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  1. Book: Medizinische Proben und Abfälle

    Gadomski, Sylvia / Koch, Bodo

    richtig klassifizieren, kennzeichnen, verpacken und transportieren

    2023  

    Author's details Sylvia Gadomski, Bodo Koch
    Keywords Absender ; Ansteckungsgefährliche Stoffe ; Arzt ; Gefahrgut ; Klasse 6.2 ; Klinikleiter ; Krankenhaus ; Ladungssicherung ; Postversand ; Unterweisung ; Hardcover, Softcover / Recht/Sonstiges ; Deutschland ; Gesundheitsschädlicher Stoff ; Krankenhausabfall ; Transportverpackung ; Transport
    Subject Transportwesen ; Gefährliches Gut ; Gefahrgüter ; Versandverpackung ; Krankenhausmüll ; Krankenhaus ; Klinikabfall ; Klinikmüll ; Gesundheitsgefährdender Stoff ; Gesundheitsgefährlicher Stoff ; Gesundheitsschädliche Stoffe
    Language German
    Size 90 Seiten, Illustrationen
    Edition [4. Auflage]
    Publisher ecomed Sicherheit
    Publishing place Landsberg am Lech
    Publishing country Germany
    Document type Book
    Old title Vorangegangen ist
    HBZ-ID HT030595674
    ISBN 978-3-609-69569-3 ; 3-609-69569-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2024 A 37 available for loan (reading room) Lesesaal EG

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  2. Book: Medizinische Proben und Abfälle

    Gadomski, Sylvia / Koch, Bodo

    richtig klassifizieren, kennzeichnen, verpacken und transportieren

    2021  

    Author's details Sylvia Gadomski, Bodo Koch
    Keywords Absender ; Ansteckungsgefährliche Stoffe ; Arzt ; Gefahrgut ; Klasse 6.2 ; Klinikleiter ; Krankenhaus ; Ladungssicherung ; Postversand ; Unterweisung ; Deutschland ; Gesundheitsschädlicher Stoff ; Krankenhausabfall ; Transportverpackung ; Transport
    Subject Versandverpackung ; Transportwesen ; Gefährliches Gut ; Gefahrgüter ; Krankenhausmüll ; Krankenhaus ; Klinikabfall ; Klinikmüll ; Gesundheitsgefährdender Stoff ; Gesundheitsgefährlicher Stoff ; Gesundheitsschädliche Stoffe
    Language German
    Size 88 Seiten, Illustrationen, 21 cm x 14.8 cm
    Edition [3. Auflage]
    Publisher ecomed Sicherheit
    Publishing place Landsberg
    Publishing country Germany
    Document type Book
    Old title Vorangegangen ist
    HBZ-ID HT020896280
    ISBN 978-3-609-69476-4 ; 3-609-69476-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2021 A 413 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Inhibitor of DNA binding proteins revealed as orchestrators of steady state, stress and malignant hematopoiesis.

    Singh, Shweta / Sarkar, Tanmoy / Jakubison, Brad / Gadomski, Stephen / Spradlin, Andrew / Gudmundsson, Kristbjorn O / Keller, Jonathan R

    Frontiers in immunology

    2022  Volume 13, Page(s) 934624

    Abstract: Adult mammalian hematopoiesis is a dynamic cellular process that provides a continuous supply of myeloid, lymphoid, erythroid/megakaryocyte cells for host survival. This process is sustained by regulating hematopoietic stem cells (HSCs) quiescence, ... ...

