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  1. Article ; Online: Characteristics of the high ioduria concentrations in schoolchildren and adolescents in Colombia.

    Galindo, Marisol / Forero, Ana Yibby / Romero, Jhon

    Revista peruana de medicina experimental y salud publica

    2021  Volume 38, Issue 1, Page(s) 24–32

    Abstract: Objetives: To determine the characteristics of high ioduria concentrations in schoolchildren and adolescents in Colombia.: Materials and methods: Secondary analysis of the 2015 National Survey of the Nutritional Situation in Colombia in participants ... ...

    Title translation Características de las concentraciones elevadas de yoduria en escolares y adolescentes de Colombia.
    Abstract Objetives: To determine the characteristics of high ioduria concentrations in schoolchildren and adolescents in Colombia.
    Materials and methods: Secondary analysis of the 2015 National Survey of the Nutritional Situation in Colombia in participants aged 5 to 17 years, which included the measurement of ioduria. The criteria to measure the nutritional status of iodine were based on the median urinary iodine concentration in µg / L defined by the World Health Organization (WHO), where values ​​<100 are considered deficient, between 100-199 adequate, 200-299 above the requirements and> 300 excessive. Odds ratio measurements were also performed through logistic regression analysis.
    Results: The national median iodine for schoolchildren and adolescents was 406.8 µg / L and 410.8 µg / L respectively, higher in the urban area (410.5 µg / L), in the Atlantic region the highest level was found for schoolchildren (423.7 µg / L) and in the central for adolescents (427.7 µg / L). 4.4% of schoolchildren and 2.2% of adolescents presented deficiency and in more than 75% of the population, there was excessive intake of iodine. The factors associated with excessive iodine intake in schoolchildren were age, ethnicity, region and wealth index, and for adolescents gender and geographic area.
    Conclusions: The iodine concentrations in Colombian schoolchildren and adolescents are higher than adequate according to WHO, the deficiency is very low and a serious public health problem occurs due to excessive iodine intake in three-quarters of the population.
    MeSH term(s) Adolescent ; Child ; Colombia/epidemiology ; Cross-Sectional Studies ; Humans ; Iodine ; Nutritional Status ; Sodium Chloride, Dietary
    Chemical Substances Sodium Chloride, Dietary ; Iodine (9679TC07X4)
    Language English
    Publishing date 2021-06-25
    Publishing country Peru
    Document type Journal Article
    ZDB-ID 2120092-0
    ISSN 1726-4642 ; 1726-4642
    ISSN (online) 1726-4642
    ISSN 1726-4642
    DOI 10.17843/rpmesp.2021.381.5793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Isolation of Bacillus cereus in school restaurants in Colombia

    Forero, Ana Yibby / Galindo, Marisol / Morales, Gina E

    Biomedica : revista del Instituto Nacional de Salud

    2018  Volume 38, Issue 3, Page(s) 338–344

    MeSH term(s) Bacillus cereus/isolation & purification ; Colombia/epidemiology ; Cross-Sectional Studies ; Diarrhea/etiology ; Diarrhea/microbiology ; Disease Outbreaks ; Edible Grain/microbiology ; Enterotoxins/isolation & purification ; Food Handling/methods ; Food Handling/standards ; Food Microbiology ; Food Preservation/methods ; Food Preservation/standards ; Foodborne Diseases/epidemiology ; Foodborne Diseases/microbiology ; Humans ; Hygiene ; Oryza/microbiology ; Schools ; Water Supply
    Chemical Substances Enterotoxins ; enterotoxin, Bacillus cereus
    Language English
    Publishing date 2018-09-01
    Publishing country Colombia
    Document type Journal Article
    ISSN 0120-4157
    ISSN 0120-4157
    DOI 10.7705/biomedica.v38i3.3802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Seroprevalence of SARS-CoV-2 Antibodies in Children and Adolescents: Results From a Population-Based Survey in 10 Colombian Cities.

    Mercado-Reyes, Marcela María / Daza, Marcela / Pacheco, Angélica / Meneses-Gil, María Ximena / Galindo, Marisol / Catama, Jenssy / Botero, Luz Stefany / Muñoz, Lyda / Quinche, German / Ospina, Martha Lucía

    Global pediatric health

    2022  Volume 9, Page(s) 2333794X221085385

    Abstract: Background. ...

