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  1. Article ; Online: Cochlear implantation in single-sided deafness: a single-center experience of 138 cases.

    Morelli, L / Fancello, Virginia / Gaino, F / Cagliero, G / Caruso, A / Sanna, M

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2023  Volume 280, Issue 10, Page(s) 4427–4432

    Abstract: Objectives: Assess the outcomes in patients who underwent cochlear implant (CI) for single-sided deafness (SSD).: Methods: All patients affected by SSD who underwent CI at Gruppo Otologico, Piacenza, from October 2012 to May 2022 with at least 6 ... ...

    Abstract Objectives: Assess the outcomes in patients who underwent cochlear implant (CI) for single-sided deafness (SSD).
    Methods: All patients affected by SSD who underwent CI at Gruppo Otologico, Piacenza, from October 2012 to May 2022 with at least 6 months of follow-up were selected in the study group. The analysis included subjective and objective measures performed pre-operative and up to 24 months after surgery. Hearing threshold on both sides was evaluated with a weighted four-frequency average (PTA [0.5 kHz + 1 kHz + 2 kHz + 4 kHz]/4) on pure tone audiometry and speech audiometry (Speech Discrimination Score, SDS). The Speech Spatial and Qualities of Hearing scale (SSQ Questionnaire) for binaural hearing benefits and sound localization, the Tinnitus Handicap Inventory Questionnaire (THI) and Dizziness Handicap Inventory Questionnaire (DHI) were used for subjective assessment.
    Results: Data from 138 patients, 69 males and 69 females, (mean age 49 years, range 17-77 years) underwent CI for SSD were examined. Single-sided hearing deprivation average before undergoing CI surgery was 2.5 years (range 3 months-35 years). There was a significant reduction of THI and DHI scores compared to pre-operative scores alongside a referred improvement in social, physical, and emotional well-being through the SSQ questionnaire.
    Conclusions: To the best of our knowledge, this paper descried the largest cohort of SSD who underwent CI in a single institution. According to our findings CI in patients affected by SSD represents a valuable tool for an overall improvement of tinnitus and dizziness but also quality of life, after at least 6 months of follow-up. Further studies are desirable to improve rehabilitation pathways and possibly set new standards of care of this condition.
    MeSH term(s) Male ; Female ; Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Cochlear Implantation ; Tinnitus/surgery ; Quality of Life ; Dizziness ; Audiometry, Pure-Tone ; Vertigo ; Deafness/surgery ; Deafness/rehabilitation
    Language English
    Publishing date 2023-04-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-023-07959-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Vocal Cord Monitoring by Flexible Fiberoptic Laryngoscopy During Thyroid Radiofrequency Ablation.

    Valcavi, Roberto / Gaino, Francesca / Novizio, Roberto / Mercante, Giuseppe

    VideoEndocrinology

    2023  Volume 10, Issue 3, Page(s) 41–43

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Journal Article
    ISSN 2329-9738
    ISSN 2329-9738
    DOI 10.1089/ve.2023.0012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: CORONA-steps for tracheotomy in COVID-19 patients: A staff-safe method for airway management.

    Ferreli, Fabio / Gaino, Francesca / Cecconi, Maurizio / Costantini, Elena / Spriano, Giuseppe / Mercante, Giuseppe

    Oral oncology

    2020  Volume 105, Page(s) 104728

    MeSH term(s) Airway Management ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Tracheotomy
    Keywords covid19
    Language English
    Publishing date 2020-04-17
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2020.104728
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  4. Article ; Online: Treatment of COVID-19 olfactory dysfunction with olfactory training, palmitoylethanolamide with luteolin, or combined therapy: a blinded controlled multicenter randomized trial.

