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  1. AU="Galindo, R"
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  1. Artikel: Sol-Gel ceramic glazes with photocatalytic activity.

    Monrós, G / Llusar, M / Badenes, J / Galindo, R

    Journal of sol-gel science and technology

    2022  Band 102, Heft 3, Seite(n) 535–549

    Abstract: A frit is a glassy ceramic composition that has been fused, quenched, and granulated. A single frit or a mixture of frits and ceramic materials forms a ceramic glaze. The purpose of this pre-fusion is to render any soluble and/or toxic components ... ...

    Abstract A frit is a glassy ceramic composition that has been fused, quenched, and granulated. A single frit or a mixture of frits and ceramic materials forms a ceramic glaze. The purpose of this pre-fusion is to render any soluble and/or toxic components insoluble by rendering it inert in a glassy composition with silica and other added oxides. The ceramic glaze dispersed in water (ceramic slip) is deposited on a ceramic body and fired for waterproofing and aesthetic purposes. Multicomponent frits (zinc-potassium borosilicate system) with similar behavior to conventional ceramic frits for single-firing ceramic glazes ("monoporosa" glazes fired at 1080 °C) were prepared by Sol-Gel methods (monophasic and polyphasic gels) avoiding the pre-fusion and characterized as photocatalytic agents (showing high degradation activity on Orange II). The effect of doping with bandgap modifiers (V
    Sprache Englisch
    Erscheinungsdatum 2022-04-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1472726-2
    ISSN 1573-4846 ; 0928-0707
    ISSN (online) 1573-4846
    ISSN 0928-0707
    DOI 10.1007/s10971-022-05787-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Human chorionic gonadotropin decreases cerebral cystic encephalomalacia and parvalbumin interneuron degeneration in a pro-inflammatory model of mouse neonatal hypoxia-ischemia.

    Miller, Ben / Crider, Alexander / Aravamuthan, Bhooma / Galindo, Rafael

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The pregnancy hormone, human chorionic gonadotropin (hCG) is an immunoregulatory and neurotrophic glycoprotein of potential clinical utility in the neonate at risk for cerebral injury. Despite its well-known role in its ability to modulate the innate ... ...

    Abstract The pregnancy hormone, human chorionic gonadotropin (hCG) is an immunoregulatory and neurotrophic glycoprotein of potential clinical utility in the neonate at risk for cerebral injury. Despite its well-known role in its ability to modulate the innate immune response during pregnancy, hCG has not been demonstrated to affect the pro-degenerative actions of inflammation in neonatal hypoxia-ischemia (HI). Here we utilize a neonatal mouse model of mild HI combined with intraperitoneal administration of lipopolysaccharide (LPS) to evaluate the neuroprotective actions of hCG in the setting of endotoxin-mediated systemic inflammation. Intraperitoneal treatment of hCG shortly prior to LPS injection significantly decreased tissue loss and cystic degeneration in the hippocampal and cerebral cortex in the term-equivalent neonatal mouse exposed to mild HI. Noting that parvalbumin immunoreactive interneurons have been broadly implicated in neurodevelopmental disorders, it is notable that hCG significantly improved the injury-mediated reduction of these neurons in the cerebral cortex, striatum and hippocampus. The above findings were associated with a decrease in the amount of Iba1 immunoreactive microglia in most of these brain regions. These observations implicate hCG as an agent capable of improving the neurological morbidity associated with peripheral inflammation in the neonate affected by HI. Future preclinical studies should aim at demonstrating added neuroprotective benefit by hCG in the context of therapeutic hypothermia and further exploring the mechanisms responsible for this effect. This research is likely to advance the therapeutic role of gonadotropins as a treatment for neonates with neonatal brain injury.
    Sprache Englisch
    Erscheinungsdatum 2024-03-30
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.03.27.587006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Editorial: Neonatal and pediatric brain injury: novel therapeutics and perspective.

