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Book: Obstetricia en esquemas

Gadow, Enrique C

2004

Author's details	Gadow, Fiorillo [editores]
MeSH term(s)	Obstetrics ; Pregnancy Complications
Language	Spanish
Size	xvii, 457 p. :, ill.
Edition	1. ed. de Editorial El Ateneo.
Publisher	El Ateneo
Publishing place	Buenos Aires
Document type	Book
ISBN	9789500204101 ; 950024010X ; 950020410X ; 9789500240109
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Prenatal screening for chromosome abnormalities in a region with no access to termination of pregnancy.

Paolini, Cynthia I / Gadow, Andrea / Petracchi, Florencia / Igarzabal, Laura / Quadrelli, Roberto / Gadow, Enrique C

Prenatal diagnosis

2009 Volume 29, Issue 7, Page(s) 659–663

Abstract: Objective: To analyze the different variables that affect couples' decision-making about prenatal screening of chromosome abnormalities in a population with limited access to prenatal diagnosis and no legal termination of pregnancy (TOP).: Methods: ... ...

Abstract	Objective: To analyze the different variables that affect couples' decision-making about prenatal screening of chromosome abnormalities in a population with limited access to prenatal diagnosis and no legal termination of pregnancy (TOP). Methods: From February through August 2004, 79 couples who requested for prenatal screening at centers from Argentina and Uruguay participated in a study. A cross-sectional survey was administered to assess attitudes toward prenatal screening, the decision-making process, and knowledge and attitudes toward TOP. Results: Mean maternal age was 32.8 +/- 0.4 years. Among the couples, 88.61% knew that TOP due to fetal anomalies is not legal in their countries. When asked about the possibility of TOP in case of a serious fetal anomaly, 53% would contemplate this option. Conclusion: Prenatal screening is a common practice worldwide. However, unlike most developed countries, our region has a limited access to prenatal diagnosis and no legal TOP. Those couples who stated that 'reassurance about fetal well-being' was the most important reason to perform prenatal screening had more positive attitudes toward TOP than those who considered this screening important 'to be better prepared to receive the baby'. Our findings can be used to inform and revise current health-care policies.
MeSH term(s)	Abortion, Eugenic/legislation & jurisprudence ; Abortion, Eugenic/psychology ; Adult ; Attitude to Health ; Chromosome Disorders/diagnosis ; Chromosome Disorders/therapy ; Cross-Sectional Studies ; Decision Making ; Female ; Genetic Counseling/psychology ; Genetic Counseling/utilization ; Genetic Testing/utilization ; Health Services Accessibility/legislation & jurisprudence ; Humans ; Maternal Age ; Pregnancy ; Prenatal Diagnosis/utilization ; Referral and Consultation ; Social Class
Language	English
Publishing date	2009-07
Publishing country	England
Document type	Journal Article
ZDB-ID	82031-3
ISSN	1097-0223 ; 0197-3851
ISSN (online)	1097-0223
ISSN	0197-3851
DOI	10.1002/pd.2270
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Article ; Online: Environmental risk factors and perinatal outcomes in preterm newborns, according to family recurrence of prematurity.

Krupitzki, Hugo B / Gadow, Enrique C / Gili, Juan A / Comas, Belén / Cosentino, Viviana R / Saleme, César / Murray, Jeffrey C / Lopez Camelo, Jorge S

American journal of perinatology

2012 Volume 30, Issue 6, Page(s) 451–461

Abstract: Objective: We analyzed the role of environmental risk factors, sociodemographic characteristics, clinical characteristics, and reproductive history in preterm births and their associated perinatal outcomes in families classified according to their ... ...