    Di Stadio, Arianna / Gallina, Salvatore / Cocuzza, Salvatore / De Luca, Pietro / Ingrassia, Angelo / Oliva, Simone / Sireci, Federico / Camaioni, Angelo / Ferreli, Fabio / Mercante, Giuseppe / Gaino, Francesca / Pace, Gian Marco / La Mantia, Ignazio / Brenner, Michael J

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2023  Volume 280, Issue 11, Page(s) 4949–4961

    Abstract: Purpose: Few evidence-based therapies are available for chronic olfactory dysfunction after COVID-19. This study investigated the relative efficacy of olfactory training alone, co-ultramicronized palmitoylethanolamide with luteolin (um-PEA-LUT, an anti- ... ...

    Abstract Purpose: Few evidence-based therapies are available for chronic olfactory dysfunction after COVID-19. This study investigated the relative efficacy of olfactory training alone, co-ultramicronized palmitoylethanolamide with luteolin (um-PEA-LUT, an anti-neuroinflammatory supplement) alone, or combined therapy for treating chronic olfactory dysfunction from COVID-19.
    Methods: This double-blinded controlled, placebo-controlled multicenter randomized clinical trial was conducted in 202 patients with persistent COVID-19 olfactory dysfunction of > 6 month duration. After a screening nasal endoscopy, patients were randomized to: (1) olfactory training and placebo; (2) once daily um-PEA-LUT alone; (3) twice daily um-PEA-LUT alone; or (4) combination of once daily um-PEA-LUT with olfactory training. Olfactory testing (Sniffin' Sticks odor identification test) was performed at baseline and at 1, 2, and 3 months. The primary outcome was recovery of over three points on olfactory testing, with outcomes compared at T
    Results: All patients completed the study, and there were no adverse events. At 90 days, odor identification scores improved by > 3 points in 89.2% of patients receiving combined therapy vs. 36.8% receiving olfactory training with placebo, 40% receiving twice daily um-PEA-LUT alone, and 41.6% receiving once daily um-PEA-LUT alone (p < 0.00001). Patients receiving treatment with um-PEA-LUT alone demonstrated subclinical improvement (< 3 point odor identification improvement) more often than patients receiving olfactory training with placebo (p < 0.0001.) CONCLUSIONS: Olfactory training plus once daily um-PEA-LUT resulted in greater olfactory recovery than either therapy alone in patients with long-term olfactory function due to COVID-19.
    Trial registration: 20112020PGFN on clinicaltrials.gov.
    Level of evidence: 1b (Individual Randomized Clinical Trial).
    MeSH term(s) Humans ; COVID-19/complications ; Luteolin ; Olfactory Training ; Smell ; Olfaction Disorders/drug therapy ; Olfaction Disorders/etiology
    Chemical Substances palmidrol (6R8T1UDM3V) ; Luteolin (KUX1ZNC9J2)
    Language English
    Publishing date 2023-06-28
    Publishing country Germany
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-023-08085-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis.

    Russo, Elena / Guizzardi, Mathilda / Canali, Luca / Gaino, Francesca / Costantino, Andrea / Mazziotti, Gherardo / Lania, Andrea / Uccella, Silvia / Di Tommaso, Luca / Ferreli, Fabio / Malvezzi, Luca / Spriano, Giuseppe / Mercante, Giuseppe

    Reviews in endocrine & metabolic disorders

    2023  Volume 24, Issue 6, Page(s) 1205–1216

    Abstract: Background: Inflammation has been associated with tumor development and circulating inflammatory biomarkers have been proposed as possible predictors of recurrence of several solid tumors. However, the role of inflammation markers in differentiated ... ...