    Abstract Background.
    Language English
    Publishing date 2022-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785531-4
    ISSN 2333-794X ; 2333-794X
    ISSN (online) 2333-794X
    ISSN 2333-794X
    DOI 10.1177/2333794X221085385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Comparison of Anti-SARS-CoV-2 IgG Antibody Responses Generated by the Administration of Ad26.COV2.S, AZD1222, BNT162b2, or CoronaVac: Longitudinal Prospective Cohort Study in the Colombian Population, 2021/2022.

    Malagón-Rojas, Jeadran / Mercado-Reyes, Marcela / Toloza-Pérez, Yesith G / Galindo, Marisol / Palma, Ruth M / Catama, Jenssy / Bedoya, Juan F / Parra-Barrera, Eliana L / Meneses, Ximena / Barbosa, Juliana / Tavera-Rodríguez, Pilar / Bermúdez-Forero, Andrea / Ospina-Martínez, Martha Lucía

    Vaccines

    2022  Volume 10, Issue 10

    Abstract: To mitigate the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), vaccines have been rapidly developed and introduced in many countries. In Colombia, the population was vaccinated with ... ...

    Abstract To mitigate the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), vaccines have been rapidly developed and introduced in many countries. In Colombia, the population was vaccinated with four vaccines. Therefore, this research aimed to determine the ability of the vaccines introduced in the National Vaccination Plan to prevent SARS-CoV-2 infection and induce seroconversion and sought to investigate the longevity of antibodies in the blood. We conducted a prospective, nonprobabilistic, consecutive cross-sectional cohort study in a population with access to vaccination with CoronaVac, Ad26.COV2.S, AZD1222, and BNT162b2 from March 2021 to March 2022. The study included 1327 vaccinated people. A plurality of participants were vaccinated with BNT162b2 (36.1%;
    Language English
    Publishing date 2022-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10101609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Low Neutralizing Antibody Titers against the Mu Variant of SARS-CoV-2 in 31 BNT162b2 Vaccinated Individuals in Colombia.

    Álvarez-Díaz, Diego A / Muñoz, Ana Luisa / Tavera-Rodríguez, Pilar / Herrera-Sepúlveda, María T / Ruiz-Moreno, Hector Alejandro / Laiton-Donato, Katherine / Franco-Muñoz, Carlos / Pelaez-Carvajal, Dioselina / Cuellar, Diego / Muñoz-Suarez, Alejandra M / Galindo, Marisol / Arias-Ramírez, Edgar J / Mercado-Reyes, Marcela

    Vaccines

    2022  Volume 10, Issue 2

    Abstract: Global surveillance programs for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are showing the emergence of variants with mutations in the spike protein. Genomic and laboratory surveillance are important to determine if these variants may ... ...

    Abstract Global surveillance programs for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are showing the emergence of variants with mutations in the spike protein. Genomic and laboratory surveillance are important to determine if these variants may be more infectious or less susceptible to antiviral treatments and vaccine-induced antibodies. Three of the most predominant SARS-CoV-2 variants in Colombia during the epidemiological peaks of 2021 were isolated: Mu, a variant of interest; Gamma, a variant of concern; B.1.111, which lacks genetic markers associated with greater virulence. Microneutralization assays were performed by incubating 120 mean tissue culture infectious doses (TCID50) of each SARS-CoV-2 isolate with five two-fold serial dilutions of sera from 31 BNT162b2-vaccinated volunteers. The mean neutralization titer (MN50) was calculated by the Reed-Muench method. At the end of August, Mu represented 49% of coronavirus disease 2019 (COVID-19) cases in Colombia, followed by 25% of Gamma. In contrast, B.1.111 became almost undetectable. The evaluation of neutralizing antibodies suggests that patients vaccinated with BNT162b2 generate neutralizing antibody titers against the Mu variant at significantly lower concentrations relative to B.1.111 and Gamma. This study shows the importance of continuing surveillance programs of emerging variants, as well as the need to evaluate the neutralizing antibody response induced by other vaccines.
    Language English
    Publishing date 2022-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10020180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Neutralizing Antibody Responses Elicited by Inactivated Whole Virus and Genetic Vaccines against Dominant SARS-CoV-2 Variants during the Four Epidemic Peaks of COVID-19 in Colombia.

