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  1. Article ; Online: Antioxidant, Anti-inflammatory, and Immunomodulatory Roles of Nonvitamin Antioxidants in Anti-SARS-CoV-2 Therapy.

    Pisoschi, Aurelia Magdalena / Iordache, Florin / Stanca, Loredana / Gajaila, Iuliana / Ghimpeteanu, Oana Margarita / Geicu, Ovidiu Ionut / Bilteanu, Liviu / Serban, Andreea Iren

    Journal of medicinal chemistry

    2022  Volume 65, Issue 19, Page(s) 12562–12593

    Abstract: Viral pathologies encompass activation of pro-oxidative pathways and inflammatory burst. Alleviating overproduction of reactive oxygen species and cytokine storm in COVID-19 is essential to counteract the immunogenic damage in endothelium and alveolar ... ...

    Abstract Viral pathologies encompass activation of pro-oxidative pathways and inflammatory burst. Alleviating overproduction of reactive oxygen species and cytokine storm in COVID-19 is essential to counteract the immunogenic damage in endothelium and alveolar membranes. Antioxidants alleviate oxidative stress, cytokine storm, hyperinflammation, and diminish the risk of organ failure. Direct antiviral roles imply: impact on viral spike protein, interference with the ACE2 receptor, inhibition of dipeptidyl peptidase 4, transmembrane protease serine 2 or furin, and impact on of helicase, papain-like protease, 3-chyomotrypsin like protease, and RNA-dependent RNA polymerase. Prooxidative environment favors conformational changes in the receptor binding domain, promoting the affinity of the spike protein for the host receptor. Viral pathologies imply a vicious cycle, oxidative stress promoting inflammatory responses, and vice versa. The same was noticed with respect to the relationship antioxidant impairment-viral replication. Timing, dosage, pro-oxidative activities, mutual influences, and interference with other antioxidants should be carefully regarded. Deficiency is linked to illness severity.
    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Anti-Inflammatory Agents ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Cytokine Release Syndrome ; Dipeptidyl Peptidase 4 ; Furin ; Humans ; Papain ; RNA-Dependent RNA Polymerase ; Reactive Oxygen Species ; SARS-CoV-2 ; Serine ; Spike Glycoprotein, Coronavirus/metabolism ; COVID-19 Drug Treatment
    Chemical Substances Anti-Inflammatory Agents ; Antioxidants ; Antiviral Agents ; Reactive Oxygen Species ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Serine (452VLY9402) ; RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; Dipeptidyl Peptidase 4 (EC 3.4.14.5) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Furin (EC 3.4.21.75) ; Papain (EC 3.4.22.2)
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.2c01134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
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  2. Article ; Online: Comparative study of the influence of hawthorn (Crataegus monogyna) berry ethanolic extract and butylated hydroxylanisole (BHA) on lipid peroxidation, myoglobin oxidation, consistency and firmness of minced pork during refrigeration.

    Papuc, Camelia / Predescu, Corina Nicoleta / Tudoreanu, Liliana / Nicorescu, Valentin / Gâjâilă, Iuliana

    Journal of the science of food and agriculture

    2017  

    Abstract: Background: Following public concern on the use of synthetic food antioxidants, there is an increasing demand for the application of mixed or purified natural antioxidants to maintain quality of meat products quality during storage. The aim of this ... ...

    Abstract Background: Following public concern on the use of synthetic food antioxidants, there is an increasing demand for the application of mixed or purified natural antioxidants to maintain quality of meat products quality during storage. The aim of this research was to investigate the effect of ethanolic extract of hawthorn berry, compared to butylated hydroxylanisole (BHA), on lipid peroxidation, myoglobin oxidation, protein electrophoresis pattern, consistency and firmness of minced pork during refrigeration at 4 °C, and to identify the relationship between chemical modifications and consistency variation.
    Results: After 6 days of refrigeration it was found that the thiobarbituric acid reactive substances value of minced pork containing 200 mg GAE kg
    Conclusion: Hawthorn berry ethanolic extract was more effective than BHA in reducing lipid oxidation and protein degradation, for maintaining firmness and consistency of minced pork during 6 days of refrigeration at 4 °C. © 2017 Society of Chemical Industry.
    Language English
    Publishing date 2017-08-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 184116-6
    ISSN 1097-0010 ; 0022-5142
    ISSN (online) 1097-0010
    ISSN 0022-5142
    DOI 10.1002/jsfa.8599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 808: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Determination of Relationships between Milk Composition and Cheese Yield using Principal Component Analysis and Logit Model

    GÂJÂILĂ, Iuliana / GÂJÂILĂ, Gabriel / DOBREA, Mimi / COTOR, Gabriel

    Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine

    Issue (1)

    Abstract: Cheese yield is affected by many factors including milk quality and composition. The application of a factor analysis method, so called Principal Components Analysis (PCA), has the final goal of establishing and analyzing those variables which influence ... ...

    Abstract Cheese yield is affected by many factors including milk quality and composition. The application of a factor analysis method, so called Principal Components Analysis (PCA), has the final goal of establishing and analyzing those variables which influence in a meaningful way the cheese yield. The study was focused on a set of dates regarding the cow, buffalo, ewe and goat milk constituents and cheese, available in the related work. The data was then used in a principal component analysis, identifying such a number of 5 variables involved in cheese yield and also variables which determine the different textures.
    Language English
    Document type Article
    ISSN 1843-5270
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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  4. Article: Evaluation of the Level Selection and Functional Maturation of the T cells in the Blood of Pigs, Depending on Age of the Animal

    GÂJÂILĂ, Gabriel / COTOR, Gabriel / GÂJÂILĂ, Iuliana

    Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine

    Issue (1)

    Abstract: The existence of cellular separation particularities insures the degree of purity of the T lymphocytes. T cells were separated by centrifugation discontinuous Percoll density gradient and the population selected based on the different adhesion ability of ...

