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  1. Article ; Online: Transcranial photobiomodulation increases intrinsic brain activity within irradiated areas in early Alzheimer's disease: Potential link with cerebral metabolism.

    Gaggi, Naomi L / Collins, Katherine A / Gonzalez-Castillo, Javier / Hurtado, Aura M / Castellanos, Francisco Xavier / Osorio, Ricardo / Cassano, Paolo / Iosifescu, Dan V

    Brain stimulation

    2024  Volume 17, Issue 2, Page(s) 208–210

    MeSH term(s) Alzheimer Disease ; Humans ; Brain/radiation effects ; Low-Level Light Therapy/methods ; Aged ; Male ; Female
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2024.02.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6740: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Generalization of content and emotional prosody across speakers varying in gender in youth with Autism Spectrum Disorder.

    Brooks, Patricia J / Gaggi, Naomi L / Ploog, Bertram O

    Research in developmental disabilities

    2018  Volume 83, Page(s) 57–68

    Abstract: Aims: We employed a discrimination-choice procedure, embedded in a custom-made videogame, to evaluate whether youth with Autism Spectrum Disorder (ASD), including nonverbal individuals, distinguish sentences on the basis of emotional tone-of-voice and ... ...

    Abstract Aims: We employed a discrimination-choice procedure, embedded in a custom-made videogame, to evaluate whether youth with Autism Spectrum Disorder (ASD), including nonverbal individuals, distinguish sentences on the basis of emotional tone-of-voice and generalize linguistic information across speaker gender.
    Methods and procedures: Thirteen youth with ASD (7-21 years) and 13 age-matched typical controls heard pairs of pre-recorded sentences varying in lexical content and prosody (e.g., enthusiastic "Dave rode a bike'' vs. grouchy "Mark held a key''). After training to select a target sentence, participants heard test probes comprising re-combinations of the content and prosodic features of the sentences. Interspersed generalization trials used a voice opposite in gender to the voice used in training.
    Outcomes and results: Youth with ASD were less accurate than controls in discriminating sentences based on emotional tone-of-voice. Nonverbal and verbal youth did not differ in this regard. The ASD group showed only slight decrements in generalizing to the opposite-gender voice.
    Conclusions and implications: The finding of intact generalization of linguistic information across male/female speakers contrasts with the widely held view that autism is characterized by deficits in generalization. This suggests the need to test generalization under varying task demands to identify limits on performance.
    MeSH term(s) Acoustic Stimulation/methods ; Adolescent ; Autism Spectrum Disorder/diagnosis ; Autism Spectrum Disorder/psychology ; Child ; Emotions ; Female ; Humans ; Language ; Male ; Speech Discrimination Tests/instrumentation ; Speech Discrimination Tests/methods ; Speech Perception ; Video Games ; Voice Quality ; Young Adult
    Language English
    Publishing date 2018-08-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639175-8
    ISSN 1873-3379 ; 0891-4222
    ISSN (online) 1873-3379
    ISSN 0891-4222
    DOI 10.1016/j.ridd.2018.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2592: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Temporal dynamics of cerebral blood flow during the first year after moderate-severe traumatic brain injury: A longitudinal perfusion MRI study.

    Gaggi, Naomi L / Ware, Jeffrey B / Dolui, Sudipto / Brennan, Daniel / Torrellas, Julia / Wang, Ze / Whyte, John / Diaz-Arrastia, Ramon / Kim, Junghoon J

    NeuroImage. Clinical

    2023  Volume 37, Page(s) 103344

    Abstract: Traumatic brain injury (TBI) is associated with alterations in cerebral blood flow (CBF), which may underlie functional disability and precipitate TBI-induced neurodegeneration. Although it is known that chronic moderate-severe TBI (msTBI) causes ... ...