    Mukai, Takeo / Galindo, Rafael / Coq, Jacques-Olivier

    Frontiers in pediatrics

    2023  Band 11, Seite(n) 1210749

    Sprache Englisch
    Erscheinungsdatum 2023-05-16
    Erscheinungsland Switzerland
    Dokumenttyp Editorial
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1210749
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Posterior Reversible Encephalopathy Syndrome in a Patient With Macrophage Activation Syndrome and Herpes Simplex Virus 2.

    Luster, Joshua D / Galindo, Ricardo

    Cureus

    2021  Band 13, Heft 8, Seite(n) e17273

    Abstract: Posterior reversible encephalopathy syndrome (PRES) is a symptomatic and radiographic syndrome characterized by neurologic changes and concomitant neuroimaging findings typically involving posterior cerebral white matter edema. While there are many ... ...

    Abstract Posterior reversible encephalopathy syndrome (PRES) is a symptomatic and radiographic syndrome characterized by neurologic changes and concomitant neuroimaging findings typically involving posterior cerebral white matter edema. While there are many competing views on the pathophysiology of PRES, inflammatory conditions, particularly autoimmune diseases, tend to have some degree of correlation. Most cases where patients who have PRES and autoimmune diseases typically involve systemic lupus erythematosus. There is relatively little information in the literature on PRES occurring in adult patients with hemophagocytic lymphohistiocytosis (HLH)/macrophage activation syndrome or of concomitant herpes simplex virus 2 (HSV2) infection. Here, we present the case of a patient with PRES in the setting of adult-onset Still's disease and HLH with concomitant HSV2 infection.
    Sprache Englisch
    Erscheinungsdatum 2021-08-18
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.17273
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Kratom Retail Availability in Fort Worth, Texas.

    LoParco, C R / Yockey, R A / Sekhon, V K / Olsson, S / Galindo, R / Balasundaram, R / Agwuncha, T / Rossheim, M E

    Journal of psychoactive drugs

    2023  Band 56, Heft 1, Seite(n) 8–13

    Abstract: Kratom use is associated with cannabis use, so retail availability may also be related. Kratom and Delta-8 THC (a psychoactive cannabis product) are federally unregulated, marketed as "natural," and often used for pain relief and/or relaxation. Kratom ... ...

    Abstract Kratom use is associated with cannabis use, so retail availability may also be related. Kratom and Delta-8 THC (a psychoactive cannabis product) are federally unregulated, marketed as "natural," and often used for pain relief and/or relaxation. Kratom may have greater retail availability in more socioeconomically deprived areas because harmful substances are frequently marketed to lower-income communities. This study examined kratom retail availability in Fort Worth, Texas. Locations with alcohol, tobacco, and/or CBD licenses were called in July 2022: 1,025/1,223 (84%) answered the phone.
    Mesh-Begriff(e) Humans ; Texas ; Mitragyna ; Cannabis
    Sprache Englisch
    Erscheinungsdatum 2023-02-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 392405-1
    ISSN 2159-9777 ; 0279-1072
    ISSN (online) 2159-9777
    ISSN 0279-1072
    DOI 10.1080/02791072.2023.2181243
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: From the borders edge to the brink of death: A case of a traumatic pancreatic injury and Whipple procedure in the Rio Grande Valley.

    Alia, Valentine S / Alvarado, Ed W / Diaz, Edward M / Albo, Daniel / Galindo, Roger

    Trauma case reports

    2023  Band 48, Seite(n) 100940

    Abstract: The traumatic pancreatoduodenectomy, also known as the traumatic Whipple, is a specialized surgical procedure often reserved for extreme cases in which an individual suffers traumatic injuries to the pancreas, duodenum, or periampullary structures. ... ...

