LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 26

Search options

  1. Article ; Online: Multiple lineage switches in KMT2A rearranged infant leukemia, responsive to combination therapy with CPX-351 and inotuzumab.

    Sperlazza, Justin / Galeotti, Jonathan / Hucks, George / Alexander, Thomas B

    Pediatric blood & cancer

    2023  Volume 70, Issue 11, Page(s) e30645

    MeSH term(s) Infant ; Humans ; Cytarabine ; Leukemia ; Daunorubicin
    Chemical Substances CPX-351 ; Cytarabine (04079A1RDZ) ; Daunorubicin (ZS7284E0ZP)
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Letter
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.30645
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Enasidenib-induced eosinophilic differentiation in a patient with acute myeloid leukaemia with IDH2 and U2AF1 mutations.

    Galeotti, Jonathan / Coombs, Catherine C

    British journal of haematology

    2018  Volume 184, Issue 4, Page(s) 496

    MeSH term(s) Aged ; Aminopyridines/administration & dosage ; Cell Differentiation/drug effects ; Eosinophils/metabolism ; Eosinophils/pathology ; Humans ; Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/metabolism ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Male ; Mutation ; Splicing Factor U2AF/genetics ; Splicing Factor U2AF/metabolism ; Triazines/administration & dosage
    Chemical Substances Aminopyridines ; Splicing Factor U2AF ; Triazines ; U2AF1 protein, human ; enasidenib (3T1SS4E7AG) ; IDH2 protein, human (EC 1.1.1.41) ; Isocitrate Dehydrogenase (EC 1.1.1.41)
    Language English
    Publishing date 2018-10-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.15609
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.182: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Clinical and molecular features of FLT3 juxtamembrane domain missense mutations in acute myeloid leukaemia.

    Jensen, Christopher E / Montgomery, Nathan D / Galeotti, Jonathan / Foster, Matthew C / Zeidner, Joshua F

    Journal of cellular and molecular medicine

    2022  

    Language English
    Publishing date 2022-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.17608
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5752: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Comprehensive genomic profiling reveals molecular subsets of

    Johnson, Steven M / Haberberger, James / Galeotti, Jonathan / Ramkissoon, Lori / Coombs, Catherine C / Richardson, Daniel R / Foster, Matthew C / Duncan, Daniel / Montgomery, Nathan D / Ferguson, Naomi L / Zeidner, Joshua F

    Leukemia & lymphoma

    2024  Volume 65, Issue 2, Page(s) 209–218

    Abstract: A large-scale genomic analysis of patients ... ...

    Abstract A large-scale genomic analysis of patients with
    MeSH term(s) Adult ; Humans ; Myeloproliferative Disorders/genetics ; Spliceosomes/genetics ; Spliceosomes/pathology ; Transcription Factors/genetics ; Neoplasms ; Genomics ; Mutation ; Leukemia, Myeloid, Acute/genetics ; Prognosis ; Repressor Proteins/genetics
    Chemical Substances Transcription Factors ; ASXL1 protein, human ; Repressor Proteins
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2023.2277672
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: A reappraisal of ASXL1 mutation sites and the cohesin-binding motif in myeloid disease.

    Johnson, Steven M / Haberberger, James / Galeotti, Jonathan / Ramkissoon, Lori / Coombs, Catherine C / Richardson, Daniel R / Foster, Matthew C / Duncan, Daniel / Zeidner, Joshua F / Ferguson, Naomi L / Montgomery, Nathan D

    Blood cancer journal

    2023  Volume 13, Issue 1, Page(s) 96

    MeSH term(s) Humans ; Chromosomal Proteins, Non-Histone/genetics ; Cell Cycle Proteins/genetics ; Mutation ; Leukemia, Myeloid, Acute/genetics ; Repressor Proteins/genetics ; Cohesins
    Chemical Substances Chromosomal Proteins, Non-Histone ; Cell Cycle Proteins ; ASXL1 protein, human ; Repressor Proteins
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Letter
    ZDB-ID 2600560-8
    ISSN 2044-5385 ; 2044-5385
    ISSN (online) 2044-5385
    ISSN 2044-5385
    DOI 10.1038/s41408-023-00876-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: A Novel Approach: Local Resection for Ampullary GIST-Case Report and Review of Literature.

