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  1. Article ; Online: Neoadjuvant immunotherapy for dMMR/MSI-H locally advanced rectal cancer: The future new standard approach?

    Cabezón-Gutiérrez, Luis / Custodio-Cabello, Sara / Palka-Kotlowska, Magda / Díaz-Pérez, David / Mateos-Dominguez, Maria / Galindo-Jara, Pablo

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2022  Volume 49, Issue 2, Page(s) 323–328

    Abstract: Introduction: This is a review of the evidence from studies of the efficacy and tolerability of neoadjuvant immunotherapy for mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) Locally Advanced Rectal Cancer (LARC).: Methods: ...

    Abstract Introduction: This is a review of the evidence from studies of the efficacy and tolerability of neoadjuvant immunotherapy for mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) Locally Advanced Rectal Cancer (LARC).
    Methods: For this review, we searched EMBASE and MEDLINE until 22 September 2022. The terms used in the search included mismatch repair-deficient, microsatellite instability, rectal cancer, neoadjuvant and immunotherapy.
    Results: A total of 92 studies were obtained but only 9 were selected for the final analysis (one prospective and eight retrospective studies), including less than 20 patients per study. Neoadjuvant immunotherapy provides overall response rates of 100% (with and completed clinical response between 40 and 100%).
    Conclusion: Our review discusses completed prospective and retrospective studies, ongoing clinical trials, and the clinical practice of using neoadjuvant immunotherapy for MSI-H/dMMR LARC. The promising results obtained, would open the door to exploring other alternatives for these patients, offering the possibility of avoiding chemoradiation therapy and surgery in the future.
    MeSH term(s) Humans ; Retrospective Studies ; Prospective Studies ; Neoadjuvant Therapy/methods ; Microsatellite Instability ; Colorectal Neoplasms/drug therapy ; Rectal Neoplasms ; Neoplasms, Second Primary ; Immunotherapy ; DNA Mismatch Repair
    Language English
    Publishing date 2022-10-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2022.10.018
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  2. Article: Non-antibiotic treatment of uncomplicated acute diverticulitis is applicable and safe in our environment. A prospective multicenter study.

    Serrano González, Javier / Román García de León, Laura / Galindo Jara, Pablo / Lucena de la Poza, José Luis / Sánchez Movilla, Arsenio / Colao García, Laura / García Schiever, Jesús Gabriel / Varillas Delgado, David

    Revista espanola de enfermedades digestivas

    2023  Volume 116, Issue 3, Page(s) 140–147

    Abstract: Introduction: acute diverticulitis is one of the most frequent underlying causes behind individuals attending the Emergency Room with abdominal pain. The most widespread therapy for acute uncomplicated diverticulitis includes outpatient treatment with ... ...

    Abstract Introduction: acute diverticulitis is one of the most frequent underlying causes behind individuals attending the Emergency Room with abdominal pain. The most widespread therapy for acute uncomplicated diverticulitis includes outpatient treatment with antibiotics; however, several publications indicate that patients can also be successfully treated without antibiotics. The results of the implementation of this more recent protocol in two hospitals in Madrid are presented.
    Methods: an observational prospective study was performed. Participants were patients diagnosed with uncomplicated acute diverticulitis at two hospitals in Madrid, Hospital Universitario de Torrejón and Hospital Universitario Puerta de Hierro Majadahonda, between December 2018 and August 2021, treated on an outpatient basis without antibiotic therapy. The study group was compared with a control group, composed of patients diagnosed with uncomplicated acute diverticulitis and treated with outpatient antibiotic therapy at Hospital Universitario Puerta de Hierro between March 2015 and March 2018.
    Results: three hundred and sixty-one patients were included, 182 in the study group and 179 in the control group. Diverticulitis was persistent in 19 patients (10.4 %) in the study group, who were not treated with antibiotics, and in five patients (2.8 %) in the control group, treated with outpatient antibiotic therapy (p = 0.004). Recurrences occurred in 23 patients (12.6 %) in the study group, and in 53 patients (29.6 %) in the control group (p < 0.0001). The analysis of the complications found no significant differences between both groups (p = 0.109). No urgent surgical intervention or mortality was recorded in the study group.
    Conclusions: in our environment, symptomatic non-antibiotic treatment of uncomplicated acute diverticulitis cases is safe, without showing a higher rate of complications. Although, there seems to be a worse initial symptom control.
    MeSH term(s) Humans ; Prospective Studies ; Acute Disease ; Diverticulitis/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Ambulatory Care ; Diverticulitis, Colonic/drug therapy ; Diverticulitis, Colonic/complications ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-06
    Publishing country Spain
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2023.9737/2023
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  3. Article ; Online: Analysis of adherence to HIV-positive quality of care indicators and their impact on service quality perceptions in patients: a Spanish cross-sectional study.

