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  1. Book: L' epatologo e Internet

    Gaeta, Giovanni B. / Piccinino, Felice

    manuale pratico di accesso alla Rete con una selezione di indirizzi Web

    (Il medico in Rete)

    2001  

    Author's details G. B. Gaeta ... Presentazione F. Piccinino
    Series title Il medico in Rete
    Keywords Hepatologie ; Internet
    Language Italian
    Size VIII, 104 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Milano u.a.
    Publishing country Italy
    Document type Book
    HBZ-ID HT013164871
    ISBN 88-470-0143-9 ; 978-88-470-0143-5
    Database Catalogue ZB MED Medicine, Health

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    2001 A 5590 order for loan Magazin

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  2. Article ; Online: Prophylaxis of Hepatitis B Virus (HBV) Re-Infection in Liver Transplantation: Is the Reappearance of Hepatitis B Surface Antigen (HBsAg) Significant?

    Brancaccio, Giuseppina / Gaeta, Giovanni B

    Annals of transplantation

    2020  Volume 25, Page(s) e920969

    Abstract: The recurrence of hepatitis B virus (HBV) infection after orthotopic liver transplantation (OLT) was in the past a primary cause of organ loss or mortality. Currently, post-OLT prophylaxis with anti-HBs immunoglobulins plus a nucleos(t)ide analogue has ... ...

    Abstract The recurrence of hepatitis B virus (HBV) infection after orthotopic liver transplantation (OLT) was in the past a primary cause of organ loss or mortality. Currently, post-OLT prophylaxis with anti-HBs immunoglobulins plus a nucleos(t)ide analogue has virtually abolished the risk of re-infection. Some studies have proposed to simplify prophylaxis by discontinuing immunoglobulins while continuing the analogue alone. This review analysed the available studies, focusing on the recurrence of HBsAg in serum and its biological effects. In all, 16 studies were retrieved, mainly observational or retrospective, each enrolling 14 to 80 patients. Our review of the literature found that HBsAg re-appeared in 0% to 24% of the patients, generally with HBV DNA undetectable in plasma. One study measured HBsAg using a new ultra-sensitive method, which could allow a reappraisal of the incidence of recurrence. This review discusses the role of HBV surface proteins in inducing hepatocellular carcinoma, particularly when mutations in the C-terminal occur that induce stop-codons that cause defects of secretion and retention of truncated protein S, resulting in direct cell toxicity and cancer. The data on the suspension of immunoglobulins in the prophylaxis regimes of post-transplant re infection do not appear sufficiently robust for an extensive and safe application in clinical practice.
    MeSH term(s) Antiviral Agents/therapeutic use ; Hepatitis B/immunology ; Hepatitis B/metabolism ; Hepatitis B/prevention & control ; Hepatitis B Antibodies/blood ; Hepatitis B Surface Antigens/immunology ; Hepatitis B Surface Antigens/metabolism ; Hepatitis B virus/immunology ; Humans ; Immunoglobulins/therapeutic use ; Liver Transplantation/adverse effects ; Postoperative Complications/immunology ; Postoperative Complications/metabolism ; Postoperative Complications/prevention & control ; Reinfection/metabolism ; Reinfection/prevention & control
    Chemical Substances Antiviral Agents ; Hepatitis B Antibodies ; Hepatitis B Surface Antigens ; Immunoglobulins
    Language English
    Publishing date 2020-03-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1484710-3
    ISSN 2329-0358 ; 1425-9524
    ISSN (online) 2329-0358
    ISSN 1425-9524
    DOI 10.12659/AOT.920969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Letter: clinical outcomes of patients with hepatitis D infection in the liver transplant setting-authors' reply.

    Brancaccio, Giuseppina / Gaeta, Giovanni B

    Alimentary pharmacology & therapeutics

    2020  Volume 51, Issue 4, Page(s) 484

    MeSH term(s) Hepatitis D ; Humans ; Liver Transplantation
    Language English
    Publishing date 2020-01-28
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.15625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recent breakthroughs in the treatment of chronic hepatitis Delta.

    Brancaccio, Giuseppina / Gaeta, Laura / Vitale, Alessandro / Gaeta, Giovanni B

    Le infezioni in medicina

    2022  Volume 30, Issue 2, Page(s) 204–210

    Abstract: Hepatitis Delta virus (HDV) is responsible for the most aggressive form of chronic hepatitis, which may evolve towards cirrhosis, hepatocellular carcinoma and death within few years. During the last 30 years the only available therapy was interferon or ... ...

