LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="GabrielVirella"
  2. AU="He, Jinzhi"
  3. AU="Sergio Recuenco Cabrera"
  4. AU="Kratochwill, Klaus"
  5. AU="Somaye Ansari"
  6. AU="McCoy, Andrew M"
  7. AU="Abbas, Muhammad Mujtaba"
  8. AU="Yan Zhang"
  9. AU="Gueziri, Houssem-Eddine"
  10. AU="Johnson, Anna M"
  11. AU="Gutiérrez-Zufiaurre, María Nieves"
  12. AU="Härter, Andreas"
  13. AU="Hossbach, T"
  14. AU="Samr-Ul-Husnain"
  15. AU="Mukawera, Espérance"
  16. AU=Almaqwashi Ali A.
  17. AU="Workman, R L"
  18. AU="Gordini, Giovanni"
  19. AU=Beck Andrew H.
  20. AU="Aybar, N"
  21. AU="Majidian Ba, Mandy"
  22. AU=Botero-Rodriguez Felipe AU=Botero-Rodriguez Felipe
  23. AU="Pozo, Franco Andres Del"
  24. AU="Ohno, Hideaki"
  25. AU="Mohit"
  26. AU="Jzerman, Hans I"
  27. AU="Deepali Jain"
  28. AU=Cimen S.
  29. AU="Laskey, Daniel"
  30. AU="Pérez, Noelia"
  31. AU="Shaf Keshavjee"
  32. AU=Stewart J. D.
  33. AU="Victor Daka"
  34. AU="Iglesias, C"
  35. AU="Williams, Howard L."
  36. AU=Tilmann Christopher
  37. AU=Stefansson Steingrimur
  38. AU="Schindler, Tobias"
  39. AU="Araújo, Cristina de O"
  40. AU=Goda Jayant S.
  41. AU="Peditto, Piera"
  42. AU="Dünn, Hans-Wilhelm"
  43. AU=Tyznik Aaron J.
  44. AU="Siddiqui, Fasih Sami"
  45. AU="Abt, S."
  46. AU="Sultana, Sufia"
  47. AU="Yuan, Shengwang"
  48. AU="Sedehizadeh, Saam"
  49. AU=Jeon Young-Woo
  50. AU=Narayanan Navaneeth
  51. AU=Beckwith Kyle A.
  52. AU=Anderson Robert H
  53. AU=Trindade P A
  54. AU=Gohil R
  55. AU="Zhengyi, Wu"
  56. AU=Wessels J A M
  57. AU="Porter, Lavinia"
  58. AU=Al-Mayman Sulaiman

Suchergebnis

Treffer 1 - 2 von insgesamt 2

Suchoptionen

  1. Artikel ; Online: The role of the immune system in the pathogenesis of diabetic complications

    GabrielVirella

    Frontiers in Endocrinology, Vol

    2014  Band 5

    Schlagwörter Diabetes Complications ; Immune System ; Pathogenesis ; diabetic complications ; Editorial ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2014-07-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: The Pathogenic Role of the Adaptive Immune Response to Modified LDL in Diabetes

    GabrielVirella / MariaF.Lopes-Virella

    Frontiers in Endocrinology, Vol

    2012  Band 3

    Abstract: The main causes of morbidity and mortality in diabetes are macro and microvascular complications, including atherosclerosis, nephropathy, and retinopathy. As the definition of atherosclerosis as a chronic inflammatory disease became widely accepted, it ... ...

    Abstract The main causes of morbidity and mortality in diabetes are macro and microvascular complications, including atherosclerosis, nephropathy, and retinopathy. As the definition of atherosclerosis as a chronic inflammatory disease became widely accepted, it became important to define the triggers of vascular inflammation. Oxidative and other modifications of lipids and lipoproteins emerged as major pathogenic factors in atherosclerosis. Modified forms of LDL (mLDL) are proinflammatory by themselves, but, in addition, mLDLs including oxidized, malondialdehyde (MDA)-modified, and Advanced Glycation End (AGE)-product-modified LDL induce autoimmune responses in humans. The autoimmune response involves T cells in the arterial wall and synthesis of IgG antibodies. The IgG autoantibodies that react with mLDLs generate immune complexes (IC) both intra and extravascularly, and those IC activate the complement system as well as phagocytic cells via the ligation of Fcγ receptors. In vitro studies proved that the pro-inflammatory activity of IC containing mLDL (mLDL-IC) is several-fold higher than that of the modified LDL molecules. Clinical studies support the pathogenic role of mLDL-IC in the development of macrovasccular disease patients with diabetes. In type 1 diabetes, high levels of oxidized and AGE- LDL in IC were associated with internal carotid intima-media thickening and coronary calcification. In type 2 diabetes, high levels of MDA-LDL in IC predicted the occurrence of myocardial infarction. There is also evidence that mLDL-IC are involved in the pathogenesis of diabetic nephropathy and retinopathy. The pathogenic role of mLDL-IC is not unique to diabetic patients, because those IC are also detected in non-diabetic individuals. But mLDL IC are likely to reach higher concentrations and have a more prominent pathogenic role in diabetes due to increased antigenic load secondary to high oxidative stress and to enhanced autoimmune responses in type 1 diabetes.
    Schlagwörter Atherosclerosis ; LDL modification in diabetes ; immune complexes ; autoimmune response to modified LDL ; diabetic complications ; oxidized LDL ; oxidized LDL antibodies ; nephropathy ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2012-06-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang