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Article: Rôle de l’IPA dans l’empowerment du patient atteint de schizophrénie et usage des directives anticipées incitatives en psychiatrie.

Saint-Julien Guizonne, Raïssa / Le Gal, Christophe

2023 Volume 68, Issue 876, Page(s) 22–25

Abstract: Interruption of treatment and lack of follow-up are the main causes of relapses and iterative emergency hospitalizations of people with schizophrenia. Recognition of mental illness, adherence to therapy and the ability to attribute psychotic phenomena to ...

Title translation	Role of the IPA in the empowerment of the patient with schizophrenia and use of incentive advance directives in psychiatry.
Abstract	Interruption of treatment and lack of follow-up are the main causes of relapses and iterative emergency hospitalizations of people with schizophrenia. Recognition of mental illness, adherence to therapy and the ability to attribute psychotic phenomena to the pathology promote patient empowerment. In terms of APN's skills, it seems interesting to understand how the proactive supervision of people suffering from schizophrenia by this professional can meet the empowerment needs of this population.
MeSH term(s)	Humans ; Schizophrenia ; Motivation ; Advance Directives ; Psychiatry ; Advanced Practice Nursing
Language	French
Publishing date	2023-06-22
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	604655-1
ISSN	0038-0814
ISSN	0038-0814
DOI	10.1016/j.soin.2023.05.006
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Article ; Online: The longevity and reversibility of quiescence in

Gal, Csenge / Cochrane, Grace A / Morgan, Brian A / Rallis, Charalampos / Bähler, Jürg / Whitehall, Simon K

Cell cycle (Georgetown, Tex.)

2023 Volume 22, Issue 17, Page(s) 1921–1936

Abstract: Quiescence (G0) is a reversible non-dividing state that facilitates cellular survival in adverse conditions. Here, we demonstrate that the HIRA histone chaperone complex is required for the reversibility and longevity of nitrogen starvation-induced ... ...

Abstract	Quiescence (G0) is a reversible non-dividing state that facilitates cellular survival in adverse conditions. Here, we demonstrate that the HIRA histone chaperone complex is required for the reversibility and longevity of nitrogen starvation-induced quiescence in
MeSH term(s)	Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Schizosaccharomyces pombe Proteins/metabolism ; Histone Chaperones/genetics ; Cell Division ; Cell Cycle Proteins/metabolism ; Nitrogen/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	Schizosaccharomyces pombe Proteins ; Histone Chaperones ; Cell Cycle Proteins ; Nitrogen (N762921K75) ; hip1 protein, S pombe ; Transcription Factors
Language	English
Publishing date	2023-08-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.1080/15384101.2023.2249705
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Article ; Online: Better later: evening practice is advantageous for motor skill consolidation in the elderly.

Korman, Maria / Gal, Carmit / Gabitov, Ella / Karni, Avi

Learning & memory (Cold Spring Harbor, N.Y.)

2021 Volume 28, Issue 3, Page(s) 72–75

Abstract: How does the time of day of a practice session affect learning of a new motor sequence in the elderly? Participants practiced a given finger tapping sequence either during morning or evening hours. All participants robustly improved performance speed ... ...

Abstract	How does the time of day of a practice session affect learning of a new motor sequence in the elderly? Participants practiced a given finger tapping sequence either during morning or evening hours. All participants robustly improved performance speed within the session concurrent with a reorganization of the tapping pattern of the sequence. However, evening-trained participants showed additional gains overnight and at 1 wk posttraining; moreover, evening training led to a further reorganization of the tapping pattern offline. A learning experience preceding nocturnal sleep can lead to a task-specific movement routine as an expression of novel "how to" knowledge in the elderly.
MeSH term(s)	Aged ; Aging/physiology ; Female ; Humans ; Male ; Memory Consolidation/physiology ; Middle Aged ; Motor Skills/physiology ; Practice, Psychological ; Time Factors
Language	English
Publishing date	2021-02-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1204777-6
ISSN	1549-5485 ; 1072-0502
ISSN (online)	1549-5485
ISSN	1072-0502
DOI	10.1101/lm.052522.120
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Article ; Online: Randomness impacts the building of specific priors, visual exploration, and perception in object recognition.

Gal, Cécile / Țincaș, Ioana / Moca, Vasile V / Ciuparu, Andrei / Dan, Emanuela L / Smith, Marie L / Gliga, Teodora / Mureșan, Raul C

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8527

Abstract: Recognising objects is a vital skill on which humans heavily rely to respond quickly and adaptively to their environment. Yet, we lack a full understanding of the role visual information sampling plays in this process, and its relation to the individual' ... ...

Abstract	Recognising objects is a vital skill on which humans heavily rely to respond quickly and adaptively to their environment. Yet, we lack a full understanding of the role visual information sampling plays in this process, and its relation to the individual's priors. To bridge this gap, the eye-movements of 18 adult participants were recorded during a free-viewing object-recognition task using Dots stimuli
MeSH term(s)	Adult ; Humans ; Visual Perception ; Eye Movements ; Recognition, Psychology ; Records
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-59089-1
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Article: Lactobacillus gasseri

Ait Abdellah, Samira / Scanzi, Julien / Gal, Caroline / Martin, Marc / Beck, Marc / Ojetti, Veronica

Journal of clinical medicine

2022 Volume 11, Issue 24

Abstract: The potential benefits of Lactobacillus gasseri LA806 in IBS were previously identified in a comprehensive preclinical research program. The purpose of this multicenter study was to explore in real-life conditions changes in IBS symptoms and quality of ... ...

Abstract	The potential benefits of Lactobacillus gasseri LA806 in IBS were previously identified in a comprehensive preclinical research program. The purpose of this multicenter study was to explore in real-life conditions changes in IBS symptoms and quality of life in patients receiving a 4-week supplementation with L. gasseri LA806. Altogether 119 patients meeting Rome IV criteria for IBS were included, of whom 118 received the supplement. The majority of patients (71.8% (95% CI 63.6−79.9%)) manifested a ≥30% decrease in abdominal pain at 4 weeks, the mean abdominal pain score diminishing by 54.2% (from 5.3 ± 2.2 to 2.2 ± 2.4, p < 0.0001). A statistically significant decrease in abdominal pain was seen as early as the first week. A decrease of ≥30% in both abdominal pain score and global IBS symptom score was attained in 61.5% of patients (95% CI 51.7−71.2%). The mean IBS-SSS score fell by 152 ± 112 points (p = 0.001), with symptoms being attenuated in 85% of patients (CGI-I). Supplementation led to a 10-fold decrease in the number of patients reporting severe IBS symptoms. The concomitant intake of antidiarrheals, antispasmodics and analgesics decreased and quality of life scores significantly improved. These preliminary results warrant confirmation by a randomized, placebo-controlled study that this study will allow a better design.
Language	English
Publishing date	2022-12-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11247446
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Article: Generation of a DSF-Guided Refolded Bacterially Expressed Hemagglutinin Ectodomain of Influenza Virus A/Puerto Rico/8/1934 H1N1 as a Model for Influenza Vaccine Antigens.

Tofan, Vlad-Constantin / Ermeneanu, Andreea-Laura / Caraș, Iuliana / Lenghel, Alina / Ionescu, Irina-Elena / Țucureanu, Cătălin / Gal, Claudiu / Stăvaru, Crina-Georgeta / Onu, Adrian

Vaccines

2023 Volume 11, Issue 10

Abstract: Influenza virus infections represent an ongoing public health threat as well as an economic burden. Although seasonal influenza vaccines have been available for some decades, efforts are being made to generate new efficient, flexible, and cost-effective ... ...

