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  1. Article ; Online: Torpor expression is associated with differential spermatogenesis in hibernating eastern chipmunks.

    Gagnon, Marianne F / Lafleur, Christine / Landry-Cuerrier, Manuelle / Humphries, Murray M / Kimmins, Sarah

    American journal of physiology. Regulatory, integrative and comparative physiology

    2020  Volume 319, Issue 4, Page(s) R455–R465

    Abstract: Hibernators suppress physiological processes when expressing torpor, yet little is known about the effects of torpor on male reproductive physiology. Studies of hibernating mammals suggest that deep torpor negatively impacts spermatogenesis and that ... ...

    Abstract Hibernators suppress physiological processes when expressing torpor, yet little is known about the effects of torpor on male reproductive physiology. Studies of hibernating mammals suggest that deep torpor negatively impacts spermatogenesis and that transitions between torpor and euthermic arousals increase cellular oxidative stress, with potentially damaging effects on sperm. Here, we hypothesize that variation in torpor expression affects the reproductive readiness of hibernators by impacting their sperm production. To test this, we examined the relationship between torpor expression and spermatogenesis in captive eastern chipmunks (
    MeSH term(s) Animals ; Body Temperature/physiology ; DNA Damage/physiology ; Energy Metabolism/physiology ; Hibernation/physiology ; Male ; Sciuridae/physiology ; Sperm Count ; Spermatogenesis/physiology ; Temperature ; Torpor/physiology
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603839-6
    ISSN 1522-1490 ; 0363-6119
    ISSN (online) 1522-1490
    ISSN 0363-6119
    DOI 10.1152/ajpregu.00328.2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effect of torpor on host transcriptomic responses to a fungal pathogen in hibernating bats.

    Field, Kenneth A / Sewall, Brent J / Prokkola, Jenni M / Turner, Gregory G / Gagnon, Marianne F / Lilley, Thomas M / Paul White, J / Johnson, Joseph S / Hauer, Christopher L / Reeder, DeeAnn M

    Molecular ecology

    2018  

    Abstract: Hibernation, the use of prolonged torpor to depress metabolism, is employed by mammals to conserve resources during extended periods of extreme temperatures and/or resource limitation. Mammalian hibernators arouse to euthermy periodically during torpor ... ...

    Abstract Hibernation, the use of prolonged torpor to depress metabolism, is employed by mammals to conserve resources during extended periods of extreme temperatures and/or resource limitation. Mammalian hibernators arouse to euthermy periodically during torpor for reasons that are not well understood, and these arousals may facilitate immune processes. To determine whether arousals enable host responses to pathogens, we used dual RNA-Seq and a paired sampling approach to examine gene expression in a hibernating bat, the little brown myotis (Myotis lucifugus). During torpor, transcript levels differed in only a few genes between uninfected wing tissue and adjacent tissue infected with Pseudogymnoascus destructans, the fungal pathogen that causes white-nose syndrome. Within 70-80 min after emergence from torpor, large changes in gene expression were observed due to local infection, particularly in genes involved in pro-inflammatory host responses to fungal pathogens, but also in many genes involved in immune responses and metabolism. These results support the hypothesis that torpor is a period of relative immune dormancy and arousals allow for local immune responses in infected tissues during hibernation. Host-pathogen interactions were also found to regulate gene expression in the pathogen differently depending on the torpor state of the host. Hibernating species must balance the benefits of energy and water conservation achieved during torpor with the costs of decreased immune competence. Interbout arousals allow hibernators to optimize these, and other, trade-offs during prolonged hibernation by enabling host responses to pathogens within brief, periodic episodes of euthermy.
    Language English
    Publishing date 2018-08-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1126687-9
    ISSN 1365-294X ; 0962-1083
    ISSN (online) 1365-294X
    ISSN 0962-1083
    DOI 10.1111/mec.14827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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