Abstract	Objective: We analyzed the role of environmental risk factors, sociodemographic characteristics, clinical characteristics, and reproductive history in preterm births and their associated perinatal outcomes in families classified according to their histories of preterm recurrence among siblings. Study design: A retrospective study was conducted at Nuestra Señora de la Merced Maternity Hospital in the city of Tucumán, Argentina. A total of 348 preterm, non-malformed, singleton children born to multipara women were reviewed. The family history score described by Khoury was applied, and families were classified as having no, medium, or high genetic aggregation. Results: Families with no familial aggregation showed a higher rate of short length of cohabitation, maternal urinary tract infections during the current pregnancy, and maternal history of miscarriage during the previous pregnancy. Families with a high level of aggregation had a significantly higher incidence of pregnancy complications, such as diabetes, hypertension, and immunologic disorders. Conclusion: Reproductive histories clearly differed between the groups, suggesting both a different response to environmental challenges based on genetic susceptibility and the activation of different pathophysiological pathways to determine the duration of pregnancy in each woman.
MeSH term(s)	Abortion, Spontaneous/epidemiology ; Cluster Analysis ; Female ; Fetal Membranes, Premature Rupture/epidemiology ; Humans ; Infant, Newborn ; Life Style ; Male ; Pregnancy ; Pregnancy Complications/epidemiology ; Pregnancy Outcome ; Premature Birth/epidemiology ; Premature Birth/genetics ; Premature Birth/physiopathology ; Recurrence ; Retrospective Studies ; Risk Factors ; Stillbirth/epidemiology
Language	English
Publishing date	2012-11-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/s-0032-1326990
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Article ; Online: Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population.

Gimenez, Lucas G / Momany, Allison M / Poletta, Fernando A / Krupitzki, Hugo B / Gili, Juan A / Busch, Tamara D / Saleme, Cesar / Cosentino, Viviana R / Pawluk, Mariela S / Campaña, Hebe / Gadow, Enrique C / Murray, Jeffrey C / Lopez-Camelo, Jorge S

Pediatric research

2017 Volume 82, Issue 3, Page(s) 554–559

Abstract: BackgroundPreterm birth (PTB) is the leading cause of neonatal mortality and morbidity. PTB is often classified according to clinical presentation as follows: idiopathic (PTB-I), preterm premature rupture of membranes (PTB-PPROM), and medically induced ( ... ...

Abstract	BackgroundPreterm birth (PTB) is the leading cause of neonatal mortality and morbidity. PTB is often classified according to clinical presentation as follows: idiopathic (PTB-I), preterm premature rupture of membranes (PTB-PPROM), and medically induced (PTB-M). The aim of this study was to evaluate the associations between specific candidate genes and clinical subtypes of PTB.MethodsTwenty-four single-nucleotide polymorphisms (SNPs) were genotyped in 18 candidate genes in 709 infant triads. Of them, 243 were PTB-I, 256 were PTB-PPROM, and 210 were PTB-M. These data were analyzed with a Family-Based Association.ResultsPTB was nominally associated with rs2272365 in PON1, rs883319 in KCNN3, rs4458044 in CRHR1, and rs610277 in F3. Regarding clinical subtypes analysis, three SNPs were associated with PTB-I (rs2272365 in PON1, rs10178458 in COL4A3, and rs4458044 in CRHR1), rs610277 in F3 was associated with PTB-PPROM, and rs883319 in KCNN3 and rs610277 in F3 were associated with PTB-M.ConclusionOur study identified polymorphisms potentially associated with specific clinical subtypes of PTB in this Latin American population. These results could suggest a specific role of such genes in the mechanisms involved in each clinical subtype. Further studies are required to confirm our results and to determine the role of these genes in the pathophysiology of clinical subtypes.
Language	English
Publishing date	2017-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/pr.2017.109
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Article ; Online: Maternal and neonatal epidemiological features in clinical subtypes of preterm birth.

Gimenez, Lucas G / Krupitzki, Hugo B / Momany, Allison M / Gili, Juan A / Poletta, Fernando A / Campaña, Hebe / Cosentino, Viviana R / Saleme, César / Pawluk, Mariela / Murray, Jeffrey C / Castilla, Eduardo E / Gadow, Enrique C / Lopez-Camelo, Jorge S

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2015 Volume 29, Issue 19, Page(s) 3153–3161

Abstract: Objective: This study was designed to characterize and compare the maternal and newborn epidemiological characteristics through analysis of environmental factors, sociodemographic characteristics and clinical characteristics between the different ... ...

