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  1. Article: Vocal Cord Monitoring by Flexible Fiberoptic Laryngoscopy During Thyroid Radiofrequency Ablation.

    Valcavi, Roberto / Gaino, Francesca / Novizio, Roberto / Mercante, Giuseppe

    VideoEndocrinology

    2023  Volume 10, Issue 3, Page(s) 41–43

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Journal Article
    ISSN 2329-9738
    ISSN 2329-9738
    DOI 10.1089/ve.2023.0012
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  2. Article ; Online: Treatment of COVID-19 olfactory dysfunction with olfactory training, palmitoylethanolamide with luteolin, or combined therapy: a blinded controlled multicenter randomized trial.

    Di Stadio, Arianna / Gallina, Salvatore / Cocuzza, Salvatore / De Luca, Pietro / Ingrassia, Angelo / Oliva, Simone / Sireci, Federico / Camaioni, Angelo / Ferreli, Fabio / Mercante, Giuseppe / Gaino, Francesca / Pace, Gian Marco / La Mantia, Ignazio / Brenner, Michael J

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2023  Volume 280, Issue 11, Page(s) 4949–4961

    Abstract: Purpose: Few evidence-based therapies are available for chronic olfactory dysfunction after COVID-19. This study investigated the relative efficacy of olfactory training alone, co-ultramicronized palmitoylethanolamide with luteolin (um-PEA-LUT, an anti- ... ...

    Abstract Purpose: Few evidence-based therapies are available for chronic olfactory dysfunction after COVID-19. This study investigated the relative efficacy of olfactory training alone, co-ultramicronized palmitoylethanolamide with luteolin (um-PEA-LUT, an anti-neuroinflammatory supplement) alone, or combined therapy for treating chronic olfactory dysfunction from COVID-19.
    Methods: This double-blinded controlled, placebo-controlled multicenter randomized clinical trial was conducted in 202 patients with persistent COVID-19 olfactory dysfunction of > 6 month duration. After a screening nasal endoscopy, patients were randomized to: (1) olfactory training and placebo; (2) once daily um-PEA-LUT alone; (3) twice daily um-PEA-LUT alone; or (4) combination of once daily um-PEA-LUT with olfactory training. Olfactory testing (Sniffin' Sticks odor identification test) was performed at baseline and at 1, 2, and 3 months. The primary outcome was recovery of over three points on olfactory testing, with outcomes compared at T
    Results: All patients completed the study, and there were no adverse events. At 90 days, odor identification scores improved by > 3 points in 89.2% of patients receiving combined therapy vs. 36.8% receiving olfactory training with placebo, 40% receiving twice daily um-PEA-LUT alone, and 41.6% receiving once daily um-PEA-LUT alone (p < 0.00001). Patients receiving treatment with um-PEA-LUT alone demonstrated subclinical improvement (< 3 point odor identification improvement) more often than patients receiving olfactory training with placebo (p < 0.0001.) CONCLUSIONS: Olfactory training plus once daily um-PEA-LUT resulted in greater olfactory recovery than either therapy alone in patients with long-term olfactory function due to COVID-19.
    Trial registration: 20112020PGFN on clinicaltrials.gov.
    Level of evidence: 1b (Individual Randomized Clinical Trial).
    MeSH term(s) Humans ; COVID-19/complications ; Luteolin ; Olfactory Training ; Smell ; Olfaction Disorders/drug therapy ; Olfaction Disorders/etiology
    Chemical Substances palmidrol (6R8T1UDM3V) ; Luteolin (KUX1ZNC9J2)
    Language English
    Publishing date 2023-06-28
    Publishing country Germany
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-023-08085-8
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  3. Article ; Online: CORONA-steps for tracheotomy in COVID-19 patients: A staff-safe method for airway management.

    Ferreli, Fabio / Gaino, Francesca / Cecconi, Maurizio / Costantini, Elena / Spriano, Giuseppe / Mercante, Giuseppe

    Oral oncology

    2020  Volume 105, Page(s) 104728

    MeSH term(s) Airway Management ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Tracheotomy
    Keywords covid19
    Language English
    Publishing date 2020-04-17
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2020.104728
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    Zs.A 4869: Show issues Location:
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  4. Article ; Online: Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis.