    Leung, Kenneth / Worni, Mathias / Galeotti, Jonathan / Blazer, Dan

    Journal of gastrointestinal cancer

    2016  Volume 48, Issue 4, Page(s) 376–378

    MeSH term(s) Ampulla of Vater/pathology ; Ampulla of Vater/surgery ; Digestive System Surgical Procedures/methods ; Female ; Gastrointestinal Neoplasms/pathology ; Gastrointestinal Neoplasms/surgery ; Gastrointestinal Stromal Tumors/pathology ; Gastrointestinal Stromal Tumors/surgery ; Humans ; Middle Aged ; Prognosis
    Keywords covid19
    Language English
    Publishing date 2016-05-27
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2452514-5
    ISSN 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
    ISSN (online) 1941-6636 ; 1559-0739
    ISSN 1941-6628 ; 1537-3649
    DOI 10.1007/s12029-016-9839-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Erythrophagocytosis in a cyclin D1 positive plasma cell myeloma with near-tetraploid karyotypic abnormalities and cryptic MYC/IGH fusion.

    Galeotti, Jonathan / Wu, Bin / Wang, Endi

    Annals of hematology

    2016  Volume 95, Issue 3, Page(s) 515–516

    MeSH term(s) Cyclin D1/blood ; Erythroid Cells/metabolism ; Genes, myc/physiology ; Humans ; Karyotype ; Male ; Middle Aged ; Multiple Myeloma/blood ; Multiple Myeloma/diagnosis ; Multiple Myeloma/genetics ; Oncogene Proteins, Fusion/blood ; Oncogene Proteins, Fusion/genetics ; Phagocytosis/physiology ; Tetraploidy
    Chemical Substances CCND1 protein, human ; Oncogene Proteins, Fusion ; Cyclin D1 (136601-57-5)
    Language English
    Publishing date 2016-02
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-015-2551-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.181: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: A retrospective study on prephase therapy prior to definitive multiagent chemotherapy in aggressive lymphomas.

    Malpica, Luis / Mufuka, Bolanle / Galeotti, Jonathan / Tan, Xianming / Grover, Natalie / Clark, Stephen M / Beaven, Anne / Muss, Hyman / Dittus, Christopher

    Leukemia & lymphoma

    2020  Volume 61, Issue 6, Page(s) 1508–1511

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Humans ; Lymphoma, Non-Hodgkin ; Retrospective Studies
    Language English
    Publishing date 2020-02-09
    Publishing country United States
    Document type Letter
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2020.1725505
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Persistent thrombocytopaenia in a young man with splenomegaly, rebound thrombocytosis after splenectomy and subsequent pulmonary embolism: splenic littoral cell angioma and associated events.

    de Ridder, Gustaaf Gregoire / Galeotti, Jonathan / Carney, John / Wang, Endi

    BMJ case reports

    2015  Volume 2015

    Abstract: Littoral cell angioma (LCA) is a rare endothelial cell neoplasm in the spleen. Although many cases of LCA are asymptomatic, some present with signs and symptoms related to splenomegaly, whereas others manifest with haematological abnormalities, including ...

