUV
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13030445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diagnostic approach to focal liver lesions at cross-sectional imaging: a primer for beginners.

    Borgheresi, A / Agostini, A / Pierpaoli, L / Zannotti, A / Capodagli-Colarizi, S / Gabelloni, M / De Muzio, F / Brunese, M C / Bruno, F / Palumbo, P / Grassi, F / Fusco, R / Granata, V / Gandolfo, N / Miele, V / Barile, A / Giovagnoni, A

    European review for medical and pharmacological sciences

    2023  Volume 27, Issue 15, Page(s) 7201–7225

    Abstract: Liver imaging encompasses a broad spectrum of diseases in different clinical backgrounds. The available literature is vast and reported data often lacks standardization. Because of all these issues, the differential diagnosis and the characterization of ... ...

    Abstract Liver imaging encompasses a broad spectrum of diseases in different clinical backgrounds. The available literature is vast and reported data often lacks standardization. Because of all these issues, the differential diagnosis and the characterization of liver lesions can be challenging for the beginner. The aim of this narrative review is to provide the basics for an algorithm approach to liver lesions on cross-sectional imaging. First, some tips for the optimization of Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) protocols will be provided. Liver Imaging Reporting and Data System (LI-RADS, version 2018) working group is proposing the adoption of their standardized lexicon beyond the original target population of LI-RADS (i.e., liver cirrhosis). Thus, the main imaging findings will be defined following the LI-RADS lexicon. Since the contrast study is the most important for lesion characterization, this narrative review separates the lesions into avascular, hypovascular, and hypervascular, with a focus on chronic liver disease (CLD) and hepatocellular carcinoma (HCC).
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/diagnostic imaging ; Liver Neoplasms/diagnostic imaging ; Algorithms ; Diagnosis, Differential
    Language English
    Publishing date 2023-08-22
    Publishing country Italy
    Document type Review ; Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202308_33293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Imaging biomarkers in upper gastrointestinal cancers.

    Gabelloni, Michela / Faggioni, Lorenzo / Neri, Emanuele

    BJR open

    2019  Volume 1, Issue 1, Page(s) 20190001

    Abstract: In parallel with the increasingly widespread availability of high performance imaging platforms and recent progresses in pathobiological characterisation and treatment of gastrointestinal malignancies, imaging biomarkers have become a major research ... ...

    Abstract In parallel with the increasingly widespread availability of high performance imaging platforms and recent progresses in pathobiological characterisation and treatment of gastrointestinal malignancies, imaging biomarkers have become a major research topic due to their potential to provide additional quantitative information to conventional imaging modalities that can improve accuracy at staging and follow-up, predict outcome, and guide treatment planning in an individualised manner. The aim of this review is to briefly examine the status of current knowledge about imaging biomarkers in the field of upper gastrointestinal cancers, highlighting their potential applications and future perspectives in patient management from diagnosis onwards.
    Language English
    Publishing date 2019-06-24
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2513-9878
    ISSN (online) 2513-9878
    DOI 10.1259/bjro.20190001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Evidence-based Clinical Decision Support Systems for Suspected Pulmonary Embolism: Are We Ready to Go?

    Faggioni, Lorenzo / Gabelloni, Michela / Neri, Emanuele / Caramella, Davide

    Academic radiology

    2019  Volume 26, Issue 8, Page(s) 1084–1086

    MeSH term(s) Decision Support Systems, Clinical ; Emergency Service, Hospital ; Feasibility Studies ; Humans ; Pulmonary Embolism
    Language English
    Publishing date 2019-05-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2019.04.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Imaging of Adverse Events Related to Checkpoint Inhibitor Therapy.

    Vani, Vanina / Regge, Daniele / Cappello, Giovanni / Gabelloni, Michela / Neri, Emanuele

    Diagnostics (Basel, Switzerland)

    2020  Volume 10, Issue 4

    Abstract: Immunotherapy with checkpoint inhibitors (ICIs) is becoming standard of practice for an increasing number of cancer types. ICIs enhance T-cell action against the cancer cells. By unbalancing the immune system ICIs may cause dysimmune toxicities, a series ...