    Álvarez-Díaz, Diego A / Muñoz, Ana Luisa / Herrera-Sepúlveda, María T / Tavera-Rodríguez, Pilar / Laiton-Donato, Katherine / Franco-Muñoz, Carlos / Ruiz-Moreno, Héctor Alejandro / Galindo, Marisol / Catama, Jenssy D / Bermudez-Forero, Andrea / Mercado-Reyes, Marcela

    Vaccines

    2022  Volume 10, Issue 12

    Abstract: Several SARS-CoV-2 variants of concern (VOC) and interest (VOI) co-circulate in Colombia, and determining the neutralizing antibody (nAb) responses is useful to improve the efficacy of COVID-19 vaccination programs. Thus, nAb responses against SARS-CoV-2 ...

    Abstract Several SARS-CoV-2 variants of concern (VOC) and interest (VOI) co-circulate in Colombia, and determining the neutralizing antibody (nAb) responses is useful to improve the efficacy of COVID-19 vaccination programs. Thus, nAb responses against SARS-CoV-2 isolates from the lineages B.1.111, P.1 (Gamma), B.1.621 (Mu), AY.25.1 (Delta), and BA.1 (Omicron), were evaluated in serum samples from immunologically naïve individuals between 9 and 13 weeks after receiving complete regimens of CoronaVac, BNT162b2, ChAdOx1, or Ad26.COV2.S, using microneutralization assays. An overall reduction of the nAb responses against Mu, Delta, and Omicron, relative to B.1.111 and Gamma was observed in sera from vaccinated individuals with BNT162b2, ChAdOx1, and Ad26.COV2.S. The seropositivity rate elicited by all the vaccines against B.1.111 and Gamma was 100%, while for Mu, Delta, and Omicron ranged between 32 to 87%, 65 to 96%, and 41 to 96%, respectively, depending on the vaccine tested. The significant reductions in the nAb responses against the last three dominant SARS-CoV-2 lineages in Colombia indicate that booster doses should be administered following complete vaccination schemes to increase the nAb titers against emerging SARS-CoV-2 lineages.
    Language English
    Publishing date 2022-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10122144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Seroprevalence of the SARS-CoV-2 antibody in healthcare workers: a multicentre cross-sectional study in 10 Colombian cities.

    Malagón-Rojas, Jeadran Nevardo / Mercado-Reyes, Marcela / Toloza-Pérez, Yezith G / Parra Barrera, Eliana L / Palma, Marien / Muñoz, Esperanza / López, Ronald / Almentero, Julia / Rubio, Vivian V / Ibáñez, Edgar / Téllez, Eliana / Delgado-Murcia, Lucy G / Jimenez, Claudia P / Viasus-Pérez, Diego / Galindo, Marisol / Lagos, Luisa

    Occupational and environmental medicine

    2021  Volume 79, Issue 6, Page(s) 388–395

    Abstract: Background: Healthcare workers are at increased risk of infection due to occupational exposure to SARS-CoV-2-infected patients. The objective of this study was to determine the seroprevalence of SARS-CoV-2 in healthcare workers in Colombia.: Methods: ...

    Abstract Background: Healthcare workers are at increased risk of infection due to occupational exposure to SARS-CoV-2-infected patients. The objective of this study was to determine the seroprevalence of SARS-CoV-2 in healthcare workers in Colombia.
    Methods: This study is a cross-sectional study focused on estimating the seroprevalence of SARS-CoV-2 antibodies in healthcare workers from 65 hospitals in 10 cities in Colombia during the second semester of 2020. The seroprevalence was determined using an automated immunoassay (Abbott SARS-CoV-2 CLIA IgG). The study included a survey to establish the sociodemographic variables and the risk of infection. A multivariate model was used to evaluate the association between the results of seroprevalence and risk factors.
    Results: The global seroprevalence of antibodies against SARS-CoV-2 was 35% (95% Bayesian CI 33% to 37%). All the personnel reported the use of protective equipment. General services personnel and nurses presented the highest ratios of seroprevalence among the healthcare workers. Low socioeconomic strata have shown a strong association with seropositivity.
    Conclusion: This study estimates the prevalence of SARS-CoV-2 infection among healthcare workers. Even though all the personnel reported the use of protective equipment, the seroprevalence in the general services personnel and nurses was high. Also, a significant difference by cities was observed.
    MeSH term(s) Antibodies, Viral ; Bayes Theorem ; COVID-19/epidemiology ; Cities/epidemiology ; Colombia/epidemiology ; Cross-Sectional Studies ; Health Personnel ; Humans ; Immunoglobulin G ; SARS-CoV-2 ; Seroepidemiologic Studies
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2021-11-05
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180733-7
    ISSN 1470-7926 ; 1351-0711
    ISSN (online) 1470-7926
    ISSN 1351-0711
    DOI 10.1136/oemed-2021-107487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Low neutralizing antibody titers against the Mu variant of SARS-CoV-2 in BNT162b2 vaccinated individuals