    Abstract Hepatitis Delta virus (HDV) is responsible for the most aggressive form of chronic hepatitis, which may evolve towards cirrhosis, hepatocellular carcinoma and death within few years. During the last 30 years the only available therapy was interferon or peg-IFN, which was characterized by poor tolerability and modest results. The detailed knowledge of the HDV replication cycle and its interaction with HBV allowed the introduction of new drugs which are currently in phase II or III of experimentation. Basically, bulevirtide, to date the only one approved by EMA, inhibits the entry of the virus into the hepatocytes and hence its intrahepatic spread; lonafarnib inhibits the pharnesylation process of the L-HDAg, which is critical for the assembly of the HDV virion; the nucleic acid polymers (NAPs) mainly block the production/release of HBsAg. The available clinical trials with these compounds showed an excellent anti-viral activity against HDV.
    Language English
    Publishing date 2022-06-01
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2041081-5
    ISSN 2532-8689 ; 1124-9390
    ISSN (online) 2532-8689
    ISSN 1124-9390
    DOI 10.53854/liim-3002-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Treatment of chronic hepatitis due to hepatitis B and hepatitis delta virus coinfection.

    Brancaccio, Giuseppina / Gaeta, Giovanni B

    International journal of antimicrobial agents

    2019  Volume 54, Issue 6, Page(s) 697–701

    Abstract: An estimated 20-40 million individuals worldwide are infected with hepatitis delta virus (HDV), mostly with rapidly evolving liver disease. Therapy of chronic HDV infection remains an unmet need. To date, only interferon (IFN)-based therapy is ... ...

    Abstract An estimated 20-40 million individuals worldwide are infected with hepatitis delta virus (HDV), mostly with rapidly evolving liver disease. Therapy of chronic HDV infection remains an unmet need. To date, only interferon (IFN)-based therapy is recommended for HDV infection and response rates are unsatisfactory; in addition, many patients are intolerant to or ineligible for IFN treatment. In recent years, innovative approaches have been in development, including the following: targeting virus entry into hepatocytes; inhibition of the host enzyme farnesyltransferase by prenylation inhibitors, leading to inhibition of complete virion formation and release; blockade of hepatitis B surface antigen (HBsAg) secretion, inhibiting virus release; and IFN-lambda, which causes fewer adverse effects than IFN-alfa. Clinical trials are ongoing with encouraging preliminary results.
    MeSH term(s) Antiviral Agents/therapeutic use ; Coinfection ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/drug therapy ; Hepatitis D, Chronic/complications ; Hepatitis D, Chronic/drug therapy ; Humans
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2019-09-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2019.09.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3368: Show issues Location:
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    Zs.MO 500: Show issues

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  6. Article: Treatment of chronic hepatitis due to hepatitis B and hepatitis delta virus coinfection

    Brancaccio, Giuseppina / Gaeta, Giovanni B

    International journal of antimicrobial agents. 2019 Sept. 15,

    2019  

    Abstract: An estimated 20–40 million individuals worldwide are infected with hepatitis delta virus (HDV), mostly with rapidly evolving liver disease. Therapy of chronic HDV infection remains an unmet need. To date, only interferon (IFN)-based therapy is ... ...

    Abstract An estimated 20–40 million individuals worldwide are infected with hepatitis delta virus (HDV), mostly with rapidly evolving liver disease. Therapy of chronic HDV infection remains an unmet need. To date, only interferon (IFN)-based therapy is recommended for HDV infection and response rates are unsatisfactory; in addition, many patients are intolerant to or ineligible for IFN treatment. In recent years, innovative approaches have been in development, including the following: targeting virus entry into hepatocytes; inhibition of the host enzyme farnesyltransferase by prenylation inhibitors, leading to inhibition of complete virion formation and release; blockade of hepatitis B surface antigen (HBsAg) secretion, inhibiting virus release; and IFN-lambda, which causes fewer adverse effects than IFN-alfa. Clinical trials are ongoing with encouraging preliminary results.
    Keywords adverse effects ; anti-infective agents ; chronic hepatitis ; clinical trials ; geranylgeranyl diphosphate synthase ; hepatitis B ; hepatitis B antigens ; Hepatitis delta virus ; hepatocytes ; mixed infection ; patients ; secretion ; therapeutics ; virion ; viruses
    Language English
    Dates of publication 2019-0915
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2019.09.012
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Sunscreen ingredients in plasma: a threat for drug-drug interactions and toxicity among patients living with HIV?

    Maggi, Paolo / Brancaccio, Giuseppina / Gaeta, Giovanni B

    Expert opinion on drug metabolism & toxicology

    2019  Volume 15, Issue 10, Page(s) 775–778

    MeSH term(s) Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/adverse effects ; Drug Interactions ; HIV Infections/drug therapy ; Humans ; Sunscreening Agents/adverse effects ; Sunscreening Agents/pharmacokinetics
    Chemical Substances Anti-HIV Agents ; Sunscreening Agents
    Language English
    Publishing date 2019-09-24
    Publishing country England
    Document type Editorial
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1080/17425255.2019.1670164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Changing indications for liver transplant: slow decline of hepatitis viruses in Italy.