    Abstract The traumatic pancreatoduodenectomy, also known as the traumatic Whipple, is a specialized surgical procedure often reserved for extreme cases in which an individual suffers traumatic injuries to the pancreas, duodenum, or periampullary structures. Traditionally, a Whipple procedure is a complex surgery involving the removal of the head of the pancreas, duodenum, and a portion of both the bile duct and stomach, for the management of pancreatic head cancer. In underserved communities where limited access to healthcare is coupled with a higher incidence of trauma, the lack of specialized and supportive care for patients suffering from pancreatic injuries may lead to an increased morbidity and mortality rate. This case report aims to provide a detailed analysis of a patient who underwent a traumatic pancreatoduodenectomy in a medically underserved region in South Texas, while discussing the rarity of the procedure, its incidence and mortality rates, as well as the subsequent outcomes faced by individuals in this patient population.
    Sprache Englisch
    Erscheinungsdatum 2023-09-23
    Erscheinungsland Netherlands
    Dokumenttyp Case Reports
    ZDB-ID 2835433-3
    ISSN 2352-6440 ; 2352-6440
    ISSN (online) 2352-6440
    ISSN 2352-6440
    DOI 10.1016/j.tcr.2023.100940
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Mice born preterm develop gait dystonia and reduced cortical parvalbumin immunoreactivity.

    Gemperli, Kat / Folorunso, Femi / Norin, Benjamin / Joshua, Rebecca / Hill, Clayton / Rykowski, Rachel / Galindo, Rafael / Aravamuthan, Bhooma R

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Preterm birth leading to cerebral palsy (CP) is the most common cause of childhood dystonia, a movement disorder that is debilitating and often treatment refractory. Dystonia has been typically associated with dysfunction of striatal cholinergic ... ...

    Abstract Preterm birth leading to cerebral palsy (CP) is the most common cause of childhood dystonia, a movement disorder that is debilitating and often treatment refractory. Dystonia has been typically associated with dysfunction of striatal cholinergic interneurons, but clinical imaging data suggests that cortical injury may best predict dystonia following preterm birth. Furthermore, abnormal sensorimotor cortex inhibition has been found in many studies of non-CP dystonias. To assess the potential for a cortical etiology of dystonia following preterm birth, we developed a new model of preterm birth in mice. Noting that term delivery in mice on a C57BL/6J background is embryonic day 19.1 (E19.1), we induced preterm birth at the limits of pup viability at embryonic day (E) 18.3, equivalent to human 22 weeks gestation. Mice born preterm demonstrate display clinically validated metrics of dystonia during gait (leg adduction amplitude and variability) and also demonstrate reduced parvalbumin immunoreactivity in the sensorimotor cortex, suggesting dysfunction of cortical parvalbumin-positive inhibitory interneurons. Notably, reduced parvalbumin immunoreactivity or changes in parvalbumin-positive neuronal number were not observed in the striatum. These data support the association between cortical dysfunction and dystonia following preterm birth. We propose that our mouse model of preterm birth can be used to study this association and potentially also study other sequelae of extreme prematurity.
    Sprache Englisch
    Erscheinungsdatum 2024-02-02
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.02.01.578353
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Fyn-mediated phosphorylation of Menin disrupts telomere maintenance in stem cells.

    Paul, Souren / McCourt, Preston M / Le, Le Thi My / Ryu, Joohyun / Czaja, Wioletta / Bode, Ann M / Contreras-Galindo, Rafael / Dong, Zigang

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Telomeres protect chromosome ends and determine the replication potential of dividing cells. The canonical telomere sequence TTAGGG is synthesized by telomerase holoenzyme, which maintains telomere length in proliferative stem cells. Although the core ... ...

    Abstract Telomeres protect chromosome ends and determine the replication potential of dividing cells. The canonical telomere sequence TTAGGG is synthesized by telomerase holoenzyme, which maintains telomere length in proliferative stem cells. Although the core components of telomerase are well-defined, mechanisms of telomerase regulation are still under investigation. We report a novel role for the Src family kinase Fyn, which disrupts telomere maintenance in stem cells by phosphorylating the scaffold protein Menin. We found that Fyn knockdown prevented telomere erosion in human and mouse stem cells, validating the results with four telomere measurement techniques. We show that Fyn phosphorylates Menin at tyrosine 603 (Y603), which increases Menin's SUMO1 modification, C-terminal stability, and importantly, its association with the telomerase RNA component (TR). Using mass spectrometry, immunoprecipitation, and immunofluorescence experiments we found that SUMO1-Menin decreases TR's association with telomerase subunit Dyskerin, suggesting that Fyn's phosphorylation of Menin induces telomerase subunit mislocalization and may compromise telomerase function at telomeres. Importantly, we find that Fyn inhibition reduces accelerated telomere shortening in human iPSCs harboring mutations for dyskeratosis congenita.
    Sprache Englisch
    Erscheinungsdatum 2024-03-19
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.10.04.560876
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: COVID-19 in Children: Clinical Manifestations and Pharmacologic Interventions Including Vaccine Trials.

