Article ; Online: Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study.
2023 Volume 62, Issue 2, Page(s) 675–678
Abstract: The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the reaction of hTF with cisplatin. Pt binds the side chain of ... ...
| Abstract | The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the reaction of hTF with cisplatin. Pt binds the side chain of Met256 (at the N-lobe), without altering the protein overall conformation. |
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| MeSH term(s) | Humans ; Cisplatin/metabolism ; Transferrin/chemistry ; Iron/chemistry ; Protein Conformation ; Protein Binding ; Receptors, Transferrin/chemistry ; Receptors, Transferrin/metabolism |
| Chemical Substances | Cisplatin (Q20Q21Q62J) ; Transferrin ; Iron (E1UOL152H7) ; Receptors, Transferrin |
| Language | English |
| Publishing date | 2023-01-05 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 1484438-2 |
| ISSN | 1520-510X ; 0020-1669 |
| ISSN (online) | 1520-510X |
| ISSN | 0020-1669 |
| DOI | 10.1021/acs.inorgchem.2c04206 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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