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Article ; Online: Impact of exercise training associated to pyridostigmine treatment on autonomic function and inflammatory profile after myocardial infarction in rats.

Feriani, Daniele J / Souza, Gabriel I H / Carrozzi, Nicolle M / Mostarda, Cristiano / Dourado, Paulo M M / Consolim-Colombo, Fernanda M / De Angelis, Kátia / Moreno, Heitor / Irigoyen, Maria Cláudia / Rodrigues, Bruno

International journal of cardiology

2017 Volume 227, Page(s) 757–765

Abstract: Background: The effects of exercise training (ET) associated with pyridostigmine bromide (PYR) treatment on cardiac and autonomic function, as well as on inflammatory profile after myocardial infarction (MI), are unclear.: Methods: Male Wistar rats ... ...

Abstract	Background: The effects of exercise training (ET) associated with pyridostigmine bromide (PYR) treatment on cardiac and autonomic function, as well as on inflammatory profile after myocardial infarction (MI), are unclear. Methods: Male Wistar rats were randomly assigned to: control (C); sedentary+infarcted (I); sedentary+infarcted treated with PYR (IP); infarcted submitted to aerobic exercise training (IT); and infarcted submitted to treatment with PYR and aerobic exercise training (ITP). After 12weeks of ET (50-70% maximal running speed; 1h a day, 5days a week) and/or PYR treatment (0.14mg/mL on drink water), hemodynamic, autonomic and cytokines expression were performed. Results: We observed that both aerobic ET, associated or not with PYR treatment in MI animals, were able to: reduced MI area, improved systolic and diastolic function, baroreflex sensitivity, cardiovascular autonomic modulation, and tonic activity of the sympathetic and parasympathetic nervous system. Also, they led to a reduction of inflammatory profile measured at plasma, left ventricle and soleus skeletal muscle. However, additional effects were observed when ET and PYR were associated, such as an increase in vagal tonus and modulation, reduction of MI area, interferon-γ and tumor necrosis factor-α (TNF-α), as well as an increase of interleukin-10/TNF-α ratio on left ventricle. Conclusion: These data suggest that associating ET and PYR promotes some additional benefits on cardiovascular autonomic modulation and inflammatory profile in infarcted rats.
MeSH term(s)	Animals ; Baroreflex/physiology ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/blood ; Male ; Myocardial Infarction/blood ; Myocardial Infarction/therapy ; Physical Conditioning, Animal/methods ; Pyridostigmine Bromide/pharmacology ; Pyridostigmine Bromide/therapeutic use ; Random Allocation ; Rats ; Rats, Wistar ; Treatment Outcome
Chemical Substances	Cholinesterase Inhibitors ; Inflammation Mediators ; Pyridostigmine Bromide (KVI301NA53)
Language	English
Publishing date	2017-01-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2016.10.061
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Article: Graft versus lymphoma effect after early relapse following reduced-intensity sibling allogeneic stem cell transplantation for relapsed cytotoxic variant of mycosis fungoides.

Gabriel, I H / Olavarria, E / Jones, R R / Whittaker, S / Chaidos, A / Apperley, J F

Bone marrow transplantation

2007 Volume 40, Issue 4, Page(s) 401–403

MeSH term(s)	Fatal Outcome ; Graft vs Host Disease ; Graft vs Tumor Effect ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Leukoencephalopathy, Progressive Multifocal/etiology ; Male ; Middle Aged ; Mycosis Fungoides/complications ; Mycosis Fungoides/therapy ; Siblings ; Transplantation, Homologous
Language	English
Publishing date	2007-08
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	632854-4
ISSN	1476-5365 ; 0268-3369 ; 0951-3078
ISSN (online)	1476-5365
ISSN	0268-3369 ; 0951-3078
DOI	10.1038/sj.bmt.1705741
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Article ; Online: Mechanistic aspects of biosynthesis of silver nanoparticles by several Fusarium oxysporum strains.

Durán, Nelson / Marcato, Priscyla D / Alves, Oswaldo L / Souza, Gabriel I H De / Esposito, Elisa

Journal of nanobiotechnology

2005 Volume 3, Page(s) 8

Abstract: Extracellular production of metal nanoparticles by several strains of the fungus Fusarium oxysporum was carried out. It was found that aqueous silver ions when exposed to several Fusarium oxysporum strains are reduced in solution, thereby leading to the ... ...

