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  1. Article: Early COVID-19 Interventions Failed to Replicate 1918 St. Louis vs. Philadelphia Outcomes in the United States.

    Jalali, Aliea M / Peterson, Brent M / Galbadage, Thushara

    Frontiers in public health

    2020  Volume 8, Page(s) 579559

    Abstract: The Coronavirus disease 2019 (COVID-19) pandemic has elicited an abrupt pause in the United States in multiple sectors of commerce and social activity. As the US faces this health crisis, the magnitude and rigor of their initial public health response ... ...

    Abstract The Coronavirus disease 2019 (COVID-19) pandemic has elicited an abrupt pause in the United States in multiple sectors of commerce and social activity. As the US faces this health crisis, the magnitude and rigor of their initial public health response was unprecedented. As a response, the entire nation shutdown at the state-level for the duration of a ~1-3 months. These public health interventions, however, were not arbitrarily decided, but rather, implemented as a result of evidence-based practices. These practices were a result of lessons learned during the 1918 influenza pandemic and the city-level non-pharmaceutical interventions (NPIs) taken across the US. During the 1918 pandemic, two model cities, St. Louis, MO, and Philadelphia, PA, carried out two different approaches to address the spreading disease, which resulted in two distinctly different outcomes. Our group has evaluated the state-level public health response adopted by states across the US, with a focus on New York, California, Florida, and Texas, and compared the effectiveness of reducing the spread of COVID-19. Our assessments show that while the states mentioned above benefited from the implementations of early preventative measures, they inadequately replicated the desired outcomes observed in St. Louis during the 1918 crisis. Our study indicates that there are other factors, including health disparities that may influence the effectiveness of public health interventions applied. Identifying more specific health determinants may help implement targeted interventions aimed at preventing the spread of COVID-19 and improving health equity.
    MeSH term(s) COVID-19 ; Florida ; Humans ; New York ; Philadelphia/epidemiology ; SARS-CoV-2 ; Texas ; United States/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-09-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.579559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Does COVID-19 Spread Through Droplets Alone?

    Galbadage, Thushara / Peterson, Brent M / Gunasekera, Richard S

    Frontiers in public health

    2020  Volume 8, Page(s) 163

    MeSH term(s) COVID-19/epidemiology ; COVID-19/transmission ; Disease Transmission, Infectious ; Disinfectants ; Humans ; Infection Control ; Physical Distancing ; Public Health ; SARS-CoV-2/isolation & purification
    Chemical Substances Disinfectants
    Keywords covid19
    Language English
    Publishing date 2020-04-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.00163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The vital role of exercise and nutrition in COVID-19 rehabilitation: synergizing strength.

    Peterson, Brent M / Unger, Isabelle / Sun, Sunny / Park, Ji-Yeun / Kim, Jinsil / Gunasekera, Richard S / Wilson, Jason / Galbadage, Thushara

    Frontiers in sports and active living

    2023  Volume 5, Page(s) 1305175

    Abstract: Since the outset of the COVID-19 pandemic, the global healthcare community has faced the challenge of understanding and addressing the ongoing and multi-faceted SARS-CoV-2 infection outcomes. As millions of individuals worldwide continue to navigate the ... ...

    Abstract Since the outset of the COVID-19 pandemic, the global healthcare community has faced the challenge of understanding and addressing the ongoing and multi-faceted SARS-CoV-2 infection outcomes. As millions of individuals worldwide continue to navigate the complexities of post-hospitalization recovery, reinfection rates, and the increasing prevalence of Long-COVID symptoms, comprehensive COVID-19 rehabilitation strategies are greatly needed. Previous studies have highlighted the potential synergy between exercise and nutrition, suggesting that their integration into patient rehabilitation programs may yield improved clinical outcomes for survivors of COVID-19. Our group aimed to consolidate existing knowledge following the implementation of patient, intervention, comparison, and outcome (PICO) search strategies on the distinct and combined impacts of exercise and nutrition interventions in facilitating the recovery of COVID-19 patients following hospitalization, with a specific focus on their implications for both public health and clinical practice. The incorporation of targeted nutritional strategies alongside exercise-based programs may expedite patient recovery, ultimately promoting independence in performing activities of daily living (ADLs). Nonetheless, an imperative for expanded scientific inquiry remains, particularly in the realm of combined interventions. This mini-review underscores the compelling prospects offered by an amalgamated approach, advocating for the seamless integration of exercise and nutrition as integral components of post-hospitalization COVID-19 rehabilitation. The pursuit of a comprehensive understanding of the synergistic effects and effectiveness of exercise and nutrition stands as a crucial objective in advancing patient care and refining recovery strategies in the wake of this enduring global health crisis.
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2624-9367
    ISSN (online) 2624-9367
    DOI 10.3389/fspor.2023.1305175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: ORFanID: A web-based search engine for the discovery and identification of orphan and taxonomically restricted genes.