    Brancaccio, Giuseppina / Vitale, Alessandro / Signoriello, Giuseppe / Gaeta, Giovanni B / Cillo, Umberto

    Infectious diseases (London, England)

    2020  Volume 52, Issue 8, Page(s) 557–562

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adult ; Antiviral Agents/therapeutic use ; Biomarkers/blood ; Carcinoma, Hepatocellular/virology ; Disease Progression ; Europe/epidemiology ; Female ; Hepatitis B/complications ; Hepatitis B/diagnosis ; Hepatitis B/drug therapy ; Hepatitis B/mortality ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/epidemiology ; Humans ; Italy/epidemiology ; Liver Cirrhosis/virology ; Liver Failure/surgery ; Liver Failure/virology ; Liver Neoplasms/virology ; Liver Transplantation/adverse effects ; Liver Transplantation/mortality ; Liver Transplantation/trends ; Male ; Middle Aged ; Treatment Outcome
    Chemical Substances Antiviral Agents ; Biomarkers
    Language English
    Publishing date 2020-05-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2020.1763453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Telbivudine: Taking into account baseline and on-therapy predictors.

    Gaeta, Giovanni B

    Journal of hepatology

    2008  Volume 49, Issue 5, Page(s) 874–875

    Language English
    Publishing date 2008-11
    Publishing country Netherlands
    Document type Comment ; Journal Article
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2008.08.008
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  10. Article ; Online: Clinical outcomes in patients with hepatitis D, cirrhosis and persistent hepatitis B virus replication, and receiving long-term tenofovir or entecavir.

    Brancaccio, Giuseppina / Fasano, Massimo / Grossi, Adriano / Santantonio, Teresa Antonia / Gaeta, Giovanni B

    Alimentary pharmacology & therapeutics

    2019  Volume 49, Issue 8, Page(s) 1071–1076

    Abstract: Background: Suppression of hepatitis B virus (HBV) replication with nucelos(t)ide analogues should be considered for patients with chronic hepatitis D virus (HDV) infection and ongoing HBV replication.: Aim: To verify the clinical outcome after long- ... ...

    Abstract Background: Suppression of hepatitis B virus (HBV) replication with nucelos(t)ide analogues should be considered for patients with chronic hepatitis D virus (HDV) infection and ongoing HBV replication.
    Aim: To verify the clinical outcome after long-term entecavir or tenofovir treatment in patients with advanced fibrosis/cirrhosis, ineligible to peg-interferon therapy.
    Methods: Patients were prospectively followed-up at 3-6 month intervals; measured outcomes were decompensation, hepatocellular carcinoma (HCC), liver transplant and liver related death. HBV monoinfected patients receiving the same treatment served as reference after 1:1 matching by age, gender, platelet count, albumin level, bilirubin and INR.
    Results: 56 HDV patients (48 with cirrhosis; median follow-up 50 months) were enrolled; all achieved HBV DNA suppression. Death or liver transplant occurred in 19 patients, with a rate (n/1000 patient-months) of 2.92 in HDV patients vs 0.38 in HBV monoinfected patients (P < 0.001); similarly, decompensation occurred at a rate of 1.53 vs 0.13 (P = 0.015), respectively, and the rate of HCC was almost thrice in HDV cohort (3.12 vs 1.12; P = 0.02) Platelet count, Child-Pugh score and marginally HDV infection were associated with HCC development.
    Conclusion: Patients with HDV infection and advanced liver disease maintain an increased risk of severe clinical events as compared with HBV monoinfected patients, during prolonged HBV DNA suppression with potent NA.
    MeSH term(s) Adult ; Antiviral Agents/therapeutic use ; Carcinoma, Hepatocellular/epidemiology ; Female ; Follow-Up Studies ; Guanine/administration & dosage ; Guanine/analogs & derivatives ; Hepatitis B/drug therapy ; Hepatitis B virus/drug effects ; Hepatitis D, Chronic/drug therapy ; Humans ; Liver Cirrhosis/drug therapy ; Liver Neoplasms/epidemiology ; Liver Transplantation/statistics & numerical data ; Male ; Middle Aged ; Prospective Studies ; Tenofovir/therapeutic use ; Treatment Outcome
    Chemical Substances Antiviral Agents ; entecavir (5968Y6H45M) ; Guanine (5Z93L87A1R) ; Tenofovir (99YXE507IL)
    Language English
    Publishing date 2019-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.15188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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