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  1. Article: Current opportunities and challenges in ALK-positive lung cancer.

    Lin, Jessica J / Gainor, Justin F

    Translational lung cancer research

    2024  Volume 13, Issue 1, Page(s) 1–4

    Language English
    Publishing date 2024-01-22
    Publishing country China
    Document type Editorial
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-2023-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Adjuvant PD-L1 blockade in non-small-cell lung cancer.

    Gainor, Justin F

    Lancet (London, England)

    2021  Volume 398, Issue 10308, Page(s) 1281–1283

    MeSH term(s) B7-H1 Antigen ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Humans ; Lung Neoplasms/drug therapy ; Programmed Cell Death 1 Receptor
    Chemical Substances B7-H1 Antigen ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2021-09-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)02100-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Osimertinib in Patients With Non-Small Cell Lung Cancer and Uncommon EGFR Mutations-Chasing Unicorns?

    Wang, Victoria E / Gainor, Justin F

    JAMA oncology

    2023  Volume 10, Issue 1, Page(s) 52–53

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Mutation ; ErbB Receptors/genetics ; Protein Kinase Inhibitors/therapeutic use ; Acrylamides ; Aniline Compounds ; Indoles ; Pyrimidines
    Chemical Substances osimertinib (3C06JJ0Z2O) ; ErbB Receptors (EC 2.7.10.1) ; Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1) ; Acrylamides ; Aniline Compounds ; Indoles ; Pyrimidines
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2023.5004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Facts and Hopes: Immunocytokines for Cancer Immunotherapy.

    Pabani, Aliyah / Gainor, Justin F

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2023  Volume 29, Issue 19, Page(s) 3841–3849

    Abstract: The clinical development of cytokines as cancer therapeutics has been limited due to significant toxicities generally observed with systemic administration. This narrow therapeutic window, together with relatively modest efficacy, has made natural ... ...

    Abstract The clinical development of cytokines as cancer therapeutics has been limited due to significant toxicities generally observed with systemic administration. This narrow therapeutic window, together with relatively modest efficacy, has made natural cytokines unattractive drug candidates. Immunocytokines represent a class of next-generation cytokines designed to overcome the challenges associated with traditional cytokines. These agents seek to improve the therapeutic index of cytokines by using antibodies as vehicles for the targeted delivery of immunomodulatory agents within the local tumor microenvironment (TME). Various molecular formats and cytokine payloads have been studied. In this review, we provide an overview of the rationale, preclinical support, and current clinical development strategies for immunocytokines.
    MeSH term(s) Humans ; Antibodies, Monoclonal/therapeutic use ; Cytokines ; Neoplasms/drug therapy ; Drug Delivery Systems ; Immunotherapy ; Tumor Microenvironment
    Chemical Substances Antibodies, Monoclonal ; Cytokines
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-22-1837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4223: Show issues Location:
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  5. Article ; Online: Letter to the Editor Reply: Kleebayoon et al.

    Meador, Catherine B / Gainor, Justin F

    Clinical lung cancer

    2023  Volume 24, Issue 5, Page(s) e162–e163

    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2145146-1
    ISSN 1938-0690 ; 1525-7304
    ISSN (online) 1938-0690
    ISSN 1525-7304
    DOI 10.1016/j.cllc.2023.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5893: Show issues Location:
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    Zs.MO 440: Show issues

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  6. Article ; Online: First-line lorlatinib for advanced ALK-positive non-small-cell lung cancer.

    Lin, Jessica J / Gainor, Justin F

    The Lancet. Respiratory medicine

    2022  Volume 11, Issue 4, Page(s) 302–304

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/drug therapy ; Lactams ; Aminopyridines ; Lactams, Macrocyclic ; Receptor Protein-Tyrosine Kinases ; Protein Kinase Inhibitors/therapeutic use
    Chemical Substances lorlatinib (OSP71S83EU) ; Lactams ; Aminopyridines ; Lactams, Macrocyclic ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Protein Kinase Inhibitors
    Language English
    Publishing date 2022-12-16
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(22)00488-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7041: Show issues Location:
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  7. Article ; Online: Human Epidermal Growth Factor Receptor 2-Mutant Non-Small-Cell Lung Cancer: Continued Progress But Challenges Remain.

    Cooper, Alissa J / Gainor, Justin F

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2022  Volume 40, Issue 7, Page(s) 693–697

    MeSH term(s) Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Receptor, ErbB-2
    Chemical Substances ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2022-01-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.21.02550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  8. Article ; Online: Selective Targeting of RET Fusions in Lung Cancer.

    Lin, Jessica J / Gainor, Justin F

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2022  Volume 41, Issue 2, Page(s) 410–412

    MeSH term(s) Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Oncogene Proteins, Fusion/genetics ; Proto-Oncogene Proteins c-ret/genetics
    Chemical Substances Oncogene Proteins, Fusion ; RET protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-ret (EC 2.7.10.1)
    Language English
    Publishing date 2022-09-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.01644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1847: Show issues Location:
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  9. Article ; Online: Searching for Synergy: Chemotherapy and Checkpoint Inhibitors.

    Tseng, Diane / Gainor, Justin F

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2022  Volume 28, Issue 11, Page(s) 2206–2208

    Abstract: Continuation of programmed cell death protein 1 (PD-1) inhibitors in combination with chemotherapy did not improve clinical outcomes for patients with non-small cell lung cancer who progressed on prior PD-1/programmed death ligand 1 inhibitor monotherapy. ...

    Abstract Continuation of programmed cell death protein 1 (PD-1) inhibitors in combination with chemotherapy did not improve clinical outcomes for patients with non-small cell lung cancer who progressed on prior PD-1/programmed death ligand 1 inhibitor monotherapy. This highlights the need to evaluate the precise mechanisms of resistance to PD-1 axis inhibitors and explore alternative therapeutic strategies to overcome resistance. See related article by Jung et al., p. 2321.
    MeSH term(s) Antibodies, Monoclonal, Humanized ; B7-H1 Antigen/metabolism ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Humans ; Immune Checkpoint Inhibitors ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Programmed Cell Death 1 Receptor/metabolism
    Chemical Substances Antibodies, Monoclonal, Humanized ; B7-H1 Antigen ; Immune Checkpoint Inhibitors ; Programmed Cell Death 1 Receptor ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-22-0335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4223: Show issues Location:
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  10. Article: Square peg, round hole? Programmed death-1 inhibitors in epidermal growth factor receptor-mutant non-small cell lung cancer.

    Gainor, Justin F

    Journal of thoracic disease

    2018  Volume 10, Issue 1, Page(s) 25–29

    Language English
    Publishing date 2018-03-26
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2017.12.23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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