Abstract	Influenza virus infections represent an ongoing public health threat as well as an economic burden. Although seasonal influenza vaccines have been available for some decades, efforts are being made to generate new efficient, flexible, and cost-effective technologies to be transferred into production. Our work describes the development of a model influenza hemagglutinin antigen that is capable of inducing protection against viral challenge in mice. High amounts of the H1 hemagglutinin ectodomain, HA
Language	English
Publishing date	2023-09-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11101520
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Article ; Online: Bioavailability of Melatonin after Administration of an Oral Prolonged-Release Tablet and an Immediate-Release Sublingual Spray in Healthy Male Volunteers.

Ait Abdellah, Samira / Raverot, Véronique / Gal, Caroline / Guinobert, Isabelle / Bardot, Valérie / Blondeau, Claude / Claustrat, Bruno

Drugs in R&D

2023 Volume 23, Issue 3, Page(s) 257–265

Abstract: Background: The benefit of exogenous melatonin is based on its bioavailability, which depends on the galenic form, the route of administration, the dosage, and the individual absorption and rate of hepatic metabolism.: Objective: The objective of ... ...

Abstract	Background: The benefit of exogenous melatonin is based on its bioavailability, which depends on the galenic form, the route of administration, the dosage, and the individual absorption and rate of hepatic metabolism. Objective: The objective of this study is to investigate the bioavailability of melatonin after administration of an oral prolonged-release tablet (PR form) and an immediate-release sublingual spray (IR form). The main metabolite of melatonin, 6-sulfatoxymelatonin (6-SMT), was also measured, which has not been done in previous studies. Its determination is important as an index of the hepatic transformation of melatonin. Methods: In this single-center, open-label, randomized, crossover study, 14 healthy male volunteers received one tablet of the PR form (1.9 mg melatonin) or two sprays of the IR form (1 mg melatonin) during two visits separated by a washout period. Blood samples were collected over 7 and 9 h for the IR and PR form, respectively, to determine the main pharmacokinetic parameters. Results: The observed kinetics were consistent with those expected for immediate and prolonged-release forms. Pulverization of the spray resulted in an early, high plasma melatonin peak (C Conclusions: The results suggest that the galenic forms containing melatonin assessed in this study are suitable for the treatment of certain sleep disorders such as sleep onset delay and transient nocturnal awakenings for the IR form and insomnia for the PR form. Trial registry: Registration number: NCT04574141.
MeSH term(s)	Humans ; Male ; Biological Availability ; Cross-Over Studies ; Melatonin ; Tablets ; Volunteers ; Administration, Oral ; Area Under Curve
Chemical Substances	Melatonin (JL5DK93RCL) ; Tablets
Language	English
Publishing date	2023-07-12
Publishing country	New Zealand
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2020476-0
ISSN	1179-6901 ; 1174-5886
ISSN (online)	1179-6901
ISSN	1174-5886
DOI	10.1007/s40268-023-00431-9
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Article ; Online: Author Correction: Social patterning of childhood overweight in the French national ELFE cohort.

Le Gal, Camille / Lecorguillé, Marion / Poncet, Lorraine / Cissé, Aminata Hallimat / Gassama, Malamine / Simeon, Thierry / Lanoë, Jean-Louis / Melchior, Maria / Bernard, Jonathan Y / Charles, Marie-Aline / Heude, Barbara / Lioret, Sandrine

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3041

Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53416-2
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Article ; Online: Impact de l'exercice physique chez les patients atteints de mucoviscidose : revue systématique.

Le Gal, C / Vandervelde, L / Poncin, W / Reychler, G

Revue des maladies respiratoires

2016 Volume 33, Issue 7, Page(s) 573–582

Abstract: Introduction: Beneficial effects of physical exercise have been previously demonstrated in patients with chronic obstructive pulmonary disease. The aim of this systematic review was to summarize the evidence supporting physical exercise to improve on ... ...