Abstract	Objective: This study was designed to characterize and compare the maternal and newborn epidemiological characteristics through analysis of environmental factors, sociodemographic characteristics and clinical characteristics between the different clinical subtypes of preterm birth (PTB): Idiopathic (PTB-I), premature rupture of the membranes (PTB-PPROM) and medically indicated (PTB-M). The two subtypes PTB-I and PTB-PPROM grouped are called spontaneous preterm births (PTB-S). Methods: A retrospective, observational study was conducted in 1.291 preterm nonmalformed singleton live-born children to nulliparous and multiparous mother's in Tucumán-Argentina between 2005 and 2010. Over 50 maternal variables and 10 newborn variables were compared between the different clinical subtypes. The comparisons were done to identify heterogeneity between subtypes of preterm birth: (PTB-S) versus (PTB-M), and within spontaneous subtype: (PTB-I) versus (PTB-PPROM). In the same way, two conditional logistic multivariate regressions were used to compare the odds ratio (OR) between PTB-S and PTB-M, as well as PTB-I and PTB-PPROM. We matched for maternal age when comparing maternal variables and gestational age when comparing infant variables. Results: The PTB-I subtype was characterized by younger mothers of lower socio-economic status, PTB-PPROM was characterized by environmental factors resulting from inflammatory processes, and PTB-M was characterized by increased maternal or fetal risk pregnancies. Conclusions: The main risk factor for PTB-I and PTB-M was having had a prior preterm delivery; however, previous spontaneous abortion was not a risk factor, suggesting a reproductive selection mechanism.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Analysis of Variance ; Argentina/epidemiology ; Female ; Fetal Membranes, Premature Rupture/epidemiology ; Gestational Age ; Humans ; Infant, Newborn ; Logistic Models ; Odds Ratio ; Pregnancy ; Pregnancy Complications/epidemiology ; Pregnancy Outcome/epidemiology ; Premature Birth/epidemiology ; Premature Birth/etiology ; Retrospective Studies ; Risk Factors ; Socioeconomic Factors ; Young Adult
Language	English
Publishing date	2015-12-23
Publishing country	England
Document type	Comparative Study ; Journal Article ; Observational Study
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.3109/14767058.2015.1118035
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Article ; Online: Odon device for instrumental vaginal deliveries: results of a medical device pilot clinical study.

Schvartzman, Javier A / Krupitzki, Hugo / Merialdi, Mario / Betrán, Ana Pilar / Requejo, Jennifer / Nguyen, My Huong / Vayena, Effy / Fiorillo, Angel E / Gadow, Enrique C / Vizcaino, Francisco M / von Petery, Felicitas / Marroquin, Victoria / Cafferata, María Luisa / Mazzoni, Agustina / Vannevel, Valerie / Pattinson, Robert C / Gülmezoglu, A Metin / Althabe, Fernando / Bonet, Mercedes

Reproductive health

2018 Volume 15, Issue 1, Page(s) 45

Abstract: Background: A prolonged and complicated second stage of labour is associated with serious perinatal complications. The Odon device is an innovation intended to perform instrumental vaginal delivery presently under development. We present an evaluation ... ...

Abstract	Background: A prolonged and complicated second stage of labour is associated with serious perinatal complications. The Odon device is an innovation intended to perform instrumental vaginal delivery presently under development. We present an evaluation of the feasibility and safety of delivery with early prototypes of this device from an early terminated clinical study. Methods: Hospital-based, multi-phased, open-label, pilot clinical study with no control group in tertiary hospitals in Argentina and South Africa. Multiparous and nulliparous women, with uncomplicated singleton pregnancies, were enrolled during the third trimester of pregnancy. Delivery with Odon device was attempted under non-emergency conditions during the second stage of labour. The feasibility outcome was delivery with the Odon device defined as successful expulsion of the fetal head after one-time application of the device. Results: Of the 49 women enrolled, the Odon device was inserted successfully in 46 (93%), and successful Odon device delivery as defined above was achieved in 35 (71%) women. Vaginal, first and second degree perineal tears occurred in 29 (59%) women. Four women had cervical tears. No third or fourth degree perineal tears were observed. All neonates were born alive and vigorous. No adverse maternal or infant outcomes were observed at 6-weeks follow-up for all dyads, and at 1 year for the first 30 dyads. Conclusions: Delivery using the Odon device is feasible. Observed genital tears could be due to the device or the process of delivery and assessment bias. Evaluating the effectiveness and safety of the further developed prototype of the BD Odon Device™ will require a randomized-controlled trial. Trial registration: ANZCTR ACTRN12613000141741 Registered 06 February 2013. Retrospectively registered.
MeSH term(s)	Adult ; Argentina ; Cervix Uteri/injuries ; Extraction, Obstetrical/adverse effects ; Extraction, Obstetrical/instrumentation ; Extraction, Obstetrical/methods ; Female ; Humans ; Perineum/injuries ; Pilot Projects ; Pregnancy ; Pregnancy Outcome ; Proof of Concept Study ; South Africa
Language	English
Publishing date	2018-03-12
Publishing country	England
Document type	Clinical Study ; Journal Article
ZDB-ID	2149029-6
ISSN	1742-4755 ; 1742-4755
ISSN (online)	1742-4755
ISSN	1742-4755
DOI	10.1186/s12978-018-0485-8
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Article: Environmental Risk Factors and Perinatal Outcomes in Preterm Newborns, According to Family Recurrence of Prematurity

