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  1. Article ; Online: Laparoscopic versus robotic abdominal and pelvic surgery: a systematic review of randomised controlled trials.

    Kawka, Michal / Fong, Yuman / Gall, Tamara M H

    Surgical endoscopy

    2023  Volume 37, Issue 9, Page(s) 6672–6681

    Abstract: Background: The current evidence is inconclusive on whether robotic or laparoscopic surgery is the optimal platform for minimally invasive surgery. Existing comparisons techniques focus on short-term outcomes only, while potentially being confounded by ... ...

    Abstract Background: The current evidence is inconclusive on whether robotic or laparoscopic surgery is the optimal platform for minimally invasive surgery. Existing comparisons techniques focus on short-term outcomes only, while potentially being confounded by a lack of standardisation in robotic procedures. There is a pertinent need for an up-to-date comparison between minimally invasive surgical techniques. We aimed to systematically review randomised controlled trials comparing robotic and laparoscopic techniques in major surgery.
    Methods: Embase, Medline and Cochrane Library were searched from their inception to 13th September 2022. Included studies were randomised controlled trials comparing robotic and laparoscopic techniques in abdominal and pelvic surgery. The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Short-term, health-related quality of life, and long-term, outcomes were analysed.
    Results: Forty-five studies, across thirteen procedures, involving 7364 patients were included. All of the studies reported non-significant differences in mortality between robotic and laparoscopic surgery. In majority of studies, there was no significant difference in complication rate (n = 31/35, 85.6%), length of postoperative stay (n = 27/32, 84.4%), and conversion rate (n = 15/18, 83.3%). Laparoscopic surgery was associated with shorter operative time (n = 16/31, 51.6%) and lower total cost (n = 11/13, 84.6%). Twenty three studies reported on quality of life outcomes; majority (n = 14/23, 60.9%) found no significant differences.
    Conclusion: There were no significant differences between robotic surgery and laparoscopic surgery with regards to mortality and morbidity outcomes in the majority of studies. Robotic surgery was frequently associated with longer operative times and higher overall cost. Selected studies found potential benefits in post-operative recovery time, and patient-reported outcomes; however, these were not consistent across procedures and trials, with most studies being underpowered to detect differences in secondary outcomes. Future research should focus on assessing quality of life, and long-term outcomes to further elucidate where the robotic platform could lead to patient benefits, as the technology evolves.
    MeSH term(s) Humans ; Laparoscopy/methods ; Quality of Life ; Robotic Surgical Procedures ; Robotics ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-07-13
    Publishing country Germany
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-023-10275-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Author response to: Shortening surgical training through robotics: randomized clinical trial of laparoscopic versus robotic surgical learning curves.

    Jiao, Long / Gall, Tamara M H

    BJS open

    2021  Volume 5, Issue 6

    MeSH term(s) Humans ; Laparoscopy ; Learning Curve ; Robotic Surgical Procedures ; Robotics
    Language English
    Publishing date 2021-10-16
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2474-9842
    ISSN (online) 2474-9842
    DOI 10.1093/bjsopen/zrab031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comment on: Learning Curve From 450 Cases of Robot-Assisted Pancreaticoduodenectomy in a High-Volume Pancreatic Center.

    Hand, Fiona / Gall, Tamara / Jiao, Long R

    Annals of surgery open : perspectives of surgical history, education, and clinical approaches

    2022  Volume 3, Issue 1, Page(s) e137

    Language English
    Publishing date 2022-02-14
    Publishing country United States
    Document type Journal Article
    ISSN 2691-3593
    ISSN (online) 2691-3593
    DOI 10.1097/AS9.0000000000000137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Artificial intelligence in the detection, characterisation and prediction of hepatocellular carcinoma: a narrative review.

    Kawka, Michal / Dawidziuk, Aleksander / Jiao, Long R / Gall, Tamara M H

    Translational gastroenterology and hepatology

    2022  Volume 7, Page(s) 41

    Abstract: Hepatocellular carcinoma (HCC) is a significant cause of morbidity and mortality worldwide. Despite significant advancements in detection and treatment of HCC, its management remains a challenge. Artificial intelligence (AI) has played a role in medicine ...

    Abstract Hepatocellular carcinoma (HCC) is a significant cause of morbidity and mortality worldwide. Despite significant advancements in detection and treatment of HCC, its management remains a challenge. Artificial intelligence (AI) has played a role in medicine for several decades, however, clinically applicable AI-driven solutions have only started to emerge, due to gradual improvement in sensitivity and specificity of AI, and implementation of convoluted neural networks. A review of the existing literature has been conducted to determine the role of AI in HCC, and three main domains were identified in the search: detection, characterisation and prediction. Implementation of AI models into detection of HCC has immense potential, as AI excels at analysis and integration of large datasets. The use of biomarkers, with the rise of '-omics', can revolutionise the detection of HCC. Tumour characterisation (differentiation between benign masses, HCC, and other malignant tumours, as well as staging and grading) using AI was shown to be superior to classical statistical methods, based on radiological and pathological images. Finally, AI solutions for predicting treatment outcomes and survival emerged in recent years with the potential to shape future HCC guidelines. These AI algorithms based on a combination of clinical data and imaging-extracted features can also support clinical decision making, especially treatment choice. However, AI research on HCC has several limitations, hindering its clinical adoption; small sample size, single-centre data collection, lack of collaboration and transparency, lack of external validation, and model overfitting all results in low generalisability of the results that currently exist. AI has potential to revolutionise detection, characterisation and prediction of HCC, however, for AI solutions to reach widespread clinical adoption, interdisciplinary collaboration is needed, to foster an environment in which AI solutions can be further improved, validated and included in treatment algorithms. In conclusion, AI has a multifaceted role in HCC across all aspects of the disease and its importance can increase in the near future, as more sophisticated technologies emerge.
    Language English
    Publishing date 2022-10-25
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2415-1289
    ISSN (online) 2415-1289
    DOI 10.21037/tgh-20-242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Quality of life after pancreatic surgery - A systematic review.

    James, Nicole E / Chidambaram, Swathikan / Gall, Tamara Mh / Sodergren, Mikael H

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2022  Volume 24, Issue 8, Page(s) 1223–1237

    Abstract: Background: Surgery for patients with pancreatic cancer carries a high risk of major post-operative complications and only marginally improves overall survival. This review aims to assess the impact of surgical resection on health-related quality of ... ...

    Abstract Background: Surgery for patients with pancreatic cancer carries a high risk of major post-operative complications and only marginally improves overall survival. This review aims to assess the impact of surgical resection on health-related quality of life (HRQOL) of pancreatic cancer patients.
    Methods: A systematic review of the literature was performed according to the PRISMA guidelines. All studies assessing QOL using validated questionnaires in pancreatic cancer patients undergoing surgical resection were included.
    Results: Twenty-two studies were assessed. Patients reported a decrease in physical, social and global scales within the first 3 months after surgery. These values showed improvement and were comparable to baseline values by 6 months. Recovery in emotional functioning towards baseline figures was demonstrated in the first 3 months post-operatively. Symptom scales including pain, fatigue and diarrhoea deteriorated after surgery, but reverted to baseline after 3-6 months.
    Conclusions: Surgical resection for pancreatic cancer has short-term negative impact on QOL. In the longer term, this will improve and eventually recover to baseline values after 6 months. Knowledge on the impact of surgery on QOL of pancreatic cancer patients is necessary to facilitate decision-making and tailoring of surgical techniques to the individual patient.
    MeSH term(s) Humans ; Pancreatic Neoplasms/psychology ; Pancreatic Neoplasms/surgery ; Prospective Studies ; Quality of Life ; Surveys and Questionnaires ; Pancreatic Neoplasms
    Language English
    Publishing date 2022-02-28
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2022.02.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Surgical management of high-grade pancreatic injuries: Insights from a high-volume pancreaticobiliary specialty unit.

    Chui, Juanita Noeline / Kotecha, Krishna / Gall, Tamara Mh / Mittal, Anubhav / Samra, Jaswinder S

    World journal of gastrointestinal surgery

    2023  Volume 15, Issue 5, Page(s) 834–846

    Abstract: Background: The management of high-grade pancreatic trauma is controversial.: Aim: To review our single-institution experience on the surgical management of blunt and penetrating pancreatic injuries.: Methods: A retrospective review of records was ...

    Abstract Background: The management of high-grade pancreatic trauma is controversial.
    Aim: To review our single-institution experience on the surgical management of blunt and penetrating pancreatic injuries.
    Methods: A retrospective review of records was performed on all patients undergoing surgical intervention for high-grade pancreatic injuries [American Association for the Surgery of Trauma (AAST) Grade III or greater] at the Royal North Shore Hospital in Sydney between January 2001 and December 2022. Morbidity and mortality outcomes were reviewed, and major diagnostic and operative challenges were identified.
    Results: Over a twenty-year period, 14 patients underwent pancreatic resection for high-grade injuries. Seven patients sustained AAST Grade III injuries and 7 were classified as Grades IV or V. Nine underwent distal pancreatectomy and 5 underwent pancreaticoduodenectomy (PD). Overall, there was a predominance of blunt aetiologies (11/14). Concomitant intra-abdominal injuries were observed in 11 patients and traumatic haemorrhage in 6 patients. Three patients developed clinically relevant pancreatic fistulas and there was one in-hospital mortality secondary to multi-organ failure. Among stable presentations, pancreatic ductal injuries were missed in two-thirds of cases (7/12) on initial computed tomography imaging and subsequently diagnosed on repeat imaging or endoscopic retrograde cholangiopancreatography. All patients who sustained complex pancreaticoduodenal trauma underwent PD without mortality. The management of pancreatic trauma is evolving. Our experience provides valuable and locally relevant insights into future management strategies.
    Conclusion: We advocate that high-grade pancreatic trauma should be managed in high-volume hepato-pancreato-biliary specialty surgical units. Pancreatic resections including PD may be indicated and safely performed with appropriate specialist surgical, gastroenterology, and interventional radiology support in tertiary centres.
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v15.i5.834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Embryology to the rescue: restoration of hepatic blood flow via the remnant umbilical vein following iatrogenic bilateral portal vein embolization.

    Shahrestani, Sara / Mason, Emily / Jayasekara, Jayani / Gall, Tamara / Sirimanna, Pram / Mittal, Anubhav / Samra, Jaswinder

    ANZ journal of surgery

    2023  Volume 93, Issue 11, Page(s) 2760–2761

    MeSH term(s) Humans ; Portal Vein ; Umbilical Veins ; Liver ; Hepatectomy/adverse effects ; Embolization, Therapeutic/adverse effects ; Iatrogenic Disease ; Liver Neoplasms/surgery
    Language English
    Publishing date 2023-07-21
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.18617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hepatic epithelioid hemangioendothelioma (HEHE)-rare vascular malignancy mimicking cholangiocarcinoma: a case report.

    Kawka, Michal / Mak, Sau / Qiu, Shengyang / Gall, Tamara M H / Jiao, Long R

    Translational gastroenterology and hepatology

    2022  Volume 7, Page(s) 42

    Abstract: Hepatic epithelioid hemangioendothelioma (HEHE) is a rare, often misdiagnosed malignancy of vascular origin. We describe a case of a 36-year-old, who presented with a burning sensation in his chest on exercise and was believed to have bilobar ... ...

    Abstract Hepatic epithelioid hemangioendothelioma (HEHE) is a rare, often misdiagnosed malignancy of vascular origin. We describe a case of a 36-year-old, who presented with a burning sensation in his chest on exercise and was believed to have bilobar intrahepatic cholangiocarcinoma. After receiving chemotherapy with partial response, the patient underwent staged resection with modified associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) procedure-laparoscopic radiofrequency-assisted ALPPS (RALPPS). Histological examination of the stage 1 specimen revealed HEHE deposits in the left lobe of the liver. The patient proceeded to have stage 2 open right hepatectomy with concurring histology. Ninety-day follow-up computed tomography scan showed almost complete resolution of HEHE lesions. Low incidence, non-specific clinical and radiological characteristics all contribute to high HEHE misdiagnosis rate. Histological analysis can be used for confirmation of the diagnosis; however, specialist staining is required, which is not routinely performed. Multiple treatments are available against HEHE, but only liver resection and liver transplantation are potentially curative. ALPPS and its modifications (such as RALPPS) offer an alternative from conventional two-stage hepatectomy for patients with extensive bilobar HEHE, who are at risk of developing post-hepatectomy liver failure or patients with anomalous hepatic vasculature anatomy which makes portal vein embolisation (PVE) challenging.
    Language English
    Publishing date 2022-10-25
    Publishing country China
    Document type Case Reports
    ISSN 2415-1289
    ISSN (online) 2415-1289
    DOI 10.21037/tgh-20-310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Can we predict the progression of premalignant pancreatic cystic tumors to ductal adenocarcinoma?

    Chidambaram, Swathikan / Kawka, Michal / Gall, Tamara Mh / Cunningham, David / Jiao, Long R

    Future oncology (London, England)

    2022  Volume 18, Issue 23, Page(s) 2605–2612

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent malignant pancreatic tumor. Few studies have shown how often PDACs arise from cystic precursor lesions. This special report aims to summarize the evidence on the progression of precancerous ... ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent malignant pancreatic tumor. Few studies have shown how often PDACs arise from cystic precursor lesions. This special report aims to summarize the evidence on the progression of precancerous lesions to PDAC. A review of the literature found four studies that discussed pancreatic intraepithelial lesions (PanINs), three that discussed mucinous cystic neoplasms (MCN) and five that discussed intraductal papillary neoplasms (IPMNs). PanINs were the most common precursors lesion, with approximately 80% of PDACs originating from this lesion. The lack of evidence characterizing the features of PDAC precursor cystic lesions potentially leads to a subset of patients undergoing surgery unnecessarily. Advancements in molecular techniques could allow the study of cystic lesions at a genetic level, leading to more personalized management.
    MeSH term(s) Carcinoma, Pancreatic Ductal/diagnosis ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Humans ; Pancreas/pathology ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Precancerous Conditions/diagnosis ; Precancerous Conditions/genetics ; Precancerous Conditions/pathology ; Pancreatic Neoplasms
    Language English
    Publishing date 2022-06-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2021-1545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Transition from open to robotic distal pancreatectomy in a low volume pancreatic surgery country: a single Australian centre experience.

    Masuda, Hiro / Kotecha, Krishna / Gall, Tamara / Gill, Anthony J / Mittal, Anubhav / Samra, Jaswinder S

    ANZ journal of surgery

    2022  Volume 93, Issue 1-2, Page(s) 151–159

    Abstract: Background: Advances in technology and techniques have allowed for robotic distal pancreatectomies to be readily performed in patients at high volume centres. This study describes the experience of a single surgeon during the learning curve and ... ...

    Abstract Background: Advances in technology and techniques have allowed for robotic distal pancreatectomies to be readily performed in patients at high volume centres. This study describes the experience of a single surgeon during the learning curve and transition from open to robotic distal pancreatectomy in Australia, a traditionally low volume pancreatic surgery country.
    Methods: All patients undergoing distal pancreatectomy at an Australian-based tertiary referral centre between 2010 and 2021 were reviewed retrospectively. Demographic, clinicopathologic and survival data were analysed to compare perioperative and oncological outcomes between patients who underwent open, laparoscopic and robotic distal pancreatectomies.
    Results: A total of 178 distal pancreatectomies were identified for analysis during the study period. Ninety-one open distal pancreatectomies (ODP), 48 laparoscopic distal pancreatectomies (LDP), and 39 robotic distal pancreatectomies (RDP) were performed. Robotic distal pancreatectomy was non-inferior with respect to perioperative outcomes and yielded statistically non-significant advantages over LDP and ODP.
    Conclusion: RDP is feasible and can be performed safely in well-selected patients during the learning phase at large pancreatic centres in a traditionally low-volume country like Australia. Referral to large pancreatic centres where access to the robotic platform and surgeon experience is not a barrier, and where a robust multidisciplinary team meeting can take place, remains pivotal in the introduction and transition toward the robotic approach for management of patients with pancreatic body or tail lesions.
    MeSH term(s) Humans ; Pancreatectomy/methods ; Robotic Surgical Procedures/methods ; Pancreatic Neoplasms/surgery ; Retrospective Studies ; Treatment Outcome ; Operative Time ; Australia/epidemiology ; Laparoscopy/methods ; Length of Stay
    Language English
    Publishing date 2022-12-13
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.18199
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