    Gunasekera, Richard S / Raja, Komal K B / Hewapathirana, Suresh / Tundrea, Emanuel / Gunasekera, Vinodh / Galbadage, Thushara / Nelson, Paul A

    PloS one

    2023  Volume 18, Issue 10, Page(s) e0291260

    Abstract: With the numerous genomes sequenced today, it has been revealed that a noteworthy percentage of genes in a given taxon of organisms in the phylogenetic tree of life do not have orthologous sequences in other taxa. These sequences are commonly referred to ...

    Abstract With the numerous genomes sequenced today, it has been revealed that a noteworthy percentage of genes in a given taxon of organisms in the phylogenetic tree of life do not have orthologous sequences in other taxa. These sequences are commonly referred to as "orphans" or "ORFans" if found as single occurrences in a single species or as "taxonomically restricted genes" (TRGs) when found at higher taxonomic levels. Quantitative and collective studies of these genes are necessary for understanding their biological origins. However, the current software for identifying orphan genes is limited in its functionality, database search range, and very complex algorithmically. Thus, researchers studying orphan genes must harvest their data from many disparate sources. ORFanID is a graphical web-based search engine that facilitates the efficient identification of both orphan genes and TRGs at all taxonomic levels, from DNA or amino acid sequences in the NCBI database cluster and other large bioinformatics repositories. The software allows users to identify genes that are unique to any taxonomic rank, from species to domain, using NCBI systematic classifiers. It provides control over NCBI database search parameters, and the results are presented in a spreadsheet as well as a graphical display. The tables in the software are sortable, and results can be filtered using the fuzzy search functionality. The visual presentation can be expanded and collapsed by the taxonomic tree to its various branches. Example results from searches on five species and gene expression data from specific orphan genes are provided in the Supplementary Information.
    MeSH term(s) Search Engine ; Phylogeny ; Software ; Genome ; Internet
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0291260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Does COVID-19 Spread Through Droplets Alone?

    Galbadage, Thushara / Peterson, Brent M. / Gunasekera, Richard S.

    Frontiers in Public Health

    2020  Volume 8

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.00163
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Early COVID-19 Interventions Failed to Replicate 1918 St. Louis vs. Philadelphia Outcomes in the United States

    Jalali, Aliea M. / Peterson, Brent M. / Galbadage, Thushara

    Frontiers in Public Health

    2020  Volume 8

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.579559
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Online: Epidemiological Study of COVID-19 Modes of Disease Transmission

    Galbadage, Thushara / Peterson, Brent M. / Gunasekera, Richard S.

    Faculty Articles & Research

    with Molecular Basis for SARS-CoV-2 Virulence

    2020  

    Abstract: The world has been embroiled in a deadly and volatile public health crisis. The novel coronavirus disease 2019 (COVID-19), as a pandemic, has been rapidly affecting nations throughout the world with such ferocity that governments and their public health ... ...

    Abstract The world has been embroiled in a deadly and volatile public health crisis. The novel coronavirus disease 2019 (COVID-19), as a pandemic, has been rapidly affecting nations throughout the world with such ferocity that governments and their public health authorities have been forced to take drastic measures to contain the spread. Yet, despite the aggressive preventative measures in place, COVID-19 has propagated exponentially throughout the world. In response, we conducted an epidemiological study evaluating cumulative incidence, incidence rate, and mortality rate of COVID-19 to better understand the potential modes of disease transmission.in select countries experiencing a high burden of the disease. Currently, the accepted mode of disease transmission is by respiratory droplets containing the virus. Here we provide epidemiological data in conjunction with molecular mechanisms of this Severe Acute Respiratory Syndrome- Coronavirus-2 (SARS-CoV-2) and explain the possible alternative modes of disease transmission for COVID-19. Results from this investigation showed that despite aggressive droplet precautionary measures are needed to slow the spread of COVID-19.
    Keywords COVID-19 ; Coronavirus ; SARS-CoV-2 ; Fomites ; Pandemic ; Droplets ; Epidemiology ; Virus Diseases ; covid19
    Publishing date 2020-03-01T08:00:00Z
    Publisher Digital Commons @ Biola
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: Does COVID-19 Spread through Droplets Alone?