    Abstract Adult mammalian hematopoiesis is a dynamic cellular process that provides a continuous supply of myeloid, lymphoid, erythroid/megakaryocyte cells for host survival. This process is sustained by regulating hematopoietic stem cells (HSCs) quiescence, proliferation and activation under homeostasis and stress, and regulating the proliferation and differentiation of downstream multipotent progenitor (MPP) and more committed progenitor cells. Inhibitor of DNA binding (ID) proteins are small helix-loop-helix (HLH) proteins that lack a basic (b) DNA binding domain present in other family members, and function as dominant-negative regulators of other bHLH proteins (E proteins) by inhibiting their transcriptional activity. ID proteins are required for normal T cell, B cell, NK and innate lymphoid cells, dendritic cell, and myeloid cell differentiation and development. However, recent evidence suggests that ID proteins are important regulators of normal and leukemic hematopoietic stem and progenitor cells (HSPCs). This chapter will review our current understanding of the function of ID proteins in HSPC development and highlight future areas of scientific investigation.
    MeSH term(s) Animals ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; DNA ; Hematopoiesis/genetics ; Immunity, Innate ; Lymphocytes/metabolism ; Mammals/genetics
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; DNA (9007-49-2)
    Language English
    Publishing date 2022-08-05
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.934624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Handoffs and Transitions of Care: A Systematic Review, Meta-Analysis, and Practice Management Guideline from the Eastern Association for the Surgery of Trauma.

    Appelbaum, Rachel D / Puzio, Thaddeus J / Bauman, Zachary / Asfaw, Sofya / Spencer, Audrey / Dumas, Ryan P / Kaur, Kavneet / Cunningham, Kyle W / Butler, Dale / Sawhney, Jaswin S / Gadomski, Stephen / Horwood, Chelsea R / Stuever, Mary / Sapp, Alyssa / Gandhi, Rajesh / Freeman, Jennifer

    The journal of trauma and acute care surgery

    2024  

    Abstract: Background: The Joint Commission reports at least half of communication breakdowns occur during handovers or transitions of care. There is no consensus on how best to approach the transfer of care within Acute Care Surgery (ACS). We conduct a systematic ...

    Abstract Background: The Joint Commission reports at least half of communication breakdowns occur during handovers or transitions of care. There is no consensus on how best to approach the transfer of care within Acute Care Surgery (ACS). We conduct a systematic review and meta-analysis of the current data on handoffs and transitions of care in ACS patients and evaluate the impact of standardization and formalized communication processes.
    Methods: Clinically relevant questions regarding handoffs and transitions of care with clearly defined patient Population(s), Intervention(s), Comparison(s), and appropriately selected Outcomes (PICO) were determined. These centered around specific transitions of care within the setting of ACS - specifically perioperative interactions, EMS and trauma team interactions, and intra/inter floor and ICU interactions. A systematic literature review and meta-analysis was conducted utilizing the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology.
    Results: A total of 10 studies were identified for analysis. These included 5,113 patients in the standardized handoff group and 5,293 in the current process group. Standardized handoffs reduced handover errors for perioperative interactions and preventable adverse events for intra/inter floor and ICU interactions. There was insufficient data to evaluate outcomes of clinical complications and medical errors.
    Conclusion: We conditionally recommend a standardized handoff in in the field of ACS, including perioperative interactions, EMS and trauma team interactions, as well as intra-inter floor and ICU interactions.
    Level of evidence: Guideline; Systematic review/meta-analysis, Level III.
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000004285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis.

    Fielding, Claire / García-García, Andrés / Korn, Claudia / Gadomski, Stephen / Fang, Zijian / Reguera, Juan L / Pérez-Simón, José A / Göttgens, Berthold / Méndez-Ferrer, Simón

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 543

    Abstract: The sympathetic nervous system has been evolutionary selected to respond to stress and activates haematopoietic stem cells via noradrenergic signals. However, the pathways preserving haematopoietic stem cell quiescence and maintenance under proliferative ...