    Alvarez-Diaz, Diego Alejandro / Munoz, Ana L / Tavera-Rodriguez, Pilar / Herrera-Sepulveda, Maria T / Ruiz-Moreno, Hector A / Laiton-Donato, Katherine / Franco-Munoz, Carlos / Pelaez-Carvajal, Dioselina / Cuellar, Diego / Munoz-Ramirez, Alejandra M / Galindo, Marisol / Arias-Ramirez, Edgar J / Reyes, Marcela M

    medRxiv

    Abstract: Background Global surveillance programs for the virus that causes COVID-19 are showing the emergence of variants with mutations in the Spike protein, including the Mu variant, recently declared as a Variant of Interest (VOI) by the World Health ... ...

    Abstract Background Global surveillance programs for the virus that causes COVID-19 are showing the emergence of variants with mutations in the Spike protein, including the Mu variant, recently declared as a Variant of Interest (VOI) by the World Health Organization. Because these types of variants can be more infectious or less susceptible to antiviral treatments and vaccine-induced antibodies. Objectives To evaluate the sensitivity of the Mu variant (B.1.621) to neutralizing antibodies induced by the BNT162b2 vaccine. Study design Three of the most predominant SARS-CoV-2 variants in Colombia during the epidemiological peaks of 2021 were isolated. Microneutralization assays were performed by incubating 120 TCDI50 of each SARS-CoV-2 isolate with five 2-fold serial dilutions of sera from 14 BNT162b2 vaccinated volunteers. The MN50 titer was calculated by the Reed-Muench formula Results The three isolated variants were Mu, a Variant of Interest (VOI), Gamma, a variant of concern (VOC), and B.1.111 that lacks genetic markers associated with greater virulence. At the end of August, the Mu and Gamma variants were widely distributed in Colombia. Mu was predominant (49%), followed by Gamma (25%). In contrast, B.1.111 became almost undetectable. The evaluation of neutralizing antibodies suggests that patients vaccinated with BNT162-2 generate neutralizing antibody titers against the Mu variant at significantly lower concentrations relative to B.1.111 and Gamma. Conclusions This study shows the importance of continuing with surveillance programs of emerging variants as well as the need to evaluate the neutralizing antibody response induced by other vaccines circulating in the country against Mu and other variants with high epidemiological impact.
    Keywords covid19
    Language English
    Publishing date 2021-11-19
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.11.19.21266552
    Database COVID19

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  9. Article ; Online: Neutralizing responses in fully vaccinated with BNT162b2, CoronaVac, ChAdOx1, and Ad26.COV2.S against SARS-CoV-2 lineages in Colombia, 2020-2021

    Alvarez-Diaz, Diego Alejandro / Munoz, Ana Luisa / Herrera, Maria T / Tavera, Pilar / Laiton-Donato, Katherine / Franco-Munoz, Carlos / Ruiz-Moreno, Hector / Pelaez-Carvajal, Dioselina / Munoz-Suarez, Alejandra / Galindo, Marisol / Reales-Gonzalez, Jhonnatan / Catama, Jenssy D / De Arco, Beatriz H / Cobos, Tatiana / Arias-Ramirez, Edgar J. / Mercado-Reyes, Marcela

    medRxiv

    Abstract: Background By March 2022, around 34 million people in Colombia had received a complete scheme of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) including, mRNA-based vaccines, viral vectored coronavirus vaccines, or the ...

