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  1. Article: Intralesional cryosurgery for the treatment of severe stoma hypergranulation following percutaneous endoscopic gastrostomy.

    Gal-or, Nir / Gil, Tamir / Metanes, Issa / Nashshibi, Munir / Bryzgalin, Leonid / Amir, Aharon / Har-Shai, Yaron

    The Israel Medical Association journal : IMAJ

    2015  Volume 17, Issue 4, Page(s) 251–252

    MeSH term(s) Child ; Cryosurgery/methods ; Ectodermal Dysplasia/surgery ; Facies ; Failure to Thrive/surgery ; Gastrostomy/adverse effects ; Gastrostomy/methods ; Granulation Tissue/pathology ; Granulation Tissue/surgery ; Heart Defects, Congenital/surgery ; Humans ; Injections, Intralesional ; Male ; Postoperative Complications/pathology ; Postoperative Complications/surgery ; Treatment Outcome
    Language English
    Publishing date 2015-04
    Publishing country Israel
    Document type Case Reports ; Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Intralesional cryosurgery for the treatment of basal cell carcinoma of the lower extremities in elderly subjects: a feasibility study.

    Har-Shai, Yaron / Sommer, Adir / Gil, Tamir / Krausz, Judit / Gal-Or, Nir / Mettanes, Issa / Lavi, Idit / Eyal, Nir / Brizgalin, Leonid / Taran, Amir / Har-Shai, Lior / Elmalach, Irit

    International journal of dermatology

    2016  Volume 55, Issue 3, Page(s) 342–350

    Abstract: Background: Incidences of basal cell carcinoma (BCC) on the lower extremities in elderly patients are rising. Surgical approaches to the treatment of BCC are subject to possible difficulties in healing, failure of skin grafts, and wound infection. This ... ...

    Abstract Background: Incidences of basal cell carcinoma (BCC) on the lower extremities in elderly patients are rising. Surgical approaches to the treatment of BCC are subject to possible difficulties in healing, failure of skin grafts, and wound infection. This study assessed the efficacy of intralesional cryosurgery in the treatment of BCC of the lower limbs in elderly patients.
    Methods: This study included eight patients aged >60 years in whom a total of 10 nodular or superficial BCCs of the lower limbs were confirmed by biopsy. The patients' medical histories revealed comorbidities including hypertension, diabetes, hypercholesterolemia, venous insufficiency, and deep vein thrombosis of the legs, congestive heart failure, chronic renal failure, and ischemic heart disease. Using liquid nitrogen, an intralesional cryosurgery needle (CryoShape) was inserted into the tumor to facilitate its complete freezing. Treatment success was confirmed by biopsy taken approximately 3 months after complete healing of the cryo-wound.
    Results: The average size of the lesions treated was 2.49 cm(2) (16.4 × 15.2 mm). Mean recovery time was 79.9 days. Biopsies were obtained at a mean of 85.3 days after the wound had healed. All 10 biopsies verified the complete destruction of the tumor. There was no evidence of wound infection or tumor recurrence over a follow-up period of 28 months.
    Conclusions: This study demonstrates that a single intralesional cryosurgery session can completely eradicate BCC on the lower extremities in elderly patients. This technique is associated with relatively minor complications, is well tolerated, and represents a safe and effective therapeutic modality for BCC of the lower limbs.
    MeSH term(s) Aged ; Aged, 80 and over ; Biopsy ; Carcinoma, Basal Cell/pathology ; Carcinoma, Basal Cell/surgery ; Cryosurgery/adverse effects ; Cryosurgery/methods ; Feasibility Studies ; Female ; Humans ; Lower Extremity ; Male ; Pain/etiology ; Prospective Studies ; Skin/pathology ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2016-03
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.13168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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