Abstract	Extracellular production of metal nanoparticles by several strains of the fungus Fusarium oxysporum was carried out. It was found that aqueous silver ions when exposed to several Fusarium oxysporum strains are reduced in solution, thereby leading to the formation of silver hydrosol. The silver nanoparticles were in the range of 20-50 nm in dimensions. The reduction of the metal ions occurs by a nitrate-dependent reductase and a shuttle quinone extracellular process. The potentialities of this nanotechnological design based in fugal biosynthesis of nanoparticles for several technical applications are important, including their high potential as antibacterial material.
Language	English
Publishing date	2005-07-13
Publishing country	England
Document type	Journal Article
ISSN	1477-3155
ISSN (online)	1477-3155
DOI	10.1186/1477-3155-3-8
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Article ; Online: Fish oil consumption prevents glucose intolerance and hypercorticosteronemy in footshock-stressed rats.

Eguchi, Ricardo / Scarmagnani, Flavia R / Cunha, Claudio A / Souza, Gabriel I H / Pisani, Luciana P / Ribeiro, Eliane B / Oller do Nascimento, Claudia M / Spadari-Bratfisch, Regina C / Oyama, Lila M

Lipids in health and disease

2011 Volume 10, Page(s) 71

Abstract: Background: Environmental stress plays an important role in the development of glucose intolerance influencing lipid and glucose metabolism through sympathetic nervous system, cytokines and hormones such as glucocorticoids, catecholamines and glucagon. ... ...

Abstract	Background: Environmental stress plays an important role in the development of glucose intolerance influencing lipid and glucose metabolism through sympathetic nervous system, cytokines and hormones such as glucocorticoids, catecholamines and glucagon. Otherwise, fish oil prevents glucose intolerance and insulin resistance. Although the mechanisms involved are not fully understood, it is known that sympathetic and HPA responses are blunted and catecholamines and glucocorticoids concentrations can be modulated by fish consumption. The aim of the present study was to evaluate whether fish oil, on a normal lipidic diet: 1) could prevent the effect of footshock-stress on the development of glucose intolerance; 2) modified adiponectin receptor and serum concentration; and 3) also modified TNF-α, IL-6 and interleukin-10 (IL-10) levels in adipose tissue and liver. The study was performed in thirty day-old male Wistar randomly assigned into four groups: no stressed (C) and stressed (CS) rats fed with control diet, and no stressed (F) and stressed (FS) rats fed with a fish oil rich diet. The stress was performed as a three daily footshock stress sessions. Results: Body weight, carcass fat and protein content were not different among groups. FS presented a reduction on the relative weight of RET. Basal serum glucose levels were higher in CS and FS but 15 min after glucose load just CS remained with higher levels than other groups. Serum corticosterone concentration was increased in CS, this effect was inhibited in FS. However, 15 min after footshock-stress, corticosterone levels were similar among groups. IL-6 was increased in EPI of CS but fish oil consumption prevented IL-6 increase in FS. Similar levels of TNF-α and IL-10 in RET, EPI, and liver were observed among groups. Adipo R1 protein concentration was not different among groups. Footshock-stress did not modify AdipoR2 concentration, but fish oil diet increases AdipoR2 protein concentration. Conclusions: Footshock-stress promotes glucose intolerance associated to corticosterone serum level and epididymal white adipose tissue IL-6 concentration increase. The fish oil consumption by stressed rats normalized the stress responses. These results suggested that fish oil intake could be useful to minimize or prevent the development of diseases associated to the stress.
MeSH term(s)	Adiponectin/blood ; Animals ; Area Under Curve ; Blood Glucose/metabolism ; Body Composition/drug effects ; Corticosterone/blood ; Cytokines/metabolism ; Electroshock ; Feeding Behavior/drug effects ; Fish Oils/administration & dosage ; Fish Oils/pharmacology ; Glucose Intolerance/blood ; Glucose Intolerance/prevention & control ; Insulin/blood ; Male ; Organ Specificity/drug effects ; Rats ; Rats, Wistar ; Receptors, Adiponectin/metabolism ; Stress, Physiological/drug effects
Chemical Substances	Adiponectin ; Blood Glucose ; Cytokines ; Fish Oils ; Insulin ; Receptors, Adiponectin ; adiponectin receptor 1, rat ; adiponectin receptor 2, rat ; Corticosterone (W980KJ009P)
Language	English
Publishing date	2011-05-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1476-511X
ISSN (online)	1476-511X
DOI	10.1186/1476-511X-10-71
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Article ; Online: Green tea extract supplementation induces the lipolytic pathway, attenuates obesity, and reduces low-grade inflammation in mice fed a high-fat diet.