    Russo, Elena / Guizzardi, Mathilda / Canali, Luca / Gaino, Francesca / Costantino, Andrea / Mazziotti, Gherardo / Lania, Andrea / Uccella, Silvia / Di Tommaso, Luca / Ferreli, Fabio / Malvezzi, Luca / Spriano, Giuseppe / Mercante, Giuseppe

    Reviews in endocrine & metabolic disorders

    2023  Volume 24, Issue 6, Page(s) 1205–1216

    Abstract: Background: Inflammation has been associated with tumor development and circulating inflammatory biomarkers have been proposed as possible predictors of recurrence of several solid tumors. However, the role of inflammation markers in differentiated ... ...

    Abstract Background: Inflammation has been associated with tumor development and circulating inflammatory biomarkers have been proposed as possible predictors of recurrence of several solid tumors. However, the role of inflammation markers in differentiated thyroid carcinoma (DTC) is still uncertain.
    Objective: This meta-analysis aimed to assess the prognostic value of neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in patients with DTC.
    Methods: Studies investigating the association between survival and preoperative circulating inflammatory markers in DTC patients were included. The primary outcome was disease-free survival (DFS). Cumulative logarithms of the hazard ratio (log-HRs) with 95% CI were calculated through the inverse variance method using a random-effects model.
    Results: A total of 7599 patients with a mean age of 48.89 (95% CI 44.16-53.63) were included. The estimated pooled log-HRs for DFS were 0.07 for NLR (95% CI -0.12-0.26; p = 0.43), -0.58 for LMR (95% CI -1.21-0.05; p = 0.06), and 0.01 (95% CI 0-0.01; p = 0.21) for PLR.
    Conclusions: Our meta-analysis showed no association between NLR, PLR, LMR and DFS in DTC; however, more prospective data are needed to better define the association between inflammatory status and prognosis of DTC.
    MeSH term(s) Humans ; Middle Aged ; Prognosis ; Prospective Studies ; Lymphocytes/pathology ; Inflammation ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/pathology
    Language English
    Publishing date 2023-10-13
    Publishing country Germany
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2185718-0
    ISSN 1573-2606 ; 1389-9155
    ISSN (online) 1573-2606
    ISSN 1389-9155
    DOI 10.1007/s11154-023-09845-x
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  5. Article ; Online: Correction to: Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis.

    Russo, Elena / Guizzardi, Mathilda / Canali, Luca / Gaino, Francesca / Costantino, Andrea / Mazziotti, Gherardo / Lania, Andrea / Uccella, Silvia / Di Tommaso, Luca / Ferreli, Fabio / Malvezzi, Luca / Spriano, Giuseppe / Mercante, Giuseppe

    Reviews in endocrine & metabolic disorders

    2023  Volume 25, Issue 2, Page(s) 449–450

    Language English
    Publishing date 2023-11-18
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2185718-0
    ISSN 1573-2606 ; 1389-9155
    ISSN (online) 1573-2606
    ISSN 1389-9155
    DOI 10.1007/s11154-023-09851-z
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  6. Article ; Online: Trigeminal features in COVID-19 patients with smell impairment.

    Ferreli, Fabio / Di Bari, Matteo / Gaino, Francesca / Albanese, Alberto / Politi, Letterio S / Spriano, Giuseppe / Mercante, Giuseppe

    International forum of allergy & rhinology

    2021  Volume 11, Issue 8, Page(s) 1253–1255

    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; COVID-19/physiopathology ; Follow-Up Studies ; Humans ; Nasal Mucosa/innervation ; Nasal Mucosa/physiopathology ; Olfaction Disorders/diagnosis ; Olfaction Disorders/etiology ; Olfaction Disorders/physiopathology ; Recovery of Function/physiology ; SARS-CoV-2 ; Sino-Nasal Outcome Test ; Smell/physiology ; Trigeminal Nerve/physiopathology
    Language English
    Publishing date 2021-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.22796
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    Zs.A 6927: Show issues Location:
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  7. Article ; Online: Long-standing gustatory and olfactory dysfunction in COVID-19 patients: a prospective study.