    Galindo, Ramon / Chow, Heather / Rongkavilit, Chokechai

    Pediatric clinics of North America

    2021  Band 68, Heft 5, Seite(n) 961–976

    Abstract: Children usually present with milder symptoms of COVID-19 as compared with adults. Supportive care alone is appropriate for most children with COVID-19. Antiviral therapy may be required for those with severe or critical diseases. Currently there has ... ...

    Abstract Children usually present with milder symptoms of COVID-19 as compared with adults. Supportive care alone is appropriate for most children with COVID-19. Antiviral therapy may be required for those with severe or critical diseases. Currently there has been a rapid development of vaccines globally to prevent COVID-19 and several vaccines are being evaluated in children and adolescents. Currently, only the Pfizer-BioNTech messenger RNA vaccine is approved for emergency authorization use in the pediatric population ages 16 years and older.
    Mesh-Begriff(e) Adolescent ; COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Child ; Humans ; Safety ; Systemic Inflammatory Response Syndrome/prevention & control ; Vaccines, Synthetic/adverse effects ; Vaccines, Synthetic/therapeutic use
    Chemische Substanzen COVID-19 Vaccines ; Vaccines, Synthetic
    Sprache Englisch
    Erscheinungsdatum 2021-05-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 215711-1
    ISSN 1557-8240 ; 0031-3955
    ISSN (online) 1557-8240
    ISSN 0031-3955
    DOI 10.1016/j.pcl.2021.05.004
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  10. Artikel ; Online: Dynamics of GDOES-induced surface roughening in metal interfaces.

    Escobar Galindo, R / Vázquez, L

    Analytical and bioanalytical chemistry

    2014  Band 406, Heft 29, Seite(n) 7483–7495

    Abstract: The roughness induced during glow-discharge optical-emission spectroscopy (GDOES) measurements has been reported to cause a loss of resolution during GDOES depth-profiling analysis. In this paper, we undertake for the first time a study of the dynamics ... ...

    Abstract The roughness induced during glow-discharge optical-emission spectroscopy (GDOES) measurements has been reported to cause a loss of resolution during GDOES depth-profiling analysis. In this paper, we undertake for the first time a study of the dynamics of the surface morphology of chromium and titanium thin films (designed in mono and multilayer structures) under the impinging of GDOES incoming ions. We performed this study under the theoretical framework of the dynamic scaling theory, by analysing surface morphology changes, as measured ex-situ by AFM, with irradiation time. For single metal layers it was found that, after an initial surface smoothening, the surface undergoes a rapid steep roughening for both systems, with quite similar quantitative dynamics. Once this roughening ends a second temporal scaling regime arises, operating for long length scales with dynamics depending on the sputtering rate of the material. For the chromium layer, with a very high sputtering rate of 5.5 μm min(-1), this regime is consistent with the KPZ model, whereas for the titanium layer an EW scaling regime is indicated. These different scaling regimes are consistent with the development of larger surface slopes for the Cr system. In the multilayer systems, the initial roughness induced on the top Cr layer by GDOES has similar dynamics to that for single-layer Cr. However, a clear decrease in the roughness was observed once the underlying Ti layer, with a lower sputtering rate, was reached. This decrease in the induced roughness is maintained while the Ti layer is eroded. Therefore, choice of appropriate material (i.e. sputtering yield values) combinations and of their depth of location can enable tuning of GDOES-induced roughness and achieve substantial control over the depth profiling process.
    Sprache Englisch
    Erscheinungsdatum 2014-11
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-014-7827-3
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