    Gimeno-García, A / Franco-Moreno, A / Montero-Hernández, C / Arponen, S / García-Carrasco, E / Alejos, B / Corps-Fernández, D / Gaspar-García, E / Galindo-Jara, P / García-Navarro, M / Varillas-Delgado, D

    Health and quality of life outcomes

    2020  Volume 18, Issue 1, Page(s) 185

    Abstract: Background: Since the identification of human immunodeficiency virus (HIV) infection, there have been significant advances in its diagnosis and treatment, but there have been few contributions to the area of care quality. In 2010, the Spanish AIDS Study ...

    Abstract Background: Since the identification of human immunodeficiency virus (HIV) infection, there have been significant advances in its diagnosis and treatment, but there have been few contributions to the area of care quality. In 2010, the Spanish AIDS Study Group (GeSIDA) published the document "Health quality indicators of GeSIDA for the care of people infected with HIV/AIDS" in which standards are proposed for the purpose of improving and standardizing the assistance provided to people infected with HIV. The purpose of this study was to evaluate the degree of compliance with these indicators and to analyse whether adherence to the standards improves patient perception of care quality in terms of their satisfaction with the health care they have received.
    Methods: Compliance with GeSIDA indicators was analysed within a cohort of people living with HIV (PLHIV) in a hospital in the Madrid region. To evaluate patient perception, the External Consultation User Satisfaction Questionnaire (SUCE) was used, which is a tool that was previously validated in the Spanish population.
    Results: A total of 334 patients were included. The level of adherence to the indicators was 74.46%. The score on the SUCE questionnaire was 9.04 out of 10 (CI 95%: 8.90-9.19). Of the 47 indicators assessed, only 4 were related to satisfaction with health care.
    Conclusions: The levels of compliance with the indicators and patient satisfaction with health care were high. Adherence to quality indicators showed little relation to patient-reported satisfaction.
    MeSH term(s) Adult ; Cohort Studies ; Cross-Sectional Studies ; Female ; HIV Infections/psychology ; HIV Infections/therapy ; Humans ; Male ; Middle Aged ; Patient Reported Outcome Measures ; Patient Satisfaction/statistics & numerical data ; Quality Indicators, Health Care/standards ; Quality of Life ; Spain
    Language English
    Publishing date 2020-06-15
    Publishing country England
    Document type Journal Article
    ISSN 1477-7525
    ISSN (online) 1477-7525
    DOI 10.1186/s12955-020-01441-w
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  4. Article ; Online: Author response to: Comment on: Patterns of acute surgical inflammatory processes presentation of in the COVID-19 outbreak (PIACO Study): surgery may be the best treatment option.

    Guadalajara, H / Muñoz de Nova, J L / Fernandez Gonzalez, S / Yiasemidou, M / Recarte Rico, M / Juez, L D / García Septiem, J / Galindo Jara, P / García Virosta, M / Lobo Martínez, E / Martín-Pérez, E / García-Olmo, D

    The British journal of surgery

    2021  Volume 108, Issue 1, Page(s) e42–e43

    MeSH term(s) COVID-19 ; Disease Outbreaks ; Humans ; Inflammation ; SARS-CoV-2
    Language English
    Publishing date 2021-02-26
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znaa022
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    Uk I Zs.66: Show issues Location:
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  5. Article ; Online: The SARS-CoV-2 first wave impact in the acute inflammatory surgical pathologies.