Cunha, Cláudio A / Lira, Fábio S / Rosa Neto, José C / Pimentel, Gustavo D / Souza, Gabriel I H / da Silva, Camila Morais Gonçalves / de Souza, Cláudio T / Ribeiro, Eliane B / Sawaya, Alexandra Christine Helena Frankland / Oller do Nascimento, Cláudia M / Rodrigues, Bruno / de Oliveira Carvalho, Patrícia / Oyama, Lila M

Mediators of inflammation

2013 Volume 2013, Page(s) 635470

Abstract: The aim of this study was to evaluate the effects of green tea Camellia sinensis extract on proinflammatory molecules and lipolytic protein levels in adipose tissue of diet-induced obese mice. Animals were randomized into four groups: CW (chow diet and ... ...

Abstract	The aim of this study was to evaluate the effects of green tea Camellia sinensis extract on proinflammatory molecules and lipolytic protein levels in adipose tissue of diet-induced obese mice. Animals were randomized into four groups: CW (chow diet and water); CG (chow diet and water + green tea extract); HW (high-fat diet and water); HG (high-fat diet and water + green tea extract). The mice were fed ad libitum with chow or high-fat diet and concomitantly supplemented (oral gavage) with 400 mg/kg body weight/day of green tea extract (CG and HG, resp.). The treatments were performed for eight weeks. UPLC showed that in 10 mg/mL green tea extract, there were 15 μg/mg epigallocatechin, 95 μg/mg epigallocatechin gallate, 20.8 μg/mg epicatechin gallate, and 4.9 μg/mg gallocatechin gallate. Green tea administered concomitantly with a high-fat diet increased HSL, ABHD5, and perilipin in mesenteric adipose tissue, and this was associated with reduced body weight and adipose tissue gain. Further, we observed that green tea supplementation reduced inflammatory cytokine TNFα levels, as well as TLR4, MYD88, and TRAF6 proinflammatory signalling. Our results show that green tea increases the lipolytic pathway and reduces adipose tissue, and this may explain the attenuation of low-grade inflammation in obese mice.
MeSH term(s)	Adiponectin/metabolism ; Animals ; Catechin/analogs & derivatives ; Catechin/therapeutic use ; Chromatography, High Pressure Liquid ; Diet, High-Fat/adverse effects ; Enzyme-Linked Immunosorbent Assay ; Interleukin-10/metabolism ; Lipolysis/drug effects ; Mice ; Myeloid Differentiation Factor 88/metabolism ; Obesity/drug therapy ; TNF Receptor-Associated Factor 6/metabolism ; Tea/chemistry ; Toll-Like Receptor 4/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Adiponectin ; Myeloid Differentiation Factor 88 ; TNF Receptor-Associated Factor 6 ; Tea ; Tlr4 protein, mouse ; Toll-Like Receptor 4 ; Tumor Necrosis Factor-alpha ; gallocatechin gallate (0C056HB16M) ; Interleukin-10 (130068-27-8) ; Catechin (8R1V1STN48) ; epicatechin gallate (92587OVD8Z) ; epigallocatechin gallate (BQM438CTEL)
Language	English
Publishing date	2013-01-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2013/635470
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Zs.A 3575: Show issues

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Article ; Online: High-fat diets rich in soy or fish oil distinctly alter hypothalamic insulin signaling in rats.

Pimentel, Gustavo D / Dornellas, Ana P S / Rosa, José C / Lira, Fábio S / Cunha, Cláudio A / Boldarine, Valter T / de Souza, Gabriel I H / Hirata, Aparecida E / Nascimento, Cláudia M O / Oyama, Lila M / Watanabe, Regina L H / Ribeiro, Eliane B

The Journal of nutritional biochemistry

2011 Volume 23, Issue 7, Page(s) 822–828

Abstract: Hypothalamic insulin inhibits food intake, preventing obesity. High-fat feeding with polyunsaturated fats may be obesogenic, but their effect on insulin action has not been elucidated. The present study evaluated insulin hypophagia and hypothalamic ... ...