    Abstract The existence of cellular separation particularities insures the degree of purity of the T lymphocytes. T cells were separated by centrifugation discontinuous Percoll density gradient and the population selected based on the different adhesion ability of nylon fibers by adhesion molecules present on the surface. The most efficient separation occurs by using Percoll density of 1.077 g/ml and 3 g nylon fiber/column.
    Language English
    Document type Article
    ISSN 1843-5270
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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  5. Article: The effect of overpopulation on Neutrophile/Lymphocyte ratio and WBC values, in normal and Propranolol treated rats

    COTOR, G / GAJAILA, G / DOBREA, Mimi / GAJAILA, Iuliana

    Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine

    Issue (1)

    Abstract: Our study evaluate the effects of the overpopulation stress on some leucogram parameters in normal and Propranolol treated rats. In this purpose 18 adult Wistar rats were separated in standard cages, for 6 days, in 3 experimental groups,. The density of ... ...

    Abstract Our study evaluate the effects of the overpopulation stress on some leucogram parameters in normal and Propranolol treated rats. In this purpose 18 adult Wistar rats were separated in standard cages, for 6 days, in 3 experimental groups,. The density of rats varies: Group I = 3 rats/cage; Group II = 6 rats/cage; Group III = 6 rats/cage. The rats belonging to the Group III were injected with Propranolol (5 mg/kg, s.c.). In the 6th day of the experiment blood samples were collected. The WBC count and N/L ratio were determined. The WBC values were significantly increased (P < 0.05) in Group II, compared to Group I (6.77 %) and III (7.71%). This leukocytosis was an adaptive response to overpopulation stress. These results suggest that in this response is involved predominantly the sympatho-adrenal mechanism. The N/L ration were significantly increased (P < 0.05) in Group II, compared to Group I (16.94 %). This parameter was increased in Group II, compared to Group III (6.15%). But this increase was not significant, statistically speaking. According to our results the overpopulation in rat seems to be a very stressful factor. Given that Propranolol had a weak effect on N/L ratio, means that, in this case, the sympatho-adrenal mechanism is not the only involved mechanism.
    Language English
    Document type Article
    ISSN 1843-5270
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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  6. Article: The effect induced by changing of conditions of maintenance and exploitations of draft horses, over some blood parameters

    COTOR, Gabriel / GAJAILA, G / DOBREA, Mimi / GAJAILA, Iuliana

    Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine

    Issue (1)

    Abstract: Our study evaluates the effects of the changing of conditions of exploitations of draft horses, over some blood parameters. In this purpose were monitored 6 adult draft horses. Until the start of the experiment the horses were kept in home hibernal ... ...

    Abstract Our study evaluates the effects of the changing of conditions of exploitations of draft horses, over some blood parameters. In this purpose were monitored 6 adult draft horses. Until the start of the experiment the horses were kept in home hibernal manure (800 m altitude). In spring the horses were transferred in the logging area. The tested parameters were evaluated four times. First (1st), evaluation was made immediately before the transfer of horses. The second evaluation (2nd) was made as soon as the horses arrived at the logging area (1000 m altitude). The third evaluation (3rd) was made after a week of intense work in logging area. The fourth evaluation (4th) was made after three weeks of intense work. Every evaluation blood samples were collected. RBC count, WBC count and N/L ratio were performed. The RBC values were significantly increased (P < 0.05) in 2nd(12.29 %), 3rd(7.66 %) and 4th(6.66 %) evaluations compared to 1st evaluation. This polycythemia represents an adaptive response to transport, hard work stress and altitude hypoxia. The WBC values were significantly increased (P < 0.05) in 2nd(28.5 %), 3rd(16.66 %) and 4th(14.52 %) evaluations compared to 1st evaluation. This leukocytosis seems to be an adaptive response to transportation and hard work stress. The N/L ration were significantly increased (P < 0.05) in 2nd(57.59 %), 3rd(51.30 %) and 4th(24.52 %) evaluations compared to 1st evaluation. According to these results, the horse transportation and logging work seems to be very stressful factors.
    Language English
    Document type Article
    ISSN 1843-5270
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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  7. Article: The Influence of PH on The Growth of Some Lactobacillus Strains with Different Origins

    DOBREA (POPESCU), Anca / SAVU, Constantin / DOBREA, Mimi / GÂJÂILĂ, Iuliana / COTOR, Gabriel / GEOGESCU, Mara / MURARIU, Gabriel / GEORGESCU, Lucian

    Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine

    Issue (1)

    Abstract: In this work, influence of pH (the values ranged between 2,0 and 11,5) on growth of nine Lactobacillus strains was been investigated. A significant acid tolerance was observed in all Lactobacillus investigated strains. The values of DO600 registered an ... ...

    Abstract In this work, influence of pH (the values ranged between 2,0 and 11,5) on growth of nine Lactobacillus strains was been investigated. A significant acid tolerance was observed in all Lactobacillus investigated strains. The values of DO600 registered an increase starting from pH values 3.5 or 4.0. The maximum DO600 values of the most strains were recorded in the pH values ranged between 5.0 and 6.0 except Lactobacillus salivarius strains isolated from the dental root canal that showed the maximum DO600 values at neutral pH. At the Lactobacillus strains isolated from the dental root canal, as for the probiotic Lactobacillus rhamnosus GG strain and Lactobacillus salivarius B and D strains of oral origin a high degree of tolerance of alkaline pH was observed. These strains were able to multiply at pH values ≥ 10,5.
    Language English
    Document type Article
    ISSN 1843-5270
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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