    Abstract Background: Inflammation has been associated with tumor development and circulating inflammatory biomarkers have been proposed as possible predictors of recurrence of several solid tumors. However, the role of inflammation markers in differentiated thyroid carcinoma (DTC) is still uncertain.
    Objective: This meta-analysis aimed to assess the prognostic value of neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in patients with DTC.
    Methods: Studies investigating the association between survival and preoperative circulating inflammatory markers in DTC patients were included. The primary outcome was disease-free survival (DFS). Cumulative logarithms of the hazard ratio (log-HRs) with 95% CI were calculated through the inverse variance method using a random-effects model.
    Results: A total of 7599 patients with a mean age of 48.89 (95% CI 44.16-53.63) were included. The estimated pooled log-HRs for DFS were 0.07 for NLR (95% CI -0.12-0.26; p = 0.43), -0.58 for LMR (95% CI -1.21-0.05; p = 0.06), and 0.01 (95% CI 0-0.01; p = 0.21) for PLR.
    Conclusions: Our meta-analysis showed no association between NLR, PLR, LMR and DFS in DTC; however, more prospective data are needed to better define the association between inflammatory status and prognosis of DTC.
    MeSH term(s) Humans ; Middle Aged ; Prognosis ; Prospective Studies ; Lymphocytes/pathology ; Inflammation ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/pathology
    Language English
    Publishing date 2023-10-13
    Publishing country Germany
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2185718-0
    ISSN 1573-2606 ; 1389-9155
    ISSN (online) 1573-2606
    ISSN 1389-9155
    DOI 10.1007/s11154-023-09845-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correction to: Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis.

    Russo, Elena / Guizzardi, Mathilda / Canali, Luca / Gaino, Francesca / Costantino, Andrea / Mazziotti, Gherardo / Lania, Andrea / Uccella, Silvia / Di Tommaso, Luca / Ferreli, Fabio / Malvezzi, Luca / Spriano, Giuseppe / Mercante, Giuseppe

    Reviews in endocrine & metabolic disorders

    2023  Volume 25, Issue 2, Page(s) 449–450

    Language English
    Publishing date 2023-11-18
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2185718-0
    ISSN 1573-2606 ; 1389-9155
    ISSN (online) 1573-2606
    ISSN 1389-9155
    DOI 10.1007/s11154-023-09851-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ecological status improvement over a decade along the Ligurian coast according to a macroalgae based index (CARLIT).

    De La Fuente, Gina / Chiantore, Mariachiara / Gaino, Federico / Asnaghi, Valentina

    PloS one

    2018  Volume 13, Issue 12, Page(s) e0206826

    Abstract: According to the Water Framework Directive, within 2015 European Union countries must reach and maintain the "good" Ecological Status (ES), quantified through indices based on key biological elements as indicators. Along the Ligurian shallow rocky coasts ...

    Abstract According to the Water Framework Directive, within 2015 European Union countries must reach and maintain the "good" Ecological Status (ES), quantified through indices based on key biological elements as indicators. Along the Ligurian shallow rocky coasts (NW Italy), a macroalgae based index (CARtography of LITtoral and upper-sublittoral benthic communities, CARLIT), calibrated according to national characteristics and management needs, has been applied by the Regional Environmental Agency over the last ten years. In 2015, at least a "good" ES was achieved in all Ligurian water bodies except one, located in the Eastern Ligurian coastline, characterized by the lack of the most sensitive species, Cystoseira amentacea var. stricta. A general ES improvement has been observed along the Ligurian coastline, also in comparison with other quality indices (macroinvertebrates and fecal bacteria), and in particular in the Genoa water body, as proved by a relevant increase of C. amentacea abundance, probably as a consequence of enhancement in wastewater treatments. In the present study, the reliability of the observed improvement of the ES over a decade has been assessed, teasing apart intra-seasonal and operator-related variability. These results support the reliability of monitoring procedures carried out though the CARLIT Index and highlight the need and the effectiveness of reduction measures for anthropogenic impacts in order to achieve the ES required by European directives.
    MeSH term(s) Ecosystem ; Italy ; Microalgae/classification ; Microalgae/growth & development ; Phaeophyceae/classification ; Phaeophyceae/growth & development
    Language English
    Publishing date 2018-12-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0206826
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  8. Article ; Online: Trigeminal features in COVID-19 patients with smell impairment.