    Abstract The sympathetic nervous system has been evolutionary selected to respond to stress and activates haematopoietic stem cells via noradrenergic signals. However, the pathways preserving haematopoietic stem cell quiescence and maintenance under proliferative stress remain largely unknown. Here we found that cholinergic signals preserve haematopoietic stem cell quiescence in bone-associated (endosteal) bone marrow niches. Bone marrow cholinergic neural signals increase during stress haematopoiesis and are amplified through cholinergic osteoprogenitors. Lack of cholinergic innervation impairs balanced responses to chemotherapy or irradiation and reduces haematopoietic stem cell quiescence and self-renewal. Cholinergic signals activate α7 nicotinic receptor in bone marrow mesenchymal stromal cells leading to increased CXCL12 expression and haematopoietic stem cell quiescence. Consequently, nicotine exposure increases endosteal haematopoietic stem cell quiescence in vivo and impairs hematopoietic regeneration after haematopoietic stem cell transplantation in mice. In humans, smoking history is associated with delayed normalisation of platelet counts after allogeneic haematopoietic stem cell transplantation. These results suggest that cholinergic signals preserve stem cell quiescence under proliferative stress.
    MeSH term(s) Animals ; Bone Marrow/metabolism ; Chemokine CXCL12/metabolism ; Cholinergic Agents/metabolism ; Glial Cell Line-Derived Neurotrophic Factor Receptors/genetics ; Hematopoiesis/physiology ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/metabolism ; Humans ; Mesenchymal Stem Cells/metabolism ; Mice ; Receptors, Adrenergic, beta-3/metabolism ; Risk Factors
    Chemical Substances Adrb3 protein, mouse ; CXCL12 protein, human ; Chemokine CXCL12 ; Cholinergic Agents ; Gfra2 protein, mouse ; Glial Cell Line-Derived Neurotrophic Factor Receptors ; Receptors, Adrenergic, beta-3
    Language English
    Publishing date 2022-01-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-28175-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Thesis: Erhebung über das Vorkommen der Infektionskrankheiten Lungen-Tuberkolose, Hepatitis B und Lues bei der freiwilligen Untersuchung von Asylbewerbern aus A: Osteuropa und dem Mittleren Osten und B: Asien und Afrika im Gesundheitsamt Braunschweig in den Jahren 1990 und 1991

    Petersen- von Gadomski, Sabine / Gadomski, Bodo S. von

    1994  

    Author's details vorgelegt von Sabine Petersen- von Gadomski und Bodo S. von Gadomski
    Language German
    Size 76 Bl.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hannover, Med. Hochsch., Diss., 1995
    HBZ-ID HT006808636
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    95 E 2218 order for loan Magazin

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  7. Article ; Online: Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.

    Gadomski, Stephen / Singh, Satyendra K / Singh, Shweta / Sarkar, Tanmoy / Klarmann, Kimberly D / Berenschot, Maximillian / Seaman, Steven / Jakubison, Brad / Gudmundsson, Kristbjorn O / Lockett, Stephen / Keller, Jonathan R

    Cell reports

    2020  Volume 31, Issue 4, Page(s) 107572

    Abstract: Investigating mechanisms that regulate endothelial cell (EC) growth and survival is important for understanding EC homeostasis and how ECs maintain stem cell niches. We report here that targeted loss of Id genes in adult ECs results in dilated, leaky ... ...

    Abstract Investigating mechanisms that regulate endothelial cell (EC) growth and survival is important for understanding EC homeostasis and how ECs maintain stem cell niches. We report here that targeted loss of Id genes in adult ECs results in dilated, leaky sinusoids and a pro-inflammatory state that increases in severity over time. Disruption in sinusoidal integrity leads to increased hematopoietic stem cell (HSC) proliferation, differentiation, migration, and exhaustion. Mechanistically, sinusoidal ECs (SECs) show increased apoptosis because of reduced Bcl2-family gene expression following Id gene ablation. Furthermore, Id1
    MeSH term(s) Animals ; Cell Survival/physiology ; Disease Models, Animal ; Endothelial Cells/metabolism ; Endothelial Cells/physiology ; Female ; Hematopoiesis/physiology ; Humans ; Inhibitor of Differentiation Protein 1/metabolism ; Inhibitor of Differentiation Proteins/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Regeneration/physiology
    Chemical Substances Idb1 protein, mouse ; Inhibitor of Differentiation Protein 1 ; Inhibitor of Differentiation Proteins ; Idb3 protein, mouse (135845-89-5)
    Language English
    Publishing date 2020-04-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2020.107572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.

    Gadomski, Stephen / Fielding, Claire / García-García, Andrés / Korn, Claudia / Kapeni, Chrysa / Ashraf, Sadaf / Villadiego, Javier / Toro, Raquel Del / Domingues, Olivia / Skepper, Jeremy N / Michel, Tatiana / Zimmer, Jacques / Sendtner, Regine / Dillon, Scott / Poole, Kenneth E S / Holdsworth, Gill / Sendtner, Michael / Toledo-Aral, Juan J / De Bari, Cosimo /
    McCaskie, Andrew W / Robey, Pamela G / Méndez-Ferrer, Simón

    Cell stem cell

    2022  Volume 29, Issue 4, Page(s) 528–544.e9

    Abstract: The autonomic nervous system is a master regulator of homeostatic processes and stress responses. Sympathetic noradrenergic nerve fibers decrease bone mass, but the role of cholinergic signaling in bone has remained largely unknown. Here, we describe ... ...

