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  1. Article ; Online: Tezepelumab: una nueva opción para el tratamiento del asma grave.

    Maldonado-Ríos, Valente Armando / Ardila-Herrera, Juan Camilo / Galicia-Sánchez, Luz María / Celis-Preciado, Carlos Andrés

    Revista medica del Instituto Mexicano del Seguro Social

    2023  Volume 61, Issue 6, Page(s) 841–848

    Abstract: In Latin America, asthma is a public health problem with a significant impact on both patients and health systems. The greater understanding of the pathophysiology and the recognition of the central role that inflammation has in the severity of asthma ... ...

    Title translation Tezepelumab: a new option for the treatment of severe asthma.
    Abstract In Latin America, asthma is a public health problem with a significant impact on both patients and health systems. The greater understanding of the pathophysiology and the recognition of the central role that inflammation has in the severity of asthma has favored the development of monoclonal antibodies that have IL-5, IL-4, IL-13 and IgE as therapeutic targets. Although these therapeutic alternatives promote better control of the disease, not all patients respond favorably to these treatments. Therefore, it is of particular interest to explore monoclonal antibodies such as Tezepelumab, directed against thymic stromal lymphopoietin (TSLP), an alarmin (epithelial cytokine) that participates in the initiation and perpetuation of inflammation in Asthma. Therefore, in this review, we will show the clinical efficacy of tezepelumab in reducing the annual rate of exacerbations, improving lung function, and reducing bronchial hyperreactivity, regardless of the patient's baseline biomarker levels. Therefore, this new molecule is a highly effective therapeutic option for patients with severe asthma.
    MeSH term(s) Humans ; Asthma/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use ; Cytokines/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Inflammation
    Chemical Substances tezepelumab (RJ1IW3B4QX) ; Antibodies, Monoclonal, Humanized ; Cytokines ; Antibodies, Monoclonal
    Language Spanish
    Publishing date 2023-11-06
    Publishing country Mexico
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 732133-8
    ISSN 2448-5667 ; 0443-5117 ; 0484-7849
    ISSN (online) 2448-5667
    ISSN 0443-5117 ; 0484-7849
    DOI 10.5281/zenodo.10064422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identification of genomic copy number variations in lung benign metastasizing leiomyomatosis.

    Hernández-Plata, Everardo / Velázquez-Wong, Ana Claudia / Jiménez-Ramírez, Carmina / Fernández-Ramírez, Fernando / Galicia-Sánchez, Luz María / Flores-García, César Antonio / Hernández-Hernández, José Manuel / Rosas-Vargas, Haydeé / Huicochea-Montiel, Juan Carlos / Espinosa-Poblano, Eliseo

    The clinical respiratory journal

    2019  Volume 13, Issue 2, Page(s) 105–113

    Abstract: Objectives: Lung metastasizing leiomyomatosis (LML) is an infrequently diagnosed pathology developed after sexual maturation, commonly preceded by uterine myomas. Symptoms can include difficulties to breathe, cough, dyspnea and pain, because of ... ...

    Abstract Objectives: Lung metastasizing leiomyomatosis (LML) is an infrequently diagnosed pathology developed after sexual maturation, commonly preceded by uterine myomas. Symptoms can include difficulties to breathe, cough, dyspnea and pain, because of mechanical obstruction exerted by expanding local growing leiomyomas. Lung leiomyomas are normally detected by imaging studies, but nowadays the precise diagnosis demands histological characterization of biopsies obtained from the affected tissues. The purpose of the present study was to determine the presence of genomic alterations in circulating cells of LML.
    Methods: Immunohistochemical characterization of a lung biopsy extracted by thoracoscopy was performed. Pathologic proliferative smooth muscle cells were observed in a major lung metastasizing nodule, with a growing pattern similar to a uterine myoma. The presence of cellular linages different to smooth muscle cells was discarded by testing the presence of a battery of molecular markers. Also, a normal karyotype was determine by GTG-banding cytogenetic study, but a high density microarray analysis revealed six submicroscopic chromosomal regions displaying genomic abnormalities: microduplications were detected on chromosomes 4, 14, 17 and 22; and microdeletions on chromosomes 8 and 10.
    Conclusion: This study remarks the relevance of submicroscopic chromosomal analysis of unusual pathologic conditions such as Benign Metastasizing Leiomyomatosis. This propitiate a better understanding of the molecular basis on the development of the pathology, in order to reckon on minimally invasive diagnostic methods, and to design appropriate treatments.
    MeSH term(s) Adult ; DNA Copy Number Variations/genetics ; Epigenomics ; Female ; Genomics/methods ; Humans ; Karyotype ; Leiomyomatosis/diagnostic imaging ; Leiomyomatosis/genetics ; Leiomyomatosis/pathology ; Leiomyomatosis/surgery ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Lung Neoplasms/secondary ; Lung Neoplasms/surgery ; Myoma/complications ; Myoma/pathology ; Myoma/surgery ; Neoplasm Metastasis/pathology ; Neoplasms/etiology ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplastic Cells, Circulating/metabolism ; Risk Factors ; Thoracoscopy/methods ; Tomography, X-Ray Computed/methods ; Uterine Neoplasms/genetics ; Uterine Neoplasms/pathology ; Uterine Neoplasms/secondary
    Language English
    Publishing date 2019-01-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2442214-9
    ISSN 1752-699X ; 1752-6981
    ISSN (online) 1752-699X
    ISSN 1752-6981
    DOI 10.1111/crj.12987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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