    Guadalajara, H / Muñoz de Nova, J L / Yiasemidou, M / Recarte Rico, M / Juez, L D / García Septiem, J / Galindo Jara, P / García Virosta, M / Lobo Martínez, E / Martín-Pérez, E / Fernandez Gonzalez, S / Lopez-Fernandez, O / García-Olmo, D

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 19645

    Abstract: Anecdotal evidence suggests that community infection control measures during the COVID-19 outbreak have modified the number and natural history of acute surgical inflammatory processes (ASIP-appendicitis, cholecystitis, diverticulitis and perianal ... ...

    Abstract Anecdotal evidence suggests that community infection control measures during the COVID-19 outbreak have modified the number and natural history of acute surgical inflammatory processes (ASIP-appendicitis, cholecystitis, diverticulitis and perianal abscesses) admissions. This study aims to evaluate the impact of the COVID-19 pandemic on the presentation and treatment ASIP and quantify the effect of COVID-19 infection on the outcomes of ASIP patients. This was a multicentre, comparative study, whereby ASIP cases from 2019, 2020 and 2021 (March 14th to May 2nd) were analyzed. Data regarding patient and disease characteristics as well as outcomes, were collected from sixteen centres in Madrid, and one in Seville (Spain). The number of patients treated for ASIP in 2019 was 822 compared to 521 in 2020 and 835 in 2021. This 1/3rd reduction occurs mainly in patients with mild cases, while the number of severe cases was similar. Surgical standards suffered a step back during the first wave: Lower laparoscopic approach and longer length of stay. We also found a more conservative approach to the patients this year, non-justified by clinical circumstances. Luckily these standards improved again in 2021. The positive COVID-19 status itself did not have a direct impact on mortality. Strikingly, none of the 33 surgically treated COVID positive patients during both years died postoperatively. This is an interesting finding which, if confirmed through future research with a larger sample size of COVID-19 positive patients, can expedite the recovery phase of acute surgical services.
    MeSH term(s) Adult ; Aged ; Appendicitis/complications ; Appendicitis/epidemiology ; Appendicitis/pathology ; Appendicitis/surgery ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/pathology ; COVID-19/virology ; Cholecystitis/complications ; Cholecystitis/epidemiology ; Cholecystitis/pathology ; Cholecystitis/surgery ; Diverticulitis/complications ; Diverticulitis/epidemiology ; Diverticulitis/pathology ; Diverticulitis/surgery ; Female ; Humans ; Laparoscopy ; Length of Stay ; Male ; Middle Aged ; Pandemics ; SARS-CoV-2/isolation & purification ; Severity of Illness Index ; Spain/epidemiology
    Language English
    Publishing date 2021-10-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-98878-w
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  6. Article ; Online: Patterns of acute surgical inflammatory processes presentation of in the COVID-19 outbreak (PIACO Study): Surgery may be the best treatment option.

    Guadalajara, H / Muñoz de Nova, J L / Fernandez Gonzalez, S / Yiasemidou, M / Recarte Rico, M / Juez, L D / García Septiem, J / Galindo Jara, P / García Virosta, M / Lobo Martínez, E / Martín-Pérez, E / García-Olmo, D

    The British journal of surgery

    2020  Volume 107, Issue 11, Page(s) e494–e495

    MeSH term(s) Abscess/epidemiology ; Abscess/therapy ; Anus Diseases/epidemiology ; Anus Diseases/therapy ; Appendicitis/epidemiology ; Appendicitis/therapy ; COVID-19/diagnosis ; COVID-19/epidemiology ; Case-Control Studies ; Cholecystitis/epidemiology ; Cholecystitis/therapy ; Conservative Treatment ; Digestive System Surgical Procedures/statistics & numerical data ; Diverticulitis/epidemiology ; Diverticulitis/therapy ; Humans ; Logistic Models ; Pandemics ; Severity of Illness Index ; Spain/epidemiology ; Time-to-Treatment
    Keywords covid19
    Language English
    Publishing date 2020-08-21
    Publishing country England
    Document type Letter ; Multicenter Study
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.11950
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  7. Article: Poorly differentiated colonic adenocarcinoma showing rhabdoid feature: An extremely unusual anatomopathological diagnosis.