    Abstract Traumatic brain injury (TBI) is associated with alterations in cerebral blood flow (CBF), which may underlie functional disability and precipitate TBI-induced neurodegeneration. Although it is known that chronic moderate-severe TBI (msTBI) causes decreases in CBF, the temporal dynamics during the early chronic phase of TBI remain unknown. Using arterial spin labeled (ASL) perfusion magnetic resonance imaging (MRI), we examined longitudinal CBF changes in 29 patients with msTBI at 3, 6, and 12 months post-injury in comparison to 35 demographically-matched healthy controls (HC). We investigated the difference between the two groups and the within-subject time effect in the TBI patients using whole-brain voxel-wise analysis. Mean CBF in gray matter (GM) was lower in the TBI group compared to HC at 6 and 12 months post-injury. Within the TBI group, we identified widespread regional decreases in CBF from 3 to 6 months post-injury. In contrast, there were no regions with decreasing CBF from 6 to 12 months post-injury, indicating stabilization of hypoperfusion. There was instead a small area of increase in CBF observed in the right precuneus. These CBF changes were not accompanied by cortical atrophy. The change in CBF was correlated with change in executive function from 3 to 6 months post-injury in TBI patients, suggesting functional relevance of CBF measures. Understanding the time course of TBI-induced hypoperfusion and its relationship with cognitive improvement could provide an optimal treatment window to benefit long-term outcome.
    MeSH term(s) Humans ; Magnetic Resonance Angiography/methods ; Brain Injuries, Traumatic/diagnostic imaging ; Brain/blood supply ; Brain Injury, Chronic ; Cerebrovascular Circulation/physiology ; Spin Labels ; Perfusion ; Magnetic Resonance Imaging/methods
    Chemical Substances Spin Labels
    Language English
    Publishing date 2023-02-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2701571-3
    ISSN 2213-1582 ; 2213-1582
    ISSN (online) 2213-1582
    ISSN 2213-1582
    DOI 10.1016/j.nicl.2023.103344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people.

    Jacobs, Tovia / Jacobson, Sean R / Fortea, Juan / Berger, Jeffrey S / Vedvyas, Alok / Marsh, Karyn / He, Tianshe / Gutierrez-Jimenez, Eugenio / Fillmore, Nathanael R / Bubu, Omonigho M / Gonzalez, Moses / Figueredo, Luisa / Gaggi, Naomi L / Plaska, Chelsea Reichert / Pomara, Nunzio / Blessing, Esther / Betensky, Rebecca / Rusinek, Henry / Zetterberg, Henrik /
    Blennow, Kaj / Glodzik, Lidia / Wisniewski, Thomas M / Leon, Mony J / Osorio, Ricardo S / Ramos-Cejudo, Jaime

    Research square

    2024  

    Abstract: Background: An elevated neutrophil-lymphocyte ratio (NLR) in blood has been associated with Alzheimer's disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD, prompting investigation into ... ...

    Abstract Background: An elevated neutrophil-lymphocyte ratio (NLR) in blood has been associated with Alzheimer's disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD, prompting investigation into whether the NLR is directly linked with AD pathology or a result of underlying comorbidities. Herein, we explored the relationship between the NLR and AD biomarkers in the cerebrospinal fluid (CSF) of cognitively unimpaired (CU) subjects. Adjusting for sociodemographics, APOE4, and common comorbidities, we investigated these associations in two cohorts: the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the M.J. de Leon CSF repository at NYU. Specifically, we examined associations between the NLR and cross-sectional measures of amyloid-β42 (Aβ42), total tau (t-tau), and phosphorylated tau
    Results: A total of 111 ADNI and 190 NYU participants classified as CU with available NLR, CSF, and covariate data were included. Compared to NYU, ADNI participants were older (73.79 vs. 61.53, p < 0.001), had a higher proportion of males (49.5% vs. 36.8%, p = 0.042), higher BMIs (27.94 vs. 25.79, p < 0.001), higher prevalence of hypertensive history (47.7% vs. 16.3%, p < 0.001), and a greater percentage of Aβ-positivity (34.2% vs. 20.0%, p = 0.009). In the ADNI cohort, we found cross-sectional associations between the NLR and CSF Aβ42 (β=-12.193, p = 0.021), but not t-tau or p-tau. In the NYU cohort, we found cross-sectional associations between the NLR and CSF t-tau (β = 26.812, p = 0.019) and p-tau (β = 3.441, p = 0.015), but not Aβ42. In the NYU cohort alone, subjects classified as Aβ+ (n = 38) displayed a stronger association between the NLR and t-tau (β = 100.476, p = 0.037) compared to Aβ- subjects or the non-stratified cohort. In both cohorts, the same associations observed in the cross-sectional analyses were observed after incorporating longitudinal CSF data.
    Conclusions: We report associations between the NLR and Aβ42 in the older ADNI cohort, and between the NLR and t-tau and p-tau
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-4076789/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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