    Ferreli, Fabio / Gaino, Francesca / Russo, Elena / Di Bari, Matteo / Rossi, Vanessa / De Virgilio, Armando / Malvezzi, Luca / Colombo, Giovanni / Cristalli, Giovanni / Spriano, Giuseppe / Mercante, Giuseppe

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2022  Volume 279, Issue 9, Page(s) 4633–4640

    Abstract: Purpose: Our study aimed to describe recovery of gustatory dysfunction (GD) and olfactory dysfunction (OD) in COVID-19 patients, and to analyze variables associated with early or late recovery.: Methods: Telephone surveys were administered during an ... ...

    Abstract Purpose: Our study aimed to describe recovery of gustatory dysfunction (GD) and olfactory dysfunction (OD) in COVID-19 patients, and to analyze variables associated with early or late recovery.
    Methods: Telephone surveys were administered during an 18-month follow-up after COVID-19 diagnosis. One hundred and thirty-two included patients rated olfactory and gustatory function at each follow-up.
    Results: One hundred and twenty-nine patients reported GD, of whom 91 (70.5%) reported severe GD, and 99 patients reported OD, of whom 84 (84.9%) reported severe OD. Seventy-two/129 (55.8%) and 52/99 (52.5%) patients reported an improvement in GD and in OD during the first 7 days from the onset, respectively. At 3-month follow-up, 110/120 patients (85.3%) recovered from GD, while 80/99 patients (80.8%) recovered from OD. At 18-month follow-up, a total of 120/129 patients (93.0%) recovered from GD and 86/99 patients (86.9%) recovered from OD; while 10 patients (7.0%) still reported GD and 13 patients (13.1%) still reported OD. Severe GD/OD at presentation were associated with late complete recovery of taste/smell (p = 0.019 and p = 0.034, respectively). Improvement over the first 7 days from onset was significantly associated with faster recovery (p < 0.001).
    Conclusions: More than 80% of patients reported complete recovery of olfactory/gustatory function in the first 3 months after symptom onset. At 18-month follow-up, patients reporting complete recovery of gustatory and olfactory function were 93% and 87%, respectively. Severity of chemosensory dysfunction at the onset was negatively correlated to recovery, and improvement of taste and/or smell function within the first 7 days from symptom onset was significantly associated with early resolution.
    MeSH term(s) COVID-19/complications ; COVID-19 Testing ; Humans ; Olfaction Disorders/diagnosis ; Olfaction Disorders/etiology ; Prevalence ; Prospective Studies ; SARS-CoV-2 ; Smell ; Taste Disorders/diagnosis ; Taste Disorders/etiology
    Language English
    Publishing date 2022-06-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-022-07428-1
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  8. Article ; Online: Long-term olfactory dysfunction in COVID-19 patients: 18-month follow-up study.

    Ferreli, Fabio / Gaino, Francesca / Russo, Elena / Di Bari, Matteo / Rossi, Vanessa / De Virgilio, Armando / Di Stadio, Arianna / Spriano, Giuseppe / Mercante, Giuseppe

    International forum of allergy & rhinology

    2022  Volume 12, Issue 8, Page(s) 1078–1080

    MeSH term(s) COVID-19 ; Follow-Up Studies ; Humans ; Olfaction Disorders/epidemiology ; SARS-CoV-2 ; Smell
    Language English
    Publishing date 2022-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.22990
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  9. Article ; Online: "L" shape technique for endoscopic sinus surgery: An alternative method.

    Ferreli, Fabio / Mercante, Giuseppe / De Virgilio, Armando / Cugini, Giovanni / Pirola, Francesca / Gaino, Francesca / Malvezzi, Luca / Spriano, Giuseppe / Colombo, Giovanni

    American journal of otolaryngology

    2020  Volume 41, Issue 5, Page(s) 102471

    Abstract: Background: Several techniques for performing ethmoidectomy have been reported. We describe a safe, effective and efficient technique during functional endoscopic sinus surgery (FESS). We present text, images and videos to illustrate our preferred ... ...