    Abstract Littoral cell angioma (LCA) is a rare endothelial cell neoplasm in the spleen. Although many cases of LCA are asymptomatic, some present with signs and symptoms related to splenomegaly, whereas others manifest with haematological abnormalities, including anaemia and/or thrombocytopaenia (ie, hypersplenism). We report a case of LCA presenting with chronic thrombocytopaenia, probably due to splenic sequestration of platelets or phagocytosis of platelets by neoplastic cells. Following therapeutic splenectomy, the patient suffered from a marked rebound thrombocytosis and subsequently developed pulmonary embolisms. He was treated with anticoagulant therapy combined with antiplatelet therapy, and his symptoms were quickly resolved. This case emphasises an exclusion of primary splenic disorders in patients with chronic thrombocytopaenia, especially in those with splenomegaly and the contemplation of thromboembolism prophylaxis postsplenectomy.
    MeSH term(s) Adult ; Anticoagulants/therapeutic use ; Chronic Disease ; Hemangioma/complications ; Hemangioma/diagnostic imaging ; Hemangioma/drug therapy ; Humans ; Male ; Platelet Aggregation Inhibitors/therapeutic use ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/drug therapy ; Pulmonary Embolism/complications ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/drug therapy ; Spleen/diagnostic imaging ; Spleen/surgery ; Splenectomy ; Splenic Neoplasms/complications ; Splenic Neoplasms/diagnostic imaging ; Splenic Neoplasms/drug therapy ; Splenomegaly/complications ; Splenomegaly/diagnostic imaging ; Splenomegaly/drug therapy ; Thrombocytopenia/complications ; Thrombocytopenia/drug therapy ; Thrombocytosis/complications ; Thrombocytosis/diagnostic imaging ; Thrombocytosis/drug therapy ; Tomography, X-Ray Computed
    Chemical Substances Anticoagulants ; Platelet Aggregation Inhibitors
    Language English
    Publishing date 2015-11-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2015-212882
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Bilineal evolution of a U2AF1-mutated clone associated with acquisition of distinct secondary mutations.

    Montgomery, Nathan D / Galeotti, Jonathan / Johnson, Steven M / Commander, Leah / Weimer, Eric T / Chandra, Pranil K / Nazir, Tariq / Alexander, Thomas B / Zeidner, Joshua F / Foster, Matthew C

    Blood advances

    2021  Volume 5, Issue 24, Page(s) 5612–5616

    Abstract: Rare hematologic malignancies display evidence of both myeloid and lymphoid differentiation. Here, we describe such a novel bilineal event discovered in an adult woman with B-lymphoblastic leukemia (BLL). At the time of BLL diagnosis, the patient had a ... ...

    Abstract Rare hematologic malignancies display evidence of both myeloid and lymphoid differentiation. Here, we describe such a novel bilineal event discovered in an adult woman with B-lymphoblastic leukemia (BLL). At the time of BLL diagnosis, the patient had a normal karyotype and a bulk sequencing panel identified pathogenic variants in BCOR, EZH2, RUNX1, and U2AF1, a genotype more typical of myeloid neoplasia. Additionally, the patient was noted to have 3-year history of cytopenias, and morphologic dyspoiesis was noted on post-treatment samples, raising the possibility of an antecedent hematologic disorder. To investigate the clonal architecture of her disease, we performed targeted sequencing on fractionated samples enriched for either B-lymphoblasts or circulating granulocytes. These studies revealed a truncal founder mutation in the spliceosome gene U2AF1 in both fractions, while distinct secondary mutations were present only in B-lymphoblasts (BCOR, NRAS) or myeloid cells (ASXL1, EZH2, RUNX1). These results indicate that both processes evolved from a common U2AF1-mutated precursor, which then acquired additional mutations during a process of divergent evolution and bilineal differentiation. Our findings highlight an atypical mechanism of BLL leukemogenesis and demonstrate the potential utility of fractionated sequencing in the characterization of acute leukemia.
    MeSH term(s) Adult ; Clone Cells ; Female ; Humans ; Leukemia, Myeloid, Acute/genetics ; Mutation ; Myeloproliferative Disorders ; Splicing Factor U2AF
    Chemical Substances Splicing Factor U2AF ; U2AF1 protein, human
    Language English
    Publishing date 2021-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2021005308
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 7153: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top