    Abstract The autonomic nervous system is a master regulator of homeostatic processes and stress responses. Sympathetic noradrenergic nerve fibers decrease bone mass, but the role of cholinergic signaling in bone has remained largely unknown. Here, we describe that early postnatally, a subset of sympathetic nerve fibers undergoes an interleukin-6 (IL-6)-induced cholinergic switch upon contacting the bone. A neurotrophic dependency mediated through GDNF-family receptor-α2 (GFRα2) and its ligand, neurturin (NRTN), is established between sympathetic cholinergic fibers and bone-embedded osteocytes, which require cholinergic innervation for their survival and connectivity. Bone-lining osteoprogenitors amplify and propagate cholinergic signals in the bone marrow (BM). Moderate exercise augments trabecular bone partly through an IL-6-dependent expansion of sympathetic cholinergic nerve fibers. Consequently, loss of cholinergic skeletal innervation reduces osteocyte survival and function, causing osteopenia and impaired skeletal adaptation to moderate exercise. These results uncover a cholinergic neuro-osteocyte interface that regulates skeletogenesis and skeletal turnover through bone-anabolic effects.
    MeSH term(s) Cholinergic Agents ; Cholinergic Fibers ; Glial Cell Line-Derived Neurotrophic Factor Receptors/physiology ; Interleukin-6 ; Osteogenesis
    Chemical Substances Cholinergic Agents ; Glial Cell Line-Derived Neurotrophic Factor Receptors ; Interleukin-6
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2022.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6589: Show issues Location:
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  9. Article ; Online: Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging.

    Singh, Satyendra K / Singh, Shweta / Gadomski, Stephen / Sun, Lei / Pfannenstein, Alexander / Magidson, Valentin / Chen, Xiongfong / Kozlov, Serguei / Tessarollo, Lino / Klarmann, Kimberly D / Keller, Jonathan R

    Cell stem cell

    2018  Volume 23, Issue 2, Page(s) 252–265.e8

    Abstract: Defining mechanisms that maintain tissue stem cells during homeostasis, stress, and aging is important for improving tissue regeneration and repair and enhancing cancer therapies. Here, we show that Id1 is induced in hematopoietic stem cells (HSCs) by ... ...

    Abstract Defining mechanisms that maintain tissue stem cells during homeostasis, stress, and aging is important for improving tissue regeneration and repair and enhancing cancer therapies. Here, we show that Id1 is induced in hematopoietic stem cells (HSCs) by cytokines that promote HSC proliferation and differentiation, suggesting that it functions in stress hematopoiesis. Genetic ablation of Id1 increases HSC self-renewal in serial bone marrow transplantation (BMT) assays, correlating with decreases in HSC proliferation, mitochondrial biogenesis, and reactive oxygen species (ROS) production. Id1
    MeSH term(s) Aging/metabolism ; Animals ; Cells, Cultured ; Hematopoietic Stem Cells/metabolism ; Inhibitor of Differentiation Protein 1/deficiency ; Inhibitor of Differentiation Protein 1/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Stress, Physiological
    Chemical Substances Idb1 protein, mouse ; Inhibitor of Differentiation Protein 1
    Language English
    Publishing date 2018-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2018.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Investigational surgery of the canine frontal sinus.

    Gadomski, S P / Lowry, L D

    Transactions - Pennsylvania Academy of Ophthalmology and Otolaryngology

    1986  Volume 38, Issue 2, Page(s) 415–421

    MeSH term(s) Animals ; Dogs ; Frontal Sinus/anatomy & histology ; Frontal Sinus/physiology ; Frontal Sinus/surgery ; Mucous Membrane/physiology ; Regeneration
    Language English
    Publishing date 1986
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603877-3
    ISSN 0048-3206
    ISSN 0048-3206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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