Title translation	Impact of physical exercise in cystic fibrosis patients: A systematic review.
Abstract	Introduction: Beneficial effects of physical exercise have been previously demonstrated in patients with chronic obstructive pulmonary disease. The aim of this systematic review was to summarize the evidence supporting physical exercise to improve on lung function, exercise capacity and quality of life in cystic fibrosis patients. Methods: Medline database was used to search clinical studies from 2000 to 2015. We also analyzed the bibliographic section of the included studies, in order to identify additional references. Results: A total of 17 studies were identified. A great disparity was found in the results of the different studies. No systematic benefit was found on lung function, exercise capacity or quality of life. No relationship between the type of program and the benefits achieved was observed. Conclusions: Evidence that physical exercise benefits lung function, exercise capacity and quality of life in cystic fibrosis patient is inconsistent and evidence does not support a particular standardized program for all patients.
MeSH term(s)	Cystic Fibrosis/physiopathology ; Cystic Fibrosis/therapy ; Exercise/physiology ; Exercise Tolerance/physiology ; Humans ; Maximal Respiratory Pressures ; Quality of Life ; Respiration
Language	French
Publishing date	2016-09
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	605743-3
ISSN	1776-2588 ; 0301-0279 ; 0761-8425
ISSN (online)	1776-2588
ISSN	0301-0279 ; 0761-8425
DOI	10.1016/j.rmr.2015.08.006
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Article: Clusters of Responders and Predictive Factors for Response to Supplementation with Boswellia, Turmeric, and Red Algae Extracts in Painful Knee Osteoarthritis: A Prospective Observational Study Using an Arsenal of Patient-Centered Measures.

Ait Abdellah, Samira / Gal, Caroline / Leblanc, Anne / Trouvin, Anne-Priscille / Perrot, Serge

Open access rheumatology : research and reviews

2021 Volume 13, Page(s) 1–13

Abstract: Purpose: This observational study evaluated a combination of boswellia, turmeric, and red algae extracts in patients with knee osteoarthritis (KOA). Given the growing interest in patient-centered care in osteoarthritis, effects were assessed by an ... ...

Abstract	Purpose: This observational study evaluated a combination of boswellia, turmeric, and red algae extracts in patients with knee osteoarthritis (KOA). Given the growing interest in patient-centered care in osteoarthritis, effects were assessed by an arsenal of patient-reported outcome measures (PROMs): Patient Acceptable Symptom Scale (PASS), Minimal Clinically Important Improvement (MCII), Patient Global Impression of Change (PGIC), and Lequesne algofunctional index (LAFI). Patients also completed a list of 17 items on pain quality. Patients and methods: Patients with painful unilateral or bilateral KOA had to take 1-4 capsules per day of a dietary supplement containing boswellia, turmeric, and red algae extracts for 90 days. Patients completed PROMs on Days 0 (baseline), 10, 20, 30, 60, and/or 90. Results: A total of 118 patients [female: 69.5%; age: 62.9 (9.5) years, mean (SD)] were included in the study and took at least one capsule. Mean (SD) follow-up duration was 100.7 (54.9) days. Pain relief was maximal on Day 90: 64.5% of patients were responders (positive PASS); 68.8% and 58.4% had MCII and PGIC scores indicating positive effect (score ≥3) or global improvement (score ≥5); 73.3% (versus 47.5% at baseline) were mildly/moderately disabled (LAFI score <8); 55.2% had meaningful decrease (-30%) in pain intensity (VAS), 35.1% (versus 59.2% at baseline) took analgesics as supplementary treatment. Median time to the first PASS change was 34 days. Pain intensity (VAS), as well as two pain characteristics (ie, "Stabbing pain" and "Widespread pain"), were independent factors associated with non-response on Day 30. Four clusters of responders were isolated according to pain characteristics, with one cluster exhibiting a higher responder rate. Conclusion: The results of this preliminary study suggest that the combination of boswellia, turmeric, and red algae extracts tested could improve KOA patients. Beyond these results, this study showed the importance of PROMs and specific pain qualitative descriptors for the accurate evaluation of dietary supplement approaches in painful conditions.
Language	English
Publishing date	2021-01-08
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2508169-X
ISSN	1179-156X
ISSN	1179-156X
DOI	10.2147/OARRR.S287078
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