    Abstract Background: Several techniques for performing ethmoidectomy have been reported. We describe a safe, effective and efficient technique during functional endoscopic sinus surgery (FESS). We present text, images and videos to illustrate our preferred technique during an antero-posterior ethmoidectomy and to provide a multimedia tool for educational purpose.
    Methods: A description of the technique without prospective or retrospective data is reported. A complete ethmoidectomy with an L-shape approach is described step-by-step, using the backbiting circular and miniature cutting forceps, with safe exposure of the lamina papyracea (LP) and skull base.
    Results: In our hands, the L-shape approach for chronic rhinosinusitis with or without polyposis, performed with punch circular cutting and miniature cutting forceps, allowed for a reliably safe and efficient ethmoidectomy.
    Conclusion: The technique described can be added to the armamentarium of the endoscopic sinus surgeon.
    MeSH term(s) Chronic Disease ; Endoscopy/methods ; Ethmoid Bone/surgery ; Ethmoid Sinus/surgery ; Ethmoid Sinusitis/surgery ; Humans ; Otorhinolaryngologic Surgical Procedures/education ; Otorhinolaryngologic Surgical Procedures/instrumentation ; Otorhinolaryngologic Surgical Procedures/methods ; Skull Base/surgery ; Surgical Instruments
    Language English
    Publishing date 2020-04-01
    Publishing country United States
    Document type Video-Audio Media
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2020.102471
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  10. Article ; Online: Trans-Oral Robotic Surgery in the Management of a Supraglottic Solitary Fibrous Tumor.

    De Virgilio, Armando / Mercante, Giuseppe / Costantino, Andrea / Pellini, Raul / Petruzzi, Gerardo / Yiu, Philip / Gaino, Francesca / Spriano, Giuseppe

    The Journal of craniofacial surgery

    2020  Volume 31, Issue 5, Page(s) e491–e493

    Abstract: Trans-oral robotic surgery (TORS) has become increasingly widespread for the head and neck surgery procedures. In this paper, the authors describe the first reported TORS in the management of a laryngeal solitary fibrous tumor (SFT). A 77-year-old woman ... ...

    Abstract Trans-oral robotic surgery (TORS) has become increasingly widespread for the head and neck surgery procedures. In this paper, the authors describe the first reported TORS in the management of a laryngeal solitary fibrous tumor (SFT). A 77-year-old woman suffered from progressive dysphonia lasting 2 years and occasional dyspnea. A submucosal mass of about 4 cm in diameter involving the left supraglottis and left aryepiglottic fold was detected during the flexible fibre-optic laryngeal examination. Magnetic resonance imaging revealed a solid, well-demarcated mass (36 × 25 mm), hyperintense with nonhomogeneous contrast enhancement in T2-weighted sequences. The lesion was successfully removed en bloc using the daVinci Xi system (Intuitive Surgical, Sunnyvale, CA) equipped with 3 robotic arms (1 3-dimensional endoscopic arm, 1 monopolar cautery, 1 bipolar Maryland forceps). The postoperative course was regular, and the endoscopic examination at 1 month showed normal laryngeal morphology and function. Trans-oral robotic surgery has proved to be a good alternative to conventional trans-oral approaches in the treatment of laryngeal SFT. The lesion was completely removed without intraoperative complications, and postoperative morbidity was minimized. Further comparative studies are recommended to define if TORS could become the gold standard for the surgical treatment of laryngeal SFTs.
    MeSH term(s) Aged ; Endoscopy ; Female ; Humans ; Laryngeal Neoplasms/diagnostic imaging ; Laryngeal Neoplasms/surgery ; Robotic Surgical Procedures ; Solitary Fibrous Tumors/diagnostic imaging ; Solitary Fibrous Tumors/surgery
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000006555
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