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Book ; Thesis: Development and application of coherent anti-Stokes Raman scattering imaging methods for the characterization of cells and tissue

Galli, Roberta

2014

Author's details	von Roberta Galli
Language	English
Size	X, 146 S. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dresden, Univ., Diss., 2014
HBZ-ID	HT018412267
Database	Catalogue ZB MED Medicine, Health

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Article: Vibrational spectroscopy and multiphoton microscopy for label-free visualization of nervous system degeneration and regeneration.

Galli, Roberta / Uckermann, Ortrud

Biophysical reviews

2023 Volume 16, Issue 2, Page(s) 219–235

Abstract: Neurological disorders, including spinal cord injury, peripheral nerve injury, traumatic brain injury, and neurodegenerative diseases, pose significant challenges in terms of diagnosis, treatment, and understanding the underlying pathophysiological ... ...

Abstract	Neurological disorders, including spinal cord injury, peripheral nerve injury, traumatic brain injury, and neurodegenerative diseases, pose significant challenges in terms of diagnosis, treatment, and understanding the underlying pathophysiological processes. Label-free multiphoton microscopy techniques, such as coherent Raman scattering, two-photon excited autofluorescence, and second and third harmonic generation microscopy, have emerged as powerful tools for visualizing nervous tissue with high resolution and without the need for exogenous labels. Coherent Raman scattering processes as well as third harmonic generation enable label-free visualization of myelin sheaths, while their combination with two-photon excited autofluorescence and second harmonic generation allows for a more comprehensive tissue visualization. They have shown promise in assessing the efficacy of therapeutic interventions and may have future applications in clinical diagnostics. In addition to multiphoton microscopy, vibrational spectroscopy methods such as infrared and Raman spectroscopy offer insights into the molecular signatures of injured nervous tissues and hold potential as diagnostic markers. This review summarizes the application of these label-free optical techniques in preclinical models and illustrates their potential in the diagnosis and treatment of neurological disorders with a special focus on injury, degeneration, and regeneration. Furthermore, it addresses current advancements and challenges for bridging the gap between research findings and their practical applications in a clinical setting.
Language	English
Publishing date	2023-10-05
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2486483-3
ISSN	1867-2469 ; 1867-2450
ISSN (online)	1867-2469
ISSN	1867-2450
DOI	10.1007/s12551-023-01158-2
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Article ; Online: The Neurosphere Assay (NSA) Applied to Neural Stem Cells (NSCs) and Cancer Stem Cells (CSCs).

Galli, Rossella

Methods in molecular biology (Clifton, N.J.)

2019 Volume 1953, Page(s) 139–149

Abstract: The discovery of neural stem cells (NSCs) in the mammalian brain has raised many expectations as these unique cells might recapitulate different neurological diseases, including brain tumors, both from a functional and molecular perspective. Proper in ... ...

Abstract	The discovery of neural stem cells (NSCs) in the mammalian brain has raised many expectations as these unique cells might recapitulate different neurological diseases, including brain tumors, both from a functional and molecular perspective. Proper in vitro culturing of NSCs has emerged as a critical methodological issue, given that it should preserve the in vivo features of NSCs, with particular emphasis on cell heterogeneity. At the same time, the methodology for NSC culturing should allow the production of large amounts of cells to be exploited not only for prospective clinical applications but also for drug screening. Direct in vitro selection of NSCs and, very recently, cancer stem cells (CSCs) by means of defined serum-free conditions represents the most reliable methodology to obtain long-term expanding SC lines. Here we describe the methods currently employed to enrich for NSCs/CSCs based on the neurosphere assay (NSA) and their adaptation to specific assays for testing the efficacy of neuroactive compounds.
MeSH term(s)	Animals ; Cell Culture Techniques/methods ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Self Renewal/drug effects ; Cell Separation/methods ; Cell Survival/drug effects ; Cells, Cultured ; Drug Evaluation, Preclinical/methods ; Humans ; Mice ; Neoplastic Stem Cells/cytology ; Neoplastic Stem Cells/drug effects ; Neural Stem Cells/cytology ; Neural Stem Cells/drug effects ; Rats
Language	English
Publishing date	2019-03-25
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-9145-7_9
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Article ; Online: Patient-Related Outcome Measures for Oculomotor Symptoms in the Cerebellar Ataxias: Insights from Non-Cerebellar Disorders.