Abstract	Hypothalamic insulin inhibits food intake, preventing obesity. High-fat feeding with polyunsaturated fats may be obesogenic, but their effect on insulin action has not been elucidated. The present study evaluated insulin hypophagia and hypothalamic signaling after central injection in rats fed either control diet (15% energy from fat) or high-fat diets (50% energy from fat) enriched with either soy or fish oil. Soy rats had increased fat pad weight and serum leptin with normal body weight, serum lipid profile and peripheral insulin sensitivity. Fish rats had decreased body and fat pad weight, low leptin and corticosterone levels, and improved serum lipid profile. A 20-mU dose of intracerebroventricular (ICV) insulin inhibited food intake in control and fish groups, but failed to do so in the soy group. Hypothalamic protein levels of IR, IRS-1, IRS-2, Akt, mTOR, p70S6K and AMPK were similar among groups. ICV insulin stimulated IR tyrosine phosphorylation in control (68%), soy (36%) and fish (34%) groups. Tyrosine phosphorylation of the pp185 band was significantly stimulated in control (78%) and soy (53%) rats, but not in fish rats. IRS-1 phosphorylation was stimulated only in control rats (94%). Akt serine phosphorylation was significantly stimulated only in control (90%) and fish (78%) rats. The results showed that, rather than the energy density, the fat type was a relevant aspect of high-fat feeding, since blockade of hypothalamic insulin signal transmission and insulin hypophagia was promoted only by the high-fat soy diet, while they were preserved in the rats fed with the high-fat fish diet.
MeSH term(s)	Adipose Tissue/metabolism ; Animals ; Diet, High-Fat ; Dietary Fats/administration & dosage ; Energy Intake ; Fish Oils/administration & dosage ; Hypothalamus/drug effects ; Hypothalamus/metabolism ; Insulin/metabolism ; Insulin Resistance ; Leptin/blood ; Male ; Phosphorylation ; Rats ; Rats, Wistar ; Signal Transduction/drug effects ; Soybean Oil/administration & dosage ; Glycine max ; Weight Gain
Chemical Substances	Dietary Fats ; Fish Oils ; Insulin ; Leptin ; Soybean Oil (8001-22-7)
Language	English
Publishing date	2011-08-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2011.04.006
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Zs.A 2838: Show issues

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Article ; Online: Higher BMI is not a barrier to stem cell mobilization with standard doses of plerixafor and G-CSF.

Basak, G W / Wiktor-Jedrzejczak, W / Apperley, J F / Douglas, K W / Gabriel, I H / Geraldes, C / Hübel, K / Jaksic, O / Koristek, Z / Lanza, F / Lemoli, R / Mikala, G / Selleslag, D / Worel, N / Mohty, M / Duarte, R F

Bone marrow transplantation

2011 Volume 47, Issue 7, Page(s) 1003–1005

MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Benzylamines ; Body Mass Index ; Contraindications ; Cyclams ; Female ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Hematopoietic Stem Cell Mobilization/methods ; Heterocyclic Compounds/administration & dosage ; Hodgkin Disease/pathology ; Humans ; Lymphoma, Non-Hodgkin/pathology ; Male ; Middle Aged ; Multiple Myeloma/pathology ; Obesity/physiopathology ; Overweight/physiopathology ; Retrospective Studies ; Thinness/physiopathology ; Young Adult
Chemical Substances	Benzylamines ; Cyclams ; Heterocyclic Compounds ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; plerixafor (S915P5499N)
Language	English
Publishing date	2011-10-10
Publishing country	England
Document type	Letter
ZDB-ID	632854-4
ISSN	1476-5365 ; 0268-3369 ; 0951-3078
ISSN (online)	1476-5365
ISSN	0268-3369 ; 0951-3078
DOI	10.1038/bmt.2011.199
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Article ; Online: European data on stem cell mobilization with plerixafor in non-Hodgkin's lymphoma, Hodgkin's lymphoma and multiple myeloma patients. A subgroup analysis of the European Consortium of stem cell mobilization.

