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  1. AU="Gaier, Eric D"
  2. AU="Chandler Crews"
  3. AU="Comte, Marie-Hélène"
  4. AU="Cohen, Or"
  5. AU="Abdellatifi, Mohamed"
  6. AU="Luebbe, Elizabeth"
  7. AU="Emidio, Adriana"
  8. AU=Masmejan Sophie
  9. AU="Samantha Ridley"
  10. AU="Moghaddam-Alvandi, Arash"
  11. AU="Khanolkar, Amey R."
  12. AU="Vasquez Martinez, Rodolfo"
  13. AU="Morgan, E"

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  1. Artikel ; Online: Comments on: Partial Recovery of Amblyopia After Fellow Eye Ischemic Optic Neuropathy: Response.

    Gaier, Eric D / Bear, Mark F

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2023  Band 44, Heft 1, Seite(n) e210–e211

    Mesh-Begriff(e) Humans ; Amblyopia/diagnosis ; Amblyopia/therapy ; Optic Neuropathy, Ischemic/diagnosis ; Visual Acuity
    Sprache Englisch
    Erscheinungsdatum 2023-10-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0000000000001996
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: SARS-CoV-2-Related Cranial Nerve-6 Palsy Should Not Be Confused With Orbital Myositis Affecting the Lateral Rectus Muscle: Response.

    Baldwin, Grace / Gaier, Eric D / Hennein, Lauren

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-03-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0000000000002126
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Isolated Sixth Nerve Palsy and COVID-19: Response.

    Baldwin, Grace / Gaier, Eric D / Hennein, Lauren

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-03-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0000000000002128
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Aberrant regeneration of accommodation in pediatric inferior division oculomotor palsy.

    Weinert, Marguerite C / Bal, Sila / Heidary, Gena / Gaier, Eric D

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2024  , Seite(n) 103917

    Abstract: Aberrant regeneration occurs in forms of oculomotor motor nerve palsy and frequently involves the pupil, but the incidence and functional impact of ciliary muscle involvement in pediatric patients is sparsely reported in the literature. A 4-year-old girl ...

    Abstract Aberrant regeneration occurs in forms of oculomotor motor nerve palsy and frequently involves the pupil, but the incidence and functional impact of ciliary muscle involvement in pediatric patients is sparsely reported in the literature. A 4-year-old girl presented with inflammatory oculomotor motor nerve paresis affecting the inferior division. Initial treatment focused on her inability to accommodate through her physiologic +2.5 D hyperopia and the prevention and treatment of amblyopia. She subsequently developed aberrant regeneration of the pupil, with miosis on adduction. Following eye muscle surgery for residual exotropia and hypertropia, her dry refraction was noted to be more myopic in the affected eye on adduction, mirroring aberrant pupillary constriction. Recognition of pediatric aberrant regeneration of accommodation may influence surgical planning for oculomotor nerve palsy and/or management of amblyopia.
    Sprache Englisch
    Erscheinungsdatum 2024-04-07
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2024.103917
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Reply.

    Gaier, Eric D / Chinn, Ryan N / Wilkinson, Carol L / Hunter, David G

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2024  Band 28, Heft 1, Seite(n) 103825

    Sprache Englisch
    Erscheinungsdatum 2024-01-23
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2023.11.023
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Isolated Sixth Nerve Palsy and COVID-19: A Recurrent Case in a 7-Month-Old Child and Analysis of Reported Cases.

    Baldwin, Grace E / Gaier, Eric D / Hennein, Lauren M

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2023  

    Abstract: Background: With the SARS-CoV-2 pandemic (COVID-19), data on central and peripheral nervous system involvement, including those causing cranial nerve 6 (CN6) palsy, have been limited to case reports. To extract clinically relevant features of COVID-19- ... ...

    Abstract Background: With the SARS-CoV-2 pandemic (COVID-19), data on central and peripheral nervous system involvement, including those causing cranial nerve 6 (CN6) palsy, have been limited to case reports. To extract clinically relevant features of COVID-19-related CN6 palsy, we report on a recurrent pediatric case and analysis of reported cases associated with infection or immunization.
    Methods: A PubMed search revealed 18 cases of isolated CN6 palsy in addition to the index case (n = 19). Clinical characteristics, workup, and temporal associations between systemic symptoms onset or vaccination, symptoms onset, and resolution were compiled and analyzed.
    Results: The median age of CN6 onset was 43 years (interquartile range [IQR]: 28-52). Sixteen cases (84.2%) were associated with COVID-19 illness and 3 (15.8%) were associated with COVID-19 vaccination. Four cases (23.5%) had positive neuroimaging findings. The median latency from first COVID-19 symptoms or vaccination to onset of CN6 palsy was 6 days (IQR: 2.3-16), and the median time from onset to resolution was 30 days (IQR: 14-60). Latency to onset of CN6 palsy was significantly and directly associated with time to resolution (R2 = 0.401, P = 0.010). Patients who had a positive SARS-CoV-2 antibody test had significantly longer days from symptoms to onset (6.0 vs 24.5, P = 0.030), and patients with a positive SARS-CoV-2 polymerase chain reaction test had a significantly shorter time to resolution (17.50 vs 90, P = 0.042).
    Conclusions: Isolated CN6 palsy from COVID-19 is rare, can occur in infants as young as 7 months, and can be recurrent. Longer latency from systemic symptoms onset portends greater recovery times, and this relationship may reflect multiple mechanisms by which COVID-19 (and/or an immune response thereto) causes cranial neuropathies with direct clinical relevance.
    Sprache Englisch
    Erscheinungsdatum 2023-08-30
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0000000000001989
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Factors associated with visual acuity improvement with a binocular digital therapeutic for amblyopia.