    Ferreli, Fabio / Di Bari, Matteo / Gaino, Francesca / Albanese, Alberto / Politi, Letterio S / Spriano, Giuseppe / Mercante, Giuseppe

    International forum of allergy & rhinology

    2021  Volume 11, Issue 8, Page(s) 1253–1255

    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; COVID-19/physiopathology ; Follow-Up Studies ; Humans ; Nasal Mucosa/innervation ; Nasal Mucosa/physiopathology ; Olfaction Disorders/diagnosis ; Olfaction Disorders/etiology ; Olfaction Disorders/physiopathology ; Recovery of Function/physiology ; SARS-CoV-2 ; Sino-Nasal Outcome Test ; Smell/physiology ; Trigeminal Nerve/physiopathology
    Language English
    Publishing date 2021-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.22796
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  9. Article ; Online: Long-standing gustatory and olfactory dysfunction in COVID-19 patients: a prospective study.

    Ferreli, Fabio / Gaino, Francesca / Russo, Elena / Di Bari, Matteo / Rossi, Vanessa / De Virgilio, Armando / Malvezzi, Luca / Colombo, Giovanni / Cristalli, Giovanni / Spriano, Giuseppe / Mercante, Giuseppe

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2022  Volume 279, Issue 9, Page(s) 4633–4640

    Abstract: Purpose: Our study aimed to describe recovery of gustatory dysfunction (GD) and olfactory dysfunction (OD) in COVID-19 patients, and to analyze variables associated with early or late recovery.: Methods: Telephone surveys were administered during an ... ...

    Abstract Purpose: Our study aimed to describe recovery of gustatory dysfunction (GD) and olfactory dysfunction (OD) in COVID-19 patients, and to analyze variables associated with early or late recovery.
    Methods: Telephone surveys were administered during an 18-month follow-up after COVID-19 diagnosis. One hundred and thirty-two included patients rated olfactory and gustatory function at each follow-up.
    Results: One hundred and twenty-nine patients reported GD, of whom 91 (70.5%) reported severe GD, and 99 patients reported OD, of whom 84 (84.9%) reported severe OD. Seventy-two/129 (55.8%) and 52/99 (52.5%) patients reported an improvement in GD and in OD during the first 7 days from the onset, respectively. At 3-month follow-up, 110/120 patients (85.3%) recovered from GD, while 80/99 patients (80.8%) recovered from OD. At 18-month follow-up, a total of 120/129 patients (93.0%) recovered from GD and 86/99 patients (86.9%) recovered from OD; while 10 patients (7.0%) still reported GD and 13 patients (13.1%) still reported OD. Severe GD/OD at presentation were associated with late complete recovery of taste/smell (p = 0.019 and p = 0.034, respectively). Improvement over the first 7 days from onset was significantly associated with faster recovery (p < 0.001).
    Conclusions: More than 80% of patients reported complete recovery of olfactory/gustatory function in the first 3 months after symptom onset. At 18-month follow-up, patients reporting complete recovery of gustatory and olfactory function were 93% and 87%, respectively. Severity of chemosensory dysfunction at the onset was negatively correlated to recovery, and improvement of taste and/or smell function within the first 7 days from symptom onset was significantly associated with early resolution.
    MeSH term(s) COVID-19/complications ; COVID-19 Testing ; Humans ; Olfaction Disorders/diagnosis ; Olfaction Disorders/etiology ; Prevalence ; Prospective Studies ; SARS-CoV-2 ; Smell ; Taste Disorders/diagnosis ; Taste Disorders/etiology
    Language English
    Publishing date 2022-06-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-022-07428-1
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  10. Article ; Online: Long-term olfactory dysfunction in COVID-19 patients: 18-month follow-up study.

    Ferreli, Fabio / Gaino, Francesca / Russo, Elena / Di Bari, Matteo / Rossi, Vanessa / De Virgilio, Armando / Di Stadio, Arianna / Spriano, Giuseppe / Mercante, Giuseppe

    International forum of allergy & rhinology

    2022  Volume 12, Issue 8, Page(s) 1078–1080

    MeSH term(s) COVID-19 ; Follow-Up Studies ; Humans ; Olfaction Disorders/epidemiology ; SARS-CoV-2 ; Smell
    Language English
    Publishing date 2022-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.22990
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