Hübel, K / Fresen, M M / Apperley, J F / Basak, G W / Douglas, K W / Gabriel, I H / Geraldes, C / Jaksic, O / Koristek, Z / Kröger, N / Lanza, F / Lemoli, R M / Mikala, G / Selleslag, D / Worel, N / Mohty, M / Duarte, R F

Bone marrow transplantation

2011 Volume 47, Issue 8, Page(s) 1046–1050

Abstract: The effectiveness of the novel hematopoietic stem cell mobilizing agent plerixafor was evaluated in nationwide compassionate use programs in 13 European countries. A total of 580 poor mobilizers with non-Hodgkin's lymphoma (NHL), Hodgkin's lymphoma (HL) ... ...

Abstract	The effectiveness of the novel hematopoietic stem cell mobilizing agent plerixafor was evaluated in nationwide compassionate use programs in 13 European countries. A total of 580 poor mobilizers with non-Hodgkin's lymphoma (NHL), Hodgkin's lymphoma (HL) and multiple myeloma (MM) were enrolled. All patients received plerixafor plus granulocyte CSF with or without chemotherapy. Overall, the collection yield was significantly higher in MM patients (>2.0 × 10(6) CD34+ cells/kg: 81.6%; >5.0 × 10(6) CD34+ cells/kg: 32.0%) than in NHL patients (>2.0 × 10(6) CD34+ cells/kg: 64.8%; >5.0 × 10(6) CD34+ cells/kg: 12.6%; P<0.0001) and also significantly higher in HL patients (>2.0 × 10(6) CD34+ cells/kg: 81.5%; >5.0 × 10(6) CD34+ cells/kg: 22.2%) than in NHL patients (P=0.013). In a subgroup analysis, there were no significant differences in mobilization success comparing patients with diffuse large B-cell lymphoma, follicular lymphoma and mantle cell lymphoma. Our data emphasize the role of plerixafor in poor mobilizers, but further strategies to improve the apheresis yield especially in patients with NHL are required.
MeSH term(s)	Adolescent ; Adult ; Aged ; Anti-HIV Agents/administration & dosage ; Blood Component Removal/methods ; Child ; European Union ; Female ; Granulocyte Colony-Stimulating Factor ; Hematopoietic Stem Cell Mobilization/methods ; Hematopoietic Stem Cell Transplantation ; Heterocyclic Compounds/administration & dosage ; Hodgkin Disease/blood ; Hodgkin Disease/therapy ; Humans ; Leukocyte Count ; Lymphoma, Non-Hodgkin/blood ; Lymphoma, Non-Hodgkin/therapy ; Male ; Middle Aged ; Multiple Myeloma/blood ; Multiple Myeloma/therapy ; Transplantation, Homologous
Chemical Substances	Anti-HIV Agents ; Heterocyclic Compounds ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; plerixafor (S915P5499N)
Language	English
Publishing date	2011-11-14
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Multicenter Study
ZDB-ID	632854-4
ISSN	1476-5365 ; 0268-3369 ; 0951-3078
ISSN (online)	1476-5365
ISSN	0268-3369 ; 0951-3078
DOI	10.1038/bmt.2011.216
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Article: Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NFκBp65 signaling in adult offspring

Pimentel, Gustavo D / Lira, Fábio S / Rosa, José C / Oliveira, Juliana L / Losinskas-Hachul, Ana C / Souza, Gabriel I.H / das Graças T. do Carmo, Maria / Santos, Ronaldo V.T / de Mello, Marco T / Tufik, Sérgio / Seelaender, Marília / Oyama, Lila M / Oller do Nascimento, Cláudia M / Watanabe, Regina H / Ribeiro, Eliane B / Pisani, Luciana P

Journal of nutritional biochemistry. 2012 Mar., v. 23, no. 3

2012

Abstract: We examined whether feeding pregnant and lactating rats with hydrogenated vegetable fats rich in trans fatty acids led to an increase in serum endotoxin levels and inflammation and to impaired satiety-sensing pathways in the hypothalamus of 90-day-old ... ...