    Oke, Isdin / Gaier, Eric D / Repka, Michael X

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2023  Band 27, Heft 5, Seite(n) 300–303

    Abstract: We combined data from 121 amblyopic children enrolled in two prospective open-label pilot studies and a randomized trial of a binocular digital therapeutic to identify factors associated with positive response to amblyopia treatment. Visual acuity ... ...

    Abstract We combined data from 121 amblyopic children enrolled in two prospective open-label pilot studies and a randomized trial of a binocular digital therapeutic to identify factors associated with positive response to amblyopia treatment. Visual acuity improved ≥1 line in 81% of participants after 12 weeks of therapy. Treatment response was not found to be associated with age, severity of amblyopia, or prior treatment status. Although these findings may suggest broad efficacy for this treatment approach, further investigation in larger cohorts is needed to identify factors associated with treatment response.
    Mesh-Begriff(e) Child ; Humans ; Amblyopia/therapy ; Follow-Up Studies ; Prospective Studies ; Treatment Outcome ; Video Games ; Vision, Binocular/physiology ; Visual Acuity ; Child, Preschool
    Sprache Englisch
    Erscheinungsdatum 2023-08-21
    Erscheinungsland United States
    Dokumenttyp Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2023.06.007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Cauterization-mediated restriction from penetrating orbital trauma.

    Liebman, Daniel L / Weinert, Marguerite C / Dohlman, Jenny C / Hennein, Lauren / Gaier, Eric D

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2024  Band 28, Heft 1, Seite(n) 103805

    Abstract: A healthy 32-year-old woman presented with binocular diplopia immediately after sustaining a penetrating injury to the left periocular adnexa with a hot metal skewer. Examination revealed an incomitant esotropia, with complete limitation of abduction of ... ...

    Abstract A healthy 32-year-old woman presented with binocular diplopia immediately after sustaining a penetrating injury to the left periocular adnexa with a hot metal skewer. Examination revealed an incomitant esotropia, with complete limitation of abduction of the left eye with downshoot in left gaze and normal afferent visual function. Computed tomography and magnetic resonance imaging demonstrated no fracture, but there was mild thickening of the medial rectus muscle and associated fat stranding. Lack of orbitomuscular tethering or hematoma led to the presumptive diagnosis of thermal cauterization injury causing left medial rectus restriction. Given the lack of literature on this mechanism of injury, the patient was monitored closely. She exhibited remarkable spontaneous improvement in motility over 6 months, with near orthophoria in primary gaze. However, bothersome residual esotropic diplopia in left gaze prompted a left medial rectus recession, with a good outcome. This case demonstrates that isolated extraocular muscle thermal injuries and consequential strabismus can recover spontaneously; longitudinal observation before surgical intervention may be appropriate in such cases.
    Mesh-Begriff(e) Female ; Humans ; Adult ; Diplopia/diagnosis ; Diplopia/etiology ; Strabismus/surgery ; Esotropia/surgery ; Oculomotor Muscles/diagnostic imaging ; Oculomotor Muscles/surgery ; Oculomotor Muscles/injuries ; Eye Injuries/complications ; Ophthalmologic Surgical Procedures/adverse effects ; Vision, Binocular
    Sprache Englisch
    Erscheinungsdatum 2024-01-10
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Research Support, N.I.H., Extramural
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2023.11.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Reply.

    Bleicher, Isaac D / Tainsh, Laurel T / Gaier, Eric D / Armstrong, Grayson W

    Ophthalmology

    2023  Band 131, Heft 1, Seite(n) e5

    Sprache Englisch
    Erscheinungsdatum 2023-09-26
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2023.08.016
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Metaplasticity: a key to visual recovery from amblyopia in adulthood?

    Leet, Madison P / Bear, Mark F / Gaier, Eric D

    Current opinion in ophthalmology

    2022  Band 33, Heft 6, Seite(n) 512–518

    Abstract: Purpose of review: We examine the development of amblyopia and the effectiveness of conventional and emerging therapies through the lens of the Bienenstock, Cooper, and Munro (BCM) theory of synaptic modification.: Recent findings: The BCM theory ... ...

    Abstract Purpose of review: We examine the development of amblyopia and the effectiveness of conventional and emerging therapies through the lens of the Bienenstock, Cooper, and Munro (BCM) theory of synaptic modification.
    Recent findings: The BCM theory posits metaplastic adjustment in the threshold for synaptic potentiation, governed by prior neuronal activity. Viewing established clinical principles of amblyopia treatment from the perspective of the BCM theory, occlusion, blur, or release of interocular suppression reduce visual cortical activity in the amblyopic state to lower the modification threshold and enable amblyopic eye strengthening. Although efficacy of these treatment approaches declines with age, significant loss of vision in the fellow eye by damage or disease can trigger visual acuity improvements in the amblyopic eye of adults. Likewise, reversible retinal inactivation stimulates recovery of amblyopic eye visual function in adult mice and cats.
    Summary: Conventional and emerging amblyopia treatment responses abide by the framework of BCM theory. Preclinical studies support that the dramatic reduction in cortical activity accompanying temporary retinal silencing can promote recovery from amblyopia even in adulthood, highlighting a promising therapeutic avenue.
    Mesh-Begriff(e) Amblyopia/therapy ; Animals ; Humans ; Mice ; Neuronal Plasticity ; Retina ; Visual Acuity
    Sprache Englisch
    Erscheinungsdatum 2022-09-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1049383-9
    ISSN 1531-7021 ; 1040-8738
    ISSN (online) 1531-7021
    ISSN 1040-8738
    DOI 10.1097/ICU.0000000000000901
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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