    Abstract Background By March 2022, around 34 million people in Colombia had received a complete scheme of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) including, mRNA-based vaccines, viral vectored coronavirus vaccines, or the inactivated whole virus vaccine. However, as several SARS CoV 2 variants of concern (VOC) and interest (VOI) cocirculate in the country, determining the resistance level to vaccine elicited neutralizing antibodies (nAbs) is useful to improve the efficacy of COVID-19 vaccination programs. Methods Microneutralization assays with the most prevalent SARS-CoV-2 lineages in Colombia during 2020-2021 were performed using serum samples from immunologically naive individuals between 9 and 13 weeks after receiving complete regimens of CoronaVac, BNT162b2, ChAdOx1, or Ad26.COV2.S. The mean neutralization titer (MN50) was calculated by the Reed-Muench method and used to determine differences in vaccine elicited nAbs against the SARS-CoV-2 lineages B.1.111, P.1 (Gamma), B.1.621 (Mu), and AY.25.1 (Delta). Results The most administered vaccines in the country, BNT162b2 and CoronaVac, elicited significantly different nAb responses against Mu, as the GMTs were 75.7 and 5.9 fold lower relative to the control lineage (B.1.111), while for Delta were 15.8 and 1.1-fold lower, respectively. In contrast, nAb responses against Mu and Delta were comparable between ChAd0x1-s and Ad26.COV2.S as the GMTs remained around 5 to 7 fold lower relative to B.1.111. Conclusions The emergence of SARS-CoV-2 variants in Colombia with a significant capacity to escape from vaccine elicited nAbs indicates that a booster dose is highly recommended. Furthermore, other non-pharmacological measures should be retained in the vaccinated population.
    Keywords covid19
    Language English
    Publishing date 2022-03-15
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.03.15.22272371
    Database COVID19

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  10. Article ; Online: Seroprevalence of the SARS-CoV-2 antibody in healthcare workers: a multicenter cross-sectional study in ten Colombian cities.

    Malagon-Rojas, Jeadran N. / Mercado-Reyes, Marcela / Toloza-Perez, Yesith Guillermo / Parra, Eliana Lizeth / Palma, Ruth Marien / Munoz, Esperanza / Lopez, Ronald / Almentero-Correa, Julia Edith / Rubio, Vivian Vanesa / Ibanez-Pinilla, Edgar Antonio / Tellez-Avila, Eliana Milena / Delgado, Gabriela / Jimenez-Forero, Claudia Patricia / Viasus, Diego / Galindo, Marisol / Lagos, Luisa Fernanda

    medRxiv

    Abstract: Background: SARS-CoV-2 affects mainly occupational health populations. Healthcare workers are at constant risk of infection. The objective of this study was to determine the seroprevalence of SARS-CoV-2 in healthcare workers in Colombia. Methods: This ... ...

    Abstract Background: SARS-CoV-2 affects mainly occupational health populations. Healthcare workers are at constant risk of infection. The objective of this study was to determine the seroprevalence of SARS-CoV-2 in healthcare workers in Colombia. Methods: This study is a cross-sectional study focused on estimating the seroprevalence of SARS-CoV-2 antibodies in healthcare workers from 65 hospitals in 10 cities of Colombia during the second semester of 2020. The seroprevalence was determined using an automated immunoassay (Abbott SARS-CoV-2 CLIA IgG). The study included a survey to establish the sociodemographic variables and the risk of infection. Results: The global seroprevalence of antibodies against SARS-CoV-2 was 35% (95% Bayesian Confidence Interval 33%-37%). All the personnel reported the use of protective equipment. General services personnel and nurses presented the highest rates of seroprevalence among the healthcare workers. Low socioeconomic strata have shown a strong association with seropositivity. Conclusion: This study shows the occupational risk for SARS-CoV-2 infection among healthcare workers. Even though, all the personnel reported the use of protective equipment, the seroprevalence in the general services personnel and nurses was high. Also, it was observed a significant difference by city. The results could be used to perform prevention and control in this exposed population. However, further investigation of these is required to inform sources of infection to improve the control and occupational health practices.
    Keywords covid19
    Language English
    Publishing date 2021-07-22
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.07.21.21260103
    Database COVID19

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