Abstract	We examined whether feeding pregnant and lactating rats with hydrogenated vegetable fats rich in trans fatty acids led to an increase in serum endotoxin levels and inflammation and to impaired satiety-sensing pathways in the hypothalamus of 90-day-old offspring. Pregnant and lactating Wistar rats were fed either a standard chow (Control) or one enriched with hydrogenated vegetable fat (Trans). Upon weaning, the male offspring were divided in two groups: Control-Control (CC), mothers and offspring fed the control diet; and Trans-Control (TC), mothers fed the trans diet, and offspring fed the control diet. The offspring's food intake and body weight were quantified weekly and the offspring were killed on the 90th day of life by decapitation. The blood and hypothalamus were collected from the offspring. Food intake and body weight were higher in the TC rats than in the CC rats. TC rats had increased serum endotoxin levels and increased hypothalamic cytokines, IL-6, TNF-α and IL1-β, concentrations (P<.05). TLR4, NFκBp65 and MyD88 were higher (P<.05) in the TC rats than in the CC rats. AdipoR1 was lower in the TC rats than in the CC rats. Thus, the present study shows that the mothers' hydrogenated vegetable fat intake during pregnancy and lactation led to hypothalamic inflammation and impaired satiety-sensing, which promotes deleterious metabolic consequences such as obesity, even after the withdrawal of the causal factor. In other words, the effect remains after the consumption of the standard chow by offspring.
Keywords	adults ; blood ; decapitation ; fat intake ; food intake ; hypothalamus ; inflammation ; interleukin-6 ; lactation ; mothers ; obesity ; plant fats ; pregnancy ; progeny ; rats ; trans fatty acids ; tumor necrosis factor-alpha ; vegetables ; weaning
Language	English
Dates of publication	2012-03
Size	p. 265-271.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2010.12.003
Database	NAL-Catalogue (AGRICOLA)

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Article: High-fat diets rich in soy or fish oil distinctly alter hypothalamic insulin signaling in rats

Pimentel, Gustavo D / Dornellas, Ana P.S / Rosa, José C / Lira, Fábio S / Cunha, Cláudio A / Boldarine, Valter T / de Souza, Gabriel I.H / Hirata, Aparecida E / Nascimento, Cláudia M.O / Oyama, Lila M / Watanabe, Regina L.H / Ribeiro, Eliane B

Journal of nutritional biochemistry. 2012 July, v. 23, no. 7

2012

Abstract	Hypothalamic insulin inhibits food intake, preventing obesity. High-fat feeding with polyunsaturated fats may be obesogenic, but their effect on insulin action has not been elucidated. The present study evaluated insulin hypophagia and hypothalamic signaling after central injection in rats fed either control diet (15% energy from fat) or high-fat diets (50% energy from fat) enriched with either soy or fish oil. Soy rats had increased fat pad weight and serum leptin with normal body weight, serum lipid profile and peripheral insulin sensitivity. Fish rats had decreased body and fat pad weight, low leptin and corticosterone levels, and improved serum lipid profile. A 20-mU dose of intracerebroventricular (ICV) insulin inhibited food intake in control and fish groups, but failed to do so in the soy group. Hypothalamic protein levels of IR, IRS-1, IRS-2, Akt, mTOR, p70S6K and AMPK were similar among groups. ICV insulin stimulated IR tyrosine phosphorylation in control (68%), soy (36%) and fish (34%) groups. Tyrosine phosphorylation of the pp185 band was significantly stimulated in control (78%) and soy (53%) rats, but not in fish rats. IRS-1 phosphorylation was stimulated only in control rats (94%). Akt serine phosphorylation was significantly stimulated only in control (90%) and fish (78%) rats. The results showed that, rather than the energy density, the fat type was a relevant aspect of high-fat feeding, since blockade of hypothalamic insulin signal transmission and insulin hypophagia was promoted only by the high-fat soy diet, while they were preserved in the rats fed with the high-fat fish diet.
Keywords	blood lipids ; energy ; energy density ; fish ; fish oils ; food intake ; high fat diet ; insulin ; insulin resistance ; leptin ; obesity ; phosphorylation ; polyunsaturated fatty acids ; rats ; tyrosine ; undereating
Language	English
Dates of publication	2012-07
Size	p. 822-828.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2011.04.006
Database	NAL-Catalogue (AGRICOLA)

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