Krupitzki, Hugo B. / Gadow, Enrique C. / Gili, Juan A. / Comas, Belén / Cosentino, Viviana R. / Saleme, César / Murray, Jeffrey C. / Camelo, Jorge S. Lopez

American Journal of Perinatology

2012 Volume 30, Issue 06, Page(s) 451–462

Abstract	Objective: We analyzed the role of environmental risk factors, sociodemographic characteristics, clinical characteristics, and reproductive history in preterm births and their associated perinatal outcomes in families classified according to their histories of preterm recurrence among siblings. Study Design: A retrospective study was conducted at Nuestra Señora de la Merced Maternity Hospital in the city of Tucumán, Argentina. A total of 348 preterm, nonmalformed, singleton children born to multipara women were reviewed. The family history score described by Khoury was applied, and families were classified as having no, medium, or high genetic aggregation. Results: Families with no familial aggregation showed a higher rate of short length of cohabitation, maternal urinary tract infections during the current pregnancy, and maternal history of miscarriage during the previous pregnancy. Families with a high level of aggregation had a significantly higher incidence of pregnancy complications, such as diabetes, hypertension, and immunologic disorders. Conclusion: Reproductive histories clearly differed between the groups, suggesting both a different response to environmental challenges based on genetic susceptibility and the activation of different pathophysiological pathways to determine the duration of pregnancy in each woman.
Keywords	preterm birth ; familial aggregation ; pregnancy
Language	English
Publishing date	2012-11-06
Publisher	Thieme Medical Publishers
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/s-0032-1326990
Database	Thieme publisher's database

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Article ; Online: Feasibility and safety study of a new device (Odón device) for assisted vaginal deliveries: study protocol.

Schvartzman, Javier A / Krupitzki, Hugo / Betran, Ana Pilar / Requejo, Jennifer / Bergel, Eduardo / Fiorillo, Angel E / Gadow, Enrique C / Vizcaino, Francisco M / von Petery, Felicitas / Althabe, Fernando / Belizan, Jose / Borruto, Franco / Boulvain, Michel / Di Renzo, Gian Carlo / Gülmezoglu, Metin / Hofmeyr, Justus / Judge, Kevin / Leung, Tak Yeung / Nguyen, My Huong /

Saugstad, Ola Didrik / Temmerman, Marleen / Treisser, Alain / Vayena, Effy / Merialdi, Mario

Reproductive health

2013 Volume 10, Page(s) 33

Abstract: Background: Intrapartum complications are responsible for approximately half of all maternal deaths, and two million stillbirth and neonatal deaths per year. Prolonged second stage of labour is associated with potentially fatal maternal complications ... ...