    Serrano González, Javier / García Martos, María / Román García de León, Laura / Colao García, Laura / Galindo Jara, Pablo

    Gastroenterologia y hepatologia

    2018  Volume 42, Issue 6, Page(s) 378–381

    Title translation Adenocarcinoma de colon pobremente diferenciado con diferenciación rabdoide: un diagnóstico anatomopatológico extremadamente infrecuente.
    MeSH term(s) Adenocarcinoma/chemistry ; Adenocarcinoma/drug therapy ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Aged, 80 and over ; Antimetabolites, Antineoplastic/therapeutic use ; Biomarkers, Tumor ; Cell Differentiation ; Chemotherapy, Adjuvant ; Colectomy ; Colonic Neoplasms/chemistry ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/pathology ; Colonic Neoplasms/surgery ; Combined Modality Therapy ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/therapeutic use ; Humans ; Keratins/analysis ; Male ; Neoplasm Proteins/analysis ; Rhabdoid Tumor/chemistry ; Rhabdoid Tumor/drug therapy ; Rhabdoid Tumor/pathology ; Rhabdoid Tumor/surgery ; Tumor Suppressor Protein p53/analysis ; Vimentin/analysis ; beta Catenin/analysis
    Chemical Substances Antimetabolites, Antineoplastic ; Biomarkers, Tumor ; CTNNB1 protein, human ; Neoplasm Proteins ; TP53 protein, human ; Tumor Suppressor Protein p53 ; VIM protein, human ; Vimentin ; beta Catenin ; Deoxycytidine (0W860991D6) ; Keratins (68238-35-7) ; gemcitabine (B76N6SBZ8R)
    Language Spanish
    Publishing date 2018-10-13
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 632502-6
    ISSN 0210-5705
    ISSN 0210-5705
    DOI 10.1016/j.gastrohep.2018.09.001
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    Zs.A 2044: Show issues Location:
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  8. Article ; Online: Single-port access surgery resection of a presacral schwannoma.

    Gascón Hove, M / Pueyo Rabanal, A / Cea Soriano, M / Galindo Jara, P / Garijo Álvarez, J A

    Techniques in coloproctology

    2013  Volume 18, Issue 4, Page(s) 407–408

    MeSH term(s) Humans ; Laparoscopy/methods ; Minimally Invasive Surgical Procedures/methods ; Neurilemmoma/diagnostic imaging ; Neurilemmoma/surgery ; Retroperitoneal Neoplasms/diagnostic imaging ; Retroperitoneal Neoplasms/surgery ; Sacrococcygeal Region/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2013-01-23
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-012-0968-5
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    Zs.A 5842: Show issues Location:
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  9. Article: Patterns of acute surgical inflammatory processes presentation of in the COVID-19 outbreak (PIACO Study): Surgery may be the best treatment option

    Guadalajara, H / Muñoz de Nova, J L / Fernandez Gonzalez, S / Yiasemidou, M / Recarte Rico, M / Juez, L D / García Septiem, J / Galindo Jara, P / García Virosta, M / Lobo Martínez, E / Martín-Pérez, E / García-Olmo, D

    Br. j. surg

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #724559
    Database COVID19

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  10. Article ; Online: The international PIACO study: pattern of surgical approaches for acute surgical pathologies in Spain versus UK. Was conservative treatment and open surgery during COVID-19 the way to go?

    Guadalajara, Hector / Yiasemidou, Marina / Muñoz de Nova, José Luis / Sedman, Peter / Fernandez Gonzalez, Saul / Maslekar, Sushil / Recarte Rico, María / Egan, Richard / Juez, Luz Divina / Riyad, Kallingal / García Septiem, Javier / Lockwood, Sonia / Galindo Jara, Pablo / Giorga, Andrea / García Virosta, Mariana / Hance, Julian / Lobo Martínez, Eduardo / Martín-Pérez, Elena / Howitt, Annabel /
    Jayne, David / Chetter, Ian / García-Olmo, Damian

    BJS open

    2022  Volume 6, Issue 4

    MeSH term(s) COVID-19 ; Conservative Treatment ; Humans ; Spain/epidemiology ; United Kingdom/epidemiology
    Language English
    Publishing date 2022-08-08
    Publishing country England
    Document type Journal Article
    ISSN 2474-9842
    ISSN (online) 2474-9842
    DOI 10.1093/bjsopen/zrac089
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