    Galbadage, Thushara / Peterson, Brent M. / Gunasekera, Richard S.

    Faculty Articles & Research

    2020  

    Abstract: The world has been in the midst of a swiftly unfolding public health crisis that has turned deadly. The novel coronavirus disease 2019 (COVID-19), has turned out to be a rapidly expanding pandemic affecting the nations of the world. Most governments and ... ...

    Abstract The world has been in the midst of a swiftly unfolding public health crisis that has turned deadly. The novel coronavirus disease 2019 (COVID-19), has turned out to be a rapidly expanding pandemic affecting the nations of the world. Most governments and their public health authorities worldwide have taken drastic measures to strictly contain the spread of this coronavirus. However, despite the aggressive preventative measures in place, COVID-19 has propagated exponentially across the world. Currently, the accepted mode of disease transmission is by droplets containing the virus. Here we provide epidemiological data in conjunction with biochemical molecular mechanisms of this Severe Acute Respiratory Syndrome- Coronavirus-2 (SARS-CoV-2) and explain the possible alternative modes of disease transmission. Our observed data, biochemical mechanisms, and inferences indicate that COVID-19 has a high probability of transmission through other routes as well, such as indirect routes; viz, fomites and aeros.
    Keywords COVID-19 ; Coronavirus ; SARS-CoV-2 ; Fomites ; Pandemic ; Droplets ; Community Health and Preventive Medicine ; Virus Diseases ; covid19
    Publishing date 2020-03-15T07:00:00Z
    Publisher Digital Commons @ Biola
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book ; Online: Early COVID-19 Interventions Failed to Replicate St. Louis vs. Philadelphia Outcomes in the United States

    Jalali, Aliea M. / Peterson, Brent M. / Galbadage, Thushara

    Faculty Articles & Research

    2020  

    Abstract: The Coronavirus disease 2019 (COVID-19) pandemic has elicited an abrupt pause in the United States in multiple sectors of commerce and social activity. As the US faces this health crisis, the magnitude, and rigor of their initial public health response ... ...

    Abstract The Coronavirus disease 2019 (COVID-19) pandemic has elicited an abrupt pause in the United States in multiple sectors of commerce and social activity. As the US faces this health crisis, the magnitude, and rigor of their initial public health response was unprecedented. As a response, the entire nation shutdown at the state-level for the duration of approximately one to three months. These public health interventions, however, were not arbitrarily decided, but rather, implemented as a result of evidence-based practices. These practices were a result of lessons learned during the 1918 influenza pandemic and the city-level non-pharmaceutical interventions (NPIs) taken across the US. During the 1918 pandemic, two model cities, St. Louis, MO, and Philadelphia, PA, carried out two different approaches to address the spreading disease, which resulted in two distinctly different outcomes. Our group has evaluated the state-level public health response adopted by states across the US, with a focus on New York, California, Florida, and Texas, and compared the effectiveness of reducing the spread of COVID-19. Our assessments show that while the states mentioned above benefited from the implementations of early preventative measures, they inadequately replicated the desired outcomes observed in St. Louis during the 1918 crisis. Our study indicates that there are other factors, including health disparities that may influence the effectiveness of public health interventions applied. Identifying more specific health determinants may help implement targeted interventions aimed at preventing the spread of COVID-19 and improving health equity.
    Keywords Coronavirus ; Spread ; Intervention ; Prevention ; Outcomes ; Evidence-based practice ; Health Disparities ; Influenza virus ; Community Health and Preventive Medicine ; Virus Diseases ; covid19
    Publishing date 2020-06-01T07:00:00Z
    Publisher Digital Commons @ Biola
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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