Abstract	Background: Intrapartum complications are responsible for approximately half of all maternal deaths, and two million stillbirth and neonatal deaths per year. Prolonged second stage of labour is associated with potentially fatal maternal complications such as haemorrhage and infection and it is a major cause of stillbirth and newborn morbidity and mortality. Currently, the three main options for managing prolonged second stage of labour are forceps, vacuum extractor and caesarean section. All three clinical practices require relatively expensive equipment (e.g., a surgical theatre for caesarean section) and/or highly trained staff which are often not available in low resource settings. The specific aim of the proposed study is to test the safety and feasibility of a new device (Odón device) to effectively deliver the fetus during prolonged second stage of labour. The Odón device is a low-cost technological innovation to facilitate operative vaginal delivery and designed to minimize trauma to the mother and baby. These features combined make it a potentially revolutionary development in obstetrics, particularly for improving intrapartum care and reducing maternal and perinatal morbidity and mortality in low resource settings. Methods/design: This will be a hospital-based, multicenter prospective phase 1 cohort study with no control group. Delivery with the Odón device will be attempted under normal labour and non-emergency conditions on all the women enrolled in the study. One-hundred and thirty pregnant women will be recruited in tertiary care facilities in Argentina. Safety will be assessed by examining maternal and infant outcomes until discharge. Feasibility will be evaluated by observing successful expulsion of the fetal head after one-time application of the device under standardized conditions (full cervical dilation, anterior presentation, +2 station, normal fetal heart rate). Trial registration: Australian New Zealand Clinical Trials Registry (ANZCTR). Identifier: ACTRN12613000141741.
MeSH term(s)	Adult ; Argentina ; Cohort Studies ; Equipment Safety ; Extraction, Obstetrical/instrumentation ; Extraction, Obstetrical/methods ; Feasibility Studies ; Female ; Humans ; Labor, Obstetric ; Pregnancy ; Surgical Instruments
Language	English
Publishing date	2013-07-02
Publishing country	England
Document type	Clinical Trial, Phase I ; Journal Article ; Multicenter Study
ZDB-ID	2149029-6
ISSN	1742-4755 ; 1742-4755
ISSN (online)	1742-4755
ISSN	1742-4755
DOI	10.1186/1742-4755-10-33
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Book ; Online: Feasibility and safety study of a new device (Odon device) for assisted vaginal deliveries

Leung, Tak Yeung / Judge, Kevin / Requejo, Jennifer / Bergel, Eduardo / von Petery, Felicitas / Boulvain, Michel / Gadow, Enrique C / Hofmeyr, Justus / Saugstad, Ola Didrik / Temmerman, Marleen / Treisser, Alain / Schvartzman, Javier A / Fiorillo, Angel E / Belizan, Jose / Althabe, Fernando / Betran, Ana Pilar / Borruto, Franco / Nguyen, My Huong / Gülmezoglu, Metin /

Vayena, Effy / Krupitzki, Hugo / Merialdi, Mario / Di Renzo, Gian Carlo / Vizcaino, Francisco M

study protocol

2013

Abstract: Journal Article ... Multicenter Study ... Clinical Trial, Phase I ...

Abstract	Journal Article Multicenter Study Clinical Trial, Phase I BACKGROUND: Intrapartum complications are responsible for approximately half of all maternal deaths, and two million stillbirth and neonatal deaths per year. Prolonged second stage of labour is associated with potentially fatal maternal complications such as haemorrhage and infection and it is a major cause of stillbirth and newborn morbidity and mortality. Currently, the three main options for managing prolonged second stage of labour are forceps, vacuum extractor and caesarean section. All three clinical practices require relatively expensive equipment (e.g., a surgical theatre for caesarean section) and/or highly trained staff which are often not available in low resource settings. The specific aim of the proposed study is to test the safety and feasibility of a new device (Odón device) to effectively deliver the fetus during prolonged second stage of labour. The Odón device is a low-cost technological innovation to facilitate operative vaginal delivery and designed to minimize trauma to the mother and baby. These features combined make it a potentially revolutionary development in obstetrics, particularly for improving intrapartum care and reducing maternal and perinatal morbidity and mortality in low resource settings. METHODS/DESIGN: This will be a hospital-based, multicenter prospective phase 1 cohort study with no control group. Delivery with the Odón device will be attempted under normal labour and non-emergency conditions on all the women enrolled in the study. One-hundred and thirty pregnant women will be recruited in tertiary care facilities in Argentina. Safety will be assessed by examining maternal and infant outcomes until discharge. Feasibility will be evaluated by observing successful expulsion of the fetal head after one-time application of the device under standardized conditions (full cervical dilation, anterior presentation, +2 station, normal fetal heart rate). TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry (ANZCTR). Identifier: ACTRN12613000141741.
Language	English
Publishing date	2013-07-02
Document type	Book ; Online
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