    Abstract Immunotherapy with checkpoint inhibitors (ICIs) is becoming standard of practice for an increasing number of cancer types. ICIs enhance T-cell action against the cancer cells. By unbalancing the immune system ICIs may cause dysimmune toxicities, a series of disorders broadly defined immune-related adverse events (irAEs). IrAEs may affect any organ or apparatus and most frequently involve skin, colon, endocrine organs, liver, and lungs. Early identification and appropriate treatment of irAEs can improve patient outcome. The paper aims at reviewing mechanisms of the occurrence of irAEs, the importance of a proper diagnosis and the main pillars of therapy. To provide effective guidance to the comprehension of major irAEs imaging findings will be reviewed.
    Language English
    Publishing date 2020-04-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics10040216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Pulmonary sequestration: What the radiologist should know.

    Gabelloni, Michela / Faggioni, Lorenzo / Accogli, Sandra / Aringhieri, Giacomo / Neri, Emanuele

    Clinical imaging

    2020  Volume 73, Page(s) 61–72

    Abstract: Pulmonary sequestration consists of a nonfunctioning mass of lung tissue, either sharing the pleural envelope of the normal lung (intralobar) or with its own pleura (extralobar), lacking normal communication with the tracheobronchial tree and receiving ... ...

    Abstract Pulmonary sequestration consists of a nonfunctioning mass of lung tissue, either sharing the pleural envelope of the normal lung (intralobar) or with its own pleura (extralobar), lacking normal communication with the tracheobronchial tree and receiving its arterial supply by one or more systemic vessels. It is the second most common congenital lung anomaly according to pediatric case series, but its real prevalence is likely to be underestimated, and imaging plays a key role in the diagnosis and treatment management of the condition and its potential complications. We will give a brief overview of the pathophysiology, clinical presentation and imaging findings of intra- and extralobar pulmonary sequestration, with particular reference to multidetector computed tomography as part of a powerful and streamlined diagnostic approach.
    MeSH term(s) Bronchi ; Bronchopulmonary Sequestration/diagnostic imaging ; Child ; Humans ; Lung/diagnostic imaging ; Pleura ; Radiologists
    Language English
    Publishing date 2020-12-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1028123-x
    ISSN 1873-4499 ; 0899-7071
    ISSN (online) 1873-4499
    ISSN 0899-7071
    DOI 10.1016/j.clinimag.2020.11.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Iodine Concentration and Optimization in Computed Tomography Angiography: Current Issues.

    Faggioni, Lorenzo / Gabelloni, Michela

    Investigative radiology

    2016  Volume 51, Issue 12, Page(s) 816–822

    Abstract: Computed tomography (CT) technology has seen a dramatic evolution in the recent past that has deeply changed the face of this diagnostic modality. Since the early days of helical single-slice and then multislice CT, CT angiography (CTA) has been one of ... ...

    Abstract Computed tomography (CT) technology has seen a dramatic evolution in the recent past that has deeply changed the face of this diagnostic modality. Since the early days of helical single-slice and then multislice CT, CT angiography (CTA) has been one of the most technically demanding applications, both in terms of scanning technique and contrast medium (CM) injection protocol, due to the need to acquire a large amount of high-resolution data over a limited period corresponding to the peak contrast enhancement of the arterial system. Iodine concentration is one of the main determinants of arterial enhancement in CTA, and current low-osmolar and iso-osmolar nonionic CM for intravascular administration still come in a handful of molecules, but a relatively wide range of different iodine concentrations. This gives the opportunity to optimize CTA protocols as a function of several factors such as patient characteristics, CT technology, and CM features in an attempt to maximize the diagnostic yield of CTA examinations while considering patient safety and avoiding unnecessary extra costs. Our aim is to provide an up-to-date overview of the existing evidence on how changing iodine concentration can have an impact on CTA performance, especially with the use of state-of-the-art CT and power injector technology, in the perspective of improving patient care while minimizing overall exposure to iodinated CM and ionizing radiation.
    MeSH term(s) Computed Tomography Angiography/methods ; Contrast Media/administration & dosage ; Dose-Response Relationship, Drug ; Humans ; Iodine/administration & dosage ; Radiographic Image Enhancement/methods
    Chemical Substances Contrast Media ; Iodine (9679TC07X4)
    Keywords covid19
    Language English
    Publishing date 2016-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80345-5
    ISSN 1536-0210 ; 0020-9996
    ISSN (online) 1536-0210
    ISSN 0020-9996
    DOI 10.1097/RLI.0000000000000283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Can the computed tomography texture analysis of colorectal liver metastases predict the response to first-line cytotoxic chemotherapy?

    Rabe, Etienne / Cioni, Dania / Baglietto, Laura / Fornili, Marco / Gabelloni, Michela / Neri, Emanuele

    World journal of hepatology

    2021  Volume 14, Issue 1, Page(s) 244–259

    Abstract: Background: Artificial intelligence in radiology has the potential to assist with the diagnosis, prognostication and therapeutic response prediction of various cancers. A few studies have reported that texture analysis can be helpful in predicting the ... ...

    Abstract Background: Artificial intelligence in radiology has the potential to assist with the diagnosis, prognostication and therapeutic response prediction of various cancers. A few studies have reported that texture analysis can be helpful in predicting the response to chemotherapy for colorectal liver metastases, however, the results have varied. Necrotic metastases were not clearly excluded in these studies and in most studies the full range of texture analysis features were not evaluated. This study was designed to determine if the computed tomography (CT) texture analysis results of non-necrotic colorectal liver metastases differ from previous reports. A larger range of texture features were also evaluated to identify potential new biomarkers.
    Aim: To identify potential new imaging biomarkers with CT texture analysis which can predict the response to first-line cytotoxic chemotherapy in non-necrotic colorectal liver metastases (CRLMs).
    Methods: Patients who presented with CRLMs from 2012 to 2020 were retrospectively selected on the institutional radiology information system of our private radiology practice. The inclusion criteria were non-necrotic CRLMs with a minimum size of 10 mm (diagnosed on archived 1.25 mm portal venous phase CT scans) which were treated with standard first-line cytotoxic chemotherapy (FOLFOX, FOLFIRI, FOLFOXIRI, CAPE-OX, CAPE-IRI or capecitabine). The final study cohort consisted of 29 patients. The treatment response of the CRLMs was classified according to the RECIST 1.1 criteria. By means of CT texture analysis, various first and second order texture features were extracted from a single non-necrotic target CRLM in each responding and non-responding patient. Associations between features and response to chemotherapy were assessed by logistic regression models. The prognostic accuracy of selected features was evaluated by using the area under the curve.
    Results: There were 15 responders (partial response) and 14 non-responders (7 stable and 7 with progressive disease). The responders presented with a higher number of CRLMs (
    Conclusion: Eight first and second order texture features, but particularly minimum histogram gradient intensity and long run low grey level emphasis are significantly correlated with treatment response in non-necrotic CRLMs.
    Language English
    Publishing date 2021-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573703-X
    ISSN 1948-5182
    ISSN 1948-5182
    DOI 10.4254/wjh.v14.i1.244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A deep look into radiomics.

    Scapicchio, Camilla / Gabelloni, Michela / Barucci, Andrea / Cioni, Dania / Saba, Luca / Neri, Emanuele

    La Radiologia medica

    2021  Volume 126, Issue 10, Page(s) 1296–1311

    Abstract: Radiomics is a process that allows the extraction and analysis of quantitative data from medical images. It is an evolving field of research with many potential applications in medical imaging. The purpose of this review is to offer a deep look into ... ...

    Abstract Radiomics is a process that allows the extraction and analysis of quantitative data from medical images. It is an evolving field of research with many potential applications in medical imaging. The purpose of this review is to offer a deep look into radiomics, from the basis, deeply discussed from a technical point of view, through the main applications, to the challenges that have to be addressed to translate this process in clinical practice. A detailed description of the main techniques used in the various steps of radiomics workflow, which includes image acquisition, reconstruction, pre-processing, segmentation, features extraction and analysis, is here proposed, as well as an overview of the main promising results achieved in various applications, focusing on the limitations and possible solutions for clinical implementation. Only an in-depth and comprehensive description of current methods and applications can suggest the potential power of radiomics in fostering precision medicine and thus the care of patients, especially in cancer detection, diagnosis, prognosis and treatment evaluation.
    MeSH term(s) Algorithms ; Consensus ; Data Analysis ; Data Mining/methods ; Database Management Systems/organization & administration ; Deep Learning ; Diagnostic Imaging/methods ; Diagnostic Imaging/statistics & numerical data ; Genomics/methods ; Humans ; Image Interpretation, Computer-Assisted/methods ; Machine Learning ; Medical Oncology ; Neoplasms/diagnostic imaging ; Neural Networks, Computer ; Neuroimaging ; Precision Medicine/methods ; Prognosis ; Radiology Information Systems ; Workflow
    Language English
    Publishing date 2021-07-02
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
    DOI 10.1007/s11547-021-01389-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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