Szmulewicz, David J / Galli, Rocco / Tarnutzer, Alexander A

Cerebellum (London, England)

2024

Abstract: In patients with cerebellar ataxia (CA), symptoms related to oculomotor dysfunction significantly affect quality of life (QoL). This study aimed to analyze the literature on patient-related outcome measures (PROMs) assessing QoL impacts of vestibular and ...

Abstract	In patients with cerebellar ataxia (CA), symptoms related to oculomotor dysfunction significantly affect quality of life (QoL). This study aimed to analyze the literature on patient-related outcome measures (PROMs) assessing QoL impacts of vestibular and cerebellar oculomotor abnormalities in patients with CA to identify the strengths and limitations of existing scales and highlight any areas of unmet need. A systematic review was conducted (Medline, Embase) of English-language original articles reporting on QoL measures in patients with vertigo, dizziness or CA. Pre-specified parameters were retrieved, including diseases studied, scales applied and conclusions drawn. Our search yielded 3671 articles of which 467 studies (n = 111,606 participants) were deemed relevant. The most frequently studied disease entities were (a) non-specific dizziness/gait imbalance (114 studies; 54,581 participants), (b) vestibular schwannomas (66; 15,360), and (c) vestibular disorders not further specified (66; 10,259). The Dizziness Handicap Inventory (DHI) was the most frequently used PROM to assess QoL (n = 91,851), followed by the Penn Acoustic Neuroma Quality-of-Life Scale (n = 12,027) and the Activities-Specific Balance Confidence Scale (n = 2'471). QoL-scores capturing symptoms related to oculomotor abnormalities in CA were rare, focused on visual impairments (e.g., National-Eye-Institute Visual Function Questionnaire, Oscillopsia Functional Impact, oscillopsia severity score) and were unvalidated. The DHI remains the most widely used and versatile scale for evaluating dizziness. A lack of well-established PROMs for assessing the impact of oculomotor-related symptoms on QoL in CA was noted, emphasizing the need for developing and validating a new QoL-score dedicated to the oculomotor domain for individuals with CA.
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2112586-7
ISSN	1473-4230 ; 1473-4222
ISSN (online)	1473-4230
ISSN	1473-4222
DOI	10.1007/s12311-024-01656-3
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Article: [Modern surgery for inflammatory bowel disease].

Henniger, Georg / Galli, Raffaele / Rosenberg, Robert

Therapeutische Umschau. Revue therapeutique

2023 Volume 80, Issue 9, Page(s) 417–422

Abstract: Introduction: Despite the advances in the medical management, especially biologics, there are still clear indications for operative management of IBD. For Crohn's disease, surgical therapy plays an important role after failure of medical management and ... ...

Abstract	Introduction: Despite the advances in the medical management, especially biologics, there are still clear indications for operative management of IBD. For Crohn's disease, surgical therapy plays an important role after failure of medical management and for treatment of complications. In recent years, however, there has been a change in the treatment philosophy of patients with isolated involvement of the ileocecal region, and for selected patients, primary surgical resection appears to be an equivalent treatment alternative to therapy with biologics. In ulcerative colitis, surgery offers the only curative option. In severe acute colitis, surgery is indicated when conservative treatment is not effective and/or when there is a risk of colonic perforation. Indications for elective surgery are failure of conservative therapy and malignant transformation. The ileoanal J-pouch reconstruction is the standard procedure after restorative proctocolectomy with excellent functional long-term results. The increasing complexity of indications and minimally invasive surgical techniques, as well as the demanding perioperative treatment, led to an increasing specialization in the surgical treatment of IBD patients, with IBD-surgeons collaborating as a team with gastroenterologists to optimize the outcome of IBD-patients.
MeSH term(s)	Humans ; Inflammatory Bowel Diseases/surgery ; Inflammatory Bowel Diseases/etiology ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/surgery ; Crohn Disease/diagnosis ; Crohn Disease/surgery ; Proctocolectomy, Restorative/adverse effects ; Proctocolectomy, Restorative/methods ; Postoperative Complications/etiology ; Biological Products/therapeutic use
Chemical Substances	Biological Products
Language	German
Publishing date	2023-12-14
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	82044-1
ISSN	1664-2864 ; 0040-5930
ISSN (online)	1664-2864
ISSN	0040-5930
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Article: [Intussusception and Rectal Prolapse: A Common Cause for Defecation Disorders].

Galli, Raffaele / Rosenberg, Robert / Lamm, Sebastian

Praxis

2023 Volume 112, Issue 10, Page(s) 494–499

Abstract: Introduction: A rectal prolapse is mainly a disease of the elderly population, occurring more frequently among women. The medical practitioner has an important role in the recognition and initiation of therapy for rectal prolapse. Appropriate therapy ... ...

Abstract	Introduction: A rectal prolapse is mainly a disease of the elderly population, occurring more frequently among women. The medical practitioner has an important role in the recognition and initiation of therapy for rectal prolapse. Appropriate therapy can have an important impact on symptom reduction and healthcare resources. Surgical therapy includes perineal or transabdominal surgery, with increasing use of minimally invasive techniques such as mesh rectopexy. This operation is indicated and feasible regardless of age. The management of the rectal prolapse in specialized pelvic floor centres with interdisciplinary expertise for diagnosis and therapy is recommended.
MeSH term(s)	Humans ; Female ; Aged ; Rectal Prolapse/diagnosis ; Rectal Prolapse/etiology ; Rectal Prolapse/surgery ; Defecation ; Intussusception/diagnosis ; Intussusception/etiology ; Intussusception/surgery ; Treatment Outcome ; Pelvic Floor ; Rectum/surgery ; Surgical Mesh ; Laparoscopy/methods
Language	German
Publishing date	2023-10-19
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	209026-0
ISSN	1661-8165 ; 1661-8157 ; 0369-8394
ISSN (online)	1661-8165
ISSN	1661-8157 ; 0369-8394
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Article: Clinical Raman spectroscopy of brain tumors from an interdisciplinary perspective.

Galli, Roberta / Juratli, Tareq A / Uckermann, Ortrud

Clinical neuropathology

2022 Volume 42, Issue 1, Page(s) 2–14

Abstract: Raman spectroscopy is an optical technology that probes tissue composition and is envisioned for clinical applications in neurosurgery. Here, we provide an overview of basic and translational research addressing brain tumor delineation and diagnosis and ... ...

Abstract	Raman spectroscopy is an optical technology that probes tissue composition and is envisioned for clinical applications in neurosurgery. Here, we provide an overview of basic and translational research addressing brain tumor delineation and diagnosis and identify potential scenarios for routine clinical use of Raman spectroscopy. Moreover, we discuss the practical technical requirements in the context of daily use as well as open questions regarding automated tissue assessment.
MeSH term(s)	Humans ; Brain Neoplasms/diagnosis ; Brain Neoplasms/surgery ; Neurosurgical Procedures/methods ; Spectrum Analysis, Raman/methods
Language	English
Publishing date	2022-12-06
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	603167-5
ISSN	0722-5091
ISSN	0722-5091
DOI	10.5414/NP301522
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Article ; Online: Laboratory Industry Perspectives on the Role of Self-Collection and Self-Testing in Remote Care for Sexually Transmitted Infections: How Do We Bring These Services to Scale?

Sullivan, Patrick S / Galli, Rick / Malhomme, Nick / York, James

Sexually transmitted diseases

2022 Volume 49, Issue 11S Suppl 2, Page(s) S31–S35

MeSH term(s)	Humans ; Mass Screening ; Self-Testing ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/prevention & control
Language	English
Publishing date	2022-07-14
Publishing country	United States
Document type	Editorial
ZDB-ID	435191-5
ISSN	1537-4521 ; 0148-5717
ISSN (online)	1537-4521
ISSN	0148-5717
DOI	10.1097/OLQ.0000000000001676
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Article: Chirurgische Behandlung des Kolon- und Rektumkarzinoms.

Galli, Raffaele / Rosenberg, Robert

Therapeutische Umschau. Revue therapeutique

2019 Volume 75, Issue 10, Page(s) 607–614

Abstract: Surgical treatment of colorectal ... ...

Title translation	Surgical treatment of colorectal cancer.
Abstract	Surgical treatment of colorectal cancer
MeSH term(s)	Colorectal Neoplasms/surgery ; Humans ; Laparoscopy ; Male ; Neoplasm Recurrence, Local ; Quality of Life ; Randomized Controlled Trials as Topic ; Robotic Surgical Procedures ; Treatment Outcome
Language	German
Publishing date	2019-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	82044-1
ISSN	1664-2864 ; 0040-5930
ISSN (online)	1664-2864
ISSN	0040-5930
DOI	10.1024/0040-5930/a001047
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Article ; Online: A Review of Frontal Orbital and Frontal Sinus Fractures and Associated Ocular Injuries - Level I Trauma Center - University Hospital Experience.

Viezel-Mathieu, Alex / Galli, Rafael / Lessard, Lucie

The Journal of craniofacial surgery

2021 Volume 32, Issue 4, Page(s) 1615–1618

Abstract: Background: Traumatic frontal fractures result from high force injuries and can result in significant morbidity and mortality. The purpose of the current study is to evaluate our Montreal General Hospital (MGH) experience with frontal bone fractures.: ...

Abstract	Background: Traumatic frontal fractures result from high force injuries and can result in significant morbidity and mortality. The purpose of the current study is to evaluate our Montreal General Hospital (MGH) experience with frontal bone fractures. Methods: A comprehensive review of our trauma database was performed. All adult patients (>18 years) presenting with a diagnosis of frontal sinus fracture were identified. A thorough retrospective electronic medical records search was performed and relevant data extracted. Specifically, all cases of ocular injury or sequelae were identified and an in-depth review was performed. Results: Between 2008 and 2014, 10,189 trauma patients presented to the MUHC Level 1 trauma center. A total of 1277 patients presented with a facial fracture and 140 had a frontal sinus fracture. The mean age was 43.5 years, 90% were male and the mean hospitalization time was 16.2 days. A significant proportion of patients suffered concomitant craniomaxillofacial fractures including orbital (79%), maxillary (66%), nasal (64%), zygomaticomaxillary complex (34%), nasoorbitoethmoid (31%), Lefort types I-III (18%), and mandibular (8%). Associated cervical spine injuries were documented in 16% of patients. Ocular injuries were present in 30% of subjects. 26% of patients had some form of permanent sequelae from their trauma, mainly neurological. Conclusions: Due to the intimate association of the frontal bones with the brain and the orbits, frontal sinus fractures demand a sophisticated multidisciplinary craniofacial surgical approach. Given the high rate of ocular injury of 30% as well as severe systemic injuries, the authors propose a modified treatment algorithm for these complex cases.
MeSH term(s)	Adult ; Female ; Frontal Sinus/diagnostic imaging ; Hospitals ; Humans ; Male ; Orbital Fractures/diagnostic imaging ; Orbital Fractures/epidemiology ; Orbital Fractures/surgery ; Retrospective Studies ; Skull Fractures/epidemiology ; Trauma Centers
Language	